GREMLIN Database
Q9HN03 - Uncharacterized protein
UniProt: Q9HN03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (379)
Sequences: 1273 (746)
Seq/√Len: 38.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_F53_I6.5381.00
21_W292_T4.9621.00
12_A268_L4.9471.00
84_A119_T4.2811.00
23_I108_T4.0901.00
163_E169_A3.6871.00
334_V339_I3.5671.00
170_L237_G3.1841.00
288_V292_T3.1671.00
137_T141_L3.0911.00
60_V280_S3.0051.00
136_A140_V2.9371.00
43_T46_R2.8591.00
183_F186_L2.8541.00
297_M300_A2.7451.00
87_I91_T2.5791.00
206_P217_A2.5361.00
88_A112_V2.5071.00
316_A340_I2.4831.00
36_A246_G2.3871.00
183_F188_G2.2681.00
21_W293_G2.2640.99
207_S211_R2.2610.99
327_A334_V2.2260.99
10_V14_V2.2120.99
301_L341_V2.1830.99
98_A102_A2.0890.99
55_G253_A2.0880.99
183_F190_D2.0730.99
219_A223_A2.0720.99
380_A384_G2.0510.99
193_R199_L2.0470.99
186_L190_D2.0250.99
183_F187_G1.9650.99
186_L191_A1.9620.99
213_A223_A1.9530.98
258_V286_L1.9440.98
40_N303_Q1.9430.98
57_A61_F1.8980.98
121_L126_G1.8810.98
226_L229_D1.8490.98
213_A217_A1.8470.98
42_I243_L1.8330.98
185_F188_G1.8160.98
211_R215_T1.8100.97
70_V113_T1.8050.97
178_T181_I1.7730.97
139_W143_P1.7700.97
115_A247_G1.7580.97
184_A188_G1.7560.97
219_A222_V1.7500.97
198_S201_S1.7420.97
18_F22_A1.7290.97
132_Y375_L1.6820.96
75_I120_G1.6800.96
113_T135_I1.6600.96
189_P193_R1.6480.96
217_A220_A1.6450.96
45_M49_F1.6410.95
17_L84_A1.6250.95
88_A92_A1.6190.95
20_A25_A1.6140.95
19_M92_A1.5920.95
42_I46_R1.5890.95
8_T82_P1.5820.94
204_G208_L1.5680.94
183_F191_A1.5650.94
188_G191_A1.5610.94
154_A346_G1.5380.94
16_S259_G1.5210.93
8_T86_T1.5190.93
133_Q137_T1.5080.93
210_G214_A1.5030.93
262_V282_G1.5010.93
151_Y350_A1.5000.93
153_T315_A1.4910.93
22_A97_A1.4900.92
258_V282_G1.4890.92
54_L247_G1.4880.92
188_G192_A1.4850.92
39_A243_L1.4760.92
259_G266_L1.4710.92
94_L98_A1.4530.92
367_T376_V1.4530.92
185_F189_P1.4490.91
18_F97_A1.4470.91
305_Y363_K1.4450.91
91_T381_A1.4230.91
375_L380_A1.4220.91
117_V132_Y1.4190.91
123_M386_F1.4170.90
187_G192_A1.4070.90
101_F293_G1.4030.90
35_P340_I1.3920.90
202_V210_G1.3910.90
10_V149_T1.3890.90
44_V298_I1.3820.89
29_G286_L1.3750.89
48_G291_W1.3690.89
36_A317_L1.3650.89
336_F339_I1.3620.89
218_V222_V1.3540.88
269_I278_V1.3540.88
20_A261_A1.3530.88
156_S160_T1.3520.88
301_L344_I1.3470.88
206_P209_V1.3410.88
156_S177_I1.3320.87
362_R365_A1.3310.87
293_G296_R1.3220.87
74_L359_V1.3190.87
312_R351_A1.3140.87
56_L60_V1.3070.86
75_I389_V1.3020.86
313_S317_L1.2920.86
350_A355_G1.2740.85
72_G320_S1.2640.85
351_A355_G1.2590.84
328_V331_G1.2580.84
242_L313_S1.2530.84
377_V381_A1.2480.84
384_G388_A1.2470.84
142_T338_E1.2460.84
94_L278_V1.2370.83
17_L285_G1.2340.83
165_V168_P1.2290.83
226_L230_S1.2280.83
55_G290_S1.2250.83
185_F199_L1.2230.83
185_F275_L1.2140.82
60_V283_G1.2070.82
384_G387_A1.1940.81
278_V283_G1.1940.81
242_L317_L1.1930.81
320_S347_S1.1870.81
187_G190_D1.1830.80
158_R162_H1.1810.80
193_R196_A1.1680.79
183_F195_I1.1660.79
242_L248_L1.1620.79
18_F293_G1.1550.79
176_A215_T1.1540.79
188_G198_S1.1510.78
57_A251_F1.1490.78
185_F194_S1.1440.78
184_A187_G1.1400.78
197_W201_S1.1390.78
153_T244_A1.1340.77
315_A383_Y1.1340.77
49_F176_A1.1340.77
176_A180_N1.1300.77
47_A348_G1.1280.77
360_S363_K1.1230.77
196_A199_L1.1190.76
308_L344_I1.1190.76
85_A116_V1.1060.76
157_L161_A1.1020.75
36_A96_V1.0950.75
185_F191_A1.0940.75
205_T212_G1.0930.75
110_F338_E1.0700.73
217_A221_A1.0620.73
95_L106_I1.0610.73
306_S358_G1.0600.72
258_V382_S1.0590.72
50_V291_W1.0580.72
67_S266_L1.0580.72
17_L281_G1.0560.72
224_G380_A1.0500.72
187_G199_L1.0490.72
131_K134_Q1.0450.71
108_T259_G1.0440.71
179_A236_R1.0410.71
146_G248_L1.0410.71
18_F298_I1.0380.71
54_L61_F1.0320.70
235_S310_P1.0310.70
21_W97_A1.0270.70
74_L263_G1.0210.70
10_V178_T1.0210.70
130_P272_E1.0200.69
144_F168_P1.0180.69
140_V144_F1.0180.69
35_P316_A1.0170.69
157_L178_T1.0110.69
315_A358_G1.0060.68
279_L283_G1.0000.68
115_A328_V0.9960.68
214_A218_V0.9960.68
91_T382_S0.9940.67
216_L219_A0.9940.67
72_G275_L0.9900.67
71_G111_T0.9900.67
142_T145_V0.9880.67
257_Q337_N0.9830.67
27_S31_T0.9820.67
184_A190_D0.9790.66
189_P192_A0.9770.66
34_A116_V0.9690.65
264_P282_G0.9690.65
72_G131_K0.9670.65
192_A197_W0.9630.65
174_V318_I0.9590.65
15_A325_Q0.9530.64
191_A199_L0.9500.64
88_A93_A0.9390.63
210_G219_A0.9330.62
76_V206_P0.9300.62
32_P324_A0.9300.62
248_L317_L0.9300.62
110_F114_G0.9250.62
56_L287_L0.9220.62
72_G286_L0.9220.62
91_T343_A0.9210.61
277_Y315_A0.9180.61
204_G211_R0.9140.61
255_G304_D0.9120.61
35_P154_A0.9040.60
203_A207_S0.9030.60
221_A225_A0.9020.60
319_P343_A0.9000.60
306_S324_A0.8970.59
184_A198_S0.8960.59
249_V339_I0.8950.59
157_L177_I0.8940.59
282_G290_S0.8940.59
244_A365_A0.8930.59
316_A344_I0.8910.59
258_V327_A0.8900.59
138_L142_T0.8890.59
54_L283_G0.8880.59
39_A96_V0.8870.59
40_N261_A0.8870.59
39_A80_L0.8860.58
291_W386_F0.8840.58
62_Q242_L0.8820.58
205_T224_G0.8810.58
19_M89_L0.8750.57
249_V259_G0.8720.57
72_G136_A0.8690.57
74_L288_V0.8660.57
205_T284_V0.8600.56
152_V156_S0.8590.56
90_S130_P0.8550.56
75_I384_G0.8540.56
91_T281_G0.8520.55
113_T343_A0.8490.55
163_E296_R0.8480.55
75_I158_R0.8460.55
292_T295_P0.8450.55
72_G272_E0.8440.55
189_P251_F0.8420.55
148_G202_V0.8410.54
155_R350_A0.8380.54
200_A204_G0.8380.54
305_Y364_M0.8280.53
39_A296_R0.8260.53
221_A226_L0.8230.53
141_L332_I0.8220.53
297_M341_V0.8200.53
122_A383_Y0.8200.53
75_I326_S0.8160.52
294_A302_S0.8150.52
202_V380_A0.8130.52
308_L327_A0.8120.52
351_A376_V0.8120.52
33_F42_I0.8110.52
33_F50_V0.8110.52
37_V47_A0.8110.52
52_G250_A0.8090.52
14_V17_L0.8060.51
72_G115_A0.8060.51
198_S203_A0.8050.51
200_A288_V0.8050.51
190_D194_S0.8040.51
139_W264_P0.8040.51
146_G339_I0.8040.51
257_Q260_L0.8030.51
132_Y135_I0.8020.51
107_A238_Q0.7990.51
98_A165_V0.7960.50
31_T257_Q0.7950.50
229_D338_E0.7900.50
96_V378_A0.7900.50
235_S350_A0.7880.50
206_P210_G0.7850.49
187_G194_S0.7850.49
137_T140_V0.7850.49
188_G245_L0.7840.49
322_A339_I0.7810.49
158_R360_S0.7780.49
243_L334_V0.7780.49
323_I376_V0.7750.49
111_T338_E0.7740.48
186_L189_P0.7730.48
269_I356_G0.7710.48
379_F385_V0.7710.48
382_S386_F0.7680.48
206_P214_A0.7670.48
70_V263_G0.7660.48
126_G379_F0.7620.47
211_R228_C0.7600.47
223_A388_A0.7600.47
105_P367_T0.7590.47
150_A343_A0.7580.47
42_I150_A0.7570.47
99_G290_S0.7540.47
117_V121_L0.7540.47
91_T287_L0.7530.47
98_A128_A0.7520.47
188_G194_S0.7510.46
204_G223_A0.7510.46
258_V264_P0.7490.46
131_K378_A0.7480.46
150_A319_P0.7460.46
243_L291_W0.7460.46
8_T14_V0.7420.46
357_G382_S0.7420.46
109_A337_N0.7380.45
187_G193_R0.7360.45
258_V285_G0.7350.45
308_L316_A0.7350.45
155_R159_D0.7340.45
195_I199_L0.7320.45
287_L290_S0.7300.45
56_L283_G0.7280.44
64_A329_F0.7260.44
20_A29_G0.7260.44
120_G385_V0.7250.44
217_A326_S0.7240.44
135_I147_G0.7240.44
225_A231_A0.7230.44
22_A36_A0.7210.44
92_A324_A0.7210.44
365_A372_V0.7200.44
111_T245_L0.7200.44
134_Q330_F0.7190.44
300_A367_T0.7180.44
70_V116_V0.7170.43
51_V290_S0.7160.43
71_G267_P0.7120.43
249_V308_L0.7120.43
98_A168_P0.7110.43
115_A119_T0.7110.43
229_D232_G0.7110.43
157_L244_A0.7090.43
170_L324_A0.7080.43
301_L317_L0.7070.43
120_G375_L0.7070.43
50_V386_F0.7060.42
205_T208_L0.7040.42
29_G37_V0.7040.42
220_A226_L0.7030.42
79_P98_A0.7020.42
153_T322_A0.7000.42
278_V285_G0.7000.42
246_G317_L0.7000.42
184_A192_A0.6980.42
246_G310_P0.6950.41
95_L374_S0.6930.41
318_I334_V0.6920.41
170_L305_Y0.6920.41
104_Y147_G0.6910.41
62_Q339_I0.6900.41
195_I198_S0.6900.41
183_F193_R0.6890.41
16_S89_L0.6870.41
207_S210_G0.6850.41
60_V279_L0.6830.40
36_A39_A0.6830.40
259_G337_N0.6820.40
27_S256_S0.6810.40
249_V340_I0.6790.40
13_A265_L0.6740.40
108_T295_P0.6730.40
114_G139_W0.6720.39
75_I119_T0.6720.39
120_G124_G0.6710.39
373_A377_V0.6690.39
56_L235_S0.6690.39
327_A375_L0.6680.39
27_S257_Q0.6680.39
72_G161_A0.6670.39
180_N205_T0.6670.39
328_V338_E0.6670.39
210_G218_V0.6660.39
240_H249_V0.6620.39
88_A382_S0.6620.39
51_V99_G0.6610.39
29_G290_S0.6600.38
111_T122_A0.6580.38
209_V278_V0.6570.38
222_V227_Y0.6570.38
52_G291_W0.6550.38
55_G302_S0.6540.38
173_G176_A0.6530.38
87_I389_V0.6530.38
187_G191_A0.6530.38
207_S326_S0.6520.38
8_T388_A0.6510.38
172_G176_A0.6480.37
29_G336_F0.6470.37
41_A239_R0.6440.37
159_D384_G0.6430.37
304_D338_E0.6400.37
195_I208_L0.6400.37
71_G320_S0.6400.37
69_A73_D0.6380.37
54_L241_F0.6380.37
33_F305_Y0.6360.36
71_G316_A0.6340.36
64_A346_G0.6330.36
144_F272_E0.6320.36
133_Q209_V0.6310.36
145_V222_V0.6300.36
221_A230_S0.6290.36
255_G340_I0.6220.35
26_G31_T0.6220.35
305_Y367_T0.6220.35
108_T140_V0.6210.35
16_S48_G0.6180.35
207_S226_L0.6170.35
80_L124_G0.6160.35
153_T284_V0.6160.35
213_A225_A0.6160.35
277_Y281_G0.6150.35
211_R380_A0.6150.35
14_V362_R0.6140.35
150_A276_P0.6070.34
161_A255_G0.6070.34
86_T280_S0.6060.34
38_G285_G0.6040.34
148_G379_F0.6040.34
117_V128_A0.6040.34
152_V216_L0.6020.34
52_G287_L0.6020.34
203_A380_A0.6010.34
13_A281_G0.6000.34
125_G288_V0.5990.33
280_S364_M0.5980.33
221_A224_G0.5980.33
145_V332_I0.5970.33
334_V365_A0.5960.33
369_L373_A0.5940.33
41_A113_T0.5930.33
42_I317_L0.5930.33
96_V278_V0.5930.33
180_N223_A0.5930.33
69_A342_S0.5920.33
159_D176_A0.5920.33
186_L203_A0.5920.33
211_R214_A0.5910.33
30_S256_S0.5910.33
8_T147_G0.5900.33
253_A257_Q0.5900.33
124_G146_G0.5900.33
228_C388_A0.5880.33
42_I50_V0.5880.33
210_G296_R0.5870.32
63_G264_P0.5840.32
56_L291_W0.5820.32
40_N200_A0.5800.32
296_R299_K0.5800.32
117_V127_P0.5800.32
41_A305_Y0.5800.32
112_V327_A0.5790.32
166_L169_A0.5790.32
36_A239_R0.5790.32
314_I367_T0.5790.32
121_L124_G0.5780.32
98_A212_G0.5780.32
78_M204_G0.5770.32
63_G66_V0.5760.32
12_A86_T0.5750.32
299_K304_D0.5750.32
39_A49_F0.5730.31
186_L193_R0.5730.31
190_D193_R0.5730.31
241_F309_G0.5720.31
99_G337_N0.5700.31
231_A234_A0.5700.31
43_T389_V0.5690.31
180_N224_G0.5680.31
199_L326_S0.5660.31
202_V206_P0.5660.31
81_S150_A0.5660.31
48_G355_G0.5650.31
115_A255_G0.5640.31
297_M370_A0.5640.31
10_V201_S0.5610.30
132_Y320_S0.5610.30
19_M38_G0.5590.30
144_F344_I0.5590.30
216_L226_L0.5580.30
183_F197_W0.5570.30
22_A100_V0.5530.30
190_D199_L0.5530.30
213_A218_V0.5520.30
18_F146_G0.5510.30
86_T179_A0.5510.30
188_G196_A0.5500.30
205_T217_A0.5500.30
40_N186_L0.5500.30
66_V282_G0.5490.30
365_A369_L0.5480.29
10_V156_S0.5480.29
20_A285_G0.5470.29
17_L119_T0.5470.29
70_V301_L0.5450.29
40_N176_A0.5450.29
88_A123_M0.5450.29
14_V244_A0.5440.29
145_V389_V0.5420.29
45_M345_I0.5420.29
152_V165_V0.5410.29
161_A238_Q0.5400.29
119_T309_G0.5400.29
88_A263_G0.5390.29
117_V134_Q0.5380.29
170_L175_G0.5370.29
62_Q240_H0.5370.29
385_V389_V0.5370.29
324_A367_T0.5360.29
186_L196_A0.5340.28
130_P288_V0.5310.28
96_V239_R0.5290.28
16_S265_L0.5290.28
37_V175_G0.5290.28
23_I259_G0.5280.28
315_A365_A0.5270.28
19_M34_A0.5260.28
19_M259_G0.5250.28
222_V225_A0.5250.28
10_V236_R0.5240.28
83_L325_Q0.5230.28
292_T320_S0.5210.28
185_F196_A0.5200.27
34_A326_S0.5200.27
132_Y136_A0.5200.27
184_A194_S0.5190.27
151_Y250_A0.5190.27
164_R207_S0.5180.27
204_G226_L0.5180.27
227_Y372_V0.5170.27
43_T213_A0.5160.27
217_A223_A0.5160.27
39_A67_S0.5150.27
250_A263_G0.5120.27
295_P303_Q0.5120.27
146_G319_P0.5100.27
12_A295_P0.5100.27
211_R220_A0.5090.27
33_F239_R0.5080.27
261_A314_I0.5080.27
18_F93_A0.5060.26
154_A235_S0.5060.26
182_E194_S0.5050.26
179_A275_L0.5040.26
68_E272_E0.5030.26
231_A357_G0.5030.26
69_A254_G0.5030.26
246_G251_F0.5030.26
146_G326_S0.5020.26
125_G178_T0.5020.26
83_L385_V0.5020.26
150_A174_V0.5000.26
179_A206_P0.5000.26
104_Y242_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iyzA 3 0.3511 42.8 0.973 Contact Map
2zz9A 3 0.3511 41.3 0.973 Contact Map
3gd8A 4 0.3537 34.9 0.974 Contact Map
4nefA 4 0.3919 33.1 0.975 Contact Map
3d9sA 3 0.402 31.9 0.975 Contact Map
2xq2A 2 0.514 29.6 0.975 Contact Map
2b6oA 6 0.3868 22.2 0.977 Contact Map
2kncA 1 0.1221 20.5 0.977 Contact Map
3dh4A 3 0.486 18.5 0.978 Contact Map
1j4nA 4 0.3868 16 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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