Q9HMZ1 - HALSA - GREMLIN Contacts

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Q9HMZ1 - Delta-aminolevulinic acid dehydratase

UniProt:	Q9HMZ1	Sequences: MELPHRPRRLRRDGVRDLVSETMLTPADLVAPVFVDATADERTPIPSMPGQERVPLADAVDRTREILDTGVEAIVLFGIPASKDDTGSRAYADDGIVQEATRRITSETDAYVITDVCLCEYTSHGHCGVVEADADTDPTLTVKNDETLSLLAETAVSHAEAGAEMIAPSAMTDGMVDAIRTALDDAGFSDVPIMSYAAKYESAFYGPFRDAADGAPSFGDRRHYQMDPANRREASREVALDVEQGADVLMVKPALPYLDVVSDVRREFDRPVAAYNVSGEYAMLHAAAEKGWLDLESVAHESLLSIKRAGADLIITYFAEDVAETL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	326 (314)
Sequences:	2863 (1465)
Seq/√Len:	82.7

ECOLI - HEM2
BACSU - HEM2
HALSA - Q9HMZ1
SULSO - Q980U6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_R	263_D	3.565	1.00
238_V	264_V	3.515	1.00
262_S	266_R	3.507	1.00
89_R	92_A	3.449	1.00
85_D	123_S	3.081	1.00
62_R	320_E	3.068	1.00
28_D	307_K	3.035	1.00
296_E	325_T	2.942	1.00
114_T	158_H	2.812	1.00
170_A	175_M	2.654	1.00
254_A	306_I	2.632	1.00
242_V	270_R	2.598	1.00
98_Q	157_S	2.542	1.00
303_L	322_V	2.513	1.00
101_T	112_V	2.500	1.00
238_V	249_L	2.484	1.00
160_E	188_F	2.344	1.00
156_V	182_A	2.303	1.00
105_T	164_E	2.295	1.00
141_T	190_D	2.230	1.00
20_S	227_D	2.226	1.00
285_H	295_L	2.224	1.00
231_R	260_V	2.183	1.00
143_K	146_E	2.172	1.00
42_R	52_E	2.153	1.00
91_Y	150_L	2.064	1.00
198_A	238_V	2.057	1.00
294_D	297_S	2.056	1.00
64_R	68_D	2.052	1.00
265_R	312_D	2.051	1.00
261_V	274_A	2.045	1.00
65_E	324_E	2.045	1.00
44_P	52_E	2.024	1.00
299_A	325_T	2.017	1.00
7_P	240_L	1.982	1.00
286_A	292_W	1.972	1.00
93_D	160_E	1.958	1.00
273_A	313_L	1.931	1.00
43_T	53_R	1.892	1.00
248_V	273_A	1.877	1.00
84_D	88_S	1.854	1.00
101_T	114_T	1.835	1.00
152_A	182_A	1.832	1.00
239_A	243_E	1.772	1.00
30_V	313_L	1.762	1.00
60_V	107_E	1.750	1.00
58_D	61_D	1.746	1.00
232_R	265_R	1.719	1.00
300_H	322_V	1.703	1.00
42_R	58_D	1.696	1.00
91_Y	153_E	1.680	1.00
263_D	266_R	1.668	1.00
17_D	72_E	1.658	1.00
46_P	210_D	1.639	1.00
56_L	103_R	1.620	1.00
5_H	236_R	1.620	1.00
239_A	268_F	1.604	1.00
45_I	51_Q	1.588	1.00
73_A	113_I	1.586	1.00
129_V	150_L	1.581	1.00
61_D	64_R	1.577	1.00
255_L	276_N	1.565	1.00
59_A	104_I	1.551	1.00
204_F	302_S	1.535	1.00
17_D	27_A	1.529	0.99
232_R	263_D	1.501	0.99
41_E	55_P	1.499	0.99
299_A	318_F	1.498	0.99
23_M	27_A	1.481	0.99
42_R	54_V	1.481	0.99
256_P	305_S	1.473	0.99
165_M	248_V	1.468	0.99
74_I	110_A	1.467	0.99
160_E	186_A	1.454	0.99
37_A	99_E	1.447	0.99
74_I	112_V	1.436	0.99
258_L	306_I	1.413	0.99
321_D	324_E	1.407	0.99
31_A	66_I	1.404	0.99
118_L	154_T	1.401	0.99
47_S	210_D	1.397	0.99
295_L	299_A	1.391	0.99
75_V	167_A	1.388	0.99
75_V	315_I	1.387	0.99
65_E	320_E	1.383	0.99
264_V	272_V	1.382	0.99
276_N	318_F	1.375	0.99
194_M	248_V	1.374	0.99
131_E	143_K	1.368	0.99
36_D	43_T	1.367	0.99
254_A	274_A	1.366	0.99
40_D	58_D	1.348	0.99
114_T	163_A	1.342	0.99
29_L	322_V	1.336	0.99
284_L	302_S	1.333	0.99
60_V	103_R	1.320	0.99
242_V	249_L	1.316	0.98
116_V	166_I	1.308	0.98
295_L	321_D	1.286	0.98
165_M	192_P	1.280	0.98
10_L	19_V	1.276	0.98
63_T	104_I	1.270	0.98
293_L	298_V	1.263	0.98
242_V	268_F	1.257	0.98
20_S	229_A	1.256	0.98
30_V	113_I	1.250	0.98
67_L	110_A	1.244	0.98
204_F	256_P	1.243	0.98
156_V	186_A	1.243	0.98
197_A	238_V	1.238	0.98
22_T	306_I	1.238	0.98
38_T	57_A	1.236	0.98
63_T	110_A	1.230	0.98
276_N	302_S	1.222	0.98
152_A	178_A	1.221	0.98
95_G	98_Q	1.218	0.97
111_Y	165_M	1.218	0.97
285_H	321_D	1.215	0.97
64_R	107_E	1.212	0.97
62_R	66_I	1.210	0.97
203_A	297_S	1.204	0.97
239_A	267_E	1.198	0.97
54_V	58_D	1.187	0.97
63_T	74_I	1.182	0.97
274_A	306_I	1.164	0.97
182_A	186_A	1.163	0.97
232_R	312_D	1.142	0.96
31_A	51_Q	1.139	0.96
288_A	293_L	1.135	0.96
322_V	325_T	1.134	0.96
255_L	302_S	1.132	0.96
103_R	106_S	1.123	0.96
256_P	302_S	1.121	0.96
203_A	298_V	1.117	0.96
60_V	64_R	1.117	0.96
87_G	122_T	1.114	0.96
83_K	215_A	1.110	0.96
131_E	146_E	1.101	0.95
249_L	270_R	1.096	0.95
288_A	299_A	1.095	0.95
204_F	284_L	1.092	0.95
316_T	319_A	1.090	0.95
12_R	190_D	1.085	0.95
255_L	305_S	1.080	0.95
66_I	320_E	1.074	0.95
36_D	41_E	1.074	0.95
117_C	127_C	1.072	0.95
303_L	306_I	1.069	0.95
94_D	99_E	1.067	0.95
231_R	262_S	1.065	0.94
12_R	141_T	1.061	0.94
14_G	111_Y	1.061	0.94
249_L	264_V	1.055	0.94
29_L	316_T	1.028	0.93
200_Y	226_M	1.027	0.93
131_E	141_T	1.025	0.93
124_H	130_V	1.019	0.93
105_T	112_V	1.017	0.93
133_D	141_T	1.013	0.93
71_V	323_A	1.005	0.93
13_D	192_P	1.003	0.93
53_R	213_D	0.995	0.92
113_I	167_A	0.992	0.92
229_A	304_L	0.990	0.92
265_R	269_D	0.988	0.92
15_V	111_Y	0.983	0.92
67_L	109_D	0.978	0.92
307_K	314_I	0.975	0.91
39_A	55_P	0.973	0.91
296_E	299_A	0.970	0.91
155_A	166_I	0.968	0.91
31_A	320_E	0.959	0.91
151_L	170_A	0.959	0.91
249_L	272_V	0.958	0.91
116_V	158_H	0.956	0.91
26_P	323_A	0.950	0.90
69_T	324_E	0.949	0.90
84_D	87_G	0.947	0.90
117_C	221_R	0.946	0.90
300_H	325_T	0.941	0.90
12_R	15_V	0.940	0.90
302_S	305_S	0.939	0.90
69_T	320_E	0.939	0.90
284_L	318_F	0.938	0.90
36_D	55_P	0.938	0.90
36_D	53_R	0.936	0.90
15_V	192_P	0.935	0.90
127_C	221_R	0.934	0.90
48_M	282_A	0.934	0.90
285_H	289_E	0.933	0.90
56_L	100_A	0.930	0.89
258_L	261_V	0.929	0.89
295_L	325_T	0.927	0.89
35_V	59_A	0.923	0.89
66_I	74_I	0.923	0.89
284_L	293_L	0.921	0.89
302_S	318_F	0.916	0.89
235_S	238_V	0.916	0.89
47_S	292_W	0.913	0.88
176_V	193_I	0.913	0.88
91_Y	157_S	0.912	0.88
103_R	107_E	0.909	0.88
113_I	165_M	0.904	0.88
101_T	163_A	0.904	0.88
62_R	65_E	0.901	0.88
104_I	110_A	0.898	0.88
248_V	313_L	0.893	0.87
261_V	306_I	0.891	0.87
296_E	300_H	0.890	0.87
97_V	121_Y	0.885	0.87
177_D	181_T	0.885	0.87
5_H	243_E	0.881	0.87
234_A	260_V	0.879	0.87
198_A	249_L	0.874	0.86
120_E	213_D	0.870	0.86
239_A	269_D	0.865	0.86
118_L	150_L	0.861	0.85
33_V	59_A	0.861	0.85
26_P	29_L	0.860	0.85
284_L	298_V	0.849	0.85
258_L	305_S	0.849	0.85
204_F	298_V	0.847	0.84
168_P	179_I	0.846	0.84
86_T	91_Y	0.839	0.84
64_R	67_L	0.838	0.84
194_M	313_L	0.837	0.84
288_A	295_L	0.836	0.84
150_L	154_T	0.834	0.84
261_V	311_A	0.834	0.84
38_T	41_E	0.834	0.84
63_T	103_R	0.831	0.83
150_L	153_E	0.829	0.83
30_V	315_I	0.829	0.83
148_L	178_A	0.824	0.83
158_H	166_I	0.816	0.82
40_D	57_A	0.816	0.82
300_H	304_L	0.815	0.82
285_H	318_F	0.815	0.82
175_M	195_S	0.808	0.82
249_L	268_F	0.806	0.81
149_S	153_E	0.802	0.81
285_H	299_A	0.801	0.81
56_L	96_I	0.799	0.81
286_A	290_K	0.795	0.81
284_L	288_A	0.795	0.81
235_S	264_V	0.795	0.81
104_I	112_V	0.790	0.80
78_G	127_C	0.788	0.80
41_E	58_D	0.788	0.80
101_T	158_H	0.787	0.80
204_F	255_L	0.785	0.80
276_N	284_L	0.780	0.79
155_A	179_I	0.779	0.79
269_D	272_V	0.778	0.79
78_G	117_C	0.774	0.79
116_V	170_A	0.770	0.78
24_L	29_L	0.766	0.78
318_F	325_T	0.764	0.78
198_A	264_V	0.762	0.78
130_V	142_V	0.761	0.78
59_A	63_T	0.758	0.77
78_G	221_R	0.757	0.77
102_R	160_E	0.757	0.77
102_R	106_S	0.756	0.77
319_A	323_A	0.754	0.77
24_L	322_V	0.753	0.77
33_V	76_L	0.746	0.76
117_C	120_E	0.744	0.76
120_E	127_C	0.743	0.76
33_V	62_R	0.740	0.76
13_D	111_Y	0.739	0.75
235_S	239_A	0.736	0.75
56_L	60_V	0.734	0.75
250_M	315_I	0.733	0.75
54_V	62_R	0.727	0.74
43_T	213_D	0.727	0.74
51_Q	281_Y	0.726	0.74
79_I	120_E	0.725	0.74
85_D	124_H	0.724	0.74
204_F	318_F	0.722	0.74
24_L	300_H	0.718	0.73
234_A	238_V	0.717	0.73
151_L	175_M	0.715	0.73
45_I	210_D	0.715	0.73
60_V	63_T	0.712	0.73
35_V	100_A	0.712	0.73
79_I	213_D	0.708	0.72
18_L	72_E	0.708	0.72
74_I	104_I	0.707	0.72
5_H	240_L	0.705	0.72
119_C	127_C	0.702	0.72
130_V	133_D	0.697	0.71
122_T	130_V	0.695	0.71
17_D	229_A	0.693	0.71
230_N	233_E	0.693	0.71
116_V	175_M	0.692	0.71
41_E	57_A	0.686	0.70
120_E	221_R	0.682	0.69
283_M	287_A	0.681	0.69
256_P	306_I	0.678	0.69
156_V	159_A	0.676	0.69
67_L	108_T	0.675	0.69
228_P	304_L	0.675	0.69
36_D	39_A	0.675	0.69
195_S	198_A	0.675	0.69
24_L	303_L	0.674	0.69
142_V	172_T	0.669	0.68
273_A	315_I	0.664	0.67
63_T	107_E	0.663	0.67
295_L	318_F	0.661	0.67
14_G	17_D	0.660	0.67
250_M	273_A	0.659	0.67
37_A	81_A	0.659	0.67
53_R	120_E	0.658	0.67
82_S	89_R	0.658	0.67
212_A	216_P	0.657	0.67
235_S	267_E	0.650	0.66
119_C	221_R	0.649	0.66
76_L	101_T	0.647	0.65
298_V	302_S	0.646	0.65
119_C	212_A	0.645	0.65
7_P	10_L	0.645	0.65
69_T	323_A	0.642	0.65
42_R	62_R	0.642	0.65
19_V	227_D	0.642	0.65
256_P	276_N	0.637	0.64
34_F	208_F	0.636	0.64
63_T	66_I	0.635	0.64
276_N	303_L	0.634	0.64
47_S	282_A	0.633	0.64
288_A	294_D	0.632	0.64
159_A	191_V	0.632	0.64
285_H	288_A	0.628	0.63
159_A	192_P	0.628	0.63
127_C	212_A	0.626	0.63
201_E	222_R	0.626	0.63
255_L	306_I	0.625	0.63
55_P	58_D	0.623	0.63
75_V	113_I	0.622	0.62
56_L	99_E	0.620	0.62
232_R	262_S	0.619	0.62
98_Q	154_T	0.618	0.62
147_T	151_L	0.618	0.62
299_A	321_D	0.618	0.62
49_P	292_W	0.617	0.62
299_A	302_S	0.614	0.61
71_V	320_E	0.612	0.61
75_V	78_G	0.601	0.60
182_A	185_D	0.601	0.60
265_R	270_R	0.601	0.60
130_V	143_K	0.598	0.59
222_R	297_S	0.598	0.59
98_Q	158_H	0.597	0.59
117_C	212_A	0.597	0.59
146_E	149_S	0.593	0.59
105_T	108_T	0.592	0.59
118_L	129_V	0.591	0.58
10_L	192_P	0.591	0.58
176_V	179_I	0.589	0.58
39_A	99_E	0.589	0.58
15_V	18_L	0.587	0.58
232_R	269_D	0.586	0.58
21_E	230_N	0.586	0.58
7_P	236_R	0.586	0.58
54_V	63_T	0.585	0.58
64_R	106_S	0.585	0.58
254_A	261_V	0.584	0.58
238_V	242_V	0.584	0.58
78_G	120_E	0.582	0.57
118_L	175_M	0.582	0.57
66_I	110_A	0.581	0.57
228_P	257_Y	0.580	0.57
33_V	74_I	0.579	0.57
50_G	321_D	0.579	0.57
91_Y	154_T	0.579	0.57
129_V	154_T	0.578	0.57
39_A	57_A	0.576	0.57
265_R	272_V	0.576	0.57
130_V	217_S	0.576	0.57
141_T	189_S	0.575	0.56
59_A	100_A	0.572	0.56
118_L	170_A	0.571	0.56
142_V	224_Y	0.570	0.56
61_D	107_E	0.568	0.56
69_T	72_E	0.566	0.55
184_D	189_S	0.565	0.55
141_T	223_H	0.564	0.55
79_I	83_K	0.563	0.55
71_V	110_A	0.561	0.55
166_I	179_I	0.560	0.54
180_R	184_D	0.560	0.54
212_A	221_R	0.559	0.54
23_M	28_D	0.558	0.54
263_D	267_E	0.558	0.54
79_I	117_C	0.558	0.54
43_T	120_E	0.558	0.54
87_G	118_L	0.557	0.54
79_I	127_C	0.555	0.54
34_F	275_Y	0.555	0.54
316_T	322_V	0.555	0.54
22_T	229_A	0.554	0.54
22_T	304_L	0.554	0.54
38_T	55_P	0.553	0.54
197_A	264_V	0.551	0.53
48_M	292_W	0.549	0.53
237_E	240_L	0.547	0.53
6_R	9_R	0.545	0.52
79_I	221_R	0.544	0.52
166_I	193_I	0.544	0.52
94_D	102_R	0.543	0.52
231_R	266_R	0.542	0.52
28_D	314_I	0.541	0.52
178_A	182_A	0.541	0.52
165_M	194_M	0.541	0.52
284_L	295_L	0.541	0.52
200_Y	231_R	0.540	0.52
232_R	236_R	0.540	0.52
45_I	53_R	0.539	0.52
36_D	57_A	0.537	0.51
89_R	154_T	0.537	0.51
30_V	73_A	0.537	0.51
265_R	268_F	0.536	0.51
67_L	107_E	0.536	0.51
29_L	113_I	0.535	0.51
302_S	306_I	0.534	0.51
75_V	119_C	0.534	0.51
40_D	55_P	0.534	0.51
90_A	154_T	0.533	0.51
78_G	119_C	0.530	0.51
36_D	40_D	0.527	0.50
129_V	146_E	0.527	0.50
282_A	286_A	0.526	0.50
76_L	97_V	0.526	0.50
267_E	272_V	0.524	0.50
64_R	109_D	0.523	0.50
196_Y	214_G	0.523	0.50
132_A	141_T	0.522	0.49
294_D	299_A	0.522	0.49
31_A	62_R	0.520	0.49
22_T	231_R	0.520	0.49
15_V	165_M	0.519	0.49
220_D	297_S	0.519	0.49
37_A	40_D	0.518	0.49
147_T	170_A	0.517	0.49
208_F	275_Y	0.516	0.49
306_I	311_A	0.516	0.49
78_G	96_I	0.516	0.49
65_E	69_T	0.515	0.49
75_V	221_R	0.515	0.49
262_S	265_R	0.515	0.49
146_E	150_L	0.513	0.48
154_T	157_S	0.513	0.48
89_R	120_E	0.513	0.48
32_P	208_F	0.513	0.48
114_T	155_A	0.512	0.48
158_H	163_A	0.512	0.48
254_A	305_S	0.511	0.48
300_H	303_L	0.511	0.48
24_L	304_L	0.510	0.48
61_D	65_E	0.509	0.48
76_L	104_I	0.508	0.48
61_D	68_D	0.508	0.48
33_V	63_T	0.508	0.48
39_A	42_R	0.507	0.47
318_F	321_D	0.506	0.47
64_R	160_E	0.503	0.47
264_V	267_E	0.503	0.47
287_A	292_W	0.502	0.47
142_V	223_H	0.502	0.47
287_A	293_L	0.501	0.47
44_P	289_E	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w1zA	5	0.9693	100	0.01	Contact Map
3obkA	5	0.9785	100	0.015	Contact Map
1w5qA	5	0.954	100	0.017	Contact Map
1l6sA	5	0.9755	100	0.024	Contact Map
1h7nA	5	0.9816	100	0.043	Contact Map
1pv8A	5	0.8466	100	0.052	Contact Map
3i4eA	4	0.8006	96.4	0.954	Contact Map
3lg3A	4	0.8067	96.3	0.954	Contact Map
3b8iA	4	0.7239	95.8	0.956	Contact Map
3vcrA	3	0.5828	95.7	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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