GREMLIN Database
Q9HN00 - Uncharacterized protein
UniProt: Q9HN00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (144)
Sequences: 11083 (6495)
Seq/√Len: 541.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_P142_A3.1741.00
26_I37_D2.9811.00
47_G79_Q2.9561.00
57_D91_H2.6871.00
77_R169_D2.6861.00
22_A118_Y2.6561.00
29_L33_E2.4741.00
26_I39_A2.3321.00
141_G147_E2.2541.00
70_R101_Q2.2211.00
28_P37_D2.1921.00
21_D145_T2.1871.00
122_H134_R2.0811.00
17_A20_D1.9851.00
113_G117_A1.9561.00
30_V95_I1.9531.00
85_I112_A1.8631.00
24_D41_A1.8601.00
39_A42_D1.7431.00
141_G145_T1.7321.00
72_R161_Y1.6571.00
115_A133_H1.6461.00
68_E72_R1.6241.00
27_R114_V1.6171.00
85_I115_A1.6091.00
38_V43_L1.6011.00
24_D39_A1.5801.00
148_Y167_A1.5741.00
27_R107_F1.5581.00
58_G98_R1.5181.00
29_L38_V1.5041.00
29_L105_G1.4711.00
75_H79_Q1.4561.00
66_Y100_I1.4511.00
49_V144_G1.4471.00
48_P78_A1.4281.00
50_V139_V1.4141.00
78_A168_L1.3941.00
58_G93_T1.3871.00
73_G76_E1.3801.00
70_R103_F1.3381.00
116_E121_E1.3221.00
49_V81_V1.3221.00
72_R162_D1.2931.00
22_A140_I1.2911.00
112_A116_E1.2901.00
49_V79_Q1.2871.00
28_P88_P1.2791.00
92_K96_K1.2711.00
162_D166_A1.2701.00
43_L49_V1.2551.00
112_A121_E1.2101.00
43_L81_V1.2051.00
67_S71_E1.1691.00
140_I146_V1.1451.00
120_V138_V1.1411.00
64_D158_F1.1371.00
16_V146_V1.1351.00
48_P147_E1.1281.00
52_V66_Y1.1121.00
85_I133_H1.1101.00
89_Y93_T1.0941.00
79_Q105_G1.0791.00
53_F83_V1.0781.00
163_E166_A1.0701.00
24_D40_L1.0681.00
82_G106_L1.0561.00
58_G97_D1.0501.00
120_V136_A1.0481.00
67_S70_R1.0421.00
150_W167_A1.0281.00
18_A148_Y1.0141.00
139_V167_A1.0131.00
147_E153_Q1.0111.00
92_K95_I1.0061.00
68_E71_E0.9931.00
88_P108_S0.9891.00
29_L107_F0.9851.00
136_A151_V0.9841.00
166_A169_D0.9741.00
138_V146_V0.9661.00
134_R151_V0.9641.00
52_V103_F0.9611.00
93_T96_K0.9551.00
31_T92_K0.9501.00
73_G165_E0.9441.00
114_V118_Y0.9421.00
49_V140_I0.9401.00
113_G116_E0.9391.00
87_T90_E0.9381.00
58_G90_E0.9361.00
66_Y82_G0.9341.00
159_P162_D0.9311.00
54_T82_G0.9281.00
73_G169_D0.9251.00
112_A115_A0.9241.00
64_D67_S0.9221.00
69_L80_V0.9131.00
67_S98_R0.9001.00
48_P168_L0.8971.00
30_V92_K0.8961.00
115_A121_E0.8821.00
40_L49_V0.8761.00
83_V114_V0.8621.00
46_E142_A0.8561.00
63_T98_R0.8531.00
18_A149_A0.8491.00
41_A45_A0.8451.00
22_A146_V0.8441.00
139_V150_W0.8441.00
81_V107_F0.8351.00
38_V81_V0.8291.00
50_V78_A0.8271.00
25_F118_Y0.8111.00
150_W164_L0.8101.00
22_A40_L0.8071.00
54_T57_D0.8021.00
50_V137_T0.8021.00
28_P110_P0.7931.00
69_L164_L0.7801.00
150_W163_E0.7791.00
51_L140_I0.7781.00
56_M86_S0.7751.00
45_A144_G0.7711.00
74_V165_E0.7711.00
134_R152_A0.7711.00
25_F114_V0.7701.00
73_G77_R0.7671.00
153_Q157_E0.7511.00
87_T110_P0.7491.00
31_T95_I0.7491.00
22_A114_V0.7481.00
139_V148_Y0.7411.00
65_M69_L0.7361.00
64_D68_E0.7351.00
43_L79_Q0.7311.00
148_Y163_E0.7301.00
53_F120_V0.7291.00
51_L118_Y0.7121.00
18_A146_V0.7101.00
159_P163_E0.7091.00
137_T164_L0.7081.00
85_I109_D0.6941.00
30_V88_P0.6941.00
124_P132_E0.6851.00
109_D112_A0.6811.00
165_E169_D0.6791.00
17_A149_A0.6761.00
140_I144_G0.6751.00
40_L43_L0.6671.00
77_R168_L0.6641.00
54_T91_H0.6501.00
50_V164_L0.6471.00
59_A135_P0.6431.00
90_E93_T0.6431.00
52_V65_M0.6421.00
80_V103_F0.6291.00
25_F40_L0.6281.00
52_V82_G0.6231.00
122_H125_D0.6211.00
53_F118_Y0.6201.00
55_P59_A0.6191.00
68_E161_Y0.6141.00
23_P117_A0.6071.00
16_V20_D0.5991.00
74_V78_A0.5951.00
91_H106_L0.5901.00
61_P156_P0.5901.00
150_W160_A0.5871.00
156_P159_P0.5800.99
146_V149_A0.5770.99
101_Q105_G0.5740.99
78_A139_V0.5740.99
30_V105_G0.5720.99
124_P127_M0.5710.99
45_A143_D0.5660.99
85_I121_E0.5650.99
136_A149_A0.5630.99
20_D149_A0.5620.99
77_R165_E0.5610.99
50_V168_L0.5610.99
61_P157_E0.5590.99
147_E167_A0.5560.99
122_H155_W0.5550.99
114_V117_A0.5530.99
139_V168_L0.5520.99
60_F64_D0.5470.99
56_M87_T0.5470.99
66_Y103_F0.5430.99
89_Y92_K0.5400.99
38_V107_F0.5390.99
68_E162_D0.5380.99
54_T94_T0.5340.99
31_T105_G0.5330.99
38_V42_D0.5320.99
24_D45_A0.5310.99
57_D90_E0.5300.99
69_L161_Y0.5290.99
121_E132_E0.5290.99
48_P141_G0.5270.99
33_E37_D0.5260.99
21_D45_A0.5260.99
56_M59_A0.5250.99
106_L109_D0.5210.99
95_I99_G0.5200.99
88_P92_K0.5190.99
160_A163_E0.5190.99
118_Y140_I0.5130.99
134_R155_W0.5110.99
22_A49_V0.5090.99
47_G75_H0.5080.99
29_L88_P0.5080.99
43_L105_G0.5040.98
30_V33_E0.5040.98
40_L118_Y0.5030.98
21_D24_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v2gA 2 0.8713 100 0.371 Contact Map
3a2vA 5 0.8713 100 0.371 Contact Map
1prxA 2 0.8889 100 0.375 Contact Map
3w6gA 6 0.8421 100 0.377 Contact Map
1xiyA 1 0.883 100 0.379 Contact Map
1xccA 2 0.8772 100 0.379 Contact Map
1xvwA 3 0.8889 100 0.424 Contact Map
3kebA 2 0.9415 100 0.429 Contact Map
3p7xA 3 0.9357 100 0.431 Contact Map
1q98A 2 0.9357 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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