GREMLIN Database
Q9HMZ2 - Putative acetyltransferase
UniProt: Q9HMZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (166)
Sequences: 19979 (15174)
Seq/√Len: 1177.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_A151_L2.7621.00
117_T153_K2.7221.00
15_H21_D2.3731.00
15_H77_S2.3681.00
159_E179_G2.3121.00
33_D108_P2.3011.00
100_G133_F2.2361.00
11_A118_E2.2011.00
90_F127_V2.1801.00
140_V148_Q2.1571.00
158_R161_Q2.1441.00
78_D81_N2.1091.00
8_D79_A2.0761.00
158_R176_Y2.0711.00
9_G122_L2.0431.00
140_V151_L2.0371.00
9_G118_E2.0081.00
149_A152_E1.9261.00
148_Q152_E1.9251.00
125_D129_G1.8251.00
102_L120_T1.8011.00
23_E46_L1.7931.00
124_L156_F1.7581.00
31_Q108_P1.7431.00
124_L136_V1.7061.00
134_H164_D1.6831.00
161_Q176_Y1.6601.00
22_H50_A1.6491.00
24_F84_P1.6371.00
46_L50_A1.6111.00
120_T154_L1.6001.00
88_V119_A1.5991.00
148_Q158_R1.5461.00
75_A84_P1.5441.00
148_Q176_Y1.5411.00
122_L125_D1.5231.00
106_I116_V1.5091.00
167_I172_Y1.5031.00
13_S79_A1.4811.00
142_A174_D1.4701.00
17_I75_A1.4491.00
107_A110_H1.4421.00
45_T48_D1.4401.00
152_E158_R1.4131.00
19_D54_E1.4101.00
104_Y151_L1.4081.00
145_E148_Q1.4051.00
52_S56_S1.3471.00
7_A122_L1.3451.00
8_D13_S1.3441.00
134_H172_Y1.3401.00
117_T150_A1.3231.00
77_S82_P1.3221.00
88_V123_F1.3151.00
135_R179_G1.2821.00
126_Y130_E1.2641.00
148_Q178_Y1.2571.00
85_V110_H1.2571.00
142_A161_Q1.2541.00
165_D175_T1.2401.00
24_F83_T1.2361.00
162_R177_T1.1931.00
127_V136_V1.1871.00
143_P173_V1.1721.00
104_Y147_S1.1701.00
26_Q46_L1.1621.00
116_V150_A1.1561.00
28_G107_A1.1461.00
22_H53_V1.1431.00
83_T109_D1.1051.00
76_S106_I1.0861.00
87_E105_W1.0841.00
7_A126_Y1.0771.00
127_V131_R1.0721.00
22_H46_L1.0701.00
83_T110_H1.0701.00
101_S139_H1.0631.00
50_A54_E1.0601.00
9_G12_V1.0571.00
78_D85_V1.0541.00
140_V178_Y1.0531.00
94_S97_G1.0521.00
111_Q146_A1.0451.00
34_V111_Q1.0281.00
161_Q174_D1.0251.00
163_R174_D1.0221.00
28_G105_W1.0191.00
138_A156_F1.0181.00
24_F27_Y1.0181.00
51_E55_D1.0161.00
19_D50_A1.0151.00
7_A14_L1.0121.00
108_P111_Q1.0081.00
33_D36_V1.0021.00
124_L180_L0.9891.00
135_R159_E0.9891.00
126_Y131_R0.9871.00
147_S151_L0.9851.00
117_T121_T0.9671.00
158_R178_Y0.9611.00
164_D174_D0.9521.00
99_H137_D0.9521.00
74_P123_F0.9381.00
150_A154_L0.9371.00
76_S119_A0.9301.00
151_L156_F0.9261.00
19_D57_D0.9201.00
124_L154_L0.9191.00
163_R179_G0.9181.00
44_R48_D0.9141.00
17_I87_E0.9131.00
43_I49_V0.9111.00
141_L173_V0.9011.00
13_S77_S0.8871.00
90_F123_F0.8871.00
13_S82_P0.8841.00
145_E149_A0.8841.00
78_D115_Y0.8761.00
142_A176_Y0.8751.00
121_T125_D0.8721.00
127_V133_F0.8681.00
33_D111_Q0.8661.00
99_H135_R0.8651.00
156_F180_L0.8621.00
12_V115_Y0.8601.00
117_T154_L0.8541.00
112_G146_A0.8521.00
104_Y116_V0.8361.00
12_V119_A0.8351.00
19_D22_H0.8221.00
162_R165_D0.8201.00
98_E172_Y0.8201.00
121_T154_L0.8191.00
118_E122_L0.8171.00
26_Q49_V0.8161.00
35_R38_L0.8081.00
106_I115_Y0.8061.00
101_S137_D0.7971.00
98_E167_I0.7951.00
47_D50_A0.7911.00
22_H26_Q0.7821.00
77_S84_P0.7711.00
163_R181_L0.7701.00
99_H165_D0.7681.00
23_E27_Y0.7681.00
74_P126_Y0.7681.00
37_P141_L0.7671.00
78_D110_H0.7651.00
29_R105_W0.7621.00
145_E152_E0.7611.00
51_E54_E0.7591.00
110_H113_N0.7561.00
27_Y107_A0.7531.00
21_D77_S0.7511.00
135_R181_L0.7491.00
152_E178_Y0.7461.00
104_Y120_T0.7401.00
31_Q107_A0.7271.00
139_H162_R0.7261.00
54_E58_D0.7251.00
78_D83_T0.7201.00
83_T107_A0.7181.00
167_I171_E0.7171.00
140_V147_S0.7121.00
26_Q30_N0.7101.00
78_D113_N0.7081.00
9_G14_L0.7071.00
112_G117_T0.7061.00
37_P143_P0.7031.00
27_Y83_T0.6991.00
47_D51_E0.6981.00
48_D51_E0.6951.00
27_Y109_D0.6931.00
24_F107_A0.6931.00
120_T150_A0.6911.00
164_D172_Y0.6911.00
159_E163_R0.6721.00
139_H175_T0.6691.00
140_V176_Y0.6651.00
55_D58_D0.6641.00
106_I111_Q0.6611.00
104_Y150_A0.6561.00
35_R40_D0.6471.00
11_A114_G0.6431.00
10_D118_E0.6391.00
112_G149_A0.6361.00
149_A153_K0.6321.00
28_G84_P0.6321.00
15_H75_A0.6281.00
138_A147_S0.6271.00
146_A149_A0.6221.00
168_V171_E0.6211.00
117_T146_A0.6201.00
58_D68_G0.6201.00
15_H18_E0.6151.00
56_S73_E0.6151.00
116_V120_T0.6091.00
143_P171_E0.6091.00
69_D72_D0.6071.00
31_Q111_Q0.6021.00
115_Y118_E0.5991.00
98_E134_H0.5951.00
44_R49_V0.5911.00
88_V120_T0.5911.00
12_V118_E0.5901.00
84_P87_E0.5891.00
85_V115_Y0.5881.00
142_A148_Q0.5821.00
16_P57_D0.5801.00
90_F100_G0.5801.00
32_P36_V0.5741.00
164_D181_L0.5741.00
166_A175_T0.5731.00
139_H177_T0.5721.00
49_V53_V0.5721.00
154_L180_L0.5701.00
151_L178_Y0.5701.00
100_G127_V0.5641.00
93_V100_G0.5631.00
138_A178_Y0.5601.00
91_A101_S0.5561.00
31_Q109_D0.5531.00
124_L128_F0.5531.00
168_V173_V0.5521.00
167_I170_G0.5511.00
53_V57_D0.5501.00
112_G150_A0.5461.00
137_D165_D0.5451.00
104_Y138_A0.5441.00
38_L105_W0.5431.00
137_D162_R0.5421.00
75_A78_D0.5421.00
34_V105_W0.5411.00
157_E163_R0.5401.00
100_G136_V0.5401.00
74_P77_S0.5381.00
106_I110_H0.5371.00
25_I29_R0.5281.00
92_W100_G0.5281.00
135_R165_D0.5271.00
106_I119_A0.5241.00
73_E89_A0.5221.00
23_E26_Q0.5191.00
29_R87_E0.5101.00
76_S88_V0.5101.00
102_L136_V0.5101.00
18_E21_D0.5061.00
27_Y30_N0.5061.00
25_I87_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pzjA 2 0.9415 100 0.288 Contact Map
2fckA 2 0.9202 100 0.307 Contact Map
1yreA 2 0.9149 100 0.309 Contact Map
2vzyA 3 0.883 100 0.317 Contact Map
3r9fA 1 0.9096 100 0.333 Contact Map
2z10A 2 0.9362 100 0.334 Contact Map
3tcvA 2 0.9521 100 0.334 Contact Map
1nslA 3 0.9309 100 0.344 Contact Map
3igrA 2 0.9468 100 0.351 Contact Map
3fbuA 2 0.8883 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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