GREMLIN Database
Q9HMZ3 - Heterodisulfide reductase
UniProt: Q9HMZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 677 (534)
Sequences: 3000 (1904)
Seq/√Len: 82.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
648_T656_E4.8531.00
413_E445_D3.7651.00
540_T569_T3.5591.00
437_T655_V3.5371.00
386_F390_D3.2811.00
515_Y523_G3.1871.00
434_S652_E3.1771.00
455_N495_S3.0171.00
248_D251_P2.9581.00
522_E561_E2.9161.00
392_K395_D2.8601.00
560_R564_R2.8291.00
395_D400_L2.8191.00
247_A251_P2.7761.00
189_V192_S2.7671.00
602_E610_E2.6691.00
395_D403_E2.6161.00
490_C496_Y2.5991.00
138_R141_D2.5921.00
521_V654_L2.5161.00
396_W402_F2.4881.00
394_P397_A2.4341.00
140_D144_V2.4111.00
517_Y651_T2.3711.00
391_R396_W2.3501.00
395_D398_D2.3471.00
247_A255_G2.2581.00
249_A252_E2.2581.00
395_D402_F2.2461.00
393_R397_A2.2291.00
441_T655_V2.2261.00
435_L491_T2.2241.00
387_G390_D2.2001.00
247_A252_E2.1871.00
254_I258_E2.1601.00
246_P251_P2.1351.00
252_E255_G2.1211.00
251_P255_G2.1101.00
383_G386_F2.1021.00
438_V654_L2.0881.00
422_P432_A2.0721.00
192_S196_A2.0631.00
350_E353_T2.0571.00
251_P254_I2.0551.00
246_P249_A2.0491.00
186_A192_S2.0451.00
394_P401_D2.0351.00
540_T571_D2.0221.00
378_N383_G2.0161.00
400_L403_E2.0131.00
375_A378_N1.9721.00
413_E447_G1.9701.00
258_E261_D1.9571.00
437_T659_E1.9551.00
620_R648_T1.9531.00
251_P260_E1.9371.00
397_A402_F1.9291.00
573_M608_A1.9071.00
386_F389_P1.8771.00
500_S519_Q1.8651.00
248_D252_E1.8581.00
152_V203_W1.8521.00
456_D495_S1.8341.00
397_A400_L1.8331.00
136_T182_D1.8151.00
190_D194_A1.7941.00
391_R397_A1.7941.00
247_A250_S1.7941.00
438_V521_V1.7911.00
539_D620_R1.7821.00
391_R400_L1.7711.00
380_F383_G1.7671.00
560_R572_E1.7621.00
194_A198_Y1.7591.00
372_V383_G1.7561.00
541_V653_L1.7441.00
372_V376_V1.7421.00
251_P257_S1.7301.00
246_P252_E1.7291.00
254_I259_I1.7291.00
337_S548_H1.7251.00
195_A199_P1.7241.00
384_N387_G1.7241.00
420_D495_S1.7231.00
249_A254_I1.7221.00
420_D455_N1.7171.00
521_V525_V1.7131.00
391_R394_P1.7051.00
395_D401_D1.6991.00
247_A254_I1.6981.00
247_A258_E1.6881.00
246_P258_E1.6861.00
396_W400_L1.6851.00
394_P403_E1.6851.00
198_Y202_W1.6791.00
395_D405_P1.6771.00
110_L114_V1.6661.00
430_H652_E1.6611.00
391_R395_D1.6601.00
107_A115_G1.6491.00
370_K373_E1.6401.00
248_D254_I1.6331.00
435_L489_V1.6091.00
214_A217_P1.6021.00
532_L654_L1.5991.00
598_P635_G1.5971.00
441_T658_I1.5941.00
460_I468_L1.5931.00
473_A503_Y1.5911.00
622_V653_L1.5901.00
399_D403_E1.5801.00
378_N382_K1.5771.00
444_V520_V1.5751.00
523_G527_E1.5641.00
395_D399_D1.5611.00
428_N431_I1.5511.00
392_K397_A1.5401.00
162_I177_G1.5331.00
385_T388_E1.5290.99
454_Q475_D1.5280.99
372_V375_A1.5220.99
521_V562_V1.4870.99
393_R401_D1.4820.99
329_A333_E1.4790.99
401_D404_V1.4780.99
620_R653_L1.4740.99
336_M600_P1.4710.99
396_W405_P1.4620.99
561_E564_R1.4540.99
522_E562_V1.4520.99
292_L334_S1.4510.99
655_V658_I1.4450.99
402_F405_P1.4380.99
91_S94_V1.4340.99
557_E560_R1.4310.99
391_R399_D1.4300.99
413_E486_E1.4260.99
184_L193_L1.4150.99
368_M371_N1.4000.99
378_N387_G1.3970.99
439_F489_V1.3930.99
436_A440_E1.3930.99
246_P255_G1.3930.99
480_F488_T1.3870.99
416_W435_L1.3850.99
602_E606_R1.3840.99
256_P259_I1.3820.99
250_S255_G1.3700.99
202_W205_H1.3660.99
300_D331_T1.3660.99
155_Y185_S1.3620.99
401_D405_P1.3550.99
646_E656_E1.3480.99
523_G558_A1.3470.99
303_S306_E1.3460.99
508_F512_D1.3450.99
438_V658_I1.3450.99
437_T441_T1.3420.99
372_V378_N1.3320.99
392_K396_W1.3300.99
398_D403_E1.3250.99
117_G120_I1.3220.99
250_S253_E1.3170.98
391_R398_D1.3120.98
411_S445_D1.3110.98
246_P250_S1.3060.98
254_I257_S1.2960.98
251_P258_E1.2900.98
392_K402_F1.2890.98
358_M362_L1.2880.98
248_D260_E1.2840.98
472_L476_N1.2830.98
196_A199_P1.2730.98
435_L651_T1.2720.98
526_N561_E1.2650.98
476_N499_F1.2640.98
340_A344_A1.2620.98
247_A253_E1.2590.98
365_S368_M1.2550.98
394_P400_L1.2520.98
605_I609_L1.2480.98
396_W403_E1.2480.98
329_A362_L1.2460.98
246_P254_I1.2390.98
476_N503_Y1.2380.98
201_I205_H1.2360.98
369_N373_E1.2350.98
252_E256_P1.2350.98
192_S195_A1.2330.98
170_F173_V1.2280.98
248_D258_E1.2240.98
555_E558_A1.2240.98
414_Y520_V1.2190.97
454_Q479_A1.2160.97
106_D114_V1.2150.97
247_A260_E1.2130.97
474_E478_A1.2040.97
252_E258_E1.2010.97
393_R396_W1.2010.97
378_N381_Q1.1940.97
209_A212_F1.1940.97
369_N376_V1.1930.97
200_A204_S1.1920.97
339_M350_E1.1920.97
513_S523_G1.1920.97
517_Y521_V1.1830.97
252_E257_S1.1820.97
394_P402_F1.1790.97
394_P398_D1.1780.97
364_E467_G1.1690.97
415_L483_C1.1640.97
452_D483_C1.1630.97
477_I481_D1.1610.97
438_V655_V1.1600.97
208_L212_F1.1590.97
414_Y489_V1.1570.97
531_G565_A1.1570.97
461_R466_E1.1550.96
540_T619_D1.1540.96
515_Y520_V1.1500.96
376_V384_N1.1490.96
252_E260_E1.1470.96
463_V588_G1.1460.96
156_V222_F1.1460.96
418_V432_A1.1460.96
532_L658_I1.1400.96
519_Q555_E1.1300.96
418_V449_L1.1260.96
496_Y514_V1.1240.96
616_P619_D1.1220.96
332_M358_M1.1130.96
198_Y201_I1.1120.96
194_A213_V1.1090.96
353_T505_Q1.1060.95
423_S453_E1.1060.95
397_A403_E1.0990.95
392_K403_E1.0980.95
392_K398_D1.0940.95
249_A256_P1.0940.95
492_D625_C1.0930.95
251_P256_P1.0920.95
435_L439_F1.0870.95
255_G258_E1.0750.95
436_A446_Y1.0730.95
472_L475_D1.0710.95
248_D255_G1.0700.95
391_R401_D1.0670.94
382_K386_F1.0610.94
356_T466_E1.0580.94
574_P580_S1.0570.94
253_E257_S1.0550.94
648_T652_E1.0550.94
588_G592_M1.0520.94
542_T621_F1.0470.94
249_A258_E1.0440.94
126_V188_G1.0420.94
515_Y519_Q1.0370.94
378_N386_F1.0360.94
360_R466_E1.0320.93
333_E595_D1.0320.93
154_G157_T1.0310.93
368_M372_V1.0280.93
580_S604_R1.0280.93
92_F96_E1.0270.93
162_I166_G1.0260.93
373_E380_F1.0240.93
193_L197_A1.0230.93
247_A256_P1.0210.93
231_L235_D1.0170.93
254_I260_E1.0130.93
481_D512_D1.0100.93
470_E474_E1.0100.93
494_H625_C1.0080.93
420_D456_D1.0070.93
393_R403_E1.0050.93
550_G556_F1.0050.93
388_E392_K1.0020.92
373_E376_V1.0000.92
159_G180_V0.9960.92
396_W404_V0.9950.92
519_Q523_G0.9940.92
606_R610_E0.9930.92
184_L200_A0.9870.92
246_P259_I0.9870.92
332_M355_F0.9870.92
249_A255_G0.9860.92
384_N388_E0.9850.92
620_R656_E0.9820.92
250_S254_I0.9820.92
386_F392_K0.9800.92
601_S636_R0.9770.91
606_R636_R0.9740.91
400_L405_P0.9730.91
435_L517_Y0.9730.91
519_Q558_A0.9730.91
241_R244_R0.9730.91
308_V324_T0.9720.91
601_S635_G0.9670.91
255_G260_E0.9670.91
379_A383_G0.9660.91
386_F393_R0.9660.91
415_L486_E0.9650.91
487_K513_S0.9650.91
196_A200_A0.9640.91
287_A603_E0.9640.91
444_V524_L0.9600.91
181_A221_P0.9590.91
585_G590_L0.9560.91
253_E256_P0.9550.90
252_E259_I0.9520.90
358_M361_R0.9500.90
148_F151_G0.9490.90
419_G492_D0.9460.90
372_V382_K0.9420.90
543_Y556_F0.9390.90
646_E652_E0.9390.90
253_E260_E0.9370.90
158_E161_R0.9360.90
102_S105_M0.9340.90
440_E446_Y0.9340.90
585_G631_M0.9330.89
621_F632_Y0.9310.89
371_N375_A0.9300.89
392_K401_D0.9260.89
95_G99_L0.9250.89
537_L657_A0.9240.89
546_P625_C0.9230.89
569_T617_D0.9210.89
375_A387_G0.9190.89
262_F266_Q0.9180.89
550_G580_S0.9160.89
107_A117_G0.9140.88
186_A193_L0.9110.88
434_S655_V0.9090.88
249_A260_E0.9070.88
543_Y570_L0.9070.88
199_P202_W0.9050.88
255_G259_I0.9050.88
350_E354_Q0.9040.88
376_V380_F0.9020.88
201_I204_S0.8990.88
409_E412_V0.8980.88
369_N465_E0.8940.87
376_V383_G0.8920.87
618_V638_T0.8910.87
394_P405_P0.8900.87
360_R467_G0.8860.87
391_R403_E0.8850.87
256_P262_F0.8840.87
209_A213_V0.8830.87
120_I148_F0.8810.87
373_E379_A0.8810.87
380_F386_F0.8810.87
127_R131_L0.8810.87
461_R498_T0.8800.87
270_H354_Q0.8790.86
398_D402_F0.8780.86
173_V176_V0.8760.86
154_G161_R0.8760.86
416_W491_T0.8740.86
539_D656_E0.8740.86
394_P404_V0.8740.86
377_M383_G0.8730.86
115_G118_V0.8730.86
409_E445_D0.8730.86
412_V529_A0.8720.86
141_D144_V0.8720.86
217_P220_K0.8710.86
254_I261_D0.8700.86
246_P260_E0.8660.86
392_K400_L0.8640.86
398_D401_D0.8600.85
370_K374_D0.8590.85
247_A259_I0.8590.85
249_A253_E0.8580.85
369_N372_V0.8580.85
524_L529_A0.8570.85
541_V568_V0.8540.85
375_A379_A0.8540.85
623_V630_T0.8540.85
385_T470_E0.8490.84
541_V570_L0.8450.84
541_V622_V0.8440.84
249_A259_I0.8430.84
388_E394_P0.8430.84
604_R608_A0.8400.84
388_E393_R0.8350.84
492_D495_S0.8330.83
372_V386_F0.8330.83
387_G394_P0.8310.83
248_D259_I0.8310.83
393_R398_D0.8280.83
393_R400_L0.8280.83
206_S210_L0.8280.83
376_V379_A0.8260.83
132_W184_L0.8260.83
248_D253_E0.8250.83
172_T175_F0.8230.83
368_M375_A0.8230.83
320_A323_G0.8180.82
386_F395_D0.8180.82
398_D404_V0.8170.82
393_R402_F0.8140.82
650_V654_L0.8110.82
541_V620_R0.8090.82
383_G387_G0.8060.81
516_H519_Q0.8050.81
397_A401_D0.8040.81
191_G195_A0.8030.81
210_L217_P0.8030.81
420_D492_D0.7990.81
255_G261_D0.7980.81
545_D556_F0.7980.81
369_N374_D0.7960.80
285_A596_E0.7960.80
396_W433_R0.7960.80
171_E174_S0.7950.80
390_D394_P0.7950.80
385_T390_D0.7940.80
488_T536_E0.7910.80
360_R364_E0.7910.80
151_G203_W0.7890.80
396_W401_D0.7880.80
369_N375_A0.7880.80
206_S211_G0.7880.80
342_M552_Y0.7870.80
393_R404_V0.7830.79
551_R556_F0.7830.79
518_T562_V0.7820.79
397_A405_P0.7800.79
369_N377_M0.7800.79
337_S355_F0.7760.79
208_L211_G0.7760.79
413_E446_Y0.7740.79
385_T389_P0.7730.79
412_V444_V0.7700.78
380_F384_N0.7700.78
285_A336_M0.7700.78
383_G388_E0.7690.78
522_E526_N0.7680.78
399_D404_V0.7680.78
374_D383_G0.7680.78
558_A561_E0.7630.78
236_A239_G0.7620.78
416_W432_A0.7610.77
160_V165_T0.7610.77
285_A297_V0.7590.77
419_G625_C0.7580.77
109_G158_E0.7580.77
488_T499_F0.7580.77
417_Y499_F0.7560.77
198_Y205_H0.7550.77
526_N565_A0.7550.77
92_F95_G0.7550.77
287_A604_R0.7540.77
439_F520_V0.7540.77
436_A448_I0.7530.77
399_D402_F0.7510.76
117_G148_F0.7500.76
253_E259_I0.7490.76
215_A219_A0.7470.76
369_N380_F0.7460.76
430_H433_R0.7450.76
648_T653_L0.7440.76
356_T461_R0.7440.76
251_P259_I0.7440.76
232_V274_T0.7440.76
542_T608_A0.7430.76
164_G228_Y0.7420.76
468_L472_L0.7400.75
229_A233_A0.7390.75
373_E377_M0.7370.75
277_G295_R0.7370.75
288_A603_E0.7350.75
364_E367_Q0.7330.75
601_S606_R0.7310.75
431_I652_E0.7310.75
332_M351_H0.7290.74
142_A146_A0.7280.74
478_A481_D0.7260.74
257_S261_D0.7240.74
623_V629_M0.7230.74
224_M228_Y0.7200.73
406_D410_Q0.7200.73
286_K289_G0.7200.73
282_V344_A0.7180.73
433_R436_A0.7170.73
585_G630_T0.7170.73
469_Y473_A0.7160.73
655_V659_E0.7150.73
337_S356_T0.7140.73
246_P253_E0.7120.73
492_D546_P0.7120.73
351_H354_Q0.7110.72
371_N374_D0.7040.72
392_K404_V0.7040.72
370_K378_N0.7030.72
434_S437_T0.7030.72
504_D511_A0.7030.72
536_E568_V0.7020.72
525_V565_A0.6990.71
372_V377_M0.6970.71
618_V621_F0.6970.71
375_A380_F0.6970.71
392_K405_P0.6960.71
112_F151_G0.6940.71
130_R190_D0.6940.71
416_W422_P0.6930.71
261_D264_W0.6920.70
461_R469_Y0.6870.70
477_I499_F0.6860.70
374_D377_M0.6850.70
377_M380_F0.6850.70
295_R352_V0.6810.69
206_S212_F0.6810.69
109_G154_G0.6800.69
109_G113_V0.6780.69
455_N492_D0.6770.69
518_T650_V0.6760.69
157_T160_V0.6760.69
246_P256_P0.6750.69
374_D382_K0.6750.69
521_V651_T0.6740.68
252_E264_W0.6730.68
394_P399_D0.6730.68
375_A383_G0.6720.68
102_S158_E0.6720.68
250_S258_E0.6700.68
199_P203_W0.6690.68
372_V463_V0.6690.68
566_T654_L0.6690.68
557_E561_E0.6680.68
530_L533_S0.6670.68
437_T440_E0.6650.67
556_F572_E0.6630.67
248_D256_P0.6610.67
195_A198_Y0.6600.67
260_E264_W0.6600.67
458_N544_H0.6590.67
339_M552_Y0.6590.67
515_Y524_L0.6590.67
397_A404_V0.6570.66
282_V581_F0.6570.66
258_E262_F0.6540.66
253_E258_E0.6540.66
536_E566_T0.6540.66
375_A381_Q0.6530.66
110_L113_V0.6520.66
357_E361_R0.6520.66
562_V565_A0.6490.66
371_N378_N0.6470.65
371_N376_V0.6450.65
470_E508_F0.6450.65
397_A436_A0.6440.65
249_A257_S0.6440.65
371_N387_G0.6420.65
354_Q417_Y0.6420.65
364_E368_M0.6410.65
154_G158_E0.6400.64
414_Y439_F0.6390.64
357_E360_R0.6380.64
433_R437_T0.6380.64
533_S536_E0.6370.64
93_F96_E0.6360.64
206_S209_A0.6360.64
609_L621_F0.6340.64
280_S291_P0.6340.64
171_E176_V0.6330.64
528_G531_G0.6320.63
483_C486_E0.6320.63
539_D568_V0.6310.63
297_V331_T0.6300.63
193_L204_S0.6300.63
109_G157_T0.6290.63
377_M381_Q0.6290.63
287_A599_K0.6270.63
372_V380_F0.6270.63
365_S599_K0.6270.63
143_F146_A0.6260.63
112_F183_V0.6260.63
113_V151_G0.6240.63
160_V164_G0.6230.62
217_P431_I0.6230.62
235_D239_G0.6220.62
250_S257_S0.6220.62
229_A281_S0.6210.62
542_T618_V0.6200.62
242_L274_T0.6180.62
606_R635_G0.6180.62
605_I608_A0.6170.62
321_D324_T0.6170.62
212_F221_P0.6160.62
321_D325_S0.6140.61
159_G165_T0.6140.61
385_T393_R0.6130.61
229_A274_T0.6110.61
487_K520_V0.6110.61
91_S95_G0.6100.61
150_L154_G0.6080.61
161_R165_T0.6070.60
328_D331_T0.6070.60
487_K515_Y0.6070.60
539_D619_D0.6050.60
440_E565_A0.6030.60
379_A388_E0.6030.60
256_P261_D0.6020.60
239_G243_P0.6020.60
353_T356_T0.6020.60
519_Q525_V0.6000.59
481_D509_E0.5990.59
438_V442_A0.5980.59
531_G557_E0.5980.59
269_D272_A0.5980.59
445_D537_L0.5970.59
373_E382_K0.5960.59
456_D460_I0.5960.59
178_W332_M0.5950.59
220_K223_H0.5950.59
441_T530_L0.5950.59
417_Y456_D0.5940.59
250_S259_I0.5940.59
297_V355_F0.5930.59
455_N459_D0.5930.59
462_R494_H0.5930.59
382_K390_D0.5920.58
475_D478_A0.5910.58
232_V239_G0.5900.58
479_A483_C0.5900.58
111_L225_I0.5900.58
538_D568_V0.5900.58
294_P458_N0.5890.58
355_F358_M0.5890.58
230_N233_A0.5860.58
326_V362_L0.5860.58
430_H434_S0.5860.58
148_F203_W0.5860.58
241_R245_V0.5840.57
609_L632_Y0.5840.57
372_V592_M0.5830.57
568_V657_A0.5830.57
542_T571_D0.5820.57
458_N588_G0.5800.57
484_D646_E0.5800.57
380_F465_E0.5800.57
298_I351_H0.5790.57
175_F220_K0.5790.57
282_V607_E0.5790.57
494_H626_P0.5790.57
591_W634_D0.5780.57
363_T465_E0.5780.57
556_F560_R0.5770.57
188_G192_S0.5760.56
280_S295_R0.5760.56
95_G98_Y0.5760.56
372_V594_F0.5760.56
632_Y647_I0.5760.56
303_S307_G0.5750.56
392_K399_D0.5740.56
373_E378_N0.5730.56
280_S286_K0.5720.56
396_W399_D0.5710.56
400_L404_V0.5710.56
116_V330_S0.5700.56
479_A565_A0.5700.56
336_M356_T0.5700.56
496_Y500_S0.5690.56
482_D485_Y0.5680.55
109_G112_F0.5670.55
376_V465_E0.5670.55
234_R348_D0.5660.55
233_A274_T0.5650.55
193_L198_Y0.5650.55
327_I331_T0.5650.55
422_P492_D0.5640.55
562_V654_L0.5640.55
563_V622_V0.5640.55
506_F607_E0.5640.55
94_V100_S0.5620.55
297_V625_C0.5620.55
161_R178_W0.5620.55
564_R569_T0.5610.54
424_Y476_N0.5610.54
374_D378_N0.5610.54
537_L568_V0.5590.54
191_G407_A0.5590.54
260_E263_S0.5580.54
371_N380_F0.5560.54
221_P224_M0.5550.54
162_I218_Y0.5540.54
247_A257_S0.5540.54
201_I209_A0.5520.53
458_N492_D0.5520.53
372_V379_A0.5510.53
197_A448_I0.5510.53
408_R411_S0.5510.53
388_E400_L0.5510.53
431_I648_T0.5510.53
387_G391_R0.5500.53
604_R607_E0.5500.53
621_F636_R0.5500.53
391_R405_P0.5480.53
267_L357_E0.5480.53
374_D379_A0.5480.53
397_A412_V0.5480.53
328_D362_L0.5470.53
573_M580_S0.5470.53
108_M120_I0.5460.53
191_G398_D0.5450.52
542_T616_P0.5450.52
373_E383_G0.5430.52
545_D580_S0.5430.52
269_D357_E0.5420.52
421_Y492_D0.5420.52
537_L540_T0.5420.52
235_D238_A0.5420.52
384_N389_P0.5410.52
263_S266_Q0.5410.52
543_Y560_R0.5410.52
378_N384_N0.5400.52
440_E478_A0.5400.52
194_A204_S0.5400.52
419_G546_P0.5400.52
589_G592_M0.5400.52
489_V651_T0.5400.52
274_T347_V0.5390.52
158_E297_V0.5380.51
301_L338_C0.5360.51
304_Y325_S0.5360.51
321_D326_V0.5360.51
129_Q188_G0.5360.51
391_R402_F0.5350.51
133_G137_S0.5350.51
109_G221_P0.5350.51
282_V338_C0.5340.51
491_T517_Y0.5340.51
275_K590_L0.5330.51
338_C421_Y0.5320.51
132_W197_A0.5320.51
517_Y524_L0.5310.51
262_F265_K0.5310.51
369_N378_N0.5310.51
545_D551_R0.5300.50
113_V161_R0.5290.50
186_A196_A0.5270.50
438_V651_T0.5250.50
164_G274_T0.5250.50
206_S213_V0.5250.50
428_N652_E0.5230.49
598_P603_E0.5220.49
598_P606_R0.5220.49
417_Y447_G0.5220.49
160_V163_L0.5220.49
232_V240_R0.5220.49
447_G486_E0.5220.49
459_D465_E0.5210.49
207_I211_G0.5210.49
231_L600_P0.5210.49
398_D405_P0.5200.49
229_A232_V0.5190.49
147_L150_L0.5190.49
600_P603_E0.5190.49
414_Y445_D0.5190.49
441_T657_A0.5190.49
633_E646_E0.5180.49
416_W436_A0.5180.49
148_F152_V0.5170.49
205_H209_A0.5170.49
231_L234_R0.5160.49
458_N462_R0.5160.49
551_R555_E0.5160.49
334_S596_E0.5160.49
365_S369_N0.5150.48
197_A383_G0.5150.48
394_P448_I0.5140.48
145_W148_F0.5130.48
370_K376_V0.5130.48
563_V568_V0.5130.48
601_S605_I0.5120.48
281_S344_A0.5120.48
516_H624_A0.5120.48
461_R497_N0.5120.48
442_A530_L0.5120.48
259_I264_W0.5110.48
388_E391_R0.5110.48
465_E588_G0.5110.48
585_G591_W0.5100.48
183_V229_A0.5100.48
275_K349_I0.5100.48
194_A200_A0.5090.48
438_V562_V0.5090.48
195_A441_T0.5080.48
368_M374_D0.5070.47
513_S561_E0.5060.47
440_E445_D0.5060.47
389_P393_R0.5050.47
209_A221_P0.5050.47
339_M349_I0.5040.47
542_T573_M0.5020.47
516_H524_L0.5010.47
193_L201_I0.5000.46
274_T349_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.675 100 0.723 Contact Map
3cf4A 2 0.8449 100 0.805 Contact Map
3c8yA 1 0.6721 99.9 0.87 Contact Map
1q16C 2 0.3072 99.9 0.887 Contact Map
1kf6B 1 0.3383 99.3 0.928 Contact Map
2bs2B 1 0.3279 99.3 0.93 Contact Map
2h88B 1 0.325 99.2 0.932 Contact Map
2wdqB 1 0.3235 99.2 0.933 Contact Map
1hfeL 2 0.4963 99 0.938 Contact Map
4ysxB 1 0.3161 99 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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