Q9HMY3 - HALSA - GREMLIN Contacts

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Q9HMY3 - Uroporphyrin-III C-methyltransferase

UniProt:	Q9HMY3	Sequences: MLAVDPTGAIPRGDGAVVVVTSKTGVELAADSGWTPGGGRLAAIGPATADACREAGWTVDVVPEEYTSAGLVAALDGDIDGARVEVARSDHGSAVLTDGLAEAGAYVHETVLYALTRPAGAGDSTEIAAAGDLDAALFTSSLTVEHWLAAARERGIESAAREGLADATVGAIGPPTAETAADHGISVDVVPDDAGFEALARATIEDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	207 (168)
Sequences:	2729 (2122)
Seq/√Len:	163.7

ECOLI - HEM4
BACSU - YJJA HEM4 NASF
HALSA - Q9HMY3
SULSO - Q980U3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_L	105_A	4.818	1.00
169_V	185_I	3.126	1.00
189_V	202_A	2.948	1.00
83_R	108_H	2.850	1.00
83_R	106_Y	2.847	1.00
171_A	177_A	2.845	1.00
145_E	179_T	2.668	1.00
135_A	170_G	2.622	1.00
45_G	53_R	2.503	1.00
177_A	190_V	2.339	1.00
141_S	179_T	2.257	1.00
99_G	103_A	2.224	1.00
118_P	146_H	2.223	1.00
179_T	182_D	2.109	1.00
138_F	147_W	2.102	1.00
172_I	176_T	2.064	1.00
138_F	144_V	2.042	1.00
32_S	35_T	2.042	1.00
100_L	107_V	2.028	1.00
86_V	97_T	2.015	1.00
195_G	198_A	1.997	1.00
177_A	181_A	1.947	1.00
67_T	70_G	1.944	1.00
173_G	176_T	1.927	1.00
170_G	199_L	1.888	1.00
171_A	180_A	1.808	1.00
148_L	183_H	1.799	1.00
99_G	102_E	1.785	1.00
193_D	198_A	1.770	1.00
88_R	109_E	1.746	1.00
90_D	114_A	1.744	1.00
144_V	180_A	1.730	1.00
115_L	142_L	1.711	1.00
88_R	92_G	1.687	1.00
43_A	49_A	1.661	1.00
192_D	202_A	1.577	1.00
171_A	190_V	1.541	1.00
97_T	109_E	1.534	1.00
68_S	96_L	1.507	1.00
92_G	142_L	1.490	1.00
135_A	168_T	1.470	1.00
180_A	187_V	1.434	1.00
136_A	167_A	1.375	1.00
60_D	63_P	1.352	1.00
30_A	34_W	1.351	1.00
178_E	181_A	1.336	1.00
181_A	186_S	1.330	1.00
42_A	71_L	1.330	1.00
138_F	169_V	1.328	1.00
97_T	101_A	1.317	1.00
145_E	183_H	1.304	1.00
90_D	94_A	1.289	1.00
145_E	149_A	1.267	1.00
43_A	52_C	1.246	1.00
94_A	109_E	1.234	1.00
117_R	149_A	1.201	1.00
69_A	72_V	1.196	1.00
94_A	98_D	1.195	1.00
43_A	57_W	1.187	1.00
137_L	170_G	1.182	1.00
91_H	145_E	1.171	1.00
81_G	105_A	1.157	1.00
151_A	155_G	1.143	1.00
45_G	113_Y	1.139	1.00
97_T	107_V	1.134	1.00
181_A	187_V	1.126	1.00
129_A	132_D	1.123	1.00
178_E	182_D	1.079	0.99
141_S	175_P	1.069	0.99
91_H	142_L	1.052	0.99
200_A	204_I	1.049	0.99
42_A	139_T	1.040	0.99
141_S	176_T	1.035	0.99
125_T	129_A	1.029	0.99
201_R	204_I	1.028	0.99
68_S	72_V	1.025	0.99
95_V	99_G	1.017	0.99
89_S	112_L	1.015	0.99
137_L	199_L	1.009	0.99
179_T	183_H	0.998	0.99
180_A	185_I	0.984	0.99
40_R	60_D	0.983	0.99
101_A	106_Y	0.978	0.99
118_P	121_A	0.975	0.99
86_V	92_G	0.975	0.99
148_L	185_I	0.966	0.99
174_P	178_E	0.965	0.99
98_D	102_E	0.960	0.99
173_G	191_P	0.953	0.99
31_D	35_T	0.953	0.99
168_T	189_V	0.953	0.99
91_H	115_L	0.947	0.99
86_V	109_E	0.945	0.99
96_L	175_P	0.941	0.99
121_A	124_S	0.940	0.99
72_V	99_G	0.937	0.99
92_G	115_L	0.912	0.98
41_L	57_W	0.911	0.98
79_I	105_A	0.910	0.98
120_G	124_S	0.906	0.98
48_T	113_Y	0.905	0.98
76_D	99_G	0.903	0.98
88_R	111_V	0.898	0.98
98_D	101_A	0.895	0.98
139_T	143_T	0.891	0.98
143_T	172_I	0.887	0.98
65_E	70_G	0.886	0.98
41_L	63_P	0.884	0.98
150_A	153_E	0.880	0.98
92_G	109_E	0.876	0.98
84_V	105_A	0.872	0.98
150_A	154_R	0.870	0.98
126_E	130_A	0.861	0.98
170_G	188_D	0.858	0.97
57_W	60_D	0.858	0.97
31_D	34_W	0.848	0.97
33_G	36_P	0.843	0.97
79_I	96_L	0.842	0.97
45_G	48_T	0.838	0.97
88_R	94_A	0.834	0.97
121_A	150_A	0.830	0.97
52_C	57_W	0.828	0.97
101_A	107_V	0.820	0.97
87_A	110_T	0.810	0.96
191_P	194_A	0.810	0.96
85_E	110_T	0.806	0.96
69_A	93_S	0.805	0.96
173_G	188_D	0.805	0.96
86_V	139_T	0.786	0.96
117_R	146_H	0.785	0.96
78_D	103_A	0.784	0.96
90_D	111_V	0.782	0.96
49_A	174_P	0.781	0.96
192_D	198_A	0.779	0.96
131_G	166_D	0.777	0.95
86_V	93_S	0.771	0.95
68_S	115_L	0.768	0.95
170_G	191_P	0.767	0.95
139_T	196_F	0.761	0.95
93_S	175_P	0.760	0.95
152_R	181_A	0.759	0.95
198_A	201_R	0.757	0.95
152_R	183_H	0.735	0.94
144_V	171_A	0.734	0.94
169_V	180_A	0.728	0.94
171_A	174_P	0.718	0.93
171_A	175_P	0.714	0.93
139_T	175_P	0.714	0.93
89_S	113_Y	0.706	0.93
191_P	202_A	0.702	0.92
77_G	80_D	0.698	0.92
152_R	155_G	0.698	0.92
45_G	57_W	0.695	0.92
68_S	112_L	0.694	0.92
142_L	173_G	0.686	0.91
95_V	98_D	0.684	0.91
87_A	112_L	0.683	0.91
56_G	59_V	0.681	0.91
63_P	66_Y	0.678	0.91
89_S	115_L	0.677	0.91
88_R	113_Y	0.677	0.91
108_H	111_V	0.674	0.91
71_L	75_L	0.669	0.90
149_A	153_E	0.669	0.90
46_P	51_A	0.661	0.90
52_C	113_Y	0.659	0.90
89_S	195_G	0.657	0.90
37_G	122_G	0.648	0.89
41_L	137_L	0.646	0.89
59_V	62_V	0.643	0.89
89_S	92_G	0.640	0.88
96_L	100_L	0.640	0.88
136_A	169_V	0.639	0.88
34_W	37_G	0.638	0.88
87_A	113_Y	0.633	0.88
137_L	196_F	0.633	0.88
191_P	196_F	0.632	0.88
45_G	71_L	0.622	0.87
31_D	123_D	0.621	0.87
42_A	62_V	0.621	0.87
116_T	156_I	0.619	0.87
152_R	156_I	0.616	0.86
92_G	175_P	0.614	0.86
118_P	150_A	0.611	0.86
138_F	196_F	0.607	0.86
138_F	179_T	0.604	0.85
87_A	143_T	0.602	0.85
174_P	194_A	0.600	0.85
113_Y	133_L	0.598	0.85
42_A	74_A	0.596	0.85
77_G	106_Y	0.596	0.85
128_A	131_G	0.596	0.85
155_G	181_A	0.594	0.84
137_L	200_A	0.590	0.84
126_E	129_A	0.586	0.84
42_A	60_D	0.586	0.84
68_S	92_G	0.585	0.84
125_T	128_A	0.584	0.83
42_A	173_G	0.584	0.83
135_A	202_A	0.583	0.83
66_Y	137_L	0.581	0.83
170_G	189_V	0.579	0.83
174_P	181_A	0.578	0.83
192_D	201_R	0.577	0.83
66_Y	70_G	0.575	0.82
66_Y	139_T	0.572	0.82
87_A	90_D	0.565	0.81
47_A	133_L	0.564	0.81
91_H	111_V	0.563	0.81
92_G	97_T	0.563	0.81
144_V	176_T	0.562	0.81
88_R	169_V	0.562	0.81
172_I	199_L	0.562	0.81
197_E	201_R	0.561	0.81
89_S	175_P	0.555	0.80
136_A	145_E	0.554	0.80
129_A	133_L	0.554	0.80
174_P	177_A	0.550	0.80
45_G	89_S	0.548	0.79
82_A	166_D	0.546	0.79
171_A	187_V	0.544	0.79
200_A	203_T	0.544	0.79
131_G	156_I	0.542	0.79
47_A	50_D	0.540	0.78
146_H	149_A	0.537	0.78
120_G	150_A	0.537	0.78
145_E	182_D	0.536	0.78
135_A	203_T	0.536	0.78
127_I	130_A	0.536	0.78
31_D	114_A	0.533	0.78
79_I	82_A	0.530	0.77
70_G	74_A	0.527	0.77
44_I	89_S	0.525	0.76
88_R	139_T	0.525	0.76
135_A	189_V	0.522	0.76
119_A	155_G	0.520	0.76
86_V	105_A	0.516	0.75
47_A	90_D	0.515	0.75
137_L	203_T	0.512	0.75
191_P	200_A	0.511	0.75
75_L	143_T	0.511	0.75
180_A	184_G	0.510	0.74
92_G	112_L	0.510	0.74
45_G	96_L	0.507	0.74
133_L	143_T	0.505	0.74
39_G	81_G	0.505	0.74
42_A	75_L	0.504	0.74
92_G	95_V	0.503	0.73
45_G	56_G	0.503	0.73
120_G	173_G	0.502	0.73
189_V	198_A	0.501	0.73
55_A	126_E	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3p9zA	1	0.8986	100	0.247	Contact Map
1jr2A	1	0.971	100	0.251	Contact Map
3re1A	1	0.971	100	0.256	Contact Map
4es6A	1	0.9662	100	0.266	Contact Map
3mw8A	1	0.9517	100	0.267	Contact Map
3d8tA	1	0.9662	100	0.269	Contact Map
1wcwA	1	0.9662	100	0.271	Contact Map
2qu7A	2	0.9082	96.2	0.862	Contact Map
3kkeA	2	0.9372	96.2	0.862	Contact Map
4rk6A	2	0.9324	95.9	0.865	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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