Q9HMZ3 - HALSA - GREMLIN Contacts

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Q9HMZ3 - Heterodisulfide reductase

UniProt:	Q9HMZ3	Sequences: MAVAIFLYGVYQRFATYARGSEDPTERLSNLPGRVVSAAKLVASNEKQFDRDLVAGLMHTFILWGFLTLLIGTTILAIDMDVWTKALGQSSFFVGEFYLSYSLVMDAMGLLFVVGVGVAIYRRYWVRNQRLWGKHTSREDDAFVWALFLLGVGGYVTEGVRILGTGFPSFETVSFVGWFVADVLSAAGVDGSLAAAAYPAIWWSHSILALGFVAAVPYAKPFHMISSYANLVARDADAGRRLPRVPADASPEEIGPSEIEDFSWKQLLDHDACTKCGRCSSVCPAKAAGRPLDPRDVILDLKSYREGVASGDREEVDIVADGGTSVIDASTMESCMSCMACMDACPVDIEHVTQFTEMNRRLTESGQMNKNVEDAVMNAFQKGNTFGEPDRKRPDWADDLDFEVPDAREQSVEYLWYVGDYPSYDERNQHIARSLATVFETAGVDYGILYEDEQNDGNDIRRVGEEGLYEMLAEDNIAAFDDCDYEKTVCTDPHSYNTFSNEYDQFGFENADSVYHYTQVVEGLVNEGALGLSGTELDDTVTYHDPCHLGRYNGEFEAPREVVRATGVTLDEMPRNRSDSFCCGGGGGGLWMDFDEEPKPSEERIREALEDTDAGPDVDRFVVACPMCMTMYEDGRKTGGYEDDIEITDVTELLVEAIEASGSAAASGVSETPAAAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	677 (534)
Sequences:	3000 (1904)
Seq/√Len:	82.4

BACSU - FADF
HALSA - Q9HMZ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
648_T	656_E	4.853	1.00
413_E	445_D	3.765	1.00
540_T	569_T	3.559	1.00
437_T	655_V	3.537	1.00
386_F	390_D	3.281	1.00
515_Y	523_G	3.187	1.00
434_S	652_E	3.177	1.00
455_N	495_S	3.017	1.00
248_D	251_P	2.958	1.00
522_E	561_E	2.916	1.00
392_K	395_D	2.860	1.00
560_R	564_R	2.829	1.00
395_D	400_L	2.819	1.00
247_A	251_P	2.776	1.00
189_V	192_S	2.767	1.00
602_E	610_E	2.669	1.00
395_D	403_E	2.616	1.00
490_C	496_Y	2.599	1.00
138_R	141_D	2.592	1.00
521_V	654_L	2.516	1.00
396_W	402_F	2.488	1.00
394_P	397_A	2.434	1.00
140_D	144_V	2.411	1.00
517_Y	651_T	2.371	1.00
391_R	396_W	2.350	1.00
395_D	398_D	2.347	1.00
247_A	255_G	2.258	1.00
249_A	252_E	2.258	1.00
395_D	402_F	2.246	1.00
393_R	397_A	2.229	1.00
441_T	655_V	2.226	1.00
435_L	491_T	2.224	1.00
387_G	390_D	2.200	1.00
247_A	252_E	2.187	1.00
254_I	258_E	2.160	1.00
246_P	251_P	2.135	1.00
252_E	255_G	2.121	1.00
251_P	255_G	2.110	1.00
383_G	386_F	2.102	1.00
438_V	654_L	2.088	1.00
422_P	432_A	2.072	1.00
192_S	196_A	2.063	1.00
350_E	353_T	2.057	1.00
251_P	254_I	2.055	1.00
246_P	249_A	2.049	1.00
186_A	192_S	2.045	1.00
394_P	401_D	2.035	1.00
540_T	571_D	2.022	1.00
378_N	383_G	2.016	1.00
400_L	403_E	2.013	1.00
375_A	378_N	1.972	1.00
413_E	447_G	1.970	1.00
258_E	261_D	1.957	1.00
437_T	659_E	1.955	1.00
620_R	648_T	1.953	1.00
251_P	260_E	1.937	1.00
397_A	402_F	1.929	1.00
573_M	608_A	1.907	1.00
386_F	389_P	1.877	1.00
500_S	519_Q	1.865	1.00
248_D	252_E	1.858	1.00
152_V	203_W	1.852	1.00
456_D	495_S	1.834	1.00
397_A	400_L	1.833	1.00
136_T	182_D	1.815	1.00
190_D	194_A	1.794	1.00
391_R	397_A	1.794	1.00
247_A	250_S	1.794	1.00
438_V	521_V	1.791	1.00
539_D	620_R	1.782	1.00
391_R	400_L	1.771	1.00
380_F	383_G	1.767	1.00
560_R	572_E	1.762	1.00
194_A	198_Y	1.759	1.00
372_V	383_G	1.756	1.00
541_V	653_L	1.744	1.00
372_V	376_V	1.742	1.00
251_P	257_S	1.730	1.00
246_P	252_E	1.729	1.00
254_I	259_I	1.729	1.00
337_S	548_H	1.725	1.00
195_A	199_P	1.724	1.00
384_N	387_G	1.724	1.00
420_D	495_S	1.723	1.00
249_A	254_I	1.722	1.00
420_D	455_N	1.717	1.00
521_V	525_V	1.713	1.00
391_R	394_P	1.705	1.00
395_D	401_D	1.699	1.00
247_A	254_I	1.698	1.00
247_A	258_E	1.688	1.00
246_P	258_E	1.686	1.00
396_W	400_L	1.685	1.00
394_P	403_E	1.685	1.00
198_Y	202_W	1.679	1.00
395_D	405_P	1.677	1.00
110_L	114_V	1.666	1.00
430_H	652_E	1.661	1.00
391_R	395_D	1.660	1.00
107_A	115_G	1.649	1.00
370_K	373_E	1.640	1.00
248_D	254_I	1.633	1.00
435_L	489_V	1.609	1.00
214_A	217_P	1.602	1.00
532_L	654_L	1.599	1.00
598_P	635_G	1.597	1.00
441_T	658_I	1.594	1.00
460_I	468_L	1.593	1.00
473_A	503_Y	1.591	1.00
622_V	653_L	1.590	1.00
399_D	403_E	1.580	1.00
378_N	382_K	1.577	1.00
444_V	520_V	1.575	1.00
523_G	527_E	1.564	1.00
395_D	399_D	1.561	1.00
428_N	431_I	1.551	1.00
392_K	397_A	1.540	1.00
162_I	177_G	1.533	1.00
385_T	388_E	1.529	0.99
454_Q	475_D	1.528	0.99
372_V	375_A	1.522	0.99
521_V	562_V	1.487	0.99
393_R	401_D	1.482	0.99
329_A	333_E	1.479	0.99
401_D	404_V	1.478	0.99
620_R	653_L	1.474	0.99
336_M	600_P	1.471	0.99
396_W	405_P	1.462	0.99
561_E	564_R	1.454	0.99
522_E	562_V	1.452	0.99
292_L	334_S	1.451	0.99
655_V	658_I	1.445	0.99
402_F	405_P	1.438	0.99
91_S	94_V	1.434	0.99
557_E	560_R	1.431	0.99
391_R	399_D	1.430	0.99
413_E	486_E	1.426	0.99
184_L	193_L	1.415	0.99
368_M	371_N	1.400	0.99
378_N	387_G	1.397	0.99
439_F	489_V	1.393	0.99
436_A	440_E	1.393	0.99
246_P	255_G	1.393	0.99
480_F	488_T	1.387	0.99
416_W	435_L	1.385	0.99
602_E	606_R	1.384	0.99
256_P	259_I	1.382	0.99
250_S	255_G	1.370	0.99
202_W	205_H	1.366	0.99
300_D	331_T	1.366	0.99
155_Y	185_S	1.362	0.99
401_D	405_P	1.355	0.99
646_E	656_E	1.348	0.99
523_G	558_A	1.347	0.99
303_S	306_E	1.346	0.99
508_F	512_D	1.345	0.99
438_V	658_I	1.345	0.99
437_T	441_T	1.342	0.99
372_V	378_N	1.332	0.99
392_K	396_W	1.330	0.99
398_D	403_E	1.325	0.99
117_G	120_I	1.322	0.99
250_S	253_E	1.317	0.98
391_R	398_D	1.312	0.98
411_S	445_D	1.311	0.98
246_P	250_S	1.306	0.98
254_I	257_S	1.296	0.98
251_P	258_E	1.290	0.98
392_K	402_F	1.289	0.98
358_M	362_L	1.288	0.98
248_D	260_E	1.284	0.98
472_L	476_N	1.283	0.98
196_A	199_P	1.273	0.98
435_L	651_T	1.272	0.98
526_N	561_E	1.265	0.98
476_N	499_F	1.264	0.98
340_A	344_A	1.262	0.98
247_A	253_E	1.259	0.98
365_S	368_M	1.255	0.98
394_P	400_L	1.252	0.98
605_I	609_L	1.248	0.98
396_W	403_E	1.248	0.98
329_A	362_L	1.246	0.98
246_P	254_I	1.239	0.98
476_N	503_Y	1.238	0.98
201_I	205_H	1.236	0.98
369_N	373_E	1.235	0.98
252_E	256_P	1.235	0.98
192_S	195_A	1.233	0.98
170_F	173_V	1.228	0.98
248_D	258_E	1.224	0.98
555_E	558_A	1.224	0.98
414_Y	520_V	1.219	0.97
454_Q	479_A	1.216	0.97
106_D	114_V	1.215	0.97
247_A	260_E	1.213	0.97
474_E	478_A	1.204	0.97
252_E	258_E	1.201	0.97
393_R	396_W	1.201	0.97
378_N	381_Q	1.194	0.97
209_A	212_F	1.194	0.97
369_N	376_V	1.193	0.97
200_A	204_S	1.192	0.97
339_M	350_E	1.192	0.97
513_S	523_G	1.192	0.97
517_Y	521_V	1.183	0.97
252_E	257_S	1.182	0.97
394_P	402_F	1.179	0.97
394_P	398_D	1.178	0.97
364_E	467_G	1.169	0.97
415_L	483_C	1.164	0.97
452_D	483_C	1.163	0.97
477_I	481_D	1.161	0.97
438_V	655_V	1.160	0.97
208_L	212_F	1.159	0.97
414_Y	489_V	1.157	0.97
531_G	565_A	1.157	0.97
461_R	466_E	1.155	0.96
540_T	619_D	1.154	0.96
515_Y	520_V	1.150	0.96
376_V	384_N	1.149	0.96
252_E	260_E	1.147	0.96
463_V	588_G	1.146	0.96
156_V	222_F	1.146	0.96
418_V	432_A	1.146	0.96
532_L	658_I	1.140	0.96
519_Q	555_E	1.130	0.96
418_V	449_L	1.126	0.96
496_Y	514_V	1.124	0.96
616_P	619_D	1.122	0.96
332_M	358_M	1.113	0.96
198_Y	201_I	1.112	0.96
194_A	213_V	1.109	0.96
353_T	505_Q	1.106	0.95
423_S	453_E	1.106	0.95
397_A	403_E	1.099	0.95
392_K	403_E	1.098	0.95
392_K	398_D	1.094	0.95
249_A	256_P	1.094	0.95
492_D	625_C	1.093	0.95
251_P	256_P	1.092	0.95
435_L	439_F	1.087	0.95
255_G	258_E	1.075	0.95
436_A	446_Y	1.073	0.95
472_L	475_D	1.071	0.95
248_D	255_G	1.070	0.95
391_R	401_D	1.067	0.94
382_K	386_F	1.061	0.94
356_T	466_E	1.058	0.94
574_P	580_S	1.057	0.94
253_E	257_S	1.055	0.94
648_T	652_E	1.055	0.94
588_G	592_M	1.052	0.94
542_T	621_F	1.047	0.94
249_A	258_E	1.044	0.94
126_V	188_G	1.042	0.94
515_Y	519_Q	1.037	0.94
378_N	386_F	1.036	0.94
360_R	466_E	1.032	0.93
333_E	595_D	1.032	0.93
154_G	157_T	1.031	0.93
368_M	372_V	1.028	0.93
580_S	604_R	1.028	0.93
92_F	96_E	1.027	0.93
162_I	166_G	1.026	0.93
373_E	380_F	1.024	0.93
193_L	197_A	1.023	0.93
247_A	256_P	1.021	0.93
231_L	235_D	1.017	0.93
254_I	260_E	1.013	0.93
481_D	512_D	1.010	0.93
470_E	474_E	1.010	0.93
494_H	625_C	1.008	0.93
420_D	456_D	1.007	0.93
393_R	403_E	1.005	0.93
550_G	556_F	1.005	0.93
388_E	392_K	1.002	0.92
373_E	376_V	1.000	0.92
159_G	180_V	0.996	0.92
396_W	404_V	0.995	0.92
519_Q	523_G	0.994	0.92
606_R	610_E	0.993	0.92
184_L	200_A	0.987	0.92
246_P	259_I	0.987	0.92
332_M	355_F	0.987	0.92
249_A	255_G	0.986	0.92
384_N	388_E	0.985	0.92
620_R	656_E	0.982	0.92
250_S	254_I	0.982	0.92
386_F	392_K	0.980	0.92
601_S	636_R	0.977	0.91
606_R	636_R	0.974	0.91
400_L	405_P	0.973	0.91
435_L	517_Y	0.973	0.91
519_Q	558_A	0.973	0.91
241_R	244_R	0.973	0.91
308_V	324_T	0.972	0.91
601_S	635_G	0.967	0.91
255_G	260_E	0.967	0.91
379_A	383_G	0.966	0.91
386_F	393_R	0.966	0.91
415_L	486_E	0.965	0.91
487_K	513_S	0.965	0.91
196_A	200_A	0.964	0.91
287_A	603_E	0.964	0.91
444_V	524_L	0.960	0.91
181_A	221_P	0.959	0.91
585_G	590_L	0.956	0.91
253_E	256_P	0.955	0.90
252_E	259_I	0.952	0.90
358_M	361_R	0.950	0.90
148_F	151_G	0.949	0.90
419_G	492_D	0.946	0.90
372_V	382_K	0.942	0.90
543_Y	556_F	0.939	0.90
646_E	652_E	0.939	0.90
253_E	260_E	0.937	0.90
158_E	161_R	0.936	0.90
102_S	105_M	0.934	0.90
440_E	446_Y	0.934	0.90
585_G	631_M	0.933	0.89
621_F	632_Y	0.931	0.89
371_N	375_A	0.930	0.89
392_K	401_D	0.926	0.89
95_G	99_L	0.925	0.89
537_L	657_A	0.924	0.89
546_P	625_C	0.923	0.89
569_T	617_D	0.921	0.89
375_A	387_G	0.919	0.89
262_F	266_Q	0.918	0.89
550_G	580_S	0.916	0.89
107_A	117_G	0.914	0.88
186_A	193_L	0.911	0.88
434_S	655_V	0.909	0.88
249_A	260_E	0.907	0.88
543_Y	570_L	0.907	0.88
199_P	202_W	0.905	0.88
255_G	259_I	0.905	0.88
350_E	354_Q	0.904	0.88
376_V	380_F	0.902	0.88
201_I	204_S	0.899	0.88
409_E	412_V	0.898	0.88
369_N	465_E	0.894	0.87
376_V	383_G	0.892	0.87
618_V	638_T	0.891	0.87
394_P	405_P	0.890	0.87
360_R	467_G	0.886	0.87
391_R	403_E	0.885	0.87
256_P	262_F	0.884	0.87
209_A	213_V	0.883	0.87
120_I	148_F	0.881	0.87
373_E	379_A	0.881	0.87
380_F	386_F	0.881	0.87
127_R	131_L	0.881	0.87
461_R	498_T	0.880	0.87
270_H	354_Q	0.879	0.86
398_D	402_F	0.878	0.86
173_V	176_V	0.876	0.86
154_G	161_R	0.876	0.86
416_W	491_T	0.874	0.86
539_D	656_E	0.874	0.86
394_P	404_V	0.874	0.86
377_M	383_G	0.873	0.86
115_G	118_V	0.873	0.86
409_E	445_D	0.873	0.86
412_V	529_A	0.872	0.86
141_D	144_V	0.872	0.86
217_P	220_K	0.871	0.86
254_I	261_D	0.870	0.86
246_P	260_E	0.866	0.86
392_K	400_L	0.864	0.86
398_D	401_D	0.860	0.85
370_K	374_D	0.859	0.85
247_A	259_I	0.859	0.85
249_A	253_E	0.858	0.85
369_N	372_V	0.858	0.85
524_L	529_A	0.857	0.85
541_V	568_V	0.854	0.85
375_A	379_A	0.854	0.85
623_V	630_T	0.854	0.85
385_T	470_E	0.849	0.84
541_V	570_L	0.845	0.84
541_V	622_V	0.844	0.84
249_A	259_I	0.843	0.84
388_E	394_P	0.843	0.84
604_R	608_A	0.840	0.84
388_E	393_R	0.835	0.84
492_D	495_S	0.833	0.83
372_V	386_F	0.833	0.83
387_G	394_P	0.831	0.83
248_D	259_I	0.831	0.83
393_R	398_D	0.828	0.83
393_R	400_L	0.828	0.83
206_S	210_L	0.828	0.83
376_V	379_A	0.826	0.83
132_W	184_L	0.826	0.83
248_D	253_E	0.825	0.83
172_T	175_F	0.823	0.83
368_M	375_A	0.823	0.83
320_A	323_G	0.818	0.82
386_F	395_D	0.818	0.82
398_D	404_V	0.817	0.82
393_R	402_F	0.814	0.82
650_V	654_L	0.811	0.82
541_V	620_R	0.809	0.82
383_G	387_G	0.806	0.81
516_H	519_Q	0.805	0.81
397_A	401_D	0.804	0.81
191_G	195_A	0.803	0.81
210_L	217_P	0.803	0.81
420_D	492_D	0.799	0.81
255_G	261_D	0.798	0.81
545_D	556_F	0.798	0.81
369_N	374_D	0.796	0.80
285_A	596_E	0.796	0.80
396_W	433_R	0.796	0.80
171_E	174_S	0.795	0.80
390_D	394_P	0.795	0.80
385_T	390_D	0.794	0.80
488_T	536_E	0.791	0.80
360_R	364_E	0.791	0.80
151_G	203_W	0.789	0.80
396_W	401_D	0.788	0.80
369_N	375_A	0.788	0.80
206_S	211_G	0.788	0.80
342_M	552_Y	0.787	0.80
393_R	404_V	0.783	0.79
551_R	556_F	0.783	0.79
518_T	562_V	0.782	0.79
397_A	405_P	0.780	0.79
369_N	377_M	0.780	0.79
337_S	355_F	0.776	0.79
208_L	211_G	0.776	0.79
413_E	446_Y	0.774	0.79
385_T	389_P	0.773	0.79
412_V	444_V	0.770	0.78
380_F	384_N	0.770	0.78
285_A	336_M	0.770	0.78
383_G	388_E	0.769	0.78
522_E	526_N	0.768	0.78
399_D	404_V	0.768	0.78
374_D	383_G	0.768	0.78
558_A	561_E	0.763	0.78
236_A	239_G	0.762	0.78
416_W	432_A	0.761	0.77
160_V	165_T	0.761	0.77
285_A	297_V	0.759	0.77
419_G	625_C	0.758	0.77
109_G	158_E	0.758	0.77
488_T	499_F	0.758	0.77
417_Y	499_F	0.756	0.77
198_Y	205_H	0.755	0.77
526_N	565_A	0.755	0.77
92_F	95_G	0.755	0.77
287_A	604_R	0.754	0.77
439_F	520_V	0.754	0.77
436_A	448_I	0.753	0.77
399_D	402_F	0.751	0.76
117_G	148_F	0.750	0.76
253_E	259_I	0.749	0.76
215_A	219_A	0.747	0.76
369_N	380_F	0.746	0.76
430_H	433_R	0.745	0.76
648_T	653_L	0.744	0.76
356_T	461_R	0.744	0.76
251_P	259_I	0.744	0.76
232_V	274_T	0.744	0.76
542_T	608_A	0.743	0.76
164_G	228_Y	0.742	0.76
468_L	472_L	0.740	0.75
229_A	233_A	0.739	0.75
373_E	377_M	0.737	0.75
277_G	295_R	0.737	0.75
288_A	603_E	0.735	0.75
364_E	367_Q	0.733	0.75
601_S	606_R	0.731	0.75
431_I	652_E	0.731	0.75
332_M	351_H	0.729	0.74
142_A	146_A	0.728	0.74
478_A	481_D	0.726	0.74
257_S	261_D	0.724	0.74
623_V	629_M	0.723	0.74
224_M	228_Y	0.720	0.73
406_D	410_Q	0.720	0.73
286_K	289_G	0.720	0.73
282_V	344_A	0.718	0.73
433_R	436_A	0.717	0.73
585_G	630_T	0.717	0.73
469_Y	473_A	0.716	0.73
655_V	659_E	0.715	0.73
337_S	356_T	0.714	0.73
246_P	253_E	0.712	0.73
492_D	546_P	0.712	0.73
351_H	354_Q	0.711	0.72
371_N	374_D	0.704	0.72
392_K	404_V	0.704	0.72
370_K	378_N	0.703	0.72
434_S	437_T	0.703	0.72
504_D	511_A	0.703	0.72
536_E	568_V	0.702	0.72
525_V	565_A	0.699	0.71
372_V	377_M	0.697	0.71
618_V	621_F	0.697	0.71
375_A	380_F	0.697	0.71
392_K	405_P	0.696	0.71
112_F	151_G	0.694	0.71
130_R	190_D	0.694	0.71
416_W	422_P	0.693	0.71
261_D	264_W	0.692	0.70
461_R	469_Y	0.687	0.70
477_I	499_F	0.686	0.70
374_D	377_M	0.685	0.70
377_M	380_F	0.685	0.70
295_R	352_V	0.681	0.69
206_S	212_F	0.681	0.69
109_G	154_G	0.680	0.69
109_G	113_V	0.678	0.69
455_N	492_D	0.677	0.69
518_T	650_V	0.676	0.69
157_T	160_V	0.676	0.69
246_P	256_P	0.675	0.69
374_D	382_K	0.675	0.69
521_V	651_T	0.674	0.68
252_E	264_W	0.673	0.68
394_P	399_D	0.673	0.68
375_A	383_G	0.672	0.68
102_S	158_E	0.672	0.68
250_S	258_E	0.670	0.68
199_P	203_W	0.669	0.68
372_V	463_V	0.669	0.68
566_T	654_L	0.669	0.68
557_E	561_E	0.668	0.68
530_L	533_S	0.667	0.68
437_T	440_E	0.665	0.67
556_F	572_E	0.663	0.67
248_D	256_P	0.661	0.67
195_A	198_Y	0.660	0.67
260_E	264_W	0.660	0.67
458_N	544_H	0.659	0.67
339_M	552_Y	0.659	0.67
515_Y	524_L	0.659	0.67
397_A	404_V	0.657	0.66
282_V	581_F	0.657	0.66
258_E	262_F	0.654	0.66
253_E	258_E	0.654	0.66
536_E	566_T	0.654	0.66
375_A	381_Q	0.653	0.66
110_L	113_V	0.652	0.66
357_E	361_R	0.652	0.66
562_V	565_A	0.649	0.66
371_N	378_N	0.647	0.65
371_N	376_V	0.645	0.65
470_E	508_F	0.645	0.65
397_A	436_A	0.644	0.65
249_A	257_S	0.644	0.65
371_N	387_G	0.642	0.65
354_Q	417_Y	0.642	0.65
364_E	368_M	0.641	0.65
154_G	158_E	0.640	0.64
414_Y	439_F	0.639	0.64
357_E	360_R	0.638	0.64
433_R	437_T	0.638	0.64
533_S	536_E	0.637	0.64
93_F	96_E	0.636	0.64
206_S	209_A	0.636	0.64
609_L	621_F	0.634	0.64
280_S	291_P	0.634	0.64
171_E	176_V	0.633	0.64
528_G	531_G	0.632	0.63
483_C	486_E	0.632	0.63
539_D	568_V	0.631	0.63
297_V	331_T	0.630	0.63
193_L	204_S	0.630	0.63
109_G	157_T	0.629	0.63
377_M	381_Q	0.629	0.63
287_A	599_K	0.627	0.63
372_V	380_F	0.627	0.63
365_S	599_K	0.627	0.63
143_F	146_A	0.626	0.63
112_F	183_V	0.626	0.63
113_V	151_G	0.624	0.63
160_V	164_G	0.623	0.62
217_P	431_I	0.623	0.62
235_D	239_G	0.622	0.62
250_S	257_S	0.622	0.62
229_A	281_S	0.621	0.62
542_T	618_V	0.620	0.62
242_L	274_T	0.618	0.62
606_R	635_G	0.618	0.62
605_I	608_A	0.617	0.62
321_D	324_T	0.617	0.62
212_F	221_P	0.616	0.62
321_D	325_S	0.614	0.61
159_G	165_T	0.614	0.61
385_T	393_R	0.613	0.61
229_A	274_T	0.611	0.61
487_K	520_V	0.611	0.61
91_S	95_G	0.610	0.61
150_L	154_G	0.608	0.61
161_R	165_T	0.607	0.60
328_D	331_T	0.607	0.60
487_K	515_Y	0.607	0.60
539_D	619_D	0.605	0.60
440_E	565_A	0.603	0.60
379_A	388_E	0.603	0.60
256_P	261_D	0.602	0.60
239_G	243_P	0.602	0.60
353_T	356_T	0.602	0.60
519_Q	525_V	0.600	0.59
481_D	509_E	0.599	0.59
438_V	442_A	0.598	0.59
531_G	557_E	0.598	0.59
269_D	272_A	0.598	0.59
445_D	537_L	0.597	0.59
373_E	382_K	0.596	0.59
456_D	460_I	0.596	0.59
178_W	332_M	0.595	0.59
220_K	223_H	0.595	0.59
441_T	530_L	0.595	0.59
417_Y	456_D	0.594	0.59
250_S	259_I	0.594	0.59
297_V	355_F	0.593	0.59
455_N	459_D	0.593	0.59
462_R	494_H	0.593	0.59
382_K	390_D	0.592	0.58
475_D	478_A	0.591	0.58
232_V	239_G	0.590	0.58
479_A	483_C	0.590	0.58
111_L	225_I	0.590	0.58
538_D	568_V	0.590	0.58
294_P	458_N	0.589	0.58
355_F	358_M	0.589	0.58
230_N	233_A	0.586	0.58
326_V	362_L	0.586	0.58
430_H	434_S	0.586	0.58
148_F	203_W	0.586	0.58
241_R	245_V	0.584	0.57
609_L	632_Y	0.584	0.57
372_V	592_M	0.583	0.57
568_V	657_A	0.583	0.57
542_T	571_D	0.582	0.57
458_N	588_G	0.580	0.57
484_D	646_E	0.580	0.57
380_F	465_E	0.580	0.57
298_I	351_H	0.579	0.57
175_F	220_K	0.579	0.57
282_V	607_E	0.579	0.57
494_H	626_P	0.579	0.57
591_W	634_D	0.578	0.57
363_T	465_E	0.578	0.57
556_F	560_R	0.577	0.57
188_G	192_S	0.576	0.56
280_S	295_R	0.576	0.56
95_G	98_Y	0.576	0.56
372_V	594_F	0.576	0.56
632_Y	647_I	0.576	0.56
303_S	307_G	0.575	0.56
392_K	399_D	0.574	0.56
373_E	378_N	0.573	0.56
280_S	286_K	0.572	0.56
396_W	399_D	0.571	0.56
400_L	404_V	0.571	0.56
116_V	330_S	0.570	0.56
479_A	565_A	0.570	0.56
336_M	356_T	0.570	0.56
496_Y	500_S	0.569	0.56
482_D	485_Y	0.568	0.55
109_G	112_F	0.567	0.55
376_V	465_E	0.567	0.55
234_R	348_D	0.566	0.55
233_A	274_T	0.565	0.55
193_L	198_Y	0.565	0.55
327_I	331_T	0.565	0.55
422_P	492_D	0.564	0.55
562_V	654_L	0.564	0.55
563_V	622_V	0.564	0.55
506_F	607_E	0.564	0.55
94_V	100_S	0.562	0.55
297_V	625_C	0.562	0.55
161_R	178_W	0.562	0.55
564_R	569_T	0.561	0.54
424_Y	476_N	0.561	0.54
374_D	378_N	0.561	0.54
537_L	568_V	0.559	0.54
191_G	407_A	0.559	0.54
260_E	263_S	0.558	0.54
371_N	380_F	0.556	0.54
221_P	224_M	0.555	0.54
162_I	218_Y	0.554	0.54
247_A	257_S	0.554	0.54
201_I	209_A	0.552	0.53
458_N	492_D	0.552	0.53
372_V	379_A	0.551	0.53
197_A	448_I	0.551	0.53
408_R	411_S	0.551	0.53
388_E	400_L	0.551	0.53
431_I	648_T	0.551	0.53
387_G	391_R	0.550	0.53
604_R	607_E	0.550	0.53
621_F	636_R	0.550	0.53
391_R	405_P	0.548	0.53
267_L	357_E	0.548	0.53
374_D	379_A	0.548	0.53
397_A	412_V	0.548	0.53
328_D	362_L	0.547	0.53
573_M	580_S	0.547	0.53
108_M	120_I	0.546	0.53
191_G	398_D	0.545	0.52
542_T	616_P	0.545	0.52
373_E	383_G	0.543	0.52
545_D	580_S	0.543	0.52
269_D	357_E	0.542	0.52
421_Y	492_D	0.542	0.52
537_L	540_T	0.542	0.52
235_D	238_A	0.542	0.52
384_N	389_P	0.541	0.52
263_S	266_Q	0.541	0.52
543_Y	560_R	0.541	0.52
378_N	384_N	0.540	0.52
440_E	478_A	0.540	0.52
194_A	204_S	0.540	0.52
419_G	546_P	0.540	0.52
589_G	592_M	0.540	0.52
489_V	651_T	0.540	0.52
274_T	347_V	0.539	0.52
158_E	297_V	0.538	0.51
301_L	338_C	0.536	0.51
304_Y	325_S	0.536	0.51
321_D	326_V	0.536	0.51
129_Q	188_G	0.536	0.51
391_R	402_F	0.535	0.51
133_G	137_S	0.535	0.51
109_G	221_P	0.535	0.51
282_V	338_C	0.534	0.51
491_T	517_Y	0.534	0.51
275_K	590_L	0.533	0.51
338_C	421_Y	0.532	0.51
132_W	197_A	0.532	0.51
517_Y	524_L	0.531	0.51
262_F	265_K	0.531	0.51
369_N	378_N	0.531	0.51
545_D	551_R	0.530	0.50
113_V	161_R	0.529	0.50
186_A	196_A	0.527	0.50
438_V	651_T	0.525	0.50
164_G	274_T	0.525	0.50
206_S	213_V	0.525	0.50
428_N	652_E	0.523	0.49
598_P	603_E	0.522	0.49
598_P	606_R	0.522	0.49
417_Y	447_G	0.522	0.49
160_V	163_L	0.522	0.49
232_V	240_R	0.522	0.49
447_G	486_E	0.522	0.49
459_D	465_E	0.521	0.49
207_I	211_G	0.521	0.49
231_L	600_P	0.521	0.49
398_D	405_P	0.520	0.49
229_A	232_V	0.519	0.49
147_L	150_L	0.519	0.49
600_P	603_E	0.519	0.49
414_Y	445_D	0.519	0.49
441_T	657_A	0.519	0.49
633_E	646_E	0.518	0.49
416_W	436_A	0.518	0.49
148_F	152_V	0.517	0.49
205_H	209_A	0.517	0.49
231_L	234_R	0.516	0.49
458_N	462_R	0.516	0.49
551_R	555_E	0.516	0.49
334_S	596_E	0.516	0.49
365_S	369_N	0.515	0.48
197_A	383_G	0.515	0.48
394_P	448_I	0.514	0.48
145_W	148_F	0.513	0.48
370_K	376_V	0.513	0.48
563_V	568_V	0.513	0.48
601_S	605_I	0.512	0.48
281_S	344_A	0.512	0.48
516_H	624_A	0.512	0.48
461_R	497_N	0.512	0.48
442_A	530_L	0.512	0.48
259_I	264_W	0.511	0.48
388_E	391_R	0.511	0.48
465_E	588_G	0.511	0.48
585_G	591_W	0.510	0.48
183_V	229_A	0.510	0.48
275_K	349_I	0.510	0.48
194_A	200_A	0.509	0.48
438_V	562_V	0.509	0.48
195_A	441_T	0.508	0.48
368_M	374_D	0.507	0.47
513_S	561_E	0.506	0.47
440_E	445_D	0.506	0.47
389_P	393_R	0.505	0.47
209_A	221_P	0.505	0.47
339_M	349_I	0.504	0.47
542_T	573_M	0.502	0.47
516_H	524_L	0.501	0.47
193_L	201_I	0.500	0.46
274_T	349_I	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kwlA	1	0.675	100	0.723	Contact Map
3cf4A	2	0.8449	100	0.805	Contact Map
3c8yA	1	0.6721	99.9	0.87	Contact Map
1q16C	2	0.3072	99.9	0.887	Contact Map
1kf6B	1	0.3383	99.3	0.928	Contact Map
2bs2B	1	0.3279	99.3	0.93	Contact Map
2h88B	1	0.325	99.2	0.932	Contact Map
2wdqB	1	0.3235	99.2	0.933	Contact Map
1hfeL	2	0.4963	99	0.938	Contact Map
4ysxB	1	0.3161	99	0.939	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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