GREMLIN Database
Q9HMZ7 - Uncharacterized protein
UniProt: Q9HMZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (176)
Sequences: 628 (500)
Seq/√Len: 37.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_G183_V4.1981.00
156_V181_V4.0591.00
159_W174_H3.2541.00
158_R179_E3.0981.00
151_G180_F2.8091.00
107_G155_A2.3901.00
107_G158_R2.3571.00
158_R175_A2.2810.99
42_A46_G2.1940.99
107_G111_V2.1820.99
180_F183_V2.1820.99
111_V175_A2.1780.99
111_V155_A2.1370.99
160_T181_V2.1170.99
108_T178_T2.0760.99
156_V184_T2.0470.99
111_V158_R2.0100.99
155_A158_R1.8450.98
155_A175_A1.8440.98
145_L149_A1.8270.98
107_G175_A1.7680.97
95_P99_R1.7220.96
32_V35_V1.7090.96
134_V138_F1.6960.96
161_A165_F1.6630.96
50_D54_D1.6500.95
107_G179_E1.6340.95
175_A179_E1.5580.94
137_W141_V1.5160.93
160_T164_H1.5140.93
158_R176_L1.5130.93
176_L179_E1.5060.93
62_F172_T1.5000.92
111_V179_E1.4810.92
49_L53_L1.4610.91
95_P102_F1.4570.91
43_V97_L1.4570.91
130_T138_F1.4280.90
48_V67_G1.4070.90
111_V176_L1.4060.90
118_V150_S1.4040.90
99_R104_G1.3890.89
148_L184_T1.3700.88
155_A176_L1.3570.88
155_A179_E1.3520.88
65_A102_F1.3280.87
39_L42_A1.3270.87
115_L150_S1.3090.86
107_G176_L1.2990.86
39_L46_G1.2720.84
64_G192_V1.2670.84
179_E186_A1.2520.83
152_A180_F1.2510.83
168_A172_T1.2450.83
81_R141_V1.2430.83
162_D177_M1.2360.83
158_R186_A1.2310.82
86_W187_G1.2220.82
95_P110_A1.2090.81
124_G201_R1.2070.81
76_V79_S1.2050.81
170_L177_M1.1700.79
39_L49_L1.1690.79
126_L141_V1.1670.79
98_V110_A1.1620.79
52_A83_M1.1620.79
45_G50_D1.1610.78
73_P106_V1.1570.78
112_Y187_G1.1270.76
172_T179_E1.1100.75
40_A44_L1.1070.75
148_L183_V1.1060.75
52_A55_V1.1020.75
176_L186_A1.1010.75
55_V60_L1.0970.74
162_D176_L1.0820.73
66_V92_G1.0770.73
157_F169_Y1.0760.73
194_F198_L1.0650.72
108_T173_N1.0650.72
103_G177_M1.0520.71
65_A68_V1.0430.71
115_L166_G1.0410.70
119_A143_V1.0340.70
102_F110_A1.0270.69
183_V186_A1.0240.69
46_G75_V1.0200.69
162_D169_Y1.0090.68
95_P114_S1.0060.68
71_A75_V1.0060.68
40_A94_L1.0000.67
61_V141_V0.9970.67
160_T163_Q0.9950.67
31_T34_A0.9820.66
89_L124_G0.9750.65
42_A192_V0.9690.65
114_S166_G0.9660.65
49_L163_Q0.9650.64
117_A121_V0.9590.64
185_L188_L0.9520.63
44_L148_L0.9500.63
104_G110_A0.9480.63
172_T180_F0.9470.63
99_R110_A0.9450.63
69_I171_T0.9410.63
143_V187_G0.9380.62
32_V36_I0.9360.62
143_V195_A0.9330.62
155_A180_F0.9330.62
80_W188_L0.9270.61
98_V106_V0.9250.61
162_D170_L0.9150.60
119_A186_A0.9120.60
103_G170_L0.9060.60
41_V187_G0.9040.59
72_V75_V0.9010.59
35_V53_L0.8970.59
66_V170_L0.8920.58
153_V165_F0.8900.58
60_L72_V0.8890.58
76_V86_W0.8880.58
52_A67_G0.8780.57
106_V111_V0.8730.57
173_N176_L0.8710.57
139_A194_F0.8650.56
36_I39_L0.8640.56
145_L188_L0.8640.56
37_A41_V0.8620.56
115_L132_L0.8550.55
48_V52_A0.8500.55
72_V164_H0.8480.54
152_A159_W0.8270.53
75_V141_V0.8240.52
178_T181_V0.8210.52
112_Y182_W0.8190.52
63_T117_A0.8180.52
61_V132_L0.8160.52
147_T187_G0.8160.52
45_G164_H0.8120.51
110_A144_V0.8070.51
129_F185_L0.8070.51
157_F161_A0.7990.50
36_I49_L0.7980.50
170_L176_L0.7960.50
35_V40_A0.7950.50
48_V64_G0.7920.50
158_R183_V0.7830.49
102_F106_V0.7800.48
106_V110_A0.7780.48
71_A153_V0.7740.48
116_A194_F0.7710.48
164_H181_V0.7700.48
45_G192_V0.7620.47
57_L188_L0.7610.47
134_V137_W0.7610.47
103_G162_D0.7570.46
162_D173_N0.7560.46
104_G157_F0.7500.46
42_A185_L0.7460.45
92_G165_F0.7460.45
111_V186_A0.7450.45
58_R172_T0.7380.45
119_A136_H0.7380.45
38_W70_V0.7350.44
41_V70_V0.7300.44
159_W163_Q0.7290.44
175_A186_A0.7290.44
38_W42_A0.7270.44
144_V191_G0.7270.44
104_G182_W0.7260.44
52_A192_V0.7250.44
109_F192_V0.7220.43
123_V189_A0.7200.43
106_V180_F0.7200.43
63_T189_A0.7180.43
33_N38_W0.7180.43
73_P116_A0.7080.42
29_N32_V0.7010.41
64_G68_V0.7010.41
44_L70_V0.6980.41
159_W179_E0.6930.41
106_V155_A0.6930.41
107_G186_A0.6900.41
104_G108_T0.6880.40
34_A37_A0.6860.40
48_V60_L0.6860.40
85_P180_F0.6840.40
52_A57_L0.6830.40
49_L54_D0.6820.40
53_L72_V0.6790.40
38_W165_F0.6760.39
138_F189_A0.6690.39
163_Q174_H0.6680.39
62_F105_T0.6660.38
48_V51_S0.6640.38
124_G129_F0.6610.38
169_Y194_F0.6610.38
41_V134_V0.6560.38
31_T35_V0.6540.37
88_L92_G0.6520.37
137_W149_A0.6520.37
43_V75_V0.6510.37
49_L126_L0.6510.37
149_A152_A0.6510.37
48_V63_T0.6420.36
146_V189_A0.6400.36
138_F146_V0.6380.36
36_I53_L0.6340.36
44_L96_I0.6330.36
96_I101_L0.6320.36
108_T182_W0.6300.36
40_A160_T0.6290.35
150_S204_W0.6250.35
88_L117_A0.6240.35
72_V167_T0.6240.35
114_S155_A0.6150.34
59_W62_F0.6130.34
106_V176_L0.6110.34
76_V80_W0.6080.34
155_A186_A0.6080.34
163_Q188_L0.6030.33
70_V89_L0.6010.33
53_L119_A0.6010.33
109_F188_L0.5980.33
139_A198_L0.5910.32
66_V157_F0.5910.32
75_V88_L0.5860.32
32_V90_C0.5850.32
172_T175_A0.5790.31
36_I157_F0.5790.31
71_A74_P0.5770.31
60_L83_M0.5770.31
81_R189_A0.5750.31
62_F120_L0.5740.31
155_A183_V0.5730.31
100_G168_A0.5720.31
50_D53_L0.5610.30
66_V96_I0.5600.30
144_V188_L0.5590.30
66_V151_G0.5540.30
158_R172_T0.5520.29
179_E183_V0.5520.29
106_V158_R0.5520.29
165_F185_L0.5520.29
94_L150_S0.5480.29
129_F195_A0.5470.29
50_D94_L0.5460.29
43_V196_L0.5390.28
151_G194_F0.5380.28
72_V123_V0.5340.28
87_E193_L0.5300.28
173_N177_M0.5270.28
142_L178_T0.5250.27
125_E170_L0.5230.27
64_G150_S0.5210.27
122_V131_S0.5210.27
77_F83_M0.5160.27
154_W179_E0.5100.26
64_G167_T0.5090.26
47_V56_D0.5070.26
44_L190_A0.5060.26
88_L112_Y0.5060.26
76_V122_V0.5010.26
100_G108_T0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 0.9488 27.8 0.947 Contact Map
4p6zV 1 0 27 0.947 Contact Map
4z7fA 2 0.7535 23.6 0.949 Contact Map
2micA 2 0.1907 22.9 0.949 Contact Map
4b19A 1 0.1395 19.3 0.951 Contact Map
2m20A 2 0.186 14.2 0.954 Contact Map
4tphA 2 0.814 14 0.954 Contact Map
4cbcA 3 0.4279 11.2 0.956 Contact Map
2kv5A 1 0.1349 11.2 0.956 Contact Map
2l2tA 2 0.186 11 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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