GREMLIN Database
Q9HMZ9 - Uncharacterized protein
UniProt: Q9HMZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (184)
Sequences: 6020 (4004)
Seq/√Len: 295.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A18_G4.8081.00
22_F31_A4.0511.00
18_G156_D3.2331.00
33_D36_D3.0621.00
60_P64_A2.7581.00
8_A124_R2.5671.00
66_V76_R2.3741.00
12_E16_E2.2901.00
33_D126_A2.2451.00
34_A57_F2.2041.00
61_D123_E2.1841.00
17_G36_D2.1051.00
148_D152_R2.0301.00
22_F118_A2.0261.00
21_V155_V2.0131.00
14_L125_V1.9221.00
53_K136_S1.8881.00
32_A39_A1.8661.00
135_V150_A1.8441.00
41_E45_E1.8291.00
79_M89_V1.8251.00
13_A157_A1.7891.00
143_N146_A1.7851.00
19_L46_A1.7481.00
62_V80_A1.7141.00
69_V91_C1.7061.00
174_D177_R1.6941.00
18_G42_A1.6891.00
120_A123_E1.6891.00
60_P123_E1.6791.00
37_P100_V1.6491.00
72_G75_E1.6311.00
60_P122_L1.6161.00
174_D179_E1.6081.00
180_I188_D1.5501.00
76_R80_A1.5321.00
42_A45_E1.5251.00
64_A67_E1.5101.00
11_A124_R1.4961.00
166_G185_A1.4951.00
120_A124_R1.4871.00
135_V154_R1.4871.00
37_P98_P1.4691.00
90_V181_L1.4671.00
7_L124_R1.4671.00
59_F65_A1.4631.00
11_A125_V1.4631.00
88_T109_G1.4441.00
35_L126_A1.4421.00
148_D158_V1.4411.00
90_V107_R1.4081.00
59_F112_V1.4021.00
68_H110_V1.3781.00
11_A15_R1.3571.00
61_D64_A1.3381.00
21_V147_L1.3281.00
62_V112_V1.3151.00
112_V119_V1.2981.00
41_E100_V1.2911.00
22_F121_L1.2631.00
138_E150_A1.2601.00
70_A92_E1.2491.00
145_A149_P1.2421.00
22_F130_A1.2381.00
92_E106_D1.2341.00
119_V123_E1.2281.00
9_E12_E1.2231.00
62_V76_R1.2081.00
37_P41_E1.1931.00
71_V79_M1.1921.00
41_E51_R1.1841.00
70_A95_D1.1811.00
44_F51_R1.1801.00
36_D39_A1.1791.00
12_E15_R1.1681.00
42_A156_D1.1611.00
67_E96_S1.1591.00
7_L121_L1.1551.00
69_V110_V1.1431.00
26_T170_S1.1361.00
14_L128_L1.1231.00
114_D165_P1.1181.00
13_A156_D1.1151.00
121_L159_V1.1111.00
107_R176_A1.1041.00
46_A154_R1.0881.00
114_D119_V1.0791.00
58_A130_A1.0761.00
89_V173_V1.0681.00
31_A128_L1.0671.00
8_A12_E1.0661.00
63_E66_V1.0491.00
93_K102_T1.0481.00
116_E120_A1.0391.00
32_A43_A1.0301.00
144_P160_D1.0271.00
75_E79_M1.0261.00
75_E175_V1.0261.00
48_R135_V1.0231.00
117_V161_A1.0041.00
143_N163_E0.9711.00
62_V79_M0.9681.00
113_P119_V0.9591.00
117_V159_V0.9541.00
43_A129_T0.9531.00
46_A151_F0.9481.00
113_P118_A0.9461.00
83_L87_V0.9221.00
56_S109_G0.9201.00
64_A122_L0.9111.00
87_V173_V0.9071.00
35_L98_P0.9061.00
74_T77_A0.9061.00
73_E76_R0.9021.00
93_K99_D0.9011.00
168_T185_A0.9011.00
33_D125_V0.8991.00
65_A71_V0.8941.00
14_L121_L0.8871.00
147_L158_V0.8811.00
40_I100_V0.8811.00
21_V144_P0.8751.00
17_G33_D0.8641.00
69_V108_V0.8601.00
69_V94_R0.8561.00
65_A110_V0.8551.00
78_F87_V0.8541.00
19_L42_A0.8531.00
49_R134_N0.8411.00
20_V157_A0.8371.00
15_R126_A0.8361.00
115_S118_A0.8321.00
14_L126_A0.8281.00
82_F186_V0.8281.00
35_L68_H0.8271.00
25_E113_P0.8171.00
59_F64_A0.8041.00
141_V147_L0.8041.00
58_A122_L0.8001.00
48_R154_R0.7980.99
70_A94_R0.7980.99
97_V108_V0.7950.99
79_M112_V0.7930.99
77_A81_E0.7910.99
19_L156_D0.7830.99
152_R155_V0.7830.99
57_F68_H0.7800.99
27_V134_N0.7740.99
21_V158_V0.7680.99
144_P147_L0.7660.99
65_A91_C0.7620.99
87_V171_T0.7610.99
71_V91_C0.7590.99
83_L89_V0.7550.99
31_A118_A0.7510.99
79_M83_L0.7500.99
125_V128_L0.7400.99
107_R174_D0.7370.99
21_V30_L0.7360.99
74_T175_V0.7310.99
118_A130_A0.7290.99
140_S169_G0.7280.99
91_C175_V0.7270.99
78_F82_F0.7220.99
144_P158_V0.7200.99
9_E13_A0.7050.99
53_K103_G0.7040.99
78_F175_V0.7020.99
87_V186_V0.6980.99
75_E91_C0.6960.99
135_V138_E0.6960.99
122_L128_L0.6910.99
6_A9_E0.6900.99
13_A16_E0.6890.99
146_A150_A0.6880.99
64_A127_P0.6870.98
155_V158_V0.6860.98
57_F108_V0.6840.98
180_I183_A0.6840.98
131_T134_N0.6830.98
183_A188_D0.6830.98
10_A121_L0.6830.98
17_G38_D0.6820.98
83_L112_V0.6810.98
141_V150_A0.6780.98
66_V70_A0.6760.98
67_E94_R0.6760.98
6_A159_V0.6730.98
116_E119_V0.6720.98
74_T178_G0.6720.98
71_V76_R0.6680.98
31_A130_A0.6670.98
77_A80_A0.6570.98
75_E89_V0.6570.98
27_V169_G0.6540.98
28_Y162_G0.6530.98
14_L33_D0.6480.98
10_A13_A0.6450.98
27_V132_S0.6440.98
7_L117_V0.6410.98
73_E77_A0.6350.97
133_A147_L0.6350.97
52_E139_P0.6340.97
109_G172_V0.6330.97
82_F87_V0.6240.97
56_S130_A0.6210.97
6_A157_A0.6210.97
121_L128_L0.6120.97
44_F55_L0.6110.97
9_E157_A0.6060.97
93_K106_D0.6040.97
25_E86_P0.6040.97
10_A157_A0.5990.96
38_D41_E0.5970.96
49_R136_S0.5960.96
68_H97_V0.5940.96
141_V146_A0.5890.96
66_V71_V0.5880.96
60_P119_V0.5850.96
117_V120_A0.5830.96
92_E176_A0.5810.96
112_V122_L0.5800.96
47_K131_T0.5790.96
9_E16_E0.5790.96
23_P161_A0.5770.96
37_P99_D0.5760.96
101_L108_V0.5760.96
44_F49_R0.5760.96
57_F97_V0.5750.96
47_K134_N0.5740.95
29_G49_R0.5730.95
62_V66_V0.5720.95
57_F101_L0.5720.95
79_M175_V0.5690.95
64_A112_V0.5680.95
141_V151_F0.5680.95
148_D153_A0.5680.95
32_A129_T0.5660.95
122_L125_V0.5640.95
34_A40_I0.5620.95
91_C110_V0.5610.95
25_E58_A0.5590.95
22_F58_A0.5560.95
24_T31_A0.5560.95
26_T29_G0.5550.95
59_F68_H0.5550.95
31_A121_L0.5520.94
35_L127_P0.5510.94
8_A11_A0.5490.94
113_P122_L0.5480.94
86_P186_V0.5460.94
89_V175_V0.5460.94
35_L96_S0.5440.94
145_A148_D0.5430.94
19_L32_A0.5390.94
49_R132_S0.5390.94
43_A130_A0.5380.94
174_D181_L0.5340.93
93_K98_P0.5330.93
61_D119_V0.5330.93
118_A122_L0.5280.93
44_F53_K0.5230.93
42_A46_A0.5230.93
135_V151_F0.5210.93
90_V109_G0.5180.92
78_F89_V0.5150.92
40_I101_L0.5140.92
149_P152_R0.5100.92
45_E154_R0.5070.92
44_F54_P0.5060.91
88_T111_R0.5050.91
90_V174_D0.5050.91
99_D106_D0.5030.91
85_G171_T0.5020.91
152_R158_V0.5010.91
5_D9_E0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eqaA 1 1 100 0.1 Contact Map
3l7vA 1 0.9596 100 0.158 Contact Map
1jcuA 1 0.9899 100 0.178 Contact Map
1k7jA 1 0.9646 100 0.181 Contact Map
1hruA 2 0.904 100 0.205 Contact Map
3vthA 1 0.9848 100 0.23 Contact Map
4g9iA 1 0.9899 100 0.238 Contact Map
3ttcA 1 0.9545 100 0.297 Contact Map
3venA 1 0.803 97.5 0.87 Contact Map
2wqpA 2 0.8636 44.2 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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