Q9HMY4 - HALSA - GREMLIN Contacts

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Q9HMY4 - S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase

UniProt:	Q9HMY4	Sequences: MTGTVYLVGSGPGDPELLTVKATRLLEAADVVLHDKLPGPEILSSIPEGKREDVGKRAGGERTPQSETNARLVELAEDGNDVVRLKGGDPFVFGRGGEEMLYLAEHGVDFEVVPGVTSPVAAPAAADIPVTHRDHASSVSFVTGHEDPGKDESAVDWGALADTGGTIVVLMGVGKLPEYTAALRDAGMDPETPVALVEKGTRPGQQVATGTLATIVAARDEAGISPPAITVIGGVAGLWDGVEGEP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	246 (220)
Sequences:	13068 (8430)
Seq/√Len:	568.3

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HMY4 Q9HPN2 Q9HPM9 Q9HPN0 Q9HPM0 Q9HPN3
SULSO - Q97WC9 Q97W12 Q97UT5 Q97WC5 Q97WC8 Q97WD1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_E	24_R	3.874	1.00
23_T	27_E	3.322	1.00
6_Y	25_L	2.598	1.00
125_A	205_Q	2.574	1.00
29_A	83_V	2.557	1.00
4_T	111_E	2.533	1.00
190_P	213_A	2.531	1.00
210_G	214_T	2.465	1.00
198_E	206_Q	2.446	1.00
75_L	80_N	2.423	1.00
4_T	109_D	2.280	1.00
39_G	85_L	2.232	1.00
24_R	28_A	2.176	1.00
8_V	83_V	2.157	1.00
20_V	23_T	2.111	1.00
193_P	233_G	2.091	1.00
118_S	170_L	2.082	1.00
6_Y	81_D	2.060	1.00
77_E	106_H	2.058	1.00
122_A	200_G	2.058	1.00
197_V	200_G	2.048	1.00
30_D	81_D	1.997	1.00
211_T	214_T	1.951	1.00
8_V	22_A	1.890	1.00
75_L	78_D	1.878	1.00
102_Y	106_H	1.839	1.00
199_K	204_G	1.832	1.00
210_G	218_A	1.822	1.00
194_V	215_I	1.784	1.00
30_D	80_N	1.743	1.00
24_R	27_E	1.704	1.00
9_G	113_V	1.701	1.00
4_T	81_D	1.680	1.00
31_V	75_L	1.670	1.00
156_D	159_A	1.662	1.00
25_L	113_V	1.638	1.00
182_A	185_D	1.632	1.00
73_V	106_H	1.623	1.00
16_E	21_K	1.596	1.00
102_Y	105_E	1.591	1.00
6_Y	111_E	1.588	1.00
74_E	78_D	1.561	1.00
40_P	44_S	1.549	1.00
197_V	207_V	1.546	1.00
50_K	75_L	1.489	1.00
177_P	220_D	1.485	1.00
210_G	215_I	1.483	1.00
126_A	195_A	1.480	1.00
117_T	120_V	1.477	1.00
218_A	222_A	1.470	1.00
217_A	221_E	1.442	1.00
21_K	111_E	1.436	1.00
180_T	184_R	1.426	1.00
188_M	192_T	1.423	1.00
119_P	170_L	1.417	1.00
14_D	21_K	1.411	1.00
214_T	218_A	1.404	1.00
77_E	108_V	1.388	1.00
125_A	207_V	1.375	1.00
71_R	75_L	1.373	1.00
117_T	170_L	1.367	1.00
70_A	74_E	1.356	1.00
28_A	81_D	1.348	1.00
73_V	77_E	1.345	1.00
183_L	212_L	1.336	1.00
158_G	185_D	1.334	1.00
122_A	197_V	1.330	1.00
153_S	182_A	1.323	1.00
199_K	202_R	1.321	1.00
18_L	23_T	1.318	1.00
71_R	74_E	1.312	1.00
9_G	89_D	1.305	1.00
191_E	213_A	1.297	1.00
32_V	46_I	1.285	1.00
169_V	232_I	1.261	1.00
180_T	216_V	1.248	1.00
76_A	108_V	1.230	1.00
112_V	124_A	1.224	1.00
91_F	96_G	1.221	1.00
69_N	102_Y	1.217	1.00
5_V	76_A	1.205	1.00
19_T	116_V	1.204	1.00
25_L	83_V	1.186	1.00
33_L	82_V	1.179	1.00
218_A	221_E	1.169	1.00
38_P	41_E	1.160	1.00
181_A	185_D	1.144	1.00
67_E	70_A	1.143	1.00
206_Q	222_A	1.143	1.00
196_L	228_A	1.136	1.00
194_V	212_L	1.133	1.00
208_A	218_A	1.120	1.00
23_T	45_S	1.118	1.00
33_L	72_L	1.113	1.00
177_P	181_A	1.105	1.00
18_L	22_A	1.103	1.00
61_E	64_P	1.099	1.00
7_L	96_G	1.090	1.00
183_L	232_I	1.089	1.00
168_V	231_V	1.087	1.00
141_F	170_L	1.086	1.00
5_V	103_L	1.084	1.00
195_A	209_T	1.076	1.00
73_V	102_Y	1.073	1.00
184_R	190_P	1.070	1.00
84_R	99_E	1.067	1.00
175_K	178_E	1.062	1.00
184_R	213_A	1.036	1.00
31_V	82_V	1.036	1.00
17_L	21_K	1.023	1.00
29_A	81_D	1.018	1.00
195_A	207_V	1.018	1.00
97_G	132_H	0.999	1.00
103_L	108_V	0.994	1.00
41_E	44_S	0.991	1.00
178_E	182_A	0.990	1.00
6_Y	113_V	0.990	1.00
50_K	53_D	0.990	1.00
89_D	124_A	0.986	1.00
158_G	182_A	0.982	1.00
68_T	71_R	0.979	1.00
33_L	75_L	0.973	1.00
135_H	165_G	0.967	1.00
16_E	20_V	0.962	1.00
158_G	162_D	0.962	1.00
104_A	209_T	0.958	1.00
177_P	216_V	0.955	1.00
181_A	216_V	0.953	1.00
22_A	113_V	0.951	1.00
65_Q	98_E	0.947	1.00
137_S	165_G	0.944	1.00
50_K	80_N	0.944	1.00
154_A	182_A	0.943	1.00
176_L	215_I	0.941	1.00
198_E	225_S	0.934	1.00
178_E	181_A	0.930	1.00
9_G	90_P	0.925	1.00
159_A	163_T	0.924	1.00
20_V	24_R	0.923	1.00
224_I	228_A	0.922	1.00
65_Q	69_N	0.921	1.00
100_M	110_F	0.918	1.00
104_A	127_D	0.910	1.00
33_L	71_R	0.902	1.00
121_A	201_T	0.898	1.00
6_Y	29_A	0.897	1.00
180_T	212_L	0.895	1.00
128_I	195_A	0.895	1.00
64_P	67_E	0.886	1.00
39_G	43_L	0.883	1.00
159_A	162_D	0.880	1.00
168_V	229_I	0.879	1.00
25_L	28_A	0.879	1.00
112_V	207_V	0.877	1.00
31_V	80_N	0.872	1.00
8_V	113_V	0.871	1.00
158_G	161_A	0.870	1.00
8_V	25_L	0.869	1.00
42_I	46_I	0.865	1.00
216_V	220_D	0.864	1.00
91_F	112_V	0.864	1.00
138_S	165_G	0.863	1.00
169_V	172_G	0.858	1.00
39_G	46_I	0.838	1.00
39_G	42_I	0.834	1.00
12_P	17_L	0.833	1.00
192_T	234_G	0.831	1.00
184_R	212_L	0.829	1.00
183_L	188_M	0.826	1.00
176_L	230_T	0.820	1.00
184_R	216_V	0.818	1.00
101_L	105_E	0.815	1.00
189_D	192_T	0.815	1.00
129_P	132_H	0.815	1.00
171_M	175_K	0.813	1.00
133_R	137_S	0.803	1.00
42_I	45_S	0.803	1.00
69_N	73_V	0.793	1.00
122_A	231_V	0.792	1.00
142_V	156_D	0.787	1.00
25_L	81_D	0.786	1.00
25_L	111_E	0.786	1.00
104_A	110_F	0.780	1.00
76_A	82_V	0.775	1.00
92_V	120_V	0.775	1.00
97_G	101_L	0.774	1.00
21_K	24_R	0.771	1.00
170_L	229_I	0.769	1.00
123_P	130_V	0.768	1.00
196_L	215_I	0.768	1.00
70_A	102_Y	0.766	1.00
96_G	100_M	0.765	1.00
18_L	42_I	0.765	1.00
177_P	217_A	0.757	1.00
191_E	211_T	0.756	1.00
89_D	112_V	0.753	1.00
208_A	215_I	0.752	1.00
112_V	125_A	0.746	1.00
121_A	200_G	0.745	1.00
66_S	102_Y	0.741	1.00
90_P	94_G	0.737	1.00
67_E	71_R	0.733	1.00
74_E	77_E	0.726	1.00
217_A	220_D	0.723	1.00
154_A	178_E	0.722	1.00
86_K	94_G	0.718	1.00
66_S	70_A	0.717	1.00
164_G	188_M	0.717	1.00
41_E	45_S	0.716	1.00
193_P	211_T	0.715	1.00
21_K	113_V	0.712	1.00
159_A	164_G	0.710	1.00
26_L	32_V	0.708	1.00
143_T	156_D	0.707	1.00
93_F	136_A	0.706	1.00
25_L	29_A	0.706	1.00
97_G	129_P	0.703	1.00
92_V	139_V	0.703	1.00
15_P	41_E	0.702	1.00
137_S	156_D	0.702	1.00
208_A	224_I	0.700	1.00
92_V	130_V	0.700	1.00
198_E	228_A	0.697	1.00
195_A	231_V	0.697	1.00
173_V	228_A	0.695	1.00
9_G	121_A	0.692	1.00
146_E	154_A	0.691	1.00
125_A	201_T	0.687	1.00
154_A	185_D	0.685	1.00
14_D	17_L	0.685	1.00
27_E	45_S	0.685	1.00
142_V	157_W	0.680	1.00
135_H	163_T	0.679	1.00
26_L	83_V	0.677	1.00
119_P	168_V	0.676	1.00
60_G	65_Q	0.675	1.00
70_A	106_H	0.675	1.00
91_F	124_A	0.675	1.00
34_H	51_R	0.673	1.00
6_Y	83_V	0.672	1.00
43_L	46_I	0.672	1.00
179_Y	230_T	0.668	1.00
181_A	220_D	0.668	1.00
14_D	201_T	0.664	1.00
29_A	32_V	0.661	1.00
100_M	104_A	0.661	1.00
167_I	232_I	0.657	1.00
138_S	160_L	0.652	1.00
21_K	25_L	0.649	1.00
63_T	67_E	0.648	1.00
9_G	116_V	0.644	1.00
7_L	100_M	0.643	1.00
143_T	146_E	0.639	1.00
208_A	222_A	0.637	1.00
209_T	236_A	0.630	1.00
33_L	53_D	0.621	1.00
158_G	187_G	0.620	1.00
154_A	158_G	0.618	1.00
101_L	193_P	0.616	1.00
123_P	231_V	0.614	1.00
73_V	103_L	0.613	1.00
173_V	224_I	0.611	1.00
66_S	69_N	0.610	1.00
169_V	179_Y	0.602	1.00
176_L	228_A	0.602	1.00
176_L	180_T	0.597	1.00
18_L	46_I	0.593	1.00
63_T	71_R	0.586	1.00
157_W	179_Y	0.585	1.00
73_V	108_V	0.584	1.00
40_P	43_L	0.583	1.00
121_A	125_A	0.582	1.00
139_V	168_V	0.578	1.00
214_T	217_A	0.578	1.00
101_L	132_H	0.576	1.00
22_A	83_V	0.576	1.00
59_G	68_T	0.575	1.00
131_T	166_T	0.573	1.00
135_H	234_G	0.571	0.99
167_I	183_L	0.570	0.99
46_I	51_R	0.570	0.99
122_A	229_I	0.569	0.99
155_V	158_G	0.564	0.99
120_V	130_V	0.562	0.99
69_N	98_E	0.561	0.99
15_P	45_S	0.560	0.99
176_L	224_I	0.556	0.99
53_D	68_T	0.555	0.99
51_R	75_L	0.554	0.99
34_H	52_E	0.553	0.99
142_V	169_V	0.553	0.99
36_K	53_D	0.551	0.99
69_N	72_L	0.549	0.99
172_G	179_Y	0.548	0.99
194_V	216_V	0.547	0.99
213_A	216_V	0.546	0.99
20_V	45_S	0.545	0.99
97_G	131_T	0.543	0.99
197_V	231_V	0.541	0.99
23_T	46_I	0.538	0.99
199_K	227_P	0.534	0.99
146_E	182_A	0.532	0.99
91_F	100_M	0.532	0.99
4_T	76_A	0.532	0.99
66_S	98_E	0.530	0.99
142_V	147_D	0.528	0.99
5_V	84_R	0.527	0.99
179_Y	183_L	0.525	0.99
180_T	215_I	0.524	0.99
179_Y	182_A	0.520	0.99
38_P	42_I	0.519	0.99
184_R	189_D	0.518	0.99
90_P	112_V	0.518	0.99
60_G	69_N	0.518	0.99
30_D	47_P	0.517	0.99
101_L	104_A	0.517	0.99
65_Q	68_T	0.516	0.99
162_D	187_G	0.515	0.99
26_L	46_I	0.514	0.99
39_G	45_S	0.514	0.99
103_L	110_F	0.513	0.99
147_D	155_V	0.510	0.99
27_E	47_P	0.509	0.99
200_G	207_V	0.507	0.99
9_G	117_T	0.507	0.99
7_L	110_F	0.506	0.99
36_K	226_P	0.506	0.99
218_A	223_G	0.504	0.99
144_G	175_K	0.500	0.99
160_L	163_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s4dA	4	1	100	0.168	Contact Map
2yboA	2	0.9512	100	0.176	Contact Map
1pjqA	2	0.9715	100	0.179	Contact Map
1ve2A	2	0.9146	100	0.204	Contact Map
4e16A	2	0.9268	100	0.215	Contact Map
1cbfA	2	0.9431	100	0.221	Contact Map
3kwpA	2	0.9187	100	0.232	Contact Map
3ndcA	2	0.9593	100	0.243	Contact Map
1va0A	2	0.9228	100	0.244	Contact Map
2e0nA	2	0.9024	100	0.26	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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