Q9HMZ9 - HALSA - GREMLIN Contacts

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Q9HMZ9 - Uncharacterized protein

UniProt:	Q9HMZ9	Sequences: MSTDDALAEAAEALREGGLVVFPTETVYGLAADALDPDAIEAAFEAKRRPREKPLSFAFPDVEAAVEHVAVGETERAFMAEFLPGPVTVVCEKRDSVPDVLTGGRDRVGVRVPDSEVAVALLERVAPLTATSANVSGEPSVTNPAALDPAFRARVDAVVDAGESPGGTGSTVVDVARGEILRAGAVGDAVREWLAEHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	198 (184)
Sequences:	6020 (4004)
Seq/√Len:	295.1

ECOLI - YCIO TSAC
BACSU - SUA5
HALSA - Q9HMZ9
SULSO - Q7LXP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_A	18_G	4.808	1.00
22_F	31_A	4.051	1.00
18_G	156_D	3.233	1.00
33_D	36_D	3.062	1.00
60_P	64_A	2.758	1.00
8_A	124_R	2.567	1.00
66_V	76_R	2.374	1.00
12_E	16_E	2.290	1.00
33_D	126_A	2.245	1.00
34_A	57_F	2.204	1.00
61_D	123_E	2.184	1.00
17_G	36_D	2.105	1.00
148_D	152_R	2.030	1.00
22_F	118_A	2.026	1.00
21_V	155_V	2.013	1.00
14_L	125_V	1.922	1.00
53_K	136_S	1.888	1.00
32_A	39_A	1.866	1.00
135_V	150_A	1.844	1.00
41_E	45_E	1.829	1.00
79_M	89_V	1.825	1.00
13_A	157_A	1.789	1.00
143_N	146_A	1.785	1.00
19_L	46_A	1.748	1.00
62_V	80_A	1.714	1.00
69_V	91_C	1.706	1.00
174_D	177_R	1.694	1.00
18_G	42_A	1.689	1.00
120_A	123_E	1.689	1.00
60_P	123_E	1.679	1.00
37_P	100_V	1.649	1.00
72_G	75_E	1.631	1.00
60_P	122_L	1.616	1.00
174_D	179_E	1.608	1.00
180_I	188_D	1.550	1.00
76_R	80_A	1.532	1.00
42_A	45_E	1.525	1.00
64_A	67_E	1.510	1.00
11_A	124_R	1.496	1.00
166_G	185_A	1.495	1.00
120_A	124_R	1.487	1.00
135_V	154_R	1.487	1.00
37_P	98_P	1.469	1.00
90_V	181_L	1.467	1.00
7_L	124_R	1.467	1.00
59_F	65_A	1.463	1.00
11_A	125_V	1.463	1.00
88_T	109_G	1.444	1.00
35_L	126_A	1.442	1.00
148_D	158_V	1.441	1.00
90_V	107_R	1.408	1.00
59_F	112_V	1.402	1.00
68_H	110_V	1.378	1.00
11_A	15_R	1.357	1.00
61_D	64_A	1.338	1.00
21_V	147_L	1.328	1.00
62_V	112_V	1.315	1.00
112_V	119_V	1.298	1.00
41_E	100_V	1.291	1.00
22_F	121_L	1.263	1.00
138_E	150_A	1.260	1.00
70_A	92_E	1.249	1.00
145_A	149_P	1.242	1.00
22_F	130_A	1.238	1.00
92_E	106_D	1.234	1.00
119_V	123_E	1.228	1.00
9_E	12_E	1.223	1.00
62_V	76_R	1.208	1.00
37_P	41_E	1.193	1.00
71_V	79_M	1.192	1.00
41_E	51_R	1.184	1.00
70_A	95_D	1.181	1.00
44_F	51_R	1.180	1.00
36_D	39_A	1.179	1.00
12_E	15_R	1.168	1.00
42_A	156_D	1.161	1.00
67_E	96_S	1.159	1.00
7_L	121_L	1.155	1.00
69_V	110_V	1.143	1.00
26_T	170_S	1.136	1.00
14_L	128_L	1.123	1.00
114_D	165_P	1.118	1.00
13_A	156_D	1.115	1.00
121_L	159_V	1.111	1.00
107_R	176_A	1.104	1.00
46_A	154_R	1.088	1.00
114_D	119_V	1.079	1.00
58_A	130_A	1.076	1.00
89_V	173_V	1.068	1.00
31_A	128_L	1.067	1.00
8_A	12_E	1.066	1.00
63_E	66_V	1.049	1.00
93_K	102_T	1.048	1.00
116_E	120_A	1.039	1.00
32_A	43_A	1.030	1.00
144_P	160_D	1.027	1.00
75_E	79_M	1.026	1.00
75_E	175_V	1.026	1.00
48_R	135_V	1.023	1.00
117_V	161_A	1.004	1.00
143_N	163_E	0.971	1.00
62_V	79_M	0.968	1.00
113_P	119_V	0.959	1.00
117_V	159_V	0.954	1.00
43_A	129_T	0.953	1.00
46_A	151_F	0.948	1.00
113_P	118_A	0.946	1.00
83_L	87_V	0.922	1.00
56_S	109_G	0.920	1.00
64_A	122_L	0.911	1.00
87_V	173_V	0.907	1.00
35_L	98_P	0.906	1.00
74_T	77_A	0.906	1.00
73_E	76_R	0.902	1.00
93_K	99_D	0.901	1.00
168_T	185_A	0.901	1.00
33_D	125_V	0.899	1.00
65_A	71_V	0.894	1.00
14_L	121_L	0.887	1.00
147_L	158_V	0.881	1.00
40_I	100_V	0.881	1.00
21_V	144_P	0.875	1.00
17_G	33_D	0.864	1.00
69_V	108_V	0.860	1.00
69_V	94_R	0.856	1.00
65_A	110_V	0.855	1.00
78_F	87_V	0.854	1.00
19_L	42_A	0.853	1.00
49_R	134_N	0.841	1.00
20_V	157_A	0.837	1.00
15_R	126_A	0.836	1.00
115_S	118_A	0.832	1.00
14_L	126_A	0.828	1.00
82_F	186_V	0.828	1.00
35_L	68_H	0.827	1.00
25_E	113_P	0.817	1.00
59_F	64_A	0.804	1.00
141_V	147_L	0.804	1.00
58_A	122_L	0.800	1.00
48_R	154_R	0.798	0.99
70_A	94_R	0.798	0.99
97_V	108_V	0.795	0.99
79_M	112_V	0.793	0.99
77_A	81_E	0.791	0.99
19_L	156_D	0.783	0.99
152_R	155_V	0.783	0.99
57_F	68_H	0.780	0.99
27_V	134_N	0.774	0.99
21_V	158_V	0.768	0.99
144_P	147_L	0.766	0.99
65_A	91_C	0.762	0.99
87_V	171_T	0.761	0.99
71_V	91_C	0.759	0.99
83_L	89_V	0.755	0.99
31_A	118_A	0.751	0.99
79_M	83_L	0.750	0.99
125_V	128_L	0.740	0.99
107_R	174_D	0.737	0.99
21_V	30_L	0.736	0.99
74_T	175_V	0.731	0.99
118_A	130_A	0.729	0.99
140_S	169_G	0.728	0.99
91_C	175_V	0.727	0.99
78_F	82_F	0.722	0.99
144_P	158_V	0.720	0.99
9_E	13_A	0.705	0.99
53_K	103_G	0.704	0.99
78_F	175_V	0.702	0.99
87_V	186_V	0.698	0.99
75_E	91_C	0.696	0.99
135_V	138_E	0.696	0.99
122_L	128_L	0.691	0.99
6_A	9_E	0.690	0.99
13_A	16_E	0.689	0.99
146_A	150_A	0.688	0.99
64_A	127_P	0.687	0.98
155_V	158_V	0.686	0.98
57_F	108_V	0.684	0.98
180_I	183_A	0.684	0.98
131_T	134_N	0.683	0.98
183_A	188_D	0.683	0.98
10_A	121_L	0.683	0.98
17_G	38_D	0.682	0.98
83_L	112_V	0.681	0.98
141_V	150_A	0.678	0.98
66_V	70_A	0.676	0.98
67_E	94_R	0.676	0.98
6_A	159_V	0.673	0.98
116_E	119_V	0.672	0.98
74_T	178_G	0.672	0.98
71_V	76_R	0.668	0.98
31_A	130_A	0.667	0.98
77_A	80_A	0.657	0.98
75_E	89_V	0.657	0.98
27_V	169_G	0.654	0.98
28_Y	162_G	0.653	0.98
14_L	33_D	0.648	0.98
10_A	13_A	0.645	0.98
27_V	132_S	0.644	0.98
7_L	117_V	0.641	0.98
73_E	77_A	0.635	0.97
133_A	147_L	0.635	0.97
52_E	139_P	0.634	0.97
109_G	172_V	0.633	0.97
82_F	87_V	0.624	0.97
56_S	130_A	0.621	0.97
6_A	157_A	0.621	0.97
121_L	128_L	0.612	0.97
44_F	55_L	0.611	0.97
9_E	157_A	0.606	0.97
93_K	106_D	0.604	0.97
25_E	86_P	0.604	0.97
10_A	157_A	0.599	0.96
38_D	41_E	0.597	0.96
49_R	136_S	0.596	0.96
68_H	97_V	0.594	0.96
141_V	146_A	0.589	0.96
66_V	71_V	0.588	0.96
60_P	119_V	0.585	0.96
117_V	120_A	0.583	0.96
92_E	176_A	0.581	0.96
112_V	122_L	0.580	0.96
47_K	131_T	0.579	0.96
9_E	16_E	0.579	0.96
23_P	161_A	0.577	0.96
37_P	99_D	0.576	0.96
101_L	108_V	0.576	0.96
44_F	49_R	0.576	0.96
57_F	97_V	0.575	0.96
47_K	134_N	0.574	0.95
29_G	49_R	0.573	0.95
62_V	66_V	0.572	0.95
57_F	101_L	0.572	0.95
79_M	175_V	0.569	0.95
64_A	112_V	0.568	0.95
141_V	151_F	0.568	0.95
148_D	153_A	0.568	0.95
32_A	129_T	0.566	0.95
122_L	125_V	0.564	0.95
34_A	40_I	0.562	0.95
91_C	110_V	0.561	0.95
25_E	58_A	0.559	0.95
22_F	58_A	0.556	0.95
24_T	31_A	0.556	0.95
26_T	29_G	0.555	0.95
59_F	68_H	0.555	0.95
31_A	121_L	0.552	0.94
35_L	127_P	0.551	0.94
8_A	11_A	0.549	0.94
113_P	122_L	0.548	0.94
86_P	186_V	0.546	0.94
89_V	175_V	0.546	0.94
35_L	96_S	0.544	0.94
145_A	148_D	0.543	0.94
19_L	32_A	0.539	0.94
49_R	132_S	0.539	0.94
43_A	130_A	0.538	0.94
174_D	181_L	0.534	0.93
93_K	98_P	0.533	0.93
61_D	119_V	0.533	0.93
118_A	122_L	0.528	0.93
44_F	53_K	0.523	0.93
42_A	46_A	0.523	0.93
135_V	151_F	0.521	0.93
90_V	109_G	0.518	0.92
78_F	89_V	0.515	0.92
40_I	101_L	0.514	0.92
149_P	152_R	0.510	0.92
45_E	154_R	0.507	0.92
44_F	54_P	0.506	0.91
88_T	111_R	0.505	0.91
90_V	174_D	0.505	0.91
99_D	106_D	0.503	0.91
85_G	171_T	0.502	0.91
152_R	158_V	0.501	0.91
5_D	9_E	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2eqaA	1	1	100	0.1	Contact Map
3l7vA	1	0.9596	100	0.158	Contact Map
1jcuA	1	0.9899	100	0.178	Contact Map
1k7jA	1	0.9646	100	0.181	Contact Map
1hruA	2	0.904	100	0.205	Contact Map
3vthA	1	0.9848	100	0.23	Contact Map
4g9iA	1	0.9899	100	0.238	Contact Map
3ttcA	1	0.9545	100	0.297	Contact Map
3venA	1	0.803	97.5	0.87	Contact Map
2wqpA	2	0.8636	44.2	0.941	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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