GREMLIN Database
Q9HMZ0 - Uncharacterized protein
UniProt: Q9HMZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (195)
Sequences: 4343 (3849)
Seq/√Len: 275.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_A184_L4.2501.00
160_L177_A3.8591.00
138_V188_L3.7091.00
122_A205_A3.5381.00
126_G201_A3.3341.00
138_V184_L2.8311.00
157_V177_A2.7251.00
203_N207_G2.6961.00
142_T188_L2.6661.00
160_L176_M2.6551.00
133_Y162_A2.6051.00
192_S195_V2.6011.00
185_A189_W2.5791.00
156_L181_V2.5541.00
148_P188_L2.4101.00
169_S172_A2.3641.00
187_Y196_V2.3231.00
152_A188_L2.3201.00
172_A176_M2.3001.00
156_L184_L2.2261.00
138_V155_S2.1561.00
186_L199_V2.1321.00
50_Y54_V2.0831.00
152_A181_V2.0761.00
160_L180_T2.0471.00
125_A201_A2.0431.00
127_V197_M1.8541.00
148_P152_A1.8331.00
138_V151_A1.7671.00
9_G13_S1.7401.00
126_G204_D1.7201.00
201_A205_A1.6301.00
156_L177_A1.6121.00
180_T184_L1.5931.00
49_G53_A1.5821.00
73_A77_A1.5801.00
74_Y78_V1.5771.00
194_P197_M1.5551.00
139_E142_T1.5351.00
18_E21_S1.5031.00
123_G201_A1.4851.00
155_S180_T1.4741.00
155_S184_L1.4531.00
187_Y190_T1.4011.00
149_L153_A1.4001.00
135_G193_L1.3581.00
122_A125_A1.3521.00
153_A181_V1.3411.00
103_M107_M1.3301.00
125_A197_M1.3291.00
137_A158_A1.3051.00
142_T191_H1.3021.00
179_P183_L1.3001.00
156_L160_L1.2981.00
134_R159_F1.2901.00
184_L188_L1.2901.00
186_L195_V1.2771.00
135_G139_E1.2591.00
48_A52_L1.2261.00
138_V187_Y1.2191.00
183_L196_V1.2141.00
152_A185_A1.2111.00
127_V201_A1.1951.00
95_E98_G1.1871.00
138_V142_T1.1841.00
173_A176_M1.1831.00
138_V152_A1.1811.00
72_F75_H1.1741.00
155_S187_Y1.1601.00
12_L16_G1.1571.00
169_S176_M1.1571.00
13_S17_F1.1361.00
77_A81_A1.1281.00
150_L154_V1.1181.00
177_A181_V1.1171.00
71_P75_H1.1031.00
192_S196_V1.1031.00
122_A208_L1.1021.00
136_Y140_R1.0941.00
122_A126_G1.0851.00
149_L152_A1.0831.00
156_L180_T1.0571.00
51_V55_E1.0521.00
149_L185_A1.0481.00
14_L18_E1.0441.00
145_T151_A1.0401.00
11_A14_L1.0311.00
10_L14_L1.0231.00
104_R108_A1.0181.00
160_L173_A1.0151.00
172_A175_Q1.0151.00
123_G126_G1.0091.00
36_P40_K1.0071.00
186_L196_V1.0041.00
137_A155_S1.0001.00
10_L13_S0.9951.00
187_Y192_S0.9931.00
141_V154_V0.9901.00
195_V198_A0.9801.00
79_G202_L0.9721.00
114_S209_L0.9661.00
22_R25_D0.9621.00
13_S18_E0.9581.00
146_G150_L0.9551.00
142_T148_P0.9551.00
183_L199_V0.9491.00
12_L15_G0.9481.00
17_F21_S0.9441.00
203_N206_V0.9431.00
197_M201_A0.9341.00
121_V125_A0.9301.00
32_D36_P0.9281.00
40_K43_V0.9161.00
9_G12_L0.9111.00
11_A15_G0.9051.00
15_G19_A0.9031.00
41_W45_A0.8991.00
193_L197_M0.8981.00
139_E191_H0.8981.00
196_V204_D0.8951.00
142_T151_A0.8881.00
141_V151_A0.8841.00
43_V47_V0.8841.00
21_S24_Q0.8841.00
15_G18_E0.8771.00
44_P47_V0.8691.00
43_V46_A0.8671.00
181_V184_L0.8661.00
141_V145_T0.8591.00
60_S63_G0.8561.00
14_L17_F0.8531.00
33_G36_P0.8481.00
139_E187_Y0.8481.00
70_L74_Y0.8481.00
202_L205_A0.8471.00
176_M179_P0.8401.00
181_V185_A0.8381.00
102_A105_D0.8371.00
151_A155_S0.8321.00
133_Y159_F0.8291.00
105_D109_A0.8200.99
198_A201_A0.8120.99
175_Q178_Q0.8060.99
10_L15_G0.8010.99
173_A177_A0.7960.99
103_M106_G0.7770.99
193_L196_V0.7760.99
105_D108_A0.7750.99
101_D104_R0.7680.99
125_A128_T0.7670.99
94_W98_G0.7650.99
124_T128_T0.7640.99
91_S98_G0.7570.99
135_G203_N0.7550.99
145_T150_L0.7520.99
91_S95_E0.7490.99
198_A202_L0.7480.99
41_W44_P0.7450.99
122_A201_A0.7420.99
175_Q203_N0.7330.99
162_A169_S0.7320.99
126_G197_M0.7320.99
93_L96_A0.7260.99
18_E22_R0.7230.99
170_R173_A0.7120.98
79_G83_M0.7110.98
72_F76_T0.6930.98
86_S89_L0.6920.98
70_L73_A0.6910.98
122_A204_D0.6900.98
150_L153_A0.6880.98
151_A176_M0.6810.98
14_L25_D0.6780.98
88_L92_P0.6760.98
159_F163_H0.6750.98
94_W99_T0.6750.98
39_W44_P0.6730.98
106_G109_A0.6710.98
17_F25_D0.6700.98
205_A209_L0.6690.98
32_D38_V0.6690.98
160_L172_A0.6670.98
187_Y191_H0.6590.98
118_L122_A0.6590.98
75_H79_G0.6590.98
21_S25_D0.6540.97
141_V192_S0.6540.97
123_G127_V0.6540.97
176_M180_T0.6520.97
126_G176_M0.6470.97
42_L46_A0.6470.97
164_V169_S0.6470.97
9_G18_E0.6450.97
52_L55_E0.6440.97
169_S173_A0.6440.97
40_K45_A0.6420.97
191_H196_V0.6420.97
37_H40_K0.6390.97
131_V197_M0.6340.97
92_P95_E0.6300.97
118_L208_L0.6270.97
159_F204_D0.6250.97
169_S175_Q0.6230.97
117_E121_V0.6220.96
35_E53_A0.6190.96
161_A173_A0.6180.96
16_G20_V0.6170.96
37_H42_L0.6170.96
10_L16_G0.6130.96
87_A91_S0.6130.96
45_A48_A0.6120.96
135_G192_S0.6100.96
20_V25_D0.6040.96
148_P151_A0.6030.96
146_G151_A0.6010.96
114_S117_E0.6010.96
155_S173_A0.6010.96
12_L18_E0.6010.96
190_T195_V0.5990.96
50_Y53_A0.5990.96
172_A179_P0.5980.96
103_M108_A0.5960.96
133_Y155_S0.5960.96
78_V82_A0.5920.95
146_G154_V0.5910.95
39_W42_L0.5870.95
90_F94_W0.5870.95
36_P43_V0.5850.95
9_G21_S0.5840.95
119_L123_G0.5830.95
19_A23_L0.5820.95
60_S65_T0.5820.95
121_V208_L0.5810.95
39_W43_V0.5800.95
92_P116_A0.5800.95
16_G26_R0.5770.95
121_V126_G0.5770.95
40_K44_P0.5760.95
100_A104_R0.5740.95
126_G172_A0.5730.94
15_G22_R0.5730.94
59_L64_W0.5720.94
164_V173_A0.5720.94
171_A175_Q0.5710.94
76_T80_L0.5680.94
47_V54_V0.5670.94
90_F98_G0.5660.94
44_P48_A0.5600.94
89_L93_L0.5580.94
87_A94_W0.5580.94
11_A18_E0.5570.94
134_R204_D0.5570.94
9_G15_G0.5570.94
51_V54_V0.5550.94
131_V136_Y0.5540.93
70_L76_T0.5520.93
15_G21_S0.5500.93
92_P96_A0.5490.93
12_L19_A0.5480.93
19_A22_R0.5480.93
94_W100_A0.5450.93
133_Y158_A0.5440.93
11_A17_F0.5430.93
126_G133_Y0.5420.93
185_A195_V0.5410.93
81_A85_G0.5380.92
149_L156_L0.5380.92
126_G187_Y0.5340.92
49_G59_L0.5330.92
88_L91_S0.5260.92
52_L56_G0.5250.92
13_S25_D0.5250.92
149_L181_V0.5250.92
179_P203_N0.5240.91
161_A164_V0.5240.91
56_G111_T0.5220.91
38_V44_P0.5210.91
132_P211_A0.5200.91
22_R26_R0.5170.91
57_R60_S0.5150.91
135_G187_Y0.5150.91
18_E23_L0.5120.91
71_P192_S0.5110.90
125_A187_Y0.5080.90
9_G16_G0.5070.90
176_M203_N0.5070.90
79_G199_V0.5070.90
70_L75_H0.5060.90
95_E99_T0.5050.90
160_L204_D0.5030.90
79_G203_N0.5030.90
132_P176_M0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.9318 99.9 0.489 Contact Map
4ev6A 3 0.2727 30.2 0.923 Contact Map
4i0uA 4 0.2636 23.9 0.927 Contact Map
2wswA 3 0.75 8 0.941 Contact Map
4c7rA 3 0.7409 7.2 0.942 Contact Map
4m64A 1 0.6727 5.5 0.945 Contact Map
3aqpA 1 0.2273 2.8 0.952 Contact Map
2nq2A 2 0.6182 2.8 0.953 Contact Map
4rp9A 2 0.9364 2.3 0.955 Contact Map
3h90A 3 0.8591 2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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