GREMLIN Database
Q9HMY3 - Uroporphyrin-III C-methyltransferase
UniProt: Q9HMY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (168)
Sequences: 2729 (2122)
Seq/√Len: 163.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_L105_A4.8181.00
169_V185_I3.1261.00
189_V202_A2.9481.00
83_R108_H2.8501.00
83_R106_Y2.8471.00
171_A177_A2.8451.00
145_E179_T2.6681.00
135_A170_G2.6221.00
45_G53_R2.5031.00
177_A190_V2.3391.00
141_S179_T2.2571.00
99_G103_A2.2241.00
118_P146_H2.2231.00
179_T182_D2.1091.00
138_F147_W2.1021.00
172_I176_T2.0641.00
138_F144_V2.0421.00
32_S35_T2.0421.00
100_L107_V2.0281.00
86_V97_T2.0151.00
195_G198_A1.9971.00
177_A181_A1.9471.00
67_T70_G1.9441.00
173_G176_T1.9271.00
170_G199_L1.8881.00
171_A180_A1.8081.00
148_L183_H1.7991.00
99_G102_E1.7851.00
193_D198_A1.7701.00
88_R109_E1.7461.00
90_D114_A1.7441.00
144_V180_A1.7301.00
115_L142_L1.7111.00
88_R92_G1.6871.00
43_A49_A1.6611.00
192_D202_A1.5771.00
171_A190_V1.5411.00
97_T109_E1.5341.00
68_S96_L1.5071.00
92_G142_L1.4901.00
135_A168_T1.4701.00
180_A187_V1.4341.00
136_A167_A1.3751.00
60_D63_P1.3521.00
30_A34_W1.3511.00
178_E181_A1.3361.00
181_A186_S1.3301.00
42_A71_L1.3301.00
138_F169_V1.3281.00
97_T101_A1.3171.00
145_E183_H1.3041.00
90_D94_A1.2891.00
145_E149_A1.2671.00
43_A52_C1.2461.00
94_A109_E1.2341.00
117_R149_A1.2011.00
69_A72_V1.1961.00
94_A98_D1.1951.00
43_A57_W1.1871.00
137_L170_G1.1821.00
91_H145_E1.1711.00
81_G105_A1.1571.00
151_A155_G1.1431.00
45_G113_Y1.1391.00
97_T107_V1.1341.00
181_A187_V1.1261.00
129_A132_D1.1231.00
178_E182_D1.0790.99
141_S175_P1.0690.99
91_H142_L1.0520.99
200_A204_I1.0490.99
42_A139_T1.0400.99
141_S176_T1.0350.99
125_T129_A1.0290.99
201_R204_I1.0280.99
68_S72_V1.0250.99
95_V99_G1.0170.99
89_S112_L1.0150.99
137_L199_L1.0090.99
179_T183_H0.9980.99
180_A185_I0.9840.99
40_R60_D0.9830.99
101_A106_Y0.9780.99
118_P121_A0.9750.99
86_V92_G0.9750.99
148_L185_I0.9660.99
174_P178_E0.9650.99
98_D102_E0.9600.99
173_G191_P0.9530.99
31_D35_T0.9530.99
168_T189_V0.9530.99
91_H115_L0.9470.99
86_V109_E0.9450.99
96_L175_P0.9410.99
121_A124_S0.9400.99
72_V99_G0.9370.99
92_G115_L0.9120.98
41_L57_W0.9110.98
79_I105_A0.9100.98
120_G124_S0.9060.98
48_T113_Y0.9050.98
76_D99_G0.9030.98
88_R111_V0.8980.98
98_D101_A0.8950.98
139_T143_T0.8910.98
143_T172_I0.8870.98
65_E70_G0.8860.98
41_L63_P0.8840.98
150_A153_E0.8800.98
92_G109_E0.8760.98
84_V105_A0.8720.98
150_A154_R0.8700.98
126_E130_A0.8610.98
170_G188_D0.8580.97
57_W60_D0.8580.97
31_D34_W0.8480.97
33_G36_P0.8430.97
79_I96_L0.8420.97
45_G48_T0.8380.97
88_R94_A0.8340.97
121_A150_A0.8300.97
52_C57_W0.8280.97
101_A107_V0.8200.97
87_A110_T0.8100.96
191_P194_A0.8100.96
85_E110_T0.8060.96
69_A93_S0.8050.96
173_G188_D0.8050.96
86_V139_T0.7860.96
117_R146_H0.7850.96
78_D103_A0.7840.96
90_D111_V0.7820.96
49_A174_P0.7810.96
192_D198_A0.7790.96
131_G166_D0.7770.95
86_V93_S0.7710.95
68_S115_L0.7680.95
170_G191_P0.7670.95
139_T196_F0.7610.95
93_S175_P0.7600.95
152_R181_A0.7590.95
198_A201_R0.7570.95
152_R183_H0.7350.94
144_V171_A0.7340.94
169_V180_A0.7280.94
171_A174_P0.7180.93
171_A175_P0.7140.93
139_T175_P0.7140.93
89_S113_Y0.7060.93
191_P202_A0.7020.92
77_G80_D0.6980.92
152_R155_G0.6980.92
45_G57_W0.6950.92
68_S112_L0.6940.92
142_L173_G0.6860.91
95_V98_D0.6840.91
87_A112_L0.6830.91
56_G59_V0.6810.91
63_P66_Y0.6780.91
89_S115_L0.6770.91
88_R113_Y0.6770.91
108_H111_V0.6740.91
71_L75_L0.6690.90
149_A153_E0.6690.90
46_P51_A0.6610.90
52_C113_Y0.6590.90
89_S195_G0.6570.90
37_G122_G0.6480.89
41_L137_L0.6460.89
59_V62_V0.6430.89
89_S92_G0.6400.88
96_L100_L0.6400.88
136_A169_V0.6390.88
34_W37_G0.6380.88
87_A113_Y0.6330.88
137_L196_F0.6330.88
191_P196_F0.6320.88
45_G71_L0.6220.87
31_D123_D0.6210.87
42_A62_V0.6210.87
116_T156_I0.6190.87
152_R156_I0.6160.86
92_G175_P0.6140.86
118_P150_A0.6110.86
138_F196_F0.6070.86
138_F179_T0.6040.85
87_A143_T0.6020.85
174_P194_A0.6000.85
113_Y133_L0.5980.85
42_A74_A0.5960.85
77_G106_Y0.5960.85
128_A131_G0.5960.85
155_G181_A0.5940.84
137_L200_A0.5900.84
126_E129_A0.5860.84
42_A60_D0.5860.84
68_S92_G0.5850.84
125_T128_A0.5840.83
42_A173_G0.5840.83
135_A202_A0.5830.83
66_Y137_L0.5810.83
170_G189_V0.5790.83
174_P181_A0.5780.83
192_D201_R0.5770.83
66_Y70_G0.5750.82
66_Y139_T0.5720.82
87_A90_D0.5650.81
47_A133_L0.5640.81
91_H111_V0.5630.81
92_G97_T0.5630.81
144_V176_T0.5620.81
88_R169_V0.5620.81
172_I199_L0.5620.81
197_E201_R0.5610.81
89_S175_P0.5550.80
136_A145_E0.5540.80
129_A133_L0.5540.80
174_P177_A0.5500.80
45_G89_S0.5480.79
82_A166_D0.5460.79
171_A187_V0.5440.79
200_A203_T0.5440.79
131_G156_I0.5420.79
47_A50_D0.5400.78
146_H149_A0.5370.78
120_G150_A0.5370.78
145_E182_D0.5360.78
135_A203_T0.5360.78
127_I130_A0.5360.78
31_D114_A0.5330.78
79_I82_A0.5300.77
70_G74_A0.5270.77
44_I89_S0.5250.76
88_R139_T0.5250.76
135_A189_V0.5220.76
119_A155_G0.5200.76
86_V105_A0.5160.75
47_A90_D0.5150.75
137_L203_T0.5120.75
191_P200_A0.5110.75
75_L143_T0.5110.75
180_A184_G0.5100.74
92_G112_L0.5100.74
45_G96_L0.5070.74
133_L143_T0.5050.74
39_G81_G0.5050.74
42_A75_L0.5040.74
92_G95_V0.5030.73
45_G56_G0.5030.73
120_G173_G0.5020.73
189_V198_A0.5010.73
55_A126_E0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p9zA 1 0.8986 100 0.247 Contact Map
1jr2A 1 0.971 100 0.251 Contact Map
3re1A 1 0.971 100 0.256 Contact Map
4es6A 1 0.9662 100 0.266 Contact Map
3mw8A 1 0.9517 100 0.267 Contact Map
3d8tA 1 0.9662 100 0.269 Contact Map
1wcwA 1 0.9662 100 0.271 Contact Map
2qu7A 2 0.9082 96.2 0.862 Contact Map
3kkeA 2 0.9372 96.2 0.862 Contact Map
4rk6A 2 0.9324 95.9 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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