GREMLIN Database
Q9HMZ5 - Uncharacterized protein
UniProt: Q9HMZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (170)
Sequences: 2705 (2132)
Seq/√Len: 163.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_T69_M4.0711.00
73_L101_L3.1381.00
76_G83_F3.1171.00
32_M52_G3.0281.00
62_P116_H2.8611.00
61_G112_G2.7001.00
151_F175_A2.6521.00
22_A64_W2.5891.00
18_N64_W2.5141.00
152_A159_L2.3181.00
61_G65_G2.3001.00
58_L136_M2.2351.00
107_A143_I2.2311.00
66_G105_P2.1851.00
110_L142_V2.1641.00
58_L194_T2.0361.00
25_F56_A1.8971.00
30_G82_V1.8961.00
114_V135_A1.8871.00
148_T176_G1.8771.00
70_V105_P1.8621.00
172_F177_A1.8021.00
173_L177_A1.7831.00
73_L105_P1.7611.00
98_G150_G1.7481.00
75_A80_A1.7371.00
66_G109_A1.7321.00
47_T50_V1.7201.00
33_A72_Y1.6981.00
144_Y183_E1.6851.00
103_S146_A1.6571.00
39_N42_S1.6561.00
26_A71_L1.6551.00
49_Q104_Y1.6341.00
106_F146_A1.5441.00
170_D174_V1.5101.00
180_I184_A1.4741.00
26_A68_S1.4491.00
95_A98_G1.4451.00
87_G92_T1.4441.00
34_Y86_G1.4371.00
62_P109_A1.4321.00
103_S143_I1.4091.00
144_Y176_G1.3991.00
76_G82_V1.3931.00
65_G112_G1.3871.00
26_A75_A1.3871.00
128_G131_K1.3771.00
29_T56_A1.3631.00
129_V133_V1.3481.00
146_A149_V1.3451.00
26_A30_G1.3441.00
177_A181_P1.2941.00
148_T171_A1.2821.00
67_A70_V1.2701.00
16_V20_A1.2641.00
137_V187_I1.2201.00
140_T144_Y1.2161.00
47_T104_Y1.1821.00
58_L115_A1.1551.00
151_F155_Q1.1441.00
100_Y175_A1.1271.00
72_Y83_F1.1251.00
184_A188_A1.1181.00
77_G90_L1.1131.00
150_G154_V1.1061.00
29_T53_V1.1041.00
73_L93_F1.1021.00
150_G153_I1.1011.00
51_L190_A1.1011.00
151_F157_P1.1001.00
37_F40_P1.0921.00
178_A181_P1.0891.00
69_M108_A1.0640.99
111_T139_A1.0630.99
106_F142_V1.0600.99
57_G65_G1.0590.99
145_A149_V1.0520.99
62_P112_G1.0470.99
56_A60_L1.0280.99
72_Y104_Y1.0250.99
72_Y76_G1.0180.99
60_L68_S1.0170.99
111_T135_A1.0130.99
51_L189_A1.0090.99
46_V182_A1.0090.99
28_L52_G0.9970.99
63_V116_H0.9900.99
75_A82_V0.9860.99
109_A113_L0.9850.99
77_G88_S0.9730.99
62_P113_L0.9690.99
136_M191_I0.9680.99
182_A186_K0.9670.99
64_W68_S0.9660.99
100_Y151_F0.9650.99
148_T172_F0.9630.99
100_Y143_I0.9580.99
133_V191_I0.9480.99
38_Q42_S0.9450.99
98_G102_L0.9390.99
140_T187_I0.9340.99
29_T52_G0.9330.99
21_R64_W0.9300.98
61_G64_W0.9230.98
179_F186_K0.9220.98
48_L51_L0.9210.98
56_A69_M0.9150.98
25_F60_L0.9050.98
90_L94_V0.8940.98
136_M187_I0.8920.98
16_V19_I0.8900.98
54_F111_T0.8850.98
113_L117_G0.8850.98
100_Y176_G0.8810.98
56_A68_S0.8800.98
103_S107_A0.8770.98
106_F110_L0.8750.98
54_F140_T0.8700.98
149_V152_A0.8610.98
77_G98_G0.8610.98
19_I23_A0.8600.97
50_V140_T0.8560.97
134_A138_A0.8460.97
93_F101_L0.8400.97
187_I191_I0.8290.97
50_V143_I0.8240.97
118_T131_K0.8220.97
114_V138_A0.8180.97
191_I195_R0.8130.96
22_A67_A0.8070.96
131_K134_A0.8030.96
103_S142_V0.7850.96
85_G95_A0.7740.95
154_V158_S0.7730.95
53_V108_A0.7690.95
100_Y144_Y0.7670.95
152_A158_S0.7670.95
152_A171_A0.7630.95
66_G69_M0.7620.95
102_L150_G0.7580.95
79_G89_G0.7540.95
54_F143_I0.7520.95
25_F68_S0.7440.94
102_L106_F0.7430.94
50_V182_A0.7350.94
196_S199_L0.7330.94
133_V188_A0.7290.94
130_A134_A0.7290.94
102_L146_A0.7260.94
94_V98_G0.7060.93
140_T183_E0.7040.92
84_A87_G0.7040.92
106_F109_A0.7020.92
14_Q18_N0.6950.92
127_V131_K0.6910.92
129_V191_I0.6880.92
23_A27_A0.6840.91
174_V178_A0.6780.91
25_F59_Y0.6780.91
27_A75_A0.6770.91
22_A26_A0.6760.91
146_A150_G0.6760.91
32_M35_V0.6750.91
93_F98_G0.6750.91
137_V184_A0.6740.91
18_N22_A0.6690.90
192_G196_S0.6690.90
66_G108_A0.6670.90
20_A24_V0.6660.90
114_V139_A0.6590.90
108_A112_G0.6580.90
89_G98_G0.6560.90
132_L191_I0.6500.89
29_T32_M0.6500.89
176_G180_I0.6490.89
133_V137_V0.6490.89
142_V146_A0.6460.89
54_F107_A0.6420.89
107_A142_V0.6410.88
92_T95_A0.6380.88
149_V153_I0.6360.88
38_Q41_V0.6350.88
57_G111_T0.6310.88
119_T131_K0.6310.88
195_R198_Q0.6310.88
66_G106_F0.6280.87
112_G115_A0.6260.87
144_Y148_T0.6230.87
30_G34_Y0.6220.87
113_L116_H0.6210.87
188_A192_G0.6180.87
44_A97_T0.6150.86
97_T101_L0.6130.86
28_L32_M0.6130.86
110_L138_A0.6120.86
30_G80_A0.6100.86
30_G75_A0.6090.86
59_Y197_D0.6080.86
50_V53_V0.6070.86
72_Y82_V0.6020.85
93_F102_L0.6010.85
14_Q17_E0.5980.85
37_F46_V0.5900.84
53_V57_G0.5880.84
44_A179_F0.5880.84
132_L136_M0.5870.84
45_P151_F0.5870.84
157_P172_F0.5860.84
193_I197_D0.5850.83
58_L191_I0.5820.83
23_A71_L0.5800.83
111_T136_M0.5800.83
156_R160_A0.5780.83
18_N21_R0.5780.83
39_N43_P0.5750.82
158_S170_D0.5740.82
112_G116_H0.5710.82
129_V192_G0.5710.82
152_A156_R0.5690.82
45_P84_A0.5660.81
133_V187_I0.5630.81
46_V181_P0.5600.81
44_A151_F0.5560.80
181_P184_A0.5520.80
141_V145_A0.5500.80
17_E21_R0.5490.79
51_L193_I0.5480.79
33_A84_A0.5480.79
114_V131_K0.5450.79
104_Y143_I0.5420.79
148_T175_A0.5390.78
97_T178_A0.5390.78
104_Y108_A0.5360.78
77_G102_L0.5360.78
87_G90_L0.5320.77
59_Y194_T0.5310.77
77_G93_F0.5290.77
98_G158_S0.5250.76
127_V132_L0.5250.76
29_T68_S0.5230.76
30_G72_Y0.5220.76
187_I190_A0.5190.76
135_A138_A0.5180.75
155_Q159_L0.5160.75
29_T72_Y0.5120.75
50_V186_K0.5120.75
62_P117_G0.5090.74
129_V195_R0.5080.74
57_G66_G0.5060.74
170_D173_L0.5060.74
32_M48_L0.5060.74
172_F176_G0.5010.73
140_T184_A0.5000.73
72_Y101_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dveA 3 0.901 100 0.291 Contact Map
3p5nA 2 0.797 99.9 0.594 Contact Map
4z7fA 2 0.7772 99.8 0.612 Contact Map
4tkrA 2 0.8861 99.8 0.619 Contact Map
4huqS 1 0.7822 99.8 0.626 Contact Map
3rlbA 1 0.8366 99.8 0.636 Contact Map
4hzuS 1 0.7673 99.8 0.644 Contact Map
4rfsS 1 0.8515 99.6 0.696 Contact Map
4m5bA 1 0.896 91.8 0.9 Contact Map
2ksfA 1 0.5 12.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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