GREMLIN Database
Q9HMZ1 - Delta-aminolevulinic acid dehydratase
UniProt: Q9HMZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (314)
Sequences: 2863 (1465)
Seq/√Len: 82.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_R263_D3.5651.00
238_V264_V3.5151.00
262_S266_R3.5071.00
89_R92_A3.4491.00
85_D123_S3.0811.00
62_R320_E3.0681.00
28_D307_K3.0351.00
296_E325_T2.9421.00
114_T158_H2.8121.00
170_A175_M2.6541.00
254_A306_I2.6321.00
242_V270_R2.5981.00
98_Q157_S2.5421.00
303_L322_V2.5131.00
101_T112_V2.5001.00
238_V249_L2.4841.00
160_E188_F2.3441.00
156_V182_A2.3031.00
105_T164_E2.2951.00
141_T190_D2.2301.00
20_S227_D2.2261.00
285_H295_L2.2241.00
231_R260_V2.1831.00
143_K146_E2.1721.00
42_R52_E2.1531.00
91_Y150_L2.0641.00
198_A238_V2.0571.00
294_D297_S2.0561.00
64_R68_D2.0521.00
265_R312_D2.0511.00
261_V274_A2.0451.00
65_E324_E2.0451.00
44_P52_E2.0241.00
299_A325_T2.0171.00
7_P240_L1.9821.00
286_A292_W1.9721.00
93_D160_E1.9581.00
273_A313_L1.9311.00
43_T53_R1.8921.00
248_V273_A1.8771.00
84_D88_S1.8541.00
101_T114_T1.8351.00
152_A182_A1.8321.00
239_A243_E1.7721.00
30_V313_L1.7621.00
60_V107_E1.7501.00
58_D61_D1.7461.00
232_R265_R1.7191.00
300_H322_V1.7031.00
42_R58_D1.6961.00
91_Y153_E1.6801.00
263_D266_R1.6681.00
17_D72_E1.6581.00
46_P210_D1.6391.00
56_L103_R1.6201.00
5_H236_R1.6201.00
239_A268_F1.6041.00
45_I51_Q1.5881.00
73_A113_I1.5861.00
129_V150_L1.5811.00
61_D64_R1.5771.00
255_L276_N1.5651.00
59_A104_I1.5511.00
204_F302_S1.5351.00
17_D27_A1.5290.99
232_R263_D1.5010.99
41_E55_P1.4990.99
299_A318_F1.4980.99
23_M27_A1.4810.99
42_R54_V1.4810.99
256_P305_S1.4730.99
165_M248_V1.4680.99
74_I110_A1.4670.99
160_E186_A1.4540.99
37_A99_E1.4470.99
74_I112_V1.4360.99
258_L306_I1.4130.99
321_D324_E1.4070.99
31_A66_I1.4040.99
118_L154_T1.4010.99
47_S210_D1.3970.99
295_L299_A1.3910.99
75_V167_A1.3880.99
75_V315_I1.3870.99
65_E320_E1.3830.99
264_V272_V1.3820.99
276_N318_F1.3750.99
194_M248_V1.3740.99
131_E143_K1.3680.99
36_D43_T1.3670.99
254_A274_A1.3660.99
40_D58_D1.3480.99
114_T163_A1.3420.99
29_L322_V1.3360.99
284_L302_S1.3330.99
60_V103_R1.3200.99
242_V249_L1.3160.98
116_V166_I1.3080.98
295_L321_D1.2860.98
165_M192_P1.2800.98
10_L19_V1.2760.98
63_T104_I1.2700.98
293_L298_V1.2630.98
242_V268_F1.2570.98
20_S229_A1.2560.98
30_V113_I1.2500.98
67_L110_A1.2440.98
204_F256_P1.2430.98
156_V186_A1.2430.98
197_A238_V1.2380.98
22_T306_I1.2380.98
38_T57_A1.2360.98
63_T110_A1.2300.98
276_N302_S1.2220.98
152_A178_A1.2210.98
95_G98_Q1.2180.97
111_Y165_M1.2180.97
285_H321_D1.2150.97
64_R107_E1.2120.97
62_R66_I1.2100.97
203_A297_S1.2040.97
239_A267_E1.1980.97
54_V58_D1.1870.97
63_T74_I1.1820.97
274_A306_I1.1640.97
182_A186_A1.1630.97
232_R312_D1.1420.96
31_A51_Q1.1390.96
288_A293_L1.1350.96
322_V325_T1.1340.96
255_L302_S1.1320.96
103_R106_S1.1230.96
256_P302_S1.1210.96
203_A298_V1.1170.96
60_V64_R1.1170.96
87_G122_T1.1140.96
83_K215_A1.1100.96
131_E146_E1.1010.95
249_L270_R1.0960.95
288_A299_A1.0950.95
204_F284_L1.0920.95
316_T319_A1.0900.95
12_R190_D1.0850.95
255_L305_S1.0800.95
66_I320_E1.0740.95
36_D41_E1.0740.95
117_C127_C1.0720.95
303_L306_I1.0690.95
94_D99_E1.0670.95
231_R262_S1.0650.94
12_R141_T1.0610.94
14_G111_Y1.0610.94
249_L264_V1.0550.94
29_L316_T1.0280.93
200_Y226_M1.0270.93
131_E141_T1.0250.93
124_H130_V1.0190.93
105_T112_V1.0170.93
133_D141_T1.0130.93
71_V323_A1.0050.93
13_D192_P1.0030.93
53_R213_D0.9950.92
113_I167_A0.9920.92
229_A304_L0.9900.92
265_R269_D0.9880.92
15_V111_Y0.9830.92
67_L109_D0.9780.92
307_K314_I0.9750.91
39_A55_P0.9730.91
296_E299_A0.9700.91
155_A166_I0.9680.91
31_A320_E0.9590.91
151_L170_A0.9590.91
249_L272_V0.9580.91
116_V158_H0.9560.91
26_P323_A0.9500.90
69_T324_E0.9490.90
84_D87_G0.9470.90
117_C221_R0.9460.90
300_H325_T0.9410.90
12_R15_V0.9400.90
302_S305_S0.9390.90
69_T320_E0.9390.90
284_L318_F0.9380.90
36_D55_P0.9380.90
36_D53_R0.9360.90
15_V192_P0.9350.90
127_C221_R0.9340.90
48_M282_A0.9340.90
285_H289_E0.9330.90
56_L100_A0.9300.89
258_L261_V0.9290.89
295_L325_T0.9270.89
35_V59_A0.9230.89
66_I74_I0.9230.89
284_L293_L0.9210.89
302_S318_F0.9160.89
235_S238_V0.9160.89
47_S292_W0.9130.88
176_V193_I0.9130.88
91_Y157_S0.9120.88
103_R107_E0.9090.88
113_I165_M0.9040.88
101_T163_A0.9040.88
62_R65_E0.9010.88
104_I110_A0.8980.88
248_V313_L0.8930.87
261_V306_I0.8910.87
296_E300_H0.8900.87
97_V121_Y0.8850.87
177_D181_T0.8850.87
5_H243_E0.8810.87
234_A260_V0.8790.87
198_A249_L0.8740.86
120_E213_D0.8700.86
239_A269_D0.8650.86
118_L150_L0.8610.85
33_V59_A0.8610.85
26_P29_L0.8600.85
284_L298_V0.8490.85
258_L305_S0.8490.85
204_F298_V0.8470.84
168_P179_I0.8460.84
86_T91_Y0.8390.84
64_R67_L0.8380.84
194_M313_L0.8370.84
288_A295_L0.8360.84
150_L154_T0.8340.84
261_V311_A0.8340.84
38_T41_E0.8340.84
63_T103_R0.8310.83
150_L153_E0.8290.83
30_V315_I0.8290.83
148_L178_A0.8240.83
158_H166_I0.8160.82
40_D57_A0.8160.82
300_H304_L0.8150.82
285_H318_F0.8150.82
175_M195_S0.8080.82
249_L268_F0.8060.81
149_S153_E0.8020.81
285_H299_A0.8010.81
56_L96_I0.7990.81
286_A290_K0.7950.81
284_L288_A0.7950.81
235_S264_V0.7950.81
104_I112_V0.7900.80
78_G127_C0.7880.80
41_E58_D0.7880.80
101_T158_H0.7870.80
204_F255_L0.7850.80
276_N284_L0.7800.79
155_A179_I0.7790.79
269_D272_V0.7780.79
78_G117_C0.7740.79
116_V170_A0.7700.78
24_L29_L0.7660.78
318_F325_T0.7640.78
198_A264_V0.7620.78
130_V142_V0.7610.78
59_A63_T0.7580.77
78_G221_R0.7570.77
102_R160_E0.7570.77
102_R106_S0.7560.77
319_A323_A0.7540.77
24_L322_V0.7530.77
33_V76_L0.7460.76
117_C120_E0.7440.76
120_E127_C0.7430.76
33_V62_R0.7400.76
13_D111_Y0.7390.75
235_S239_A0.7360.75
56_L60_V0.7340.75
250_M315_I0.7330.75
54_V62_R0.7270.74
43_T213_D0.7270.74
51_Q281_Y0.7260.74
79_I120_E0.7250.74
85_D124_H0.7240.74
204_F318_F0.7220.74
24_L300_H0.7180.73
234_A238_V0.7170.73
151_L175_M0.7150.73
45_I210_D0.7150.73
60_V63_T0.7120.73
35_V100_A0.7120.73
79_I213_D0.7080.72
18_L72_E0.7080.72
74_I104_I0.7070.72
5_H240_L0.7050.72
119_C127_C0.7020.72
130_V133_D0.6970.71
122_T130_V0.6950.71
17_D229_A0.6930.71
230_N233_E0.6930.71
116_V175_M0.6920.71
41_E57_A0.6860.70
120_E221_R0.6820.69
283_M287_A0.6810.69
256_P306_I0.6780.69
156_V159_A0.6760.69
67_L108_T0.6750.69
228_P304_L0.6750.69
36_D39_A0.6750.69
195_S198_A0.6750.69
24_L303_L0.6740.69
142_V172_T0.6690.68
273_A315_I0.6640.67
63_T107_E0.6630.67
295_L318_F0.6610.67
14_G17_D0.6600.67
250_M273_A0.6590.67
37_A81_A0.6590.67
53_R120_E0.6580.67
82_S89_R0.6580.67
212_A216_P0.6570.67
235_S267_E0.6500.66
119_C221_R0.6490.66
76_L101_T0.6470.65
298_V302_S0.6460.65
119_C212_A0.6450.65
7_P10_L0.6450.65
69_T323_A0.6420.65
42_R62_R0.6420.65
19_V227_D0.6420.65
256_P276_N0.6370.64
34_F208_F0.6360.64
63_T66_I0.6350.64
276_N303_L0.6340.64
47_S282_A0.6330.64
288_A294_D0.6320.64
159_A191_V0.6320.64
285_H288_A0.6280.63
159_A192_P0.6280.63
127_C212_A0.6260.63
201_E222_R0.6260.63
255_L306_I0.6250.63
55_P58_D0.6230.63
75_V113_I0.6220.62
56_L99_E0.6200.62
232_R262_S0.6190.62
98_Q154_T0.6180.62
147_T151_L0.6180.62
299_A321_D0.6180.62
49_P292_W0.6170.62
299_A302_S0.6140.61
71_V320_E0.6120.61
75_V78_G0.6010.60
182_A185_D0.6010.60
265_R270_R0.6010.60
130_V143_K0.5980.59
222_R297_S0.5980.59
98_Q158_H0.5970.59
117_C212_A0.5970.59
146_E149_S0.5930.59
105_T108_T0.5920.59
118_L129_V0.5910.58
10_L192_P0.5910.58
176_V179_I0.5890.58
39_A99_E0.5890.58
15_V18_L0.5870.58
232_R269_D0.5860.58
21_E230_N0.5860.58
7_P236_R0.5860.58
54_V63_T0.5850.58
64_R106_S0.5850.58
254_A261_V0.5840.58
238_V242_V0.5840.58
78_G120_E0.5820.57
118_L175_M0.5820.57
66_I110_A0.5810.57
228_P257_Y0.5800.57
33_V74_I0.5790.57
50_G321_D0.5790.57
91_Y154_T0.5790.57
129_V154_T0.5780.57
39_A57_A0.5760.57
265_R272_V0.5760.57
130_V217_S0.5760.57
141_T189_S0.5750.56
59_A100_A0.5720.56
118_L170_A0.5710.56
142_V224_Y0.5700.56
61_D107_E0.5680.56
69_T72_E0.5660.55
184_D189_S0.5650.55
141_T223_H0.5640.55
79_I83_K0.5630.55
71_V110_A0.5610.55
166_I179_I0.5600.54
180_R184_D0.5600.54
212_A221_R0.5590.54
23_M28_D0.5580.54
263_D267_E0.5580.54
79_I117_C0.5580.54
43_T120_E0.5580.54
87_G118_L0.5570.54
79_I127_C0.5550.54
34_F275_Y0.5550.54
316_T322_V0.5550.54
22_T229_A0.5540.54
22_T304_L0.5540.54
38_T55_P0.5530.54
197_A264_V0.5510.53
48_M292_W0.5490.53
237_E240_L0.5470.53
6_R9_R0.5450.52
79_I221_R0.5440.52
166_I193_I0.5440.52
94_D102_R0.5430.52
231_R266_R0.5420.52
28_D314_I0.5410.52
178_A182_A0.5410.52
165_M194_M0.5410.52
284_L295_L0.5410.52
200_Y231_R0.5400.52
232_R236_R0.5400.52
45_I53_R0.5390.52
36_D57_A0.5370.51
89_R154_T0.5370.51
30_V73_A0.5370.51
265_R268_F0.5360.51
67_L107_E0.5360.51
29_L113_I0.5350.51
302_S306_I0.5340.51
75_V119_C0.5340.51
40_D55_P0.5340.51
90_A154_T0.5330.51
78_G119_C0.5300.51
36_D40_D0.5270.50
129_V146_E0.5270.50
282_A286_A0.5260.50
76_L97_V0.5260.50
267_E272_V0.5240.50
64_R109_D0.5230.50
196_Y214_G0.5230.50
132_A141_T0.5220.49
294_D299_A0.5220.49
31_A62_R0.5200.49
22_T231_R0.5200.49
15_V165_M0.5190.49
220_D297_S0.5190.49
37_A40_D0.5180.49
147_T170_A0.5170.49
208_F275_Y0.5160.49
306_I311_A0.5160.49
78_G96_I0.5160.49
65_E69_T0.5150.49
75_V221_R0.5150.49
262_S265_R0.5150.49
146_E150_L0.5130.48
154_T157_S0.5130.48
89_R120_E0.5130.48
32_P208_F0.5130.48
114_T155_A0.5120.48
158_H163_A0.5120.48
254_A305_S0.5110.48
300_H303_L0.5110.48
24_L304_L0.5100.48
61_D65_E0.5090.48
76_L104_I0.5080.48
61_D68_D0.5080.48
33_V63_T0.5080.48
39_A42_R0.5070.47
318_F321_D0.5060.47
64_R160_E0.5030.47
264_V267_E0.5030.47
287_A292_W0.5020.47
142_V223_H0.5020.47
287_A293_L0.5010.47
44_P289_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w1zA 5 0.9693 100 0.01 Contact Map
3obkA 5 0.9785 100 0.015 Contact Map
1w5qA 5 0.954 100 0.017 Contact Map
1l6sA 5 0.9755 100 0.024 Contact Map
1h7nA 5 0.9816 100 0.043 Contact Map
1pv8A 5 0.8466 100 0.052 Contact Map
3i4eA 4 0.8006 96.4 0.954 Contact Map
3lg3A 4 0.8067 96.3 0.954 Contact Map
3b8iA 4 0.7239 95.8 0.956 Contact Map
3vcrA 3 0.5828 95.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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