GREMLIN Database
Q9HMX3 - Oligopeptide ABC transporter ATP-binding
UniProt: Q9HMX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (344)
Sequences: 1030 (750)
Seq/√Len: 40.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_G234_C6.5171.00
54_E236_R5.7011.00
24_D45_G5.0211.00
167_F175_I4.7641.00
249_G254_L4.6701.00
23_T83_T4.4111.00
149_L182_A4.3731.00
22_V48_F4.3411.00
26_K45_G4.1061.00
105_N186_E4.0761.00
21_E49_E3.6211.00
22_V25_L3.4671.00
56_L238_A3.1371.00
90_D93_K3.0531.00
109_V190_L3.0491.00
145_R148_E2.7971.00
209_L220_Y2.7941.00
52_E186_E2.7901.00
24_D81_E2.7611.00
18_P51_Q2.6221.00
83_T90_D2.5151.00
238_A245_I2.5091.00
138_S141_E2.4981.00
59_V239_V2.4441.00
311_E329_E2.4341.00
58_L221_L2.3801.00
152_S211_D2.2000.99
298_C304_C2.1480.99
320_T323_R2.1450.99
70_G223_I2.1420.99
152_S215_E2.1100.99
21_E85_S2.0180.99
50_I56_L1.9970.99
127_V182_A1.9870.99
27_K72_T1.9840.99
23_T49_E1.9620.99
224_A234_C1.9550.99
192_E225_H1.9510.99
48_F69_L1.9350.99
126_I179_R1.9270.99
152_S216_F1.9100.99
298_C311_E1.8830.98
26_K81_E1.8820.98
17_Q52_E1.8660.98
20_V50_I1.8530.98
179_R195_S1.8300.98
109_V173_Q1.7430.97
107_Q185_P1.7410.97
308_I332_R1.7340.97
145_R184_E1.7290.97
174_R197_L1.7220.97
28_H41_K1.7170.97
50_I221_L1.6720.97
127_V150_L1.6490.96
151_S157_A1.6370.96
66_K192_E1.6230.96
75_Q99_L1.6050.96
187_F221_L1.5980.96
249_G253_E1.5920.95
149_L181_L1.5910.95
46_V69_L1.5900.95
72_T78_T1.5900.95
320_T326_Q1.5850.95
325_E329_E1.5600.95
202_Q229_V1.5450.95
29_Y68_T1.4880.93
50_I187_F1.4790.93
126_I195_S1.4750.93
74_I108_I1.4700.93
131_L182_A1.4690.93
102_W106_A1.4670.93
62_S192_E1.4560.93
173_Q196_A1.4500.93
224_A230_V1.4470.92
56_L248_I1.4360.92
202_Q226_D1.4300.92
311_E316_I1.4180.92
323_R326_Q1.4100.91
155_L171_Q1.3830.91
211_D215_E1.3650.90
142_R146_V1.3620.90
140_A144_D1.3580.90
51_Q54_E1.3510.90
66_K225_H1.3420.89
62_S197_L1.3400.89
238_A248_I1.3340.89
27_K71_R1.3230.89
22_V88_G1.3150.88
304_C311_E1.3130.88
57_G224_A1.3030.88
48_F248_I1.2970.88
71_R171_Q1.2900.87
264_R306_A1.2890.87
24_D47_N1.2830.87
75_Q78_T1.2810.87
247_E262_Y1.2770.87
288_P299_Q1.2670.86
87_D109_V1.2660.86
59_V230_V1.2610.86
46_V245_I1.2590.86
244_K328_R1.2520.86
66_K111_Q1.2460.85
169_G174_R1.2390.85
308_I311_E1.2220.84
143_R147_K1.2200.84
29_Y77_E1.2140.84
329_E332_R1.2130.84
70_G189_V1.1980.83
62_S196_A1.1980.83
359_E362_A1.1960.83
55_T213_Q1.1950.83
128_R146_V1.1820.82
43_V69_L1.1750.82
297_G303_R1.1700.81
57_G230_V1.1670.81
250_E253_E1.1610.81
202_Q230_V1.1570.81
236_R248_I1.1450.80
316_I325_E1.1440.80
121_M125_E1.1420.80
171_Q179_R1.1410.80
204_K209_L1.1330.79
67_T108_I1.1160.78
20_V189_V1.1100.78
44_D244_K1.1020.77
286_G289_P1.1010.77
350_G354_K1.0960.77
145_R149_L1.0820.76
19_L58_L1.0820.76
109_V177_I1.0780.76
300_F303_R1.0740.76
357_D361_A1.0680.75
134_H183_L1.0680.75
298_C329_E1.0620.75
281_R284_L1.0620.75
131_L137_N1.0570.74
289_P303_R1.0520.74
350_G357_D1.0490.74
360_E363_D1.0400.73
176_G179_R1.0380.73
356_D359_E1.0360.73
359_E363_D1.0360.73
237_V254_L1.0280.72
307_K311_E1.0250.72
185_P192_E1.0230.72
66_K191_D1.0200.72
67_T269_A1.0170.71
196_A202_Q1.0160.71
317_D330_V1.0150.71
298_C303_R1.0140.71
355_Y358_I1.0070.71
50_I219_T1.0070.71
86_F105_N1.0030.70
173_Q247_E1.0010.70
206_L229_V0.9930.70
28_H44_D0.9900.69
58_L69_L0.9860.69
53_G219_T0.9850.69
62_S109_V0.9840.69
308_I331_V0.9830.69
95_T98_D0.9820.69
307_K317_D0.9810.69
318_D324_I0.9800.69
98_D101_Q0.9740.68
62_S174_R0.9720.68
31_D38_P0.9720.68
27_K43_V0.9520.66
122_T161_Y0.9500.66
346_K349_L0.9390.65
18_P49_E0.9340.65
143_R161_Y0.9330.65
147_K160_Y0.9310.65
62_S164_P0.9310.65
190_L209_L0.9250.64
327_F330_V0.9230.64
309_R313_Y0.9190.64
230_V237_V0.9170.63
269_A273_P0.9150.63
62_S173_Q0.9130.63
193_P229_V0.9120.63
247_E266_L0.9060.62
127_V146_V0.8980.62
244_K315_D0.8970.62
99_L103_R0.8890.61
196_A223_I0.8870.61
216_F219_T0.8870.61
261_P266_L0.8860.61
122_T125_E0.8790.60
110_F164_P0.8760.60
107_Q194_V0.8700.59
62_S225_H0.8690.59
48_F237_V0.8690.59
120_R165_H0.8670.59
210_E253_E0.8650.59
340_G353_S0.8620.59
171_Q284_L0.8600.58
318_D333_E0.8580.58
161_Y246_M0.8530.58
73_L167_F0.8530.58
60_G63_G0.8520.58
135_D184_E0.8520.58
168_S198_D0.8460.57
181_L208_L0.8410.57
29_Y192_E0.8390.56
318_D326_Q0.8390.56
171_Q195_S0.8350.56
47_N86_F0.8340.56
327_F332_R0.8330.56
122_T209_L0.8310.56
193_P225_H0.8300.56
307_K325_E0.8290.56
86_F187_F0.8270.55
84_V220_Y0.8260.55
44_D299_Q0.8240.55
104_K175_I0.8220.55
27_K133_A0.8210.55
194_V224_A0.8180.55
237_V251_T0.8140.54
50_I58_L0.8140.54
311_E330_V0.8140.54
355_Y359_E0.8130.54
159_H231_R0.8130.54
103_R154_G0.8120.54
28_H39_P0.8120.54
345_V349_L0.8090.54
200_S242_L0.8070.54
86_F205_I0.8060.53
286_G300_F0.8050.53
188_M194_V0.8030.53
73_L249_G0.7990.53
29_Y327_F0.7990.53
26_K44_D0.7930.52
169_G198_D0.7930.52
332_R336_R0.7910.52
60_G65_G0.7860.52
291_P295_P0.7830.51
186_E218_L0.7820.51
112_D172_R0.7820.51
76_L129_E0.7810.51
111_Q191_D0.7800.51
172_R204_K0.7770.51
284_L297_G0.7770.51
41_K44_D0.7750.51
316_I330_V0.7720.50
321_W327_F0.7710.50
319_D327_F0.7690.50
318_D321_W0.7670.50
268_S282_I0.7660.50
290_S297_G0.7650.50
89_R98_D0.7650.50
128_R209_L0.7650.50
19_L187_F0.7610.49
311_E325_E0.7600.49
358_I361_A0.7570.49
226_D229_V0.7550.49
188_M220_Y0.7510.48
357_D363_D0.7500.48
177_I224_A0.7480.48
227_L247_E0.7470.48
73_L245_I0.7460.48
87_D186_E0.7450.48
182_A220_Y0.7440.48
188_M192_E0.7440.48
167_F172_R0.7420.48
289_P295_P0.7360.47
84_V93_K0.7320.47
20_V58_L0.7320.47
67_T116_S0.7310.47
67_T84_V0.7300.46
302_T316_I0.7300.46
349_L355_Y0.7290.46
349_L352_F0.7280.46
71_R112_D0.7230.46
260_N263_T0.7210.46
171_Q175_I0.7210.46
148_E152_S0.7210.46
223_I226_D0.7200.46
304_C329_E0.7200.46
179_R189_V0.7190.45
358_I363_D0.7180.45
87_D105_N0.7180.45
55_T196_A0.7170.45
196_A229_V0.7160.45
173_Q223_I0.7160.45
154_G180_A0.7150.45
55_T218_L0.7140.45
127_V222_F0.7130.45
197_L226_D0.7110.45
67_T70_G0.7100.45
185_P225_H0.7040.44
48_F221_L0.7030.44
184_E216_F0.7020.44
193_P224_A0.7020.44
62_S185_P0.7010.44
111_Q192_E0.7000.44
57_G185_P0.7000.44
355_Y363_D0.6990.44
286_G291_P0.6980.44
124_G189_V0.6940.43
59_V71_R0.6940.43
358_I362_A0.6930.43
110_F166_Q0.6930.43
111_Q169_G0.6930.43
107_Q162_R0.6910.43
338_Q342_R0.6910.43
159_H162_R0.6880.43
58_L190_L0.6880.43
307_K316_I0.6810.42
289_P316_I0.6770.42
19_L190_L0.6760.42
126_I224_A0.6750.41
194_V229_V0.6730.41
43_V48_F0.6730.41
146_V152_S0.6710.41
129_E206_L0.6710.41
132_D142_R0.6710.41
97_S101_Q0.6700.41
108_I193_P0.6680.41
60_G168_S0.6640.40
289_P300_F0.6620.40
60_G66_K0.6620.40
325_E328_R0.6620.40
201_V223_I0.6610.40
98_D104_K0.6610.40
285_P288_P0.6610.40
65_G191_D0.6590.40
316_I358_I0.6590.40
185_P188_M0.6580.40
21_E274_D0.6580.40
73_L89_R0.6580.40
288_P291_P0.6580.40
316_I321_W0.6580.40
117_L177_I0.6570.40
227_L254_L0.6570.40
337_D340_G0.6550.40
130_P209_L0.6540.40
75_Q91_I0.6530.40
69_L234_C0.6520.39
117_L172_R0.6510.39
320_T346_K0.6500.39
94_L216_F0.6500.39
146_V160_Y0.6490.39
45_G244_K0.6480.39
153_V166_Q0.6450.39
241_Y303_R0.6440.39
280_N305_P0.6440.39
287_A334_R0.6430.39
107_Q183_L0.6420.39
263_T271_P0.6390.38
29_Y43_V0.6390.38
353_S357_D0.6370.38
103_R111_Q0.6330.38
170_G198_D0.6320.38
356_D360_E0.6320.38
353_S359_E0.6320.38
65_G198_D0.6320.38
222_F233_I0.6310.38
48_F238_A0.6290.37
341_V345_V0.6270.37
159_H194_V0.6250.37
182_A268_S0.6210.37
143_R160_Y0.6210.37
118_N126_I0.6210.37
318_D322_S0.6200.37
51_Q256_A0.6200.37
289_P301_S0.6200.37
197_L208_L0.6200.37
340_G348_R0.6190.37
335_T359_E0.6160.36
340_G354_K0.6160.36
70_G74_I0.6160.36
43_V240_M0.6150.36
261_P298_C0.6140.36
32_G156_Q0.6120.36
126_I231_R0.6100.36
58_L70_G0.6080.36
62_S131_L0.6070.36
300_F304_C0.6070.36
324_I336_R0.6060.35
56_L236_R0.6060.35
144_D352_F0.6030.35
284_L289_P0.6010.35
153_V180_A0.6000.35
217_G221_L0.6000.35
314_A343_D0.5980.35
267_L271_P0.5970.35
91_I204_K0.5960.35
47_N82_G0.5930.34
190_L222_F0.5930.34
94_L102_W0.5900.34
169_G196_A0.5900.34
316_I328_R0.5890.34
155_L195_S0.5880.34
141_E144_D0.5870.34
224_A227_L0.5850.34
258_A263_T0.5850.34
202_Q206_L0.5850.34
20_V187_F0.5840.34
121_M129_E0.5810.33
62_S66_K0.5810.33
213_Q220_Y0.5800.33
128_R182_A0.5790.33
109_V247_E0.5790.33
329_E333_E0.5790.33
174_R196_A0.5780.33
59_V223_I0.5760.33
351_T359_E0.5760.33
348_R351_T0.5750.33
190_L220_Y0.5730.33
53_G112_D0.5730.33
158_D190_L0.5730.33
338_Q362_A0.5730.33
345_V348_R0.5720.33
325_E330_V0.5710.33
328_R336_R0.5710.33
276_T343_D0.5710.33
61_E247_E0.5710.33
301_S312_A0.5680.32
65_G170_G0.5680.32
89_R151_S0.5680.32
83_T250_E0.5670.32
91_I190_L0.5670.32
322_S328_R0.5660.32
206_L226_D0.5660.32
154_G196_A0.5660.32
331_V334_R0.5660.32
25_L43_V0.5660.32
30_G37_G0.5650.32
174_R178_A0.5640.32
126_I176_G0.5640.32
313_Y324_I0.5620.32
66_K195_S0.5610.32
86_F128_R0.5610.32
303_R307_K0.5590.32
354_K362_A0.5550.31
110_F188_M0.5540.31
319_D330_V0.5530.31
339_M345_V0.5530.31
164_P226_D0.5520.31
338_Q348_R0.5490.31
71_R222_F0.5470.31
348_R353_S0.5460.31
154_G159_H0.5450.30
90_D99_L0.5440.30
219_T250_E0.5440.30
27_K107_Q0.5440.30
121_M132_D0.5430.30
95_T99_L0.5430.30
190_L218_L0.5430.30
193_P226_D0.5430.30
286_G295_P0.5400.30
111_Q179_R0.5400.30
205_I267_L0.5390.30
40_V190_L0.5380.30
357_D362_A0.5380.30
149_L202_Q0.5370.30
310_P313_Y0.5370.30
17_Q186_E0.5370.30
40_V184_E0.5350.30
195_S239_V0.5350.30
21_E28_H0.5330.30
131_L196_A0.5330.30
129_E226_D0.5330.30
241_Y261_P0.5310.29
110_F226_D0.5300.29
155_L159_H0.5300.29
171_Q174_R0.5290.29
280_N360_E0.5290.29
171_Q231_R0.5290.29
123_I354_K0.5290.29
325_E360_E0.5290.29
297_G304_C0.5290.29
147_K157_A0.5280.29
283_T288_P0.5270.29
59_V109_V0.5260.29
184_E215_E0.5250.29
347_R354_K0.5230.29
173_Q231_R0.5220.29
297_G300_F0.5220.29
91_I94_L0.5220.29
79_A94_L0.5220.29
55_T199_A0.5200.29
324_I329_E0.5190.28
18_P87_D0.5190.28
70_G187_F0.5190.28
26_K93_K0.5180.28
92_T96_G0.5170.28
142_R224_A0.5160.28
62_S206_L0.5160.28
224_A232_H0.5150.28
32_G37_G0.5150.28
284_L298_C0.5150.28
347_R351_T0.5150.28
113_P173_Q0.5140.28
110_F228_S0.5130.28
111_Q195_S0.5130.28
352_F361_A0.5130.28
23_T248_I0.5120.28
239_V247_E0.5120.28
56_L122_T0.5100.28
37_G184_E0.5080.28
146_V236_R0.5070.28
62_S226_D0.5070.28
284_L304_C0.5050.27
327_F336_R0.5050.27
42_A153_V0.5050.27
222_F229_V0.5050.27
276_T280_N0.5040.27
20_V339_M0.5040.27
126_I164_P0.5040.27
237_V255_Y0.5030.27
154_G157_A0.5020.27
68_T200_S0.5010.27
311_E318_D0.5010.27
202_Q227_L0.5000.27
261_P289_P0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.7461 100 0.339 Contact Map
4fwiB 1 0.6809 100 0.339 Contact Map
4ry2A 2 0.5506 100 0.343 Contact Map
4f4cA 1 0.5461 100 0.343 Contact Map
4q9hA 1 0.5753 100 0.368 Contact Map
1oxxK 1 0.7663 100 0.368 Contact Map
4a82A 2 0.5708 100 0.37 Contact Map
3b5xA 2 0.5708 100 0.372 Contact Map
3zdqA 2 0.5461 100 0.373 Contact Map
4mrsA 2 0.5888 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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