GREMLIN Database
Q9HMY2 - Uncharacterized protein
UniProt: Q9HMY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 475 (442)
Sequences: 220 (168)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
415_A424_V5.1651.00
32_S42_A4.5560.99
51_R155_D4.4090.99
212_L223_I3.7060.96
223_I230_A3.5120.94
30_V46_S3.4780.94
186_G456_N3.4610.94
456_N459_A3.4490.94
429_V467_V3.4160.93
142_Y185_D3.3360.92
121_H126_L3.0370.88
368_H457_E2.9670.87
292_E328_R2.8360.84
433_A437_A2.7230.82
363_D469_A2.6340.79
197_G339_R2.5070.76
138_A163_G2.4870.75
48_A145_A2.4000.72
169_Q179_N2.3900.72
135_L139_G2.3720.71
429_V464_A2.3500.71
202_G206_R2.3250.70
39_L317_A2.3220.70
423_G471_Q2.2920.69
45_A81_L2.2750.68
141_T434_A2.2740.68
139_G182_V2.2330.67
157_A182_V2.2320.66
300_D343_R2.1800.65
424_V468_L2.1680.64
197_G258_R2.1030.62
220_I319_V2.0960.61
429_V471_Q2.0520.60
142_Y146_R2.0120.58
360_V392_E2.0100.58
303_E306_T2.0050.58
378_V384_M2.0000.58
422_A472_R1.9860.57
436_A463_A1.9520.56
237_L260_T1.9230.54
51_R153_A1.9180.54
292_E299_R1.9060.54
137_G367_F1.8870.53
218_L225_N1.8800.53
364_L424_V1.8430.51
48_A148_L1.8410.51
411_V450_A1.8380.51
320_G324_C1.8330.51
105_V264_A1.8210.50
41_S141_T1.8180.50
82_F93_I1.7850.49
88_G309_N1.7760.48
159_L324_C1.7570.48
80_V289_L1.7400.47
264_A456_N1.7380.47
312_A321_L1.6990.45
203_T416_T1.6930.45
45_A83_T1.6850.45
162_V308_L1.6810.45
202_G306_T1.6510.43
161_V298_L1.6340.43
11_L127_E1.6210.42
39_L324_C1.6040.41
207_P323_V1.6020.41
426_L448_A1.6000.41
20_D436_A1.5980.41
29_L57_E1.5980.41
83_T319_V1.5960.41
88_G323_V1.5940.41
178_A190_G1.5770.40
298_L326_G1.5710.40
207_P343_R1.5690.40
143_V392_E1.5680.40
39_L465_S1.5670.40
342_H384_M1.5440.39
64_L233_F1.5380.39
58_V421_D1.5330.39
32_S178_A1.5250.38
106_I266_V1.5250.38
82_F136_S1.5250.38
404_D461_L1.5230.38
412_S444_H1.5110.38
412_S443_G1.5110.38
412_S442_G1.5110.38
414_R444_H1.5110.38
414_R443_G1.5110.38
414_R442_G1.5110.38
396_P423_G1.5040.38
46_S56_H1.5040.38
132_G300_D1.5020.37
183_A240_D1.5000.37
162_V310_A1.4950.37
420_V446_A1.4930.37
34_I313_R1.4920.37
184_A188_E1.4890.37
22_L61_S1.4880.37
309_N313_R1.4850.37
202_G401_A1.4800.37
39_L43_G1.4770.36
279_V312_A1.4670.36
89_Q201_Y1.4660.36
155_D396_P1.4570.36
159_L335_A1.4570.36
61_S68_E1.4490.35
180_T285_T1.4470.35
362_D381_V1.4360.35
54_I157_A1.4260.35
202_G303_E1.4190.34
78_G340_E1.4160.34
146_R151_T1.3950.33
36_A335_A1.3950.33
299_R310_A1.3930.33
145_A155_D1.3770.33
121_H320_G1.3730.33
213_E230_A1.3700.33
93_I452_V1.3700.33
237_L432_E1.3690.33
106_I228_Q1.3640.32
69_I161_V1.3580.32
424_V427_A1.3530.32
112_P124_P1.3430.32
305_A468_L1.3350.31
137_G142_Y1.3270.31
22_L81_L1.3250.31
112_P132_G1.3200.31
446_A465_S1.3120.30
192_L238_D1.3120.30
237_L319_V1.3100.30
48_A52_A1.3010.30
69_I304_F1.2980.30
130_D315_E1.2960.30
39_L300_D1.2880.30
28_V54_I1.2860.30
39_L146_R1.2810.29
233_F264_A1.2810.29
144_L302_S1.2620.29
105_V432_E1.2590.29
265_L275_P1.2560.29
107_A137_G1.2520.28
112_P346_L1.2510.28
12_A452_V1.2510.28
31_A162_V1.2470.28
42_A121_H1.2430.28
129_V353_V1.2400.28
137_G173_G1.2370.28
18_C122_L1.2220.27
415_A419_V1.2200.27
339_R365_Q1.2170.27
207_P303_E1.2160.27
188_E452_V1.2160.27
212_L343_R1.2150.27
300_D401_A1.2150.27
322_A358_V1.2090.27
446_A471_Q1.2000.27
360_V395_R1.1980.27
43_G106_I1.1960.27
423_G446_A1.1890.26
162_V320_G1.1820.26
45_A107_A1.1790.26
16_A470_A1.1790.26
308_L312_A1.1660.26
137_G342_H1.1490.25
153_A327_D1.1480.25
316_R319_V1.1450.25
15_A252_S1.1440.25
135_L142_Y1.1410.25
363_D465_S1.1390.25
29_L59_V1.1370.25
55_P119_D1.1360.25
420_V471_Q1.1360.25
278_E334_R1.1340.25
200_L464_A1.1340.25
252_S383_G1.1320.25
404_D466_G1.1280.24
365_Q397_I1.1270.24
430_V464_A1.1190.24
186_G417_A1.1190.24
299_R328_R1.1180.24
367_F383_G1.1170.24
212_L238_D1.1150.24
130_D445_E1.1120.24
33_H37_D1.1060.24
144_L420_V1.1050.24
164_A169_Q1.0950.24
48_A153_A1.0950.24
207_P306_T1.0930.23
419_V424_V1.0910.23
226_D392_E1.0850.23
212_L292_E1.0830.23
128_G438_G1.0780.23
465_S469_A1.0770.23
49_L131_G1.0700.23
165_V319_V1.0690.23
206_R401_A1.0630.23
177_G326_G1.0610.23
364_L468_L1.0580.22
208_L459_A1.0560.22
135_L152_D1.0540.22
289_L292_E1.0530.22
252_S369_A1.0530.22
301_A424_V1.0470.22
205_T306_T1.0430.22
134_E364_L1.0380.22
15_A112_P1.0360.22
412_S441_G1.0290.22
414_R441_G1.0290.22
441_G444_H1.0290.22
206_R378_V1.0270.22
157_A189_A1.0240.21
224_T417_A1.0240.21
426_L439_G1.0230.21
177_G310_A1.0230.21
208_L212_L1.0230.21
88_G303_E1.0210.21
364_L461_L1.0080.21
413_A426_L1.0050.21
416_T429_V1.0040.21
439_G460_F1.0030.21
227_H230_A1.0030.21
236_A270_V1.0020.21
378_V382_A1.0010.21
261_V431_R0.9960.21
168_R208_L0.9940.21
35_D38_G0.9930.21
32_S280_T0.9930.21
201_Y401_A0.9910.21
143_V256_D0.9900.21
58_V130_D0.9870.20
60_F384_M0.9840.20
120_Y430_V0.9840.20
49_L54_I0.9840.20
364_L465_S0.9820.20
164_A303_E0.9820.20
334_R346_L0.9790.20
139_G311_T0.9770.20
328_R343_R0.9760.20
157_A191_V0.9750.20
124_P179_N0.9710.20
207_P287_Y0.9670.20
54_I191_V0.9660.20
197_G377_I0.9650.20
148_L153_A0.9610.20
106_I214_Y0.9600.20
362_D465_S0.9590.20
177_G395_R0.9570.20
428_V431_R0.9560.20
134_E286_T0.9560.20
306_T384_M0.9550.20
136_S310_A0.9540.20
36_A163_G0.9530.20
22_L208_L0.9500.20
34_I60_F0.9500.20
60_F83_T0.9440.19
82_F106_I0.9440.19
43_G405_D0.9430.19
87_S112_P0.9340.19
44_I145_A0.9300.19
111_Q425_D0.9260.19
73_A311_T0.9250.19
15_A19_A0.9220.19
207_P328_R0.9220.19
200_L402_A0.9210.19
158_A185_D0.9190.19
404_D459_A0.9190.19
334_R452_V0.9180.19
137_G311_T0.9120.19
206_R303_E0.9110.19
362_D466_G0.9070.18
29_L87_S0.9030.18
365_Q383_G0.9020.18
308_L423_G0.8980.18
58_V321_L0.8970.18
265_L457_E0.8970.18
462_D466_G0.8940.18
190_G324_C0.8930.18
31_A308_L0.8920.18
160_A309_N0.8900.18
303_E326_G0.8900.18
140_A429_V0.8890.18
252_S462_D0.8890.18
22_L45_A0.8870.18
432_E461_L0.8860.18
415_A468_L0.8860.18
22_L261_V0.8860.18
81_L138_A0.8850.18
51_R145_A0.8820.18
410_K447_A0.8820.18
24_D189_A0.8790.18
296_T304_F0.8780.18
412_S449_G0.8780.18
443_G449_G0.8780.18
442_G449_G0.8780.18
444_H449_G0.8780.18
414_R449_G0.8780.18
49_L91_D0.8740.18
24_D188_E0.8690.17
30_V418_R0.8680.17
22_L361_E0.8640.17
323_V335_A0.8620.17
121_H200_L0.8620.17
85_F313_R0.8610.17
138_A161_V0.8610.17
57_E218_L0.8600.17
129_V192_L0.8600.17
60_F397_I0.8590.17
431_R455_G0.8570.17
164_A183_A0.8560.17
395_R436_A0.8550.17
463_A466_G0.8550.17
212_L320_G0.8550.17
165_V384_M0.8530.17
61_S72_I0.8530.17
26_D239_V0.8500.17
299_R339_R0.8500.17
83_T159_L0.8480.17
224_T395_R0.8480.17
33_H441_G0.8470.17
200_L413_A0.8460.17
226_D422_A0.8450.17
17_A143_V0.8450.17
63_Q313_R0.8440.17
30_V43_G0.8420.17
253_L455_G0.8410.17
127_E185_D0.8400.17
314_Y345_T0.8380.17
297_A305_A0.8360.17
83_T285_T0.8360.17
273_G320_G0.8350.17
60_F342_H0.8350.17
338_L346_L0.8340.17
64_L415_A0.8340.17
11_L130_D0.8330.17
124_P413_A0.8270.17
81_L213_E0.8250.16
145_A156_L0.8250.16
69_I266_V0.8250.16
396_P438_G0.8240.16
106_I243_D0.8230.16
179_N441_G0.8230.16
142_Y252_S0.8210.16
156_L396_P0.8160.16
183_A230_A0.8130.16
82_F210_R0.8130.16
62_K380_I0.8120.16
85_F125_L0.8120.16
69_I413_A0.8120.16
361_E366_W0.8100.16
146_R472_R0.8070.16
193_D230_A0.8070.16
183_A452_V0.8060.16
162_V324_C0.8060.16
280_T358_V0.8030.16
22_L28_V0.8020.16
139_G160_A0.8010.16
170_T203_T0.7980.16
79_T366_W0.7980.16
264_A446_A0.7970.16
285_T319_V0.7960.16
175_L384_M0.7960.16
21_A215_A0.7950.16
334_R461_L0.7940.16
16_A277_A0.7920.16
137_G266_V0.7910.16
85_F202_G0.7910.16
208_L213_E0.7890.16
422_A434_A0.7850.16
203_T267_K0.7840.16
45_A214_Y0.7840.16
52_A140_A0.7840.16
160_A164_A0.7830.16
60_F314_Y0.7820.16
33_H38_G0.7790.15
267_K431_R0.7780.15
35_D44_I0.7750.15
134_E472_R0.7720.15
300_D433_A0.7690.15
304_F328_R0.7670.15
395_R458_R0.7650.15
277_A432_E0.7640.15
12_A402_A0.7640.15
222_G365_Q0.7630.15
208_L257_E0.7630.15
234_L379_G0.7630.15
59_V66_D0.7590.15
201_Y225_N0.7550.15
88_G139_G0.7530.15
219_Y351_S0.7530.15
324_C335_A0.7520.15
13_E66_D0.7520.15
123_N179_N0.7510.15
309_N368_H0.7510.15
123_N130_D0.7500.15
309_N410_K0.7460.15
107_A141_T0.7460.15
134_E176_V0.7440.15
28_V369_A0.7420.15
301_A338_L0.7420.15
197_G328_R0.7420.15
19_A23_R0.7410.15
367_F399_A0.7400.15
106_I119_D0.7400.15
124_P166_G0.7400.15
120_Y140_A0.7390.15
285_T366_W0.7380.15
122_L144_L0.7370.15
37_D86_G0.7260.14
92_A261_V0.7260.14
36_A160_A0.7250.14
81_L107_A0.7220.14
180_T435_A0.7190.14
60_F319_V0.7190.14
26_D54_I0.7190.14
265_L427_A0.7180.14
449_G460_F0.7170.14
232_R452_V0.7170.14
204_Q312_A0.7160.14
39_L160_A0.7160.14
416_T446_A0.7160.14
346_L353_V0.7160.14
136_S297_A0.7140.14
84_D167_D0.7130.14
84_D110_H0.7130.14
84_D109_H0.7130.14
84_D108_D0.7130.14
109_H167_D0.7130.14
110_H167_D0.7130.14
108_D167_D0.7130.14
419_V423_G0.7130.14
261_V362_D0.7120.14
203_T373_I0.7110.14
175_L342_H0.7090.14
49_L193_D0.7090.14
310_A320_G0.7060.14
145_A301_A0.7060.14
62_K375_E0.7060.14
26_D432_E0.7060.14
106_I111_Q0.7040.14
83_T311_T0.7040.14
34_I139_G0.7030.14
434_A472_R0.7020.14
298_L328_R0.7020.14
23_R337_S0.7020.14
106_I348_E0.7020.14
155_D327_D0.7000.14
94_T411_V0.7000.14
372_R433_A0.6990.14
114_E220_I0.6990.14
139_G157_A0.6980.14
420_V423_G0.6980.14
416_T423_G0.6970.14
22_L366_W0.6960.14
319_V461_L0.6950.14
160_A308_L0.6930.14
313_R379_G0.6930.14
25_A54_I0.6910.14
46_S225_N0.6900.14
36_A159_L0.6890.14
366_W450_A0.6880.14
396_P429_V0.6880.14
30_V195_A0.6870.14
43_G310_A0.6860.14
28_V458_R0.6830.14
122_L317_A0.6820.14
423_G465_S0.6820.14
19_A80_V0.6820.14
327_D371_D0.6790.13
155_D165_V0.6780.13
83_T339_R0.6770.13
314_Y399_A0.6760.13
140_A234_L0.6750.13
43_G324_C0.6700.13
152_D157_A0.6670.13
183_A366_W0.6660.13
71_D310_A0.6660.13
383_G419_V0.6650.13
210_R297_A0.6640.13
138_A260_T0.6640.13
166_G311_T0.6610.13
386_L402_A0.6580.13
34_I205_T0.6580.13
289_L374_R0.6560.13
16_A398_V0.6560.13
31_A61_S0.6550.13
415_A448_A0.6540.13
367_F430_V0.6530.13
462_D470_A0.6510.13
300_D373_I0.6510.13
160_A426_L0.6510.13
279_V472_R0.6480.13
31_A80_V0.6460.13
30_V464_A0.6460.13
300_D320_G0.6460.13
273_G425_D0.6430.13
192_L425_D0.6420.13
448_A460_F0.6410.13
42_A333_E0.6400.13
395_R446_A0.6400.13
44_I282_L0.6380.13
425_D445_E0.6370.13
75_A79_T0.6370.13
242_H267_K0.6360.13
64_L379_G0.6350.13
58_V141_T0.6340.13
164_A175_L0.6330.13
31_A312_A0.6330.13
88_G292_E0.6290.13
22_L285_T0.6260.12
30_V59_V0.6250.12
156_L169_Q0.6240.12
192_L435_A0.6240.12
201_Y303_E0.6240.12
156_L471_Q0.6220.12
145_A182_V0.6190.12
134_E179_N0.6170.12
119_D188_E0.6170.12
59_V258_R0.6160.12
350_V380_I0.6150.12
117_A435_A0.6150.12
138_A409_V0.6140.12
467_V471_Q0.6130.12
69_I130_D0.6130.12
50_E137_G0.6120.12
258_R328_R0.6110.12
151_T270_V0.6110.12
112_P353_V0.6080.12
112_P221_P0.6070.12
135_L351_S0.6070.12
207_P353_V0.6070.12
46_S148_L0.6070.12
426_L447_A0.6060.12
35_D412_S0.6060.12
35_D442_G0.6060.12
35_D443_G0.6060.12
35_D444_H0.6060.12
35_D414_R0.6060.12
285_T339_R0.6050.12
136_S411_V0.6010.12
419_V472_R0.6010.12
111_Q121_H0.5980.12
95_A256_D0.5970.12
28_V158_A0.5970.12
85_F464_A0.5970.12
165_V214_Y0.5970.12
137_G312_A0.5960.12
254_D257_E0.5950.12
145_A263_S0.5940.12
92_A172_D0.5940.12
30_V168_R0.5930.12
214_Y434_A0.5920.12
250_W376_T0.5910.12
93_I374_R0.5890.12
182_V264_A0.5880.12
52_A157_A0.5880.12
361_E461_L0.5870.12
466_G470_A0.5850.12
239_V432_E0.5810.12
76_N223_I0.5780.12
90_L399_A0.5760.12
130_D370_D0.5750.12
56_H262_V0.5750.12
136_S320_G0.5720.12
111_Q190_G0.5690.11
57_E304_F0.5680.11
183_A385_A0.5670.11
208_L347_S0.5670.11
337_S434_A0.5670.11
104_P210_R0.5670.11
342_H346_L0.5660.11
162_V227_H0.5660.11
210_R305_A0.5660.11
194_T288_T0.5660.11
81_L285_T0.5650.11
28_V186_G0.5650.11
112_P323_V0.5630.11
442_G447_A0.5620.11
443_G447_A0.5620.11
414_R447_A0.5620.11
412_S447_A0.5620.11
444_H447_A0.5620.11
89_Q134_E0.5620.11
278_E452_V0.5580.11
90_L105_V0.5580.11
320_G448_A0.5570.11
342_H353_V0.5540.11
266_V416_T0.5530.11
84_D449_G0.5490.11
110_H449_G0.5490.11
414_R439_G0.5490.11
412_S439_G0.5490.11
109_H449_G0.5490.11
108_D449_G0.5490.11
167_D449_G0.5490.11
439_G444_H0.5490.11
439_G443_G0.5490.11
439_G442_G0.5490.11
320_G335_A0.5490.11
197_G207_P0.5490.11
132_G445_E0.5480.11
32_S136_S0.5460.11
38_G156_L0.5460.11
458_R462_D0.5460.11
41_S259_R0.5450.11
266_V301_A0.5450.11
198_L424_V0.5440.11
61_S238_D0.5430.11
20_D301_A0.5420.11
333_E422_A0.5420.11
426_L452_V0.5420.11
206_R306_T0.5410.11
367_F415_A0.5390.11
311_T324_C0.5380.11
165_V342_H0.5370.11
30_V333_E0.5370.11
61_S432_E0.5370.11
298_L332_L0.5360.11
48_A322_A0.5360.11
13_E217_E0.5360.11
157_A160_A0.5350.11
333_E432_E0.5350.11
356_E395_R0.5340.11
214_Y353_V0.5330.11
83_T137_G0.5330.11
350_V354_T0.5320.11
64_L377_I0.5310.11
60_F285_T0.5310.11
164_A207_P0.5290.11
39_L466_G0.5270.11
140_A228_Q0.5270.11
75_A464_A0.5260.11
431_R435_A0.5250.11
332_L352_W0.5230.11
387_S430_V0.5220.11
303_E378_V0.5210.11
39_L340_E0.5190.11
104_P186_G0.5170.11
175_L339_R0.5170.11
17_A24_D0.5170.11
106_I395_R0.5170.11
142_Y284_G0.5170.11
366_W440_D0.5170.11
379_G385_A0.5160.11
143_V264_A0.5150.11
156_L379_G0.5150.11
137_G321_L0.5150.11
128_G184_A0.5150.11
340_E435_A0.5140.11
65_D289_L0.5140.11
81_L141_T0.5130.11
225_N402_A0.5110.11
203_T431_R0.5090.11
64_L163_G0.5080.11
58_V92_A0.5060.10
181_R398_V0.5050.10
360_V466_G0.5050.10
364_L458_R0.5050.10
262_V465_S0.5040.10
168_R197_G0.5030.10
72_I237_L0.5020.10
121_H124_P0.5020.10
165_V345_T0.5020.10
161_V201_Y0.5020.10
163_G225_N0.5010.10
19_A48_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zxrA 1 0.6926 100 0.71 Contact Map
4ls9A 2 0.6295 99.9 0.842 Contact Map
4py9A 2 0.6568 99.9 0.855 Contact Map
3devA 2 0.64 99.9 0.858 Contact Map
1wpnA 2 0.3474 99.5 0.908 Contact Map
2hawA 2 0.5726 98.8 0.931 Contact Map
1k20A 2 0.5747 98 0.946 Contact Map
4rpaA 3 0.5811 98 0.947 Contact Map
2zvfA 2 0.3558 97 0.956 Contact Map
3g98A 1 0.2295 96.8 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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