GREMLIN Database
Q9HMY4 - S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase
UniProt: Q9HMY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (220)
Sequences: 13068 (8430)
Seq/√Len: 568.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E24_R3.8741.00
23_T27_E3.3221.00
6_Y25_L2.5981.00
125_A205_Q2.5741.00
29_A83_V2.5571.00
4_T111_E2.5331.00
190_P213_A2.5311.00
210_G214_T2.4651.00
198_E206_Q2.4461.00
75_L80_N2.4231.00
4_T109_D2.2801.00
39_G85_L2.2321.00
24_R28_A2.1761.00
8_V83_V2.1571.00
20_V23_T2.1111.00
193_P233_G2.0911.00
118_S170_L2.0821.00
6_Y81_D2.0601.00
77_E106_H2.0581.00
122_A200_G2.0581.00
197_V200_G2.0481.00
30_D81_D1.9971.00
211_T214_T1.9511.00
8_V22_A1.8901.00
75_L78_D1.8781.00
102_Y106_H1.8391.00
199_K204_G1.8321.00
210_G218_A1.8221.00
194_V215_I1.7841.00
30_D80_N1.7431.00
24_R27_E1.7041.00
9_G113_V1.7011.00
4_T81_D1.6801.00
31_V75_L1.6701.00
156_D159_A1.6621.00
25_L113_V1.6381.00
182_A185_D1.6321.00
73_V106_H1.6231.00
16_E21_K1.5961.00
102_Y105_E1.5911.00
6_Y111_E1.5881.00
74_E78_D1.5611.00
40_P44_S1.5491.00
197_V207_V1.5461.00
50_K75_L1.4891.00
177_P220_D1.4851.00
210_G215_I1.4831.00
126_A195_A1.4801.00
117_T120_V1.4771.00
218_A222_A1.4701.00
217_A221_E1.4421.00
21_K111_E1.4361.00
180_T184_R1.4261.00
188_M192_T1.4231.00
119_P170_L1.4171.00
14_D21_K1.4111.00
214_T218_A1.4041.00
77_E108_V1.3881.00
125_A207_V1.3751.00
71_R75_L1.3731.00
117_T170_L1.3671.00
70_A74_E1.3561.00
28_A81_D1.3481.00
73_V77_E1.3451.00
183_L212_L1.3361.00
158_G185_D1.3341.00
122_A197_V1.3301.00
153_S182_A1.3231.00
199_K202_R1.3211.00
18_L23_T1.3181.00
71_R74_E1.3121.00
9_G89_D1.3051.00
191_E213_A1.2971.00
32_V46_I1.2851.00
169_V232_I1.2611.00
180_T216_V1.2481.00
76_A108_V1.2301.00
112_V124_A1.2241.00
91_F96_G1.2211.00
69_N102_Y1.2171.00
5_V76_A1.2051.00
19_T116_V1.2041.00
25_L83_V1.1861.00
33_L82_V1.1791.00
218_A221_E1.1691.00
38_P41_E1.1601.00
181_A185_D1.1441.00
67_E70_A1.1431.00
206_Q222_A1.1431.00
196_L228_A1.1361.00
194_V212_L1.1331.00
208_A218_A1.1201.00
23_T45_S1.1181.00
33_L72_L1.1131.00
177_P181_A1.1051.00
18_L22_A1.1031.00
61_E64_P1.0991.00
7_L96_G1.0901.00
183_L232_I1.0891.00
168_V231_V1.0871.00
141_F170_L1.0861.00
5_V103_L1.0841.00
195_A209_T1.0761.00
73_V102_Y1.0731.00
184_R190_P1.0701.00
84_R99_E1.0671.00
175_K178_E1.0621.00
184_R213_A1.0361.00
31_V82_V1.0361.00
17_L21_K1.0231.00
29_A81_D1.0181.00
195_A207_V1.0181.00
97_G132_H0.9991.00
103_L108_V0.9941.00
41_E44_S0.9911.00
178_E182_A0.9901.00
6_Y113_V0.9901.00
50_K53_D0.9901.00
89_D124_A0.9861.00
158_G182_A0.9821.00
68_T71_R0.9791.00
33_L75_L0.9731.00
135_H165_G0.9671.00
16_E20_V0.9621.00
158_G162_D0.9621.00
104_A209_T0.9581.00
177_P216_V0.9551.00
181_A216_V0.9531.00
22_A113_V0.9511.00
65_Q98_E0.9471.00
137_S165_G0.9441.00
50_K80_N0.9441.00
154_A182_A0.9431.00
176_L215_I0.9411.00
198_E225_S0.9341.00
178_E181_A0.9301.00
9_G90_P0.9251.00
159_A163_T0.9241.00
20_V24_R0.9231.00
224_I228_A0.9221.00
65_Q69_N0.9211.00
100_M110_F0.9181.00
104_A127_D0.9101.00
33_L71_R0.9021.00
121_A201_T0.8981.00
6_Y29_A0.8971.00
180_T212_L0.8951.00
128_I195_A0.8951.00
64_P67_E0.8861.00
39_G43_L0.8831.00
159_A162_D0.8801.00
168_V229_I0.8791.00
25_L28_A0.8791.00
112_V207_V0.8771.00
31_V80_N0.8721.00
8_V113_V0.8711.00
158_G161_A0.8701.00
8_V25_L0.8691.00
42_I46_I0.8651.00
216_V220_D0.8641.00
91_F112_V0.8641.00
138_S165_G0.8631.00
169_V172_G0.8581.00
39_G46_I0.8381.00
39_G42_I0.8341.00
12_P17_L0.8331.00
192_T234_G0.8311.00
184_R212_L0.8291.00
183_L188_M0.8261.00
176_L230_T0.8201.00
184_R216_V0.8181.00
101_L105_E0.8151.00
189_D192_T0.8151.00
129_P132_H0.8151.00
171_M175_K0.8131.00
133_R137_S0.8031.00
42_I45_S0.8031.00
69_N73_V0.7931.00
122_A231_V0.7921.00
142_V156_D0.7871.00
25_L81_D0.7861.00
25_L111_E0.7861.00
104_A110_F0.7801.00
76_A82_V0.7751.00
92_V120_V0.7751.00
97_G101_L0.7741.00
21_K24_R0.7711.00
170_L229_I0.7691.00
123_P130_V0.7681.00
196_L215_I0.7681.00
70_A102_Y0.7661.00
96_G100_M0.7651.00
18_L42_I0.7651.00
177_P217_A0.7571.00
191_E211_T0.7561.00
89_D112_V0.7531.00
208_A215_I0.7521.00
112_V125_A0.7461.00
121_A200_G0.7451.00
66_S102_Y0.7411.00
90_P94_G0.7371.00
67_E71_R0.7331.00
74_E77_E0.7261.00
217_A220_D0.7231.00
154_A178_E0.7221.00
86_K94_G0.7181.00
66_S70_A0.7171.00
164_G188_M0.7171.00
41_E45_S0.7161.00
193_P211_T0.7151.00
21_K113_V0.7121.00
159_A164_G0.7101.00
26_L32_V0.7081.00
143_T156_D0.7071.00
93_F136_A0.7061.00
25_L29_A0.7061.00
97_G129_P0.7031.00
92_V139_V0.7031.00
15_P41_E0.7021.00
137_S156_D0.7021.00
208_A224_I0.7001.00
92_V130_V0.7001.00
198_E228_A0.6971.00
195_A231_V0.6971.00
173_V228_A0.6951.00
9_G121_A0.6921.00
146_E154_A0.6911.00
125_A201_T0.6871.00
154_A185_D0.6851.00
14_D17_L0.6851.00
27_E45_S0.6851.00
142_V157_W0.6801.00
135_H163_T0.6791.00
26_L83_V0.6771.00
119_P168_V0.6761.00
60_G65_Q0.6751.00
70_A106_H0.6751.00
91_F124_A0.6751.00
34_H51_R0.6731.00
6_Y83_V0.6721.00
43_L46_I0.6721.00
179_Y230_T0.6681.00
181_A220_D0.6681.00
14_D201_T0.6641.00
29_A32_V0.6611.00
100_M104_A0.6611.00
167_I232_I0.6571.00
138_S160_L0.6521.00
21_K25_L0.6491.00
63_T67_E0.6481.00
9_G116_V0.6441.00
7_L100_M0.6431.00
143_T146_E0.6391.00
208_A222_A0.6371.00
209_T236_A0.6301.00
33_L53_D0.6211.00
158_G187_G0.6201.00
154_A158_G0.6181.00
101_L193_P0.6161.00
123_P231_V0.6141.00
73_V103_L0.6131.00
173_V224_I0.6111.00
66_S69_N0.6101.00
169_V179_Y0.6021.00
176_L228_A0.6021.00
176_L180_T0.5971.00
18_L46_I0.5931.00
63_T71_R0.5861.00
157_W179_Y0.5851.00
73_V108_V0.5841.00
40_P43_L0.5831.00
121_A125_A0.5821.00
139_V168_V0.5781.00
214_T217_A0.5781.00
101_L132_H0.5761.00
22_A83_V0.5761.00
59_G68_T0.5751.00
131_T166_T0.5731.00
135_H234_G0.5710.99
167_I183_L0.5700.99
46_I51_R0.5700.99
122_A229_I0.5690.99
155_V158_G0.5640.99
120_V130_V0.5620.99
69_N98_E0.5610.99
15_P45_S0.5600.99
176_L224_I0.5560.99
53_D68_T0.5550.99
51_R75_L0.5540.99
34_H52_E0.5530.99
142_V169_V0.5530.99
36_K53_D0.5510.99
69_N72_L0.5490.99
172_G179_Y0.5480.99
194_V216_V0.5470.99
213_A216_V0.5460.99
20_V45_S0.5450.99
97_G131_T0.5430.99
197_V231_V0.5410.99
23_T46_I0.5380.99
199_K227_P0.5340.99
146_E182_A0.5320.99
91_F100_M0.5320.99
4_T76_A0.5320.99
66_S98_E0.5300.99
142_V147_D0.5280.99
5_V84_R0.5270.99
179_Y183_L0.5250.99
180_T215_I0.5240.99
179_Y182_A0.5200.99
38_P42_I0.5190.99
184_R189_D0.5180.99
90_P112_V0.5180.99
60_G69_N0.5180.99
30_D47_P0.5170.99
101_L104_A0.5170.99
65_Q68_T0.5160.99
162_D187_G0.5150.99
26_L46_I0.5140.99
39_G45_S0.5140.99
103_L110_F0.5130.99
147_D155_V0.5100.99
27_E47_P0.5090.99
200_G207_V0.5070.99
9_G117_T0.5070.99
7_L110_F0.5060.99
36_K226_P0.5060.99
218_A223_G0.5040.99
144_G175_K0.5000.99
160_L163_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4dA 4 1 100 0.168 Contact Map
2yboA 2 0.9512 100 0.176 Contact Map
1pjqA 2 0.9715 100 0.179 Contact Map
1ve2A 2 0.9146 100 0.204 Contact Map
4e16A 2 0.9268 100 0.215 Contact Map
1cbfA 2 0.9431 100 0.221 Contact Map
3kwpA 2 0.9187 100 0.232 Contact Map
3ndcA 2 0.9593 100 0.243 Contact Map
1va0A 2 0.9228 100 0.244 Contact Map
2e0nA 2 0.9024 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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