GREMLIN Database
Q9HMZ8 - Uncharacterized protein
UniProt: Q9HMZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (177)
Sequences: 596 (472)
Seq/√Len: 35.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_G161_N4.6211.00
128_L159_M4.0441.00
123_G158_F3.3071.00
131_F152_A2.7101.00
158_F161_N2.3540.99
76_H156_H2.2950.99
132_G136_L2.2100.99
56_A60_H2.1820.99
62_L67_L2.1750.99
86_V122_F2.1630.99
128_L162_S2.1560.99
79_H127_E2.1220.99
79_H130_E2.0970.99
58_F62_L2.0690.99
75_D127_E2.0540.99
130_E157_D2.0530.99
109_E113_V2.0240.98
130_E153_D1.9410.98
11_F15_D1.9340.98
154_T157_D1.8880.98
127_E153_D1.8860.98
124_V158_F1.8720.97
79_H157_D1.8690.97
79_H153_D1.8690.97
153_D157_D1.8380.97
127_E130_E1.8320.97
132_G159_M1.8160.97
138_T142_L1.8010.97
75_D130_E1.7990.97
63_G157_D1.7930.97
117_V121_A1.7770.96
75_D157_D1.7330.96
56_A82_S1.7320.96
133_L137_A1.6620.95
63_G130_E1.6570.95
127_E157_D1.6470.95
120_L161_N1.6150.94
106_V110_I1.5470.92
34_P74_W1.5450.92
130_E154_T1.5320.92
9_V24_G1.5300.92
75_D79_H1.5180.92
13_L16_G1.4760.91
172_G176_L1.4670.90
147_A150_G1.4480.90
13_L44_P1.4460.90
79_H154_T1.4410.89
72_P76_H1.4270.89
23_N150_G1.4190.89
25_T29_L1.3960.88
37_L47_P1.3900.88
90_G115_I1.3710.87
134_D154_T1.3620.87
56_A78_T1.3580.86
6_V138_T1.3500.86
95_R179_V1.3440.86
26_V29_L1.3290.85
157_D164_G1.3290.85
33_V36_A1.3270.85
154_T164_G1.3270.85
90_G118_V1.3180.85
59_L78_T1.3000.84
46_D74_W1.2360.81
32_L125_V1.2000.79
3_A7_G1.1940.78
127_E154_T1.1710.77
16_G155_M1.1660.77
151_L154_T1.1630.76
124_V131_F1.1500.76
119_V165_A1.1470.75
63_G75_D1.1430.75
3_A9_V1.1230.74
121_A124_V1.1200.74
47_P165_A1.1160.73
75_D154_T1.1150.73
64_S143_A1.1140.73
74_W78_T1.1130.73
63_G79_H1.1130.73
14_L163_L1.1090.73
68_Y130_E1.1040.73
25_T170_V1.1020.72
101_H110_I1.0980.72
75_D153_D1.0760.71
134_D151_L1.0710.70
132_G135_E1.0630.70
37_L40_N1.0610.69
134_D155_M1.0520.69
6_V170_V1.0490.69
128_L158_F1.0490.69
5_L57_A1.0470.68
60_H83_A1.0430.68
82_S118_V1.0370.68
22_V113_V1.0300.67
9_V13_L1.0160.66
21_V33_V1.0140.66
135_E152_A1.0000.65
9_V28_L0.9950.64
49_L57_A0.9930.64
130_E164_G0.9910.64
120_L162_S0.9760.63
87_A172_G0.9550.61
45_M100_H0.9530.61
80_A160_Y0.9390.60
63_G153_D0.9370.60
129_L141_G0.9360.60
143_A147_A0.8990.57
49_L160_Y0.8910.56
116_F169_A0.8890.56
68_Y157_D0.8770.55
140_T151_L0.8700.54
78_T123_G0.8690.54
7_G55_A0.8680.54
129_L133_L0.8680.54
32_L36_A0.8610.53
131_F156_H0.8530.53
153_D164_G0.8490.52
67_L134_D0.8480.52
110_I118_V0.8440.52
97_V113_V0.8430.52
63_G164_G0.8400.51
115_I173_Q0.8320.51
63_G127_E0.8300.51
142_L166_L0.8260.50
53_I150_G0.8200.50
93_V122_F0.8160.49
91_Y111_A0.8150.49
76_H160_Y0.8120.49
161_N164_G0.8070.49
86_V161_N0.8060.49
13_L25_T0.8030.48
7_G11_F0.7990.48
84_S92_T0.7980.48
13_L136_L0.7950.48
73_W76_H0.7820.46
80_A165_A0.7810.46
131_F135_E0.7800.46
64_S76_H0.7800.46
38_E44_P0.7710.45
119_V161_N0.7690.45
42_G113_V0.7690.45
79_H164_G0.7640.45
14_L29_L0.7630.45
86_V115_I0.7590.44
112_F173_Q0.7580.44
151_L155_M0.7570.44
10_A15_D0.7560.44
68_Y79_H0.7540.44
71_I173_Q0.7530.44
7_G166_L0.7470.43
83_A117_V0.7440.43
50_V95_R0.7420.43
141_G146_L0.7410.43
126_W130_E0.7320.42
74_W77_V0.7260.42
22_V36_A0.7260.42
140_T149_H0.7250.42
4_V7_G0.7230.41
61_S117_V0.7180.41
116_F166_L0.7140.41
3_A11_F0.7110.40
86_V119_V0.7060.40
41_Y136_L0.7040.40
89_A156_H0.7030.40
83_A126_W0.7010.40
132_G139_A0.6950.39
97_V167_V0.6920.39
150_G158_F0.6910.39
100_H163_L0.6880.39
28_L122_F0.6880.39
134_D142_L0.6810.38
115_I172_G0.6800.38
33_V139_A0.6700.37
70_S105_T0.6690.37
41_Y166_L0.6690.37
127_E164_G0.6600.36
136_L159_M0.6510.36
60_H64_S0.6490.35
34_P158_F0.6420.35
36_A176_L0.6390.35
83_A161_N0.6380.35
34_P124_V0.6370.34
68_Y75_D0.6360.34
63_G126_W0.6350.34
136_L139_A0.6310.34
6_V15_D0.6310.34
53_I66_G0.6310.34
129_L143_A0.6290.34
68_Y127_E0.6290.34
29_L101_H0.6250.34
22_V33_V0.6230.33
7_G138_T0.6190.33
87_A108_R0.6180.33
126_W157_D0.6180.33
62_L69_V0.6170.33
174_A178_G0.6120.33
76_H114_Y0.6110.32
70_S73_W0.6110.32
4_V58_F0.6080.32
13_L38_E0.6070.32
60_H78_T0.6050.32
29_L36_A0.6040.32
110_I167_V0.6030.32
109_E121_A0.6000.32
13_L113_V0.5980.31
59_L119_V0.5940.31
27_T57_A0.5930.31
101_H178_G0.5920.31
166_L174_A0.5870.31
36_A166_L0.5860.31
109_E132_G0.5850.31
90_G164_G0.5840.30
108_R172_G0.5840.30
4_V102_D0.5820.30
19_K161_N0.5810.30
135_E162_S0.5810.30
44_P94_A0.5800.30
39_R109_E0.5760.30
134_D147_A0.5750.30
89_A122_F0.5740.30
150_G164_G0.5740.30
72_P155_M0.5720.30
38_E86_V0.5700.29
76_H80_A0.5660.29
36_A97_V0.5650.29
28_L169_A0.5590.29
51_L99_C0.5550.28
134_D140_T0.5540.28
131_F159_M0.5510.28
55_A89_A0.5500.28
48_W118_V0.5500.28
29_L37_L0.5490.28
86_V163_L0.5480.28
97_V111_A0.5480.28
9_V21_V0.5470.28
67_L166_L0.5470.28
11_F22_V0.5440.28
85_L132_G0.5430.28
19_K99_C0.5420.27
118_V139_A0.5420.27
94_A139_A0.5410.27
13_L120_L0.5410.27
30_I122_F0.5400.27
75_D164_G0.5380.27
33_V66_G0.5340.27
135_E138_T0.5320.27
55_A170_V0.5300.27
10_A14_L0.5270.26
11_F14_L0.5260.26
29_L55_A0.5250.26
32_L71_I0.5250.26
142_L146_L0.5240.26
49_L80_A0.5230.26
20_A23_N0.5230.26
112_F138_T0.5200.26
21_V44_P0.5180.26
5_L80_A0.5170.26
100_H173_Q0.5160.26
23_N37_L0.5130.25
48_W52_W0.5120.25
112_F169_A0.5100.25
163_L178_G0.5080.25
27_T129_L0.5070.25
49_L53_I0.5040.25
6_V28_L0.5020.25
76_H151_L0.5020.25
37_L41_Y0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cbcA 3 0.4503 26.6 0.938 Contact Map
4ltoA 3 0.6859 12.6 0.947 Contact Map
4b19A 1 0.1571 12.5 0.947 Contact Map
2micA 2 0.2094 9.9 0.949 Contact Map
2nq2A 2 0.4869 9 0.95 Contact Map
3giaA 1 0.8115 8 0.951 Contact Map
2l2tA 2 0.2094 7.7 0.952 Contact Map
2kluA 1 0.2199 6.9 0.953 Contact Map
2m20A 2 0.199 6.8 0.953 Contact Map
4g1uA 2 0.4607 5.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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