GREMLIN Database
GSA - Glutamate-1-semialdehyde 2,1-aminomutase
UniProt: Q9HMY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (380)
Sequences: 20863 (12707)
Seq/√Len: 651.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_Q81_S4.3471.00
222_R226_H4.0391.00
382_H418_N3.8741.00
43_H51_R3.5731.00
182_A220_T3.4191.00
329_R410_D3.3161.00
99_F312_Q3.1701.00
38_S45_I3.1181.00
246_L252_E2.8901.00
318_D321_E2.8731.00
329_R406_P2.7641.00
70_Q316_E2.7251.00
74_A78_R2.6791.00
322_H326_L2.6071.00
340_E417_Q2.5661.00
405_R408_L2.4241.00
99_F315_A2.3681.00
309_E312_Q2.3381.00
220_T223_D2.3221.00
55_W412_G2.2581.00
333_G413_V2.2501.00
223_D227_D2.2201.00
70_Q309_E2.2171.00
70_Q313_Y2.2161.00
37_Q47_A2.2091.00
68_L313_Y2.1921.00
325_R406_P2.1911.00
43_H408_L2.1501.00
186_T227_D2.1501.00
378_D381_R2.1351.00
382_H422_S2.0931.00
45_I51_R2.0711.00
378_D422_S2.0001.00
333_G410_D1.9511.00
99_F308_L1.9341.00
384_A415_L1.9301.00
135_K195_D1.9151.00
341_H417_Q1.9001.00
96_H307_G1.8821.00
200_L233_I1.8731.00
328_G332_E1.8511.00
378_D382_H1.8491.00
109_L279_T1.8271.00
331_R335_A1.8241.00
72_V77_Q1.8101.00
46_D50_N1.8031.00
279_T283_E1.7981.00
313_Y317_N1.7741.00
91_E95_E1.7651.00
411_A415_L1.7611.00
185_V221_L1.7551.00
50_N383_A1.7381.00
37_Q82_D1.7221.00
98_E102_R1.7141.00
199_V225_T1.7141.00
108_E279_T1.7031.00
76_I306_A1.6911.00
113_V273_G1.6831.00
201_V221_L1.6631.00
186_T190_E1.6591.00
333_G336_A1.6311.00
76_I80_A1.6261.00
331_R349_G1.6211.00
40_D69_P1.6181.00
43_H411_A1.6171.00
345_Y359_T1.6131.00
178_P184_A1.6091.00
120_T261_T1.6031.00
341_H421_E1.5881.00
262_F274_A1.5791.00
189_F230_A1.5621.00
326_L329_R1.5221.00
139_M217_Y1.5221.00
130_Y281_V1.5111.00
183_D187_E1.5091.00
267_G272_V1.5031.00
246_L324_N1.4971.00
78_R82_D1.4691.00
51_R411_A1.4631.00
97_A112_F1.4611.00
99_F102_R1.4531.00
333_G414_L1.4471.00
135_K175_I1.4391.00
216_G219_E1.4261.00
331_R354_F1.4261.00
42_G408_L1.4241.00
326_L409_L1.4201.00
234_W250_Q1.4151.00
180_N214_V1.4111.00
104_V276_G1.4081.00
137_V196_I1.4061.00
42_G403_V1.4051.00
95_E308_L1.4001.00
322_H325_R1.4001.00
136_I198_A1.3981.00
262_F276_G1.3911.00
186_T220_T1.3831.00
110_L276_G1.3731.00
246_L251_S1.3721.00
222_R232_L1.3671.00
222_R225_T1.3671.00
309_E313_Y1.3671.00
46_D52_Y1.3611.00
382_H419_Q1.3611.00
122_S275_I1.3601.00
272_V304_M1.3411.00
266_I272_V1.3401.00
103_H315_A1.3391.00
124_V136_I1.3351.00
308_L312_Q1.3341.00
69_P74_A1.3311.00
247_G251_S1.3261.00
190_E228_H1.3261.00
417_Q421_E1.3251.00
378_D419_Q1.3231.00
36_V44_V1.3171.00
329_R333_G1.3141.00
123_A261_T1.3141.00
127_A233_I1.3031.00
321_E325_R1.3031.00
187_E191_T1.3021.00
379_C386_P1.2991.00
68_L317_N1.2961.00
259_V277_G1.2841.00
404_F409_L1.2841.00
95_E312_Q1.2841.00
177_V180_N1.2751.00
101_A110_L1.2741.00
183_D186_T1.2701.00
333_G417_Q1.2691.00
102_R315_A1.2651.00
201_V218_H1.2641.00
40_D67_D1.2571.00
326_L406_P1.2561.00
130_Y284_E1.2501.00
120_T200_L1.2431.00
38_S82_D1.2411.00
76_I302_V1.2321.00
174_T177_V1.2321.00
199_V221_L1.2301.00
253_F350_R1.2281.00
216_G253_F1.2191.00
250_Q260_T1.2141.00
337_V417_Q1.2101.00
272_V307_G1.2061.00
234_W255_I1.2041.00
74_A77_Q1.2011.00
174_T180_N1.2011.00
337_V413_V1.1961.00
266_I274_A1.1911.00
113_V275_I1.1901.00
64_L313_Y1.1871.00
256_T278_R1.1871.00
140_Q178_P1.1851.00
182_A224_L1.1821.00
109_L283_E1.1771.00
312_Q316_E1.1721.00
252_E350_R1.1591.00
72_V81_S1.1571.00
75_A309_E1.1561.00
67_D72_V1.1531.00
219_E223_D1.1521.00
178_P181_D1.1491.00
408_L411_A1.1491.00
72_V80_A1.1401.00
335_A338_V1.1361.00
176_P180_N1.1211.00
152_V200_L1.1181.00
175_I178_P1.1161.00
112_F304_M1.1151.00
133_R229_G1.1121.00
77_Q80_A1.1101.00
414_L418_N1.1011.00
186_T224_L1.1011.00
259_V275_I1.0991.00
43_H53_I1.0921.00
379_C415_L1.0851.00
379_C384_A1.0811.00
324_N328_G1.0761.00
242_R320_Y1.0761.00
40_D51_R1.0721.00
248_C262_F1.0611.00
42_G53_I1.0551.00
332_E336_A1.0531.00
219_E254_D1.0461.00
406_P410_D1.0441.00
320_Y323_V1.0431.00
117_T150_T1.0381.00
382_H415_L1.0361.00
335_A339_A1.0351.00
245_G251_S1.0331.00
313_Y316_E1.0321.00
186_T228_H1.0301.00
37_Q91_E1.0301.00
379_C419_Q1.0271.00
96_H308_L1.0161.00
384_A412_G1.0151.00
225_T230_A1.0131.00
186_T223_D1.0101.00
268_G310_T0.9971.00
177_V188_V0.9961.00
83_G86_F0.9911.00
126_L275_I0.9911.00
231_L281_V0.9881.00
411_A414_L0.9881.00
37_Q49_G0.9861.00
124_V152_V0.9791.00
119_A261_T0.9771.00
377_P381_R0.9731.00
138_V200_L0.9701.00
138_V176_P0.9671.00
179_F213_P0.9641.00
71_P306_A0.9611.00
64_L310_T0.9601.00
221_L232_L0.9561.00
35_F47_A0.9451.00
410_D414_L0.9451.00
338_V344_A0.9451.00
184_A187_E0.9431.00
204_I350_R0.9371.00
189_F196_I0.9361.00
322_H406_P0.9351.00
407_Q410_D0.9341.00
103_H247_G0.9341.00
314_A319_V0.9321.00
40_D45_I0.9301.00
107_V276_G0.9271.00
63_L265_I0.9251.00
223_D226_H0.9251.00
355_K395_A0.9241.00
99_F103_H0.9231.00
203_P234_W0.9181.00
139_M213_P0.9181.00
218_H253_F0.9081.00
314_A320_Y0.9081.00
37_Q45_I0.9051.00
224_L228_H0.9031.00
62_L268_G0.8971.00
345_Y357_V0.8951.00
135_K190_E0.8941.00
74_A81_S0.8931.00
305_A309_E0.8921.00
117_T147_Q0.8911.00
241_F314_A0.8901.00
70_Q74_A0.8891.00
35_F94_V0.8881.00
134_N195_D0.8831.00
78_R81_S0.8751.00
70_Q312_Q0.8731.00
357_V394_D0.8721.00
53_I408_L0.8711.00
198_A233_I0.8701.00
135_K196_I0.8701.00
64_L71_P0.8691.00
319_V323_V0.8661.00
212_E350_R0.8581.00
215_A219_E0.8571.00
346_T357_V0.8551.00
404_F412_G0.8541.00
55_W404_F0.8531.00
321_E324_N0.8501.00
106_S260_T0.8431.00
152_V174_T0.8411.00
175_I180_N0.8401.00
216_G220_T0.8401.00
126_L277_G0.8391.00
252_E324_N0.8381.00
229_G280_D0.8351.00
123_A233_I0.8351.00
127_A198_A0.8341.00
134_N168_P0.8331.00
103_H311_L0.8281.00
336_A340_E0.8271.00
114_N118_E0.8181.00
101_A107_V0.8171.00
42_G405_R0.8161.00
204_I353_M0.8161.00
127_A231_L0.8141.00
352_S404_F0.8111.00
175_I188_V0.8101.00
206_A238_I0.8091.00
327_G331_R0.8081.00
78_R305_A0.8071.00
53_I411_A0.8061.00
239_T353_M0.8021.00
241_F266_I0.7971.00
226_H256_T0.7961.00
222_R255_I0.7951.00
332_E335_A0.7941.00
270_F303_T0.7881.00
337_V341_H0.7861.00
130_Y231_L0.7851.00
362_G365_Q0.7841.00
333_G409_L0.7841.00
47_A91_E0.7831.00
177_V181_D0.7821.00
398_Q416_S0.7821.00
241_F311_L0.7821.00
320_Y324_N0.7811.00
247_G320_Y0.7801.00
361_D364_A0.7791.00
110_L274_A0.7691.00
135_K192_H0.7691.00
70_Q75_A0.7681.00
95_E99_F0.7671.00
100_V276_G0.7661.00
55_W384_A0.7641.00
412_G415_L0.7621.00
358_F375_Q0.7611.00
36_V39_G0.7601.00
248_C260_T0.7591.00
41_G403_V0.7571.00
295_G298_S0.7561.00
225_T232_L0.7561.00
174_T181_D0.7551.00
42_G401_N0.7551.00
418_N422_S0.7451.00
106_S256_T0.7451.00
199_V230_A0.7441.00
353_M399_R0.7431.00
336_A417_Q0.7411.00
329_R332_E0.7401.00
348_V357_V0.7401.00
71_P268_G0.7401.00
340_E421_E0.7391.00
220_T224_L0.7381.00
113_V119_A0.7381.00
80_A302_V0.7381.00
96_H304_M0.7361.00
325_R329_R0.7351.00
124_V200_L0.7331.00
92_I305_A0.7331.00
241_F262_F0.7281.00
226_H232_L0.7271.00
129_G289_G0.7261.00
212_E349_G0.7251.00
127_A259_V0.7241.00
126_L285_F0.7221.00
115_S118_E0.7211.00
90_T93_E0.7211.00
206_A353_M0.7201.00
250_Q255_I0.7201.00
184_A188_V0.7181.00
244_G252_E0.7181.00
203_P218_H0.7161.00
185_V199_V0.7161.00
213_P216_G0.7161.00
60_G399_R0.7151.00
374_R378_D0.7151.00
50_N381_R0.7101.00
56_V387_K0.7101.00
196_I230_A0.7101.00
75_A306_A0.7101.00
189_F224_L0.7091.00
204_I244_G0.7091.00
93_E97_A0.7061.00
247_G315_A0.7061.00
125_R293_Q0.7041.00
262_F266_I0.7031.00
99_F311_L0.7021.00
376_D388_T0.7001.00
326_L352_S0.6961.00
347_V354_F0.6961.00
280_D283_E0.6961.00
325_R328_G0.6951.00
92_I308_L0.6921.00
241_F247_G0.6911.00
67_D80_A0.6891.00
323_V327_G0.6891.00
132_G195_D0.6871.00
327_G349_G0.6841.00
219_E253_F0.6831.00
89_P94_V0.6831.00
192_H195_D0.6831.00
188_V191_T0.6821.00
53_I412_G0.6791.00
336_A339_A0.6761.00
57_M399_R0.6761.00
349_G354_F0.6761.00
407_Q411_A0.6731.00
120_T150_T0.6711.00
122_S293_Q0.6691.00
92_I304_M0.6691.00
357_V395_A0.6681.00
201_V232_L0.6681.00
92_I96_H0.6651.00
263_G273_G0.6631.00
358_F420_F0.6631.00
79_R82_D0.6611.00
286_T289_G0.6601.00
177_V184_A0.6601.00
347_V356_V0.6601.00
94_V98_E0.6581.00
205_L208_K0.6581.00
361_D365_Q0.6581.00
143_Y146_A0.6571.00
193_G228_H0.6571.00
232_L255_I0.6551.00
103_H248_C0.6551.00
233_I259_V0.6521.00
104_V260_T0.6501.00
375_Q379_C0.6461.00
105_P250_Q0.6461.00
139_M179_F0.6421.00
96_H272_V0.6401.00
218_H234_W0.6401.00
175_I179_F0.6391.00
329_R409_L0.6381.00
53_I384_A0.6371.00
139_M177_V0.6371.00
82_D91_E0.6371.00
341_H420_F0.6361.00
277_G282_M0.6351.00
322_H405_R0.6341.00
398_Q412_G0.6331.00
396_A416_S0.6311.00
356_V416_S0.6311.00
130_Y280_D0.6301.00
176_P179_F0.6291.00
123_A259_V0.6291.00
189_F228_H0.6291.00
401_N404_F0.6291.00
105_P108_E0.6281.00
92_I95_E0.6261.00
338_V347_V0.6251.00
242_R314_A0.6251.00
64_L319_V0.6201.00
72_V270_F0.6171.00
322_H409_L0.6151.00
181_D184_A0.6141.00
44_V385_C0.6131.00
205_L211_V0.6121.00
188_V192_H0.6121.00
126_L259_V0.6121.00
237_V261_T0.6111.00
107_V260_T0.6111.00
326_L404_F0.6091.00
419_Q422_S0.6081.00
182_A186_T0.6071.00
105_P251_S0.6061.00
139_M221_L0.6051.00
215_A253_F0.6041.00
187_E190_E0.6041.00
404_F408_L0.6041.00
131_T197_A0.6031.00
71_P310_T0.6021.00
409_L412_G0.6011.00
377_P380_E0.6011.00
133_R230_A0.6011.00
328_G331_R0.6001.00
416_S420_F0.5991.00
330_L354_F0.5991.00
379_C416_S0.5971.00
35_F89_P0.5971.00
241_F248_C0.5961.00
330_L413_V0.5961.00
359_T362_G0.5951.00
182_A185_V0.5941.00
113_V118_E0.5941.00
104_V248_C0.5941.00
42_G404_F0.5941.00
39_G44_V0.5921.00
413_V417_Q0.5921.00
106_S250_Q0.5911.00
116_G237_V0.5901.00
281_V284_E0.5901.00
215_A350_R0.5891.00
343_P359_T0.5891.00
75_A78_R0.5881.00
250_Q257_P0.5881.00
137_V188_V0.5871.00
63_L402_R0.5871.00
330_L409_L0.5861.00
104_V262_F0.5821.00
185_V220_T0.5811.00
226_H280_D0.5801.00
71_P309_E0.5791.00
79_R92_I0.5791.00
326_L405_R0.5791.00
278_R281_V0.5771.00
323_V402_R0.5761.00
103_H246_L0.5751.00
375_Q416_S0.5751.00
51_R415_L0.5741.00
37_Q40_D0.5711.00
101_A108_E0.5711.00
185_V224_L0.5701.00
137_V185_V0.5701.00
360_R364_A0.5701.00
306_A309_E0.5681.00
56_V385_C0.5681.00
403_V408_L0.5671.00
224_L227_D0.5651.00
176_P181_D0.5641.00
80_A306_A0.5601.00
133_R195_D0.5601.00
165_G168_P0.5581.00
34_T37_Q0.5571.00
383_A415_L0.5571.00
190_E227_D0.5561.00
263_G297_F0.5561.00
247_G311_L0.5561.00
415_L419_Q0.5561.00
212_E253_F0.5541.00
149_S166_I0.5541.00
140_Q176_P0.5531.00
323_V352_S0.5531.00
168_P174_T0.5521.00
203_P250_Q0.5501.00
207_N397_V0.5501.00
75_A312_Q0.5481.00
203_P239_T0.5481.00
128_R148_E0.5471.00
380_E385_C0.5471.00
330_L333_G0.5471.00
63_L314_A0.5461.00
412_G416_S0.5451.00
185_V217_Y0.5451.00
39_G62_L0.5451.00
221_L230_A0.5441.00
238_I397_V0.5431.00
415_L418_N0.5421.00
344_A420_F0.5421.00
38_S51_R0.5421.00
139_M201_V0.5411.00
300_H303_T0.5351.00
183_D220_T0.5341.00
96_H112_F0.5341.00
348_V395_A0.5341.00
72_V268_G0.5320.99
333_G337_V0.5310.99
182_A221_L0.5280.99
238_I353_M0.5280.99
124_V149_S0.5270.99
101_A104_V0.5270.99
308_L315_A0.5260.99
348_V355_K0.5260.99
156_A160_G0.5250.99
356_V398_Q0.5240.99
247_G314_A0.5240.99
64_L68_L0.5230.99
146_A294_A0.5220.99
344_A356_V0.5220.99
360_R365_Q0.5200.99
128_R164_A0.5200.99
101_A276_G0.5190.99
111_R114_N0.5190.99
177_V185_V0.5190.99
40_D43_H0.5160.99
199_V226_H0.5160.99
259_V281_V0.5130.99
343_P420_F0.5130.99
384_A411_A0.5130.99
345_Y365_Q0.5110.99
190_E194_D0.5070.99
375_Q419_Q0.5070.99
95_E98_E0.5060.99
156_A159_R0.5050.99
104_V110_L0.5040.99
335_A347_V0.5030.99
78_R309_E0.5030.99
139_M199_V0.5030.99
236_E249_A0.5030.99
231_L259_V0.5020.99
82_D92_I0.5010.99
164_A168_P0.5010.99
177_V217_Y0.5000.99
190_E195_D0.5000.99
338_V341_H0.5000.99
375_Q420_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2epjA 2 0.9258 100 0.397 Contact Map
4atqA 7 0.9146 100 0.41 Contact Map
2ykyA 4 0.9124 100 0.414 Contact Map
3oksA 2 0.9101 100 0.415 Contact Map
4uoxA 3 0.9326 100 0.421 Contact Map
4a0gA 2 0.9213 100 0.422 Contact Map
4ffcA 4 0.9236 100 0.426 Contact Map
4ao9A 2 0.9191 100 0.428 Contact Map
4e3qA 3 0.9326 100 0.429 Contact Map
4e77A 2 0.8944 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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