Q9HMX2 - HALSA - GREMLIN Contacts

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Q9HMX2 - Oligopeptide ABC transporter

UniProt:	Q9HMX2	Sequences: MQSTTPTADDDDPRDESILSIRNLQTVFRTDHEHIRAVDGISLSISPGETLGIVGESGSGKSVTARSIMGLVDAPGEVLPESSIVFDGTELTELSADQYQEVRGSGVGMIFQDPLKSLNPVYTVGNQIREALRINRGITGQEATDVAIDLLEDVAIPDPERRLDEYPNEFSGGMRQRAVIAMMLACDPDVLICDEPTTALDVTIQAQIVELLQDIQAERDLAILFITHDMGVIAEISDRVNVMYAGEFVEKAPVEELFANPKHPYTQGLLDAIPGTSVDDERLNTIEGDVPTPNQPATDCRFAPRCPKAFEDCTEVHPTHVSVSDTHDHSTACLLYPEGKSRTERVEHHRSQAPADTQGGAQE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (297)
Sequences:	25931 (18111)
Seq/√Len:	1050.9

ECOLI - PROV POTA POTG FBPC CYSA METN DPPD MALK YCJV UGPC DPPF OPPD YDCT OPPF DDPD SAPD YEHX MODC GSIA YADG YHES DDPF ARAG RBSA MACB UUP FEPC MLAF MDLA SAPF MDLB CYDC NIKE FHUC MSBA HISP CYDD YOJI FECE YECC TAUB YHDZ YTFR SSUB ETTA GLNQ LPTB PHNK LSRA PHNC GLTL LIVG PSTB SUFC YPHE ZNUC ARTP LOLD MODF THIQ FTSE LIVF BTUD NIKD XYLG ALSA FETA YBBA MGLA YEJF YDDA PHNL CCMA YBHF YNJD YBIT
BACSU - OPPD OPUAA OPUCA OPUBA DPPD YVRA MSMX YURJ METN APPD YKFD APPF TAGH YHCH YFIL OPPF YCBN YXLF YDBJ YVFR YHAQ YHEH YDIF YKPA YFMM YUSV SUNT YFMR RBSA ECFA1 YFMF YFIC YTRB FHUC YFIB BMRA YKNV TCYN YWJA YGAD YKNU YHEI YCLP YLMA CYDC CYDD BCEA YKOD YTLC SUFC YXDL ECSA YJKB YXEO YVCR SKFE ECFA2 GLNQ ARTM PSTB2 NATA FTSE TCYC YVRO PSTB1 SSUB ALBC YKNY MNTB EXPZ YTHP YCLH ZNUC YHCG YYBJ YUFO YTRE YYDI
HALSA - Q9HMX2 Q9HMX3 Q9HMW0 BTUDA Q9HNZ9 Q9HHQ5 Q9HR06 Q9HMT3 Q9HMG1 Q9HRJ6 Q9HMU8 Q9HSQ7 PSTB2 Q9HMG6 Q9HRH8 PHNC Q9HHM2 Q9HNY3 Q9HRV7 Q9HRZ9 PSTB1 Y1631 Q9HHR7 Y2317 Q9HR96 Q9HS04 Q9HT03 Q9HQA8 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q97UF2 Q97UH3 Q97UY8 Q97YY4 Q97ZC0 Q97VF5 Q97YP3 Q7LX64 Q97VK8 Q97UJ9 Q97VK9 Q97VC1 Q97YP7 Q97VF4 Q97VH6 Q97YP8 Q97YK2 Q97UD4 Q97X18 Q97YQ7 Q97U54 Q980W0 Q97Z03 Q97UH4 PSTB Y1893 Q97W42 Q7LXM4 Q7LY07 Q97UG5 Y2030 Q97V01 Q97V00 Q97VM2 Q97VY4 Q7LX80 Q97Z56 Q97YP4 Q97UC2 Q97Z96 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_E	239_R	4.307	1.00
106_G	189_D	3.671	1.00
23_N	40_G	3.444	1.00
22_R	83_S	3.418	1.00
20_S	44_S	3.285	1.00
26_T	67_S	2.935	1.00
83_S	90_E	2.753	1.00
253_P	256_E	2.715	1.00
87_D	189_D	2.655	1.00
153_D	219_R	2.550	1.00
252_A	257_L	2.544	1.00
52_G	237_S	2.501	1.00
51_L	241_N	2.491	1.00
90_E	93_E	2.478	1.00
46_S	49_E	2.454	1.00
36_R	39_D	2.441	1.00
239_R	251_K	2.432	1.00
241_N	248_F	2.391	1.00
150_L	185_A	2.385	1.00
146_V	149_D	2.380	1.00
214_D	218_E	2.334	1.00
21_I	24_L	2.327	1.00
25_Q	81_E	2.249	1.00
65_A	226_I	2.212	1.00
47_P	189_D	2.212	1.00
312_D	316_V	2.195	1.00
153_D	218_E	2.171	1.00
95_S	98_Q	2.113	1.00
139_T	142_E	2.095	1.00
27_V	36_R	2.071	1.00
20_S	85_V	2.069	1.00
25_Q	40_G	2.031	1.00
89_T	98_Q	2.012	1.00
162_R	165_E	2.000	1.00
29_R	34_H	1.978	1.00
303_A	314_T	1.942	1.00
70_G	99_Y	1.911	1.00
234_A	255_E	1.909	1.00
39_D	247_E	1.887	1.00
52_G	233_I	1.850	1.00
146_V	187_D	1.829	1.00
28_F	63_V	1.828	1.00
148_I	163_L	1.795	1.00
165_E	169_E	1.748	1.00
22_R	85_V	1.739	1.00
72_V	75_P	1.726	1.00
17_S	46_S	1.692	1.00
87_D	106_G	1.690	1.00
17_S	20_S	1.686	1.00
227_T	233_I	1.678	1.00
23_N	42_S	1.648	1.00
21_I	43_L	1.646	1.00
122_Y	126_N	1.641	1.00
133_R	143_A	1.606	1.00
27_V	34_H	1.601	1.00
309_A	314_T	1.508	1.00
129_R	147_A	1.507	1.00
158_D	161_R	1.502	1.00
125_G	163_L	1.491	1.00
149_D	153_D	1.484	1.00
209_V	232_V	1.482	1.00
89_T	94_L	1.476	1.00
99_Y	103_R	1.472	1.00
247_E	317_H	1.462	1.00
157_P	161_R	1.454	1.00
16_E	47_P	1.437	1.00
53_I	224_L	1.433	1.00
43_L	64_T	1.423	1.00
115_L	175_R	1.420	1.00
212_L	223_I	1.411	1.00
65_A	192_I	1.409	1.00
26_T	75_P	1.406	1.00
300_C	306_C	1.405	1.00
94_L	98_Q	1.404	1.00
162_R	170_F	1.398	1.00
241_N	251_K	1.387	1.00
187_D	219_R	1.379	1.00
144_T	163_L	1.370	1.00
153_D	214_D	1.354	1.00
25_Q	39_D	1.346	1.00
213_Q	216_Q	1.343	1.00
21_I	68_I	1.343	1.00
123_T	164_D	1.320	1.00
298_T	303_A	1.313	1.00
110_I	193_C	1.307	1.00
311_E	315_E	1.302	1.00
128_I	151_L	1.292	1.00
170_F	178_A	1.291	1.00
41_I	64_T	1.278	1.00
144_T	148_I	1.277	1.00
47_P	87_D	1.267	1.00
50_T	216_Q	1.266	1.00
26_T	72_V	1.264	1.00
102_V	107_V	1.261	1.00
148_I	158_D	1.261	1.00
17_S	44_S	1.258	1.00
28_F	37_A	1.253	1.00
22_R	42_S	1.252	1.00
225_F	236_I	1.249	1.00
125_G	164_D	1.239	1.00
94_L	99_Y	1.238	1.00
129_R	143_A	1.234	1.00
23_N	81_E	1.232	1.00
45_I	51_L	1.222	1.00
22_R	44_S	1.218	1.00
45_I	190_V	1.215	1.00
123_T	126_N	1.210	1.00
311_E	314_T	1.208	1.00
126_N	129_R	1.208	1.00
122_Y	130_E	1.205	1.00
24_L	74_A	1.202	1.00
247_E	301_R	1.189	1.00
267_Q	308_K	1.176	1.00
144_T	164_D	1.171	1.00
143_A	147_A	1.168	1.00
128_I	185_A	1.161	1.00
145_D	149_D	1.160	1.00
301_R	317_H	1.159	1.00
27_V	75_P	1.158	1.00
27_V	39_D	1.153	1.00
303_A	309_A	1.148	1.00
47_P	220_D	1.148	1.00
132_L	185_A	1.143	1.00
256_E	260_N	1.139	1.00
25_Q	36_R	1.129	1.00
51_L	251_K	1.127	1.00
193_C	223_I	1.127	1.00
141_Q	145_D	1.119	1.00
43_L	241_N	1.118	1.00
39_D	301_R	1.115	1.00
125_G	129_R	1.113	1.00
50_T	223_I	1.100	1.00
191_L	221_L	1.096	1.00
70_G	73_D	1.093	1.00
129_R	133_R	1.084	1.00
49_E	238_D	1.082	1.00
267_Q	271_D	1.075	1.00
240_V	254_V	1.074	1.00
69_M	109_M	1.073	1.00
161_R	165_E	1.070	1.00
213_Q	235_E	1.062	1.00
50_T	237_S	1.048	1.00
121_V	168_N	1.048	1.00
85_V	90_E	1.045	1.00
64_T	243_M	1.042	1.00
138_I	143_A	1.037	1.00
69_M	192_I	1.034	1.00
149_D	152_E	1.032	1.00
142_E	145_D	1.032	1.00
306_C	313_C	1.028	1.00
129_R	144_T	1.012	1.00
107_V	190_V	1.009	1.00
252_A	256_E	1.005	1.00
157_P	162_R	1.004	1.00
255_E	259_A	0.998	1.00
302_F	306_C	0.991	1.00
125_G	144_T	0.990	1.00
53_I	241_N	0.989	1.00
29_R	33_E	0.982	1.00
51_L	239_R	0.975	1.00
136_R	146_V	0.971	1.00
191_L	223_I	0.968	1.00
127_Q	182_M	0.959	1.00
297_A	303_A	0.956	1.00
215_I	221_L	0.955	1.00
257_L	266_T	0.942	1.00
151_L	163_L	0.940	1.00
205_Q	229_D	0.930	1.00
46_S	222_A	0.930	1.00
118_L	178_A	0.912	1.00
140_G	143_A	0.910	1.00
152_E	158_D	0.905	1.00
67_S	84_I	0.904	1.00
67_S	74_A	0.904	1.00
66_R	71_L	0.904	1.00
299_D	303_A	0.903	1.00
45_I	224_L	0.898	1.00
150_L	153_D	0.897	1.00
190_V	224_L	0.892	1.00
147_A	163_L	0.890	1.00
300_C	313_C	0.889	1.00
53_I	64_T	0.884	1.00
187_D	218_E	0.883	1.00
45_I	222_A	0.879	1.00
59_S	243_M	0.876	1.00
86_F	106_G	0.875	1.00
24_L	67_S	0.875	1.00
300_C	303_A	0.872	1.00
96_A	99_Y	0.872	1.00
38_V	67_S	0.871	1.00
119_N	122_Y	0.867	1.00
46_S	239_R	0.866	1.00
287_E	307_P	0.864	1.00
275_G	278_V	0.864	1.00
89_T	106_G	0.863	1.00
124_V	178_A	0.863	1.00
118_L	175_R	0.859	1.00
18_I	86_F	0.856	1.00
17_S	47_P	0.852	1.00
54_V	242_V	0.851	1.00
296_P	301_R	0.845	1.00
18_I	190_V	0.842	1.00
301_R	304_P	0.841	1.00
21_I	84_I	0.840	1.00
23_N	26_T	0.836	1.00
256_E	259_A	0.836	1.00
213_Q	236_I	0.831	1.00
316_V	319_T	0.828	1.00
105_S	136_R	0.827	1.00
16_E	46_S	0.823	1.00
91_L	102_V	0.819	1.00
129_R	163_L	0.819	1.00
309_A	313_C	0.819	1.00
138_I	142_E	0.818	1.00
297_A	304_P	0.817	1.00
26_T	63_V	0.816	1.00
164_D	167_P	0.808	1.00
136_R	143_A	0.808	1.00
290_V	293_P	0.807	1.00
54_V	233_I	0.807	1.00
155_A	207_Q	0.805	1.00
67_S	72_V	0.803	1.00
216_Q	238_D	0.803	1.00
310_F	314_T	0.801	1.00
312_D	315_E	0.798	1.00
271_D	284_N	0.798	1.00
139_T	143_A	0.798	1.00
26_T	38_V	0.797	1.00
292_T	295_Q	0.796	1.00
108_G	183_M	0.796	1.00
306_C	310_F	0.794	1.00
94_L	102_V	0.791	1.00
288_G	291_P	0.788	1.00
158_D	162_R	0.787	1.00
156_I	162_R	0.785	1.00
300_C	305_R	0.783	1.00
317_H	320_H	0.783	1.00
193_C	212_L	0.782	1.00
133_R	140_G	0.782	1.00
28_F	72_V	0.772	1.00
216_Q	223_I	0.770	1.00
148_I	152_E	0.770	1.00
293_P	296_P	0.769	1.00
50_T	213_Q	0.769	1.00
156_I	174_M	0.764	1.00
299_D	302_F	0.764	1.00
68_I	224_L	0.763	1.00
91_L	107_V	0.763	1.00
155_A	214_D	0.762	1.00
131_A	182_M	0.756	1.00
298_T	302_F	0.756	1.00
307_P	310_F	0.754	1.00
200_L	208_I	0.753	1.00
40_G	247_E	0.752	1.00
248_F	251_K	0.751	1.00
317_H	321_V	0.751	1.00
83_S	93_E	0.750	1.00
313_C	318_P	0.750	1.00
205_Q	232_V	0.749	1.00
254_V	258_F	0.748	1.00
110_I	180_I	0.743	1.00
197_T	232_V	0.735	1.00
146_V	150_L	0.731	1.00
69_M	107_V	0.731	1.00
19_L	68_I	0.730	1.00
303_A	307_P	0.729	1.00
41_I	248_F	0.727	1.00
47_P	222_A	0.724	1.00
268_G	286_I	0.723	1.00
230_M	258_F	0.720	1.00
84_I	92_T	0.712	1.00
135_N	186_C	0.705	1.00
66_R	72_V	0.703	1.00
122_Y	127_Q	0.700	1.00
136_R	139_T	0.695	1.00
51_L	224_L	0.695	1.00
52_G	227_T	0.695	1.00
249_V	301_R	0.694	1.00
162_R	174_M	0.693	1.00
67_S	75_P	0.693	1.00
18_I	87_D	0.692	1.00
297_A	300_C	0.691	1.00
303_A	306_C	0.690	1.00
310_F	316_V	0.690	1.00
184_L	221_L	0.688	1.00
225_F	237_S	0.687	1.00
86_F	91_L	0.687	1.00
48_G	222_A	0.686	1.00
268_G	272_A	0.683	1.00
192_I	224_L	0.682	1.00
321_V	324_S	0.681	1.00
170_F	174_M	0.679	1.00
237_S	254_V	0.679	1.00
128_I	147_A	0.677	1.00
295_Q	299_D	0.676	1.00
86_F	190_V	0.674	1.00
131_A	186_C	0.672	1.00
317_H	323_V	0.671	1.00
38_V	41_I	0.670	1.00
132_L	138_I	0.669	1.00
145_D	152_E	0.668	1.00
295_Q	298_T	0.664	1.00
256_E	324_S	0.659	1.00
90_E	94_L	0.654	1.00
288_G	292_T	0.654	1.00
302_F	305_R	0.653	1.00
50_T	236_I	0.653	1.00
108_G	188_P	0.652	1.00
66_R	109_M	0.652	1.00
89_T	102_V	0.652	1.00
309_A	317_H	0.651	1.00
309_A	312_D	0.649	1.00
113_D	116_K	0.649	1.00
68_I	84_I	0.648	1.00
310_F	324_S	0.647	1.00
187_D	221_L	0.646	1.00
206_A	210_E	0.639	1.00
199_A	205_Q	0.634	1.00
128_I	131_A	0.633	1.00
319_T	323_V	0.632	1.00
83_S	92_T	0.632	1.00
293_P	297_A	0.632	1.00
312_D	318_P	0.632	1.00
291_P	297_A	0.629	1.00
117_S	179_V	0.626	1.00
125_G	128_I	0.626	1.00
19_L	86_F	0.622	1.00
306_C	309_A	0.619	1.00
152_E	157_P	0.617	1.00
116_K	175_R	0.617	1.00
56_E	59_S	0.616	1.00
99_Y	102_V	0.615	1.00
226_I	229_D	0.614	1.00
150_L	181_A	0.614	1.00
70_G	92_T	0.613	1.00
150_L	184_L	0.610	1.00
252_A	258_F	0.608	1.00
305_R	309_A	0.606	1.00
288_G	293_P	0.606	1.00
86_F	107_V	0.606	1.00
210_E	214_D	0.606	1.00
233_I	240_V	0.605	1.00
91_L	94_L	0.604	1.00
37_A	63_V	0.602	1.00
299_D	306_C	0.602	1.00
287_E	290_V	0.602	1.00
303_A	317_H	0.599	1.00
86_F	102_V	0.599	1.00
49_E	251_K	0.598	1.00
310_F	313_C	0.594	1.00
59_S	290_V	0.594	1.00
308_K	311_E	0.592	1.00
299_D	304_P	0.587	1.00
234_A	258_F	0.587	1.00
123_T	166_Y	0.586	1.00
128_I	182_M	0.582	1.00
292_T	296_P	0.582	1.00
290_V	304_P	0.580	1.00
50_T	238_D	0.580	1.00
71_L	111_F	0.578	1.00
131_A	134_I	0.578	1.00
27_V	81_E	0.577	1.00
165_E	170_F	0.576	1.00
302_F	310_F	0.575	1.00
136_R	187_D	0.573	1.00
171_S	174_M	0.573	1.00
266_T	270_L	0.570	1.00
53_I	248_F	0.570	1.00
320_H	323_V	0.569	1.00
292_T	297_A	0.569	1.00
304_P	307_P	0.568	1.00
281_E	284_N	0.568	1.00
262_K	323_V	0.566	1.00
132_L	136_R	0.566	1.00
70_G	91_L	0.565	1.00
245_A	293_P	0.565	1.00
154_V	181_A	0.565	1.00
142_E	146_V	0.565	1.00
141_Q	144_T	0.565	1.00
233_I	237_S	0.564	1.00
145_D	148_I	0.564	1.00
137_G	143_A	0.561	1.00
151_L	162_R	0.559	1.00
44_S	239_R	0.556	1.00
23_N	82_S	0.553	1.00
91_L	99_Y	0.551	1.00
123_T	127_Q	0.550	1.00
95_S	99_Y	0.549	1.00
261_P	266_T	0.549	1.00
125_G	147_A	0.548	1.00
310_F	321_V	0.548	1.00
128_I	163_L	0.548	1.00
70_G	90_E	0.546	1.00
167_P	178_A	0.545	1.00
62_S	66_R	0.545	1.00
113_D	175_R	0.544	1.00
51_L	248_F	0.544	1.00
166_Y	169_E	0.543	1.00
128_I	178_A	0.542	1.00
96_A	103_R	0.542	1.00
124_V	127_Q	0.541	1.00
180_I	208_I	0.540	1.00
313_C	317_H	0.539	1.00
304_P	309_A	0.538	1.00
265_Y	269_L	0.538	1.00
270_L	273_I	0.537	1.00
176_Q	199_A	0.535	1.00
307_P	311_E	0.535	1.00
242_V	257_L	0.535	1.00
268_G	271_D	0.533	1.00
317_H	324_S	0.531	1.00
267_Q	270_L	0.530	1.00
124_V	151_L	0.529	1.00
131_A	185_A	0.529	1.00
147_A	185_A	0.529	1.00
319_T	322_S	0.526	1.00
24_L	84_I	0.526	1.00
210_E	235_E	0.526	1.00
277_S	280_D	0.525	1.00
137_G	140_G	0.523	1.00
298_T	314_T	0.522	1.00
127_Q	131_A	0.522	1.00
300_C	304_P	0.521	1.00
19_L	190_V	0.518	1.00
276_T	280_D	0.518	1.00
195_E	228_H	0.518	1.00
310_F	317_H	0.516	1.00
29_R	32_H	0.515	1.00
307_P	324_S	0.514	1.00
232_V	236_I	0.513	1.00
144_T	147_A	0.512	1.00
70_G	103_R	0.512	1.00
26_T	29_R	0.511	1.00
273_I	276_T	0.511	1.00
43_L	51_L	0.511	1.00
258_F	261_P	0.510	1.00
140_G	144_T	0.509	1.00
316_V	320_H	0.507	1.00
296_P	300_C	0.507	1.00
124_V	128_I	0.506	1.00
294_N	298_T	0.506	1.00
227_T	237_S	0.506	1.00
110_I	176_Q	0.502	1.00
254_V	265_Y	0.502	1.00
298_T	304_P	0.501	1.00
138_I	146_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tuiC	2	0.9146	100	0.27	Contact Map
4ry2A	2	0.6804	100	0.281	Contact Map
4f4cA	1	0.6722	100	0.285	Contact Map
4ymuJ	2	0.6612	100	0.291	Contact Map
2oljA	2	0.6667	100	0.292	Contact Map
4u00A	1	0.6639	100	0.294	Contact Map
1b0uA	2	0.6804	100	0.296	Contact Map
2yyzA	1	0.7603	100	0.296	Contact Map
4q9hA	1	0.708	100	0.297	Contact Map
4mkiB	2	0.7851	100	0.298	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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