GREMLIN Database
Q9HN01 - Uncharacterized protein
UniProt: Q9HN01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (84)
Sequences: 429 (241)
Seq/√Len: 26.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_R89_D3.7021.00
61_V79_A3.5661.00
17_I69_I3.3091.00
18_T45_R2.5350.99
87_Y91_T2.5250.99
21_R48_E2.4960.99
21_R44_S2.2870.98
30_R82_A2.1590.97
57_V68_A1.9930.95
27_F80_E1.9230.95
35_L42_Y1.8910.94
18_T72_D1.7290.91
68_A77_A1.6780.89
21_R28_C1.6670.89
60_I77_A1.5870.86
54_R80_E1.4490.81
60_I70_V1.3570.76
81_S93_G1.2970.73
18_T56_A1.2950.73
28_C46_Y1.2900.72
70_V75_G1.2710.71
41_A51_H1.2620.71
16_H73_E1.2080.67
44_S48_E1.1950.66
27_F81_S1.1800.65
18_T70_V1.1580.64
29_E33_N1.1460.63
11_P70_V1.1350.62
24_A63_A1.1310.62
76_V87_Y1.1260.62
55_D59_R1.1210.61
20_Y48_E1.1030.60
20_Y28_C1.0870.59
15_A72_D1.0830.59
34_R85_V1.0700.58
27_F47_V1.0660.57
54_R81_S1.0650.57
35_L44_S1.0320.55
83_N86_A1.0140.54
63_A79_A1.0120.53
45_R56_A1.0090.53
15_A73_E1.0080.53
65_T79_A0.9820.51
28_C44_S0.9740.51
38_L88_L0.9720.50
20_Y64_R0.9660.50
29_E32_V0.9620.50
68_A79_A0.9500.49
29_E49_P0.9350.48
84_I92_Y0.9310.47
16_H72_D0.9230.47
55_D85_V0.9210.47
55_D66_V0.9090.46
26_P47_V0.9020.45
48_E51_H0.8990.45
64_R79_A0.8860.44
24_A30_R0.8830.44
25_C28_C0.8710.43
19_L32_V0.8610.42
56_A59_R0.8590.42
21_R42_Y0.8470.41
59_R78_M0.8190.39
25_C79_A0.8100.39
43_Q57_V0.8060.38
82_A90_A0.7990.38
47_V57_V0.7980.38
23_Q29_E0.7860.37
84_I87_Y0.7860.37
22_L25_C0.7850.37
36_E39_G0.7770.36
33_N46_Y0.7640.35
20_Y45_R0.7620.35
39_G46_Y0.7580.35
39_G90_A0.7570.35
22_L49_P0.7440.34
20_Y70_V0.7330.33
21_R29_E0.7330.33
21_R46_Y0.7330.33
22_L51_H0.7250.33
23_Q90_A0.7170.32
71_D92_Y0.7120.32
23_Q46_Y0.7090.32
17_I35_L0.7070.32
55_D58_K0.7030.31
27_F54_R0.6970.31
58_K62_G0.6860.30
26_P81_S0.6790.30
23_Q56_A0.6780.30
41_A73_E0.6760.30
59_R91_T0.6730.30
57_V66_V0.6630.29
11_P76_V0.6570.29
76_V90_A0.6550.28
17_I43_Q0.6540.28
22_L63_A0.6360.27
41_A53_E0.6360.27
87_Y92_Y0.6350.27
86_A91_T0.6310.27
28_C64_R0.6310.27
27_F49_P0.6300.27
35_L91_T0.6280.27
13_S73_E0.6200.26
47_V53_E0.6130.26
37_E57_V0.5970.25
14_D83_N0.5970.25
60_I85_V0.5890.25
56_A60_I0.5780.24
52_S66_V0.5780.24
15_A70_V0.5700.24
33_N48_E0.5620.23
19_L44_S0.5600.23
10_P35_L0.5510.23
19_L69_I0.5470.22
15_A43_Q0.5450.22
54_R93_G0.5440.22
46_Y53_E0.5400.22
13_S19_L0.5320.22
70_V79_A0.5270.21
24_A45_R0.5270.21
19_L29_E0.5240.21
58_K63_A0.5240.21
11_P14_D0.5180.21
11_P58_K0.5160.21
52_S55_D0.5120.21
26_P80_E0.5030.20
22_L26_P0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vlnA 2 0.9583 99.3 0.643 Contact Map
3q18A 2 0.9479 99.3 0.644 Contact Map
4agsA 3 0.8646 99.3 0.645 Contact Map
4lmwA 2 0.875 99.3 0.647 Contact Map
4o7hA 2 0.8229 99.3 0.648 Contact Map
3rbtA 2 0.9792 99.3 0.649 Contact Map
4kh7A 2 0.8854 99.3 0.651 Contact Map
3einA 2 0.8125 99.3 0.651 Contact Map
3f6dA 2 0.8229 99.3 0.652 Contact Map
4puaA 2 0.9896 99.3 0.652 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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