GREMLIN Database
Q9HMX7 - Uncharacterized protein
UniProt: Q9HMX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (125)
Sequences: 718 (576)
Seq/√Len: 51.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_F29_L4.4691.00
96_R100_Q3.8601.00
73_A93_T3.6931.00
73_A103_A3.0971.00
130_D133_T2.8281.00
40_F90_T2.7031.00
10_R120_E2.6181.00
31_A85_E2.5281.00
49_A94_L2.4561.00
68_E96_R2.4351.00
29_L118_V2.3681.00
16_L25_E2.2281.00
28_T32_T2.1531.00
96_R102_L2.0711.00
93_T101_A1.9080.99
30_A79_I1.8710.99
48_D67_D1.8060.99
111_V114_G1.7540.99
14_V29_L1.7420.99
42_G114_G1.7160.99
14_V116_L1.7100.99
73_A101_A1.6570.98
87_F127_R1.6370.98
19_G47_Q1.6300.98
21_E24_T1.5940.98
72_V114_G1.5770.98
21_E109_A1.5480.97
42_G116_L1.5390.97
51_L92_A1.5250.97
22_W46_V1.5120.97
42_G75_C1.4880.97
29_L33_E1.4760.97
22_W114_G1.4380.96
92_A106_L1.4250.96
54_Y133_T1.3890.95
13_V125_L1.3880.95
14_V26_L1.3850.95
16_L116_L1.3680.95
72_V92_A1.3650.95
24_T108_R1.3500.94
79_I118_V1.3000.93
25_E28_T1.2850.93
46_V109_A1.2470.91
64_A99_G1.2390.91
35_I38_A1.2230.91
75_C90_T1.2100.90
41_T76_V1.1900.89
80_A87_F1.1740.89
46_V110_T1.1210.86
26_L132_A1.0980.85
36_T124_D1.0870.85
78_N117_Y1.0820.84
55_D62_T1.0540.83
63_A107_E1.0510.83
45_A135_L1.0450.82
18_P45_A1.0430.82
46_V72_V1.0400.82
40_F75_C1.0180.81
55_D58_D1.0180.81
73_A76_V1.0110.80
43_L76_V1.0090.80
21_E110_T1.0040.80
22_W72_V1.0040.80
53_Y66_F0.9810.78
35_I120_E0.9720.77
14_V121_L0.9640.77
89_H105_H0.9600.77
15_R113_A0.9590.76
46_V94_L0.9480.76
49_A70_L0.9400.75
52_W107_E0.9200.73
19_G124_D0.9140.73
11_E119_R0.9080.72
21_E108_R0.8650.69
75_C129_H0.8590.68
40_F88_A0.8410.67
45_A112_F0.8380.66
15_R111_V0.8300.65
81_T86_P0.8170.64
113_A135_L0.8150.64
52_W61_Y0.8110.64
70_L94_L0.8090.63
56_Q113_A0.8060.63
48_D65_E0.8040.63
103_A127_R0.8000.63
36_T81_T0.7850.61
87_F136_D0.7740.60
12_F120_E0.7730.60
20_S28_T0.7690.60
40_F93_T0.7620.59
17_D81_T0.7570.58
55_D61_Y0.7560.58
31_A34_D0.7510.58
45_A54_Y0.7480.57
34_D67_D0.7390.57
51_L131_A0.7360.56
45_A113_A0.7320.56
70_L96_R0.7310.56
94_L102_L0.7270.55
56_Q112_F0.7240.55
41_T80_A0.7220.55
40_F118_V0.7160.54
46_V92_A0.7130.54
50_E65_E0.7050.53
45_A52_W0.7010.53
24_T28_T0.6950.52
12_F33_E0.6940.52
25_E29_L0.6880.51
28_T67_D0.6870.51
37_A125_L0.6750.50
53_Y61_Y0.6730.50
93_T103_A0.6640.49
37_A123_A0.6600.48
18_P112_F0.6590.48
10_R99_G0.6580.48
45_A56_Q0.6570.48
106_L109_A0.6540.48
66_F122_D0.6480.47
33_E120_E0.6450.47
18_P132_A0.6430.47
18_P130_D0.6360.46
54_Y59_F0.6330.46
39_W117_Y0.6320.45
40_F48_D0.6260.45
62_T97_R0.6250.45
65_E108_R0.6240.45
54_Y78_N0.6220.44
58_D62_T0.6210.44
46_V114_G0.6170.44
23_R130_D0.6110.43
68_E100_Q0.6100.43
50_E108_R0.6010.42
30_A122_D0.5980.42
67_D97_R0.5940.42
52_W136_D0.5890.41
20_S113_A0.5880.41
38_A118_V0.5840.41
51_L109_A0.5830.40
73_A90_T0.5810.40
16_L20_S0.5790.40
61_Y135_L0.5790.40
17_D45_A0.5770.40
76_V88_A0.5710.39
52_W103_A0.5700.39
51_L94_L0.5670.39
45_A61_Y0.5650.39
10_R112_F0.5630.38
27_E36_T0.5620.38
28_T31_A0.5620.38
19_G32_T0.5590.38
81_T92_A0.5590.38
23_R108_R0.5560.38
90_T131_A0.5540.38
68_E98_S0.5530.37
87_F107_E0.5500.37
62_T122_D0.5500.37
34_D100_Q0.5470.37
79_I97_R0.5460.37
45_A99_G0.5460.37
111_V117_Y0.5410.36
19_G111_V0.5400.36
9_G73_A0.5400.36
24_T48_D0.5390.36
14_V118_V0.5370.36
45_A59_F0.5350.36
50_E63_A0.5350.36
43_L78_N0.5340.36
11_E64_A0.5280.35
95_S101_A0.5270.35
19_G128_E0.5270.35
34_D111_V0.5260.35
33_E118_V0.5260.35
55_D88_A0.5260.35
102_L127_R0.5240.35
49_A102_L0.5230.35
23_R37_A0.5220.34
124_D131_A0.5210.34
54_Y61_Y0.5210.34
42_G112_F0.5180.34
61_Y115_E0.5160.34
30_A35_I0.5160.34
38_A80_A0.5120.34
69_P95_S0.5110.33
129_H132_A0.5080.33
34_D131_A0.5060.33
32_T129_H0.5050.33
25_E60_E0.5040.33
47_Q72_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3htnA 3 0.9856 100 0.228 Contact Map
2h6lA 3 0.9928 100 0.242 Contact Map
3hwuA 3 0.9784 100 0.256 Contact Map
2dt4A 3 0.9928 100 0.274 Contact Map
2hx0A 3 0.9281 100 0.375 Contact Map
2p6yA 3 0.8849 100 0.376 Contact Map
4bt2A 2 0.9424 54.1 0.92 Contact Map
1xv2A 2 0.9353 44 0.924 Contact Map
1hcuA 1 0.5971 34.3 0.929 Contact Map
1nxcA 1 0.5971 11 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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