GREMLIN Database
Q9HMX2 - Oligopeptide ABC transporter
UniProt: Q9HMX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (297)
Sequences: 25931 (18111)
Seq/√Len: 1050.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_E239_R4.3071.00
106_G189_D3.6711.00
23_N40_G3.4441.00
22_R83_S3.4181.00
20_S44_S3.2851.00
26_T67_S2.9351.00
83_S90_E2.7531.00
253_P256_E2.7151.00
87_D189_D2.6551.00
153_D219_R2.5501.00
252_A257_L2.5441.00
52_G237_S2.5011.00
51_L241_N2.4911.00
90_E93_E2.4781.00
46_S49_E2.4541.00
36_R39_D2.4411.00
239_R251_K2.4321.00
241_N248_F2.3911.00
150_L185_A2.3851.00
146_V149_D2.3801.00
214_D218_E2.3341.00
21_I24_L2.3271.00
25_Q81_E2.2491.00
65_A226_I2.2121.00
47_P189_D2.2121.00
312_D316_V2.1951.00
153_D218_E2.1711.00
95_S98_Q2.1131.00
139_T142_E2.0951.00
27_V36_R2.0711.00
20_S85_V2.0691.00
25_Q40_G2.0311.00
89_T98_Q2.0121.00
162_R165_E2.0001.00
29_R34_H1.9781.00
303_A314_T1.9421.00
70_G99_Y1.9111.00
234_A255_E1.9091.00
39_D247_E1.8871.00
52_G233_I1.8501.00
146_V187_D1.8291.00
28_F63_V1.8281.00
148_I163_L1.7951.00
165_E169_E1.7481.00
22_R85_V1.7391.00
72_V75_P1.7261.00
17_S46_S1.6921.00
87_D106_G1.6901.00
17_S20_S1.6861.00
227_T233_I1.6781.00
23_N42_S1.6481.00
21_I43_L1.6461.00
122_Y126_N1.6411.00
133_R143_A1.6061.00
27_V34_H1.6011.00
309_A314_T1.5081.00
129_R147_A1.5071.00
158_D161_R1.5021.00
125_G163_L1.4911.00
149_D153_D1.4841.00
209_V232_V1.4821.00
89_T94_L1.4761.00
99_Y103_R1.4721.00
247_E317_H1.4621.00
157_P161_R1.4541.00
16_E47_P1.4371.00
53_I224_L1.4331.00
43_L64_T1.4231.00
115_L175_R1.4201.00
212_L223_I1.4111.00
65_A192_I1.4091.00
26_T75_P1.4061.00
300_C306_C1.4051.00
94_L98_Q1.4041.00
162_R170_F1.3981.00
241_N251_K1.3871.00
187_D219_R1.3791.00
144_T163_L1.3701.00
153_D214_D1.3541.00
25_Q39_D1.3461.00
213_Q216_Q1.3431.00
21_I68_I1.3431.00
123_T164_D1.3201.00
298_T303_A1.3131.00
110_I193_C1.3071.00
311_E315_E1.3021.00
128_I151_L1.2921.00
170_F178_A1.2911.00
41_I64_T1.2781.00
144_T148_I1.2771.00
47_P87_D1.2671.00
50_T216_Q1.2661.00
26_T72_V1.2641.00
102_V107_V1.2611.00
148_I158_D1.2611.00
17_S44_S1.2581.00
28_F37_A1.2531.00
22_R42_S1.2521.00
225_F236_I1.2491.00
125_G164_D1.2391.00
94_L99_Y1.2381.00
129_R143_A1.2341.00
23_N81_E1.2321.00
45_I51_L1.2221.00
22_R44_S1.2181.00
45_I190_V1.2151.00
123_T126_N1.2101.00
311_E314_T1.2081.00
126_N129_R1.2081.00
122_Y130_E1.2051.00
24_L74_A1.2021.00
247_E301_R1.1891.00
267_Q308_K1.1761.00
144_T164_D1.1711.00
143_A147_A1.1681.00
128_I185_A1.1611.00
145_D149_D1.1601.00
301_R317_H1.1591.00
27_V75_P1.1581.00
27_V39_D1.1531.00
303_A309_A1.1481.00
47_P220_D1.1481.00
132_L185_A1.1431.00
256_E260_N1.1391.00
25_Q36_R1.1291.00
51_L251_K1.1271.00
193_C223_I1.1271.00
141_Q145_D1.1191.00
43_L241_N1.1181.00
39_D301_R1.1151.00
125_G129_R1.1131.00
50_T223_I1.1001.00
191_L221_L1.0961.00
70_G73_D1.0931.00
129_R133_R1.0841.00
49_E238_D1.0821.00
267_Q271_D1.0751.00
240_V254_V1.0741.00
69_M109_M1.0731.00
161_R165_E1.0701.00
213_Q235_E1.0621.00
50_T237_S1.0481.00
121_V168_N1.0481.00
85_V90_E1.0451.00
64_T243_M1.0421.00
138_I143_A1.0371.00
69_M192_I1.0341.00
149_D152_E1.0321.00
142_E145_D1.0321.00
306_C313_C1.0281.00
129_R144_T1.0121.00
107_V190_V1.0091.00
252_A256_E1.0051.00
157_P162_R1.0041.00
255_E259_A0.9981.00
302_F306_C0.9911.00
125_G144_T0.9901.00
53_I241_N0.9891.00
29_R33_E0.9821.00
51_L239_R0.9751.00
136_R146_V0.9711.00
191_L223_I0.9681.00
127_Q182_M0.9591.00
297_A303_A0.9561.00
215_I221_L0.9551.00
257_L266_T0.9421.00
151_L163_L0.9401.00
205_Q229_D0.9301.00
46_S222_A0.9301.00
118_L178_A0.9121.00
140_G143_A0.9101.00
152_E158_D0.9051.00
67_S84_I0.9041.00
67_S74_A0.9041.00
66_R71_L0.9041.00
299_D303_A0.9031.00
45_I224_L0.8981.00
150_L153_D0.8971.00
190_V224_L0.8921.00
147_A163_L0.8901.00
300_C313_C0.8891.00
53_I64_T0.8841.00
187_D218_E0.8831.00
45_I222_A0.8791.00
59_S243_M0.8761.00
86_F106_G0.8751.00
24_L67_S0.8751.00
300_C303_A0.8721.00
96_A99_Y0.8721.00
38_V67_S0.8711.00
119_N122_Y0.8671.00
46_S239_R0.8661.00
287_E307_P0.8641.00
275_G278_V0.8641.00
89_T106_G0.8631.00
124_V178_A0.8631.00
118_L175_R0.8591.00
18_I86_F0.8561.00
17_S47_P0.8521.00
54_V242_V0.8511.00
296_P301_R0.8451.00
18_I190_V0.8421.00
301_R304_P0.8411.00
21_I84_I0.8401.00
23_N26_T0.8361.00
256_E259_A0.8361.00
213_Q236_I0.8311.00
316_V319_T0.8281.00
105_S136_R0.8271.00
16_E46_S0.8231.00
91_L102_V0.8191.00
129_R163_L0.8191.00
309_A313_C0.8191.00
138_I142_E0.8181.00
297_A304_P0.8171.00
26_T63_V0.8161.00
164_D167_P0.8081.00
136_R143_A0.8081.00
290_V293_P0.8071.00
54_V233_I0.8071.00
155_A207_Q0.8051.00
67_S72_V0.8031.00
216_Q238_D0.8031.00
310_F314_T0.8011.00
312_D315_E0.7981.00
271_D284_N0.7981.00
139_T143_A0.7981.00
26_T38_V0.7971.00
292_T295_Q0.7961.00
108_G183_M0.7961.00
306_C310_F0.7941.00
94_L102_V0.7911.00
288_G291_P0.7881.00
158_D162_R0.7871.00
156_I162_R0.7851.00
300_C305_R0.7831.00
317_H320_H0.7831.00
193_C212_L0.7821.00
133_R140_G0.7821.00
28_F72_V0.7721.00
216_Q223_I0.7701.00
148_I152_E0.7701.00
293_P296_P0.7691.00
50_T213_Q0.7691.00
156_I174_M0.7641.00
299_D302_F0.7641.00
68_I224_L0.7631.00
91_L107_V0.7631.00
155_A214_D0.7621.00
131_A182_M0.7561.00
298_T302_F0.7561.00
307_P310_F0.7541.00
200_L208_I0.7531.00
40_G247_E0.7521.00
248_F251_K0.7511.00
317_H321_V0.7511.00
83_S93_E0.7501.00
313_C318_P0.7501.00
205_Q232_V0.7491.00
254_V258_F0.7481.00
110_I180_I0.7431.00
197_T232_V0.7351.00
146_V150_L0.7311.00
69_M107_V0.7311.00
19_L68_I0.7301.00
303_A307_P0.7291.00
41_I248_F0.7271.00
47_P222_A0.7241.00
268_G286_I0.7231.00
230_M258_F0.7201.00
84_I92_T0.7121.00
135_N186_C0.7051.00
66_R72_V0.7031.00
122_Y127_Q0.7001.00
136_R139_T0.6951.00
51_L224_L0.6951.00
52_G227_T0.6951.00
249_V301_R0.6941.00
162_R174_M0.6931.00
67_S75_P0.6931.00
18_I87_D0.6921.00
297_A300_C0.6911.00
303_A306_C0.6901.00
310_F316_V0.6901.00
184_L221_L0.6881.00
225_F237_S0.6871.00
86_F91_L0.6871.00
48_G222_A0.6861.00
268_G272_A0.6831.00
192_I224_L0.6821.00
321_V324_S0.6811.00
170_F174_M0.6791.00
237_S254_V0.6791.00
128_I147_A0.6771.00
295_Q299_D0.6761.00
86_F190_V0.6741.00
131_A186_C0.6721.00
317_H323_V0.6711.00
38_V41_I0.6701.00
132_L138_I0.6691.00
145_D152_E0.6681.00
295_Q298_T0.6641.00
256_E324_S0.6591.00
90_E94_L0.6541.00
288_G292_T0.6541.00
302_F305_R0.6531.00
50_T236_I0.6531.00
108_G188_P0.6521.00
66_R109_M0.6521.00
89_T102_V0.6521.00
309_A317_H0.6511.00
309_A312_D0.6491.00
113_D116_K0.6491.00
68_I84_I0.6481.00
310_F324_S0.6471.00
187_D221_L0.6461.00
206_A210_E0.6391.00
199_A205_Q0.6341.00
128_I131_A0.6331.00
319_T323_V0.6321.00
83_S92_T0.6321.00
293_P297_A0.6321.00
312_D318_P0.6321.00
291_P297_A0.6291.00
117_S179_V0.6261.00
125_G128_I0.6261.00
19_L86_F0.6221.00
306_C309_A0.6191.00
152_E157_P0.6171.00
116_K175_R0.6171.00
56_E59_S0.6161.00
99_Y102_V0.6151.00
226_I229_D0.6141.00
150_L181_A0.6141.00
70_G92_T0.6131.00
150_L184_L0.6101.00
252_A258_F0.6081.00
305_R309_A0.6061.00
288_G293_P0.6061.00
86_F107_V0.6061.00
210_E214_D0.6061.00
233_I240_V0.6051.00
91_L94_L0.6041.00
37_A63_V0.6021.00
299_D306_C0.6021.00
287_E290_V0.6021.00
303_A317_H0.5991.00
86_F102_V0.5991.00
49_E251_K0.5981.00
310_F313_C0.5941.00
59_S290_V0.5941.00
308_K311_E0.5921.00
299_D304_P0.5871.00
234_A258_F0.5871.00
123_T166_Y0.5861.00
128_I182_M0.5821.00
292_T296_P0.5821.00
290_V304_P0.5801.00
50_T238_D0.5801.00
71_L111_F0.5781.00
131_A134_I0.5781.00
27_V81_E0.5771.00
165_E170_F0.5761.00
302_F310_F0.5751.00
136_R187_D0.5731.00
171_S174_M0.5731.00
266_T270_L0.5701.00
53_I248_F0.5701.00
320_H323_V0.5691.00
292_T297_A0.5691.00
304_P307_P0.5681.00
281_E284_N0.5681.00
262_K323_V0.5661.00
132_L136_R0.5661.00
70_G91_L0.5651.00
245_A293_P0.5651.00
154_V181_A0.5651.00
142_E146_V0.5651.00
141_Q144_T0.5651.00
233_I237_S0.5641.00
145_D148_I0.5641.00
137_G143_A0.5611.00
151_L162_R0.5591.00
44_S239_R0.5561.00
23_N82_S0.5531.00
91_L99_Y0.5511.00
123_T127_Q0.5501.00
95_S99_Y0.5491.00
261_P266_T0.5491.00
125_G147_A0.5481.00
310_F321_V0.5481.00
128_I163_L0.5481.00
70_G90_E0.5461.00
167_P178_A0.5451.00
62_S66_R0.5451.00
113_D175_R0.5441.00
51_L248_F0.5441.00
166_Y169_E0.5431.00
128_I178_A0.5421.00
96_A103_R0.5421.00
124_V127_Q0.5411.00
180_I208_I0.5401.00
313_C317_H0.5391.00
304_P309_A0.5381.00
265_Y269_L0.5381.00
270_L273_I0.5371.00
176_Q199_A0.5351.00
307_P311_E0.5351.00
242_V257_L0.5351.00
268_G271_D0.5331.00
317_H324_S0.5311.00
267_Q270_L0.5301.00
124_V151_L0.5291.00
131_A185_A0.5291.00
147_A185_A0.5291.00
319_T322_S0.5261.00
24_L84_I0.5261.00
210_E235_E0.5261.00
277_S280_D0.5251.00
137_G140_G0.5231.00
298_T314_T0.5221.00
127_Q131_A0.5221.00
300_C304_P0.5211.00
19_L190_V0.5181.00
276_T280_D0.5181.00
195_E228_H0.5181.00
310_F317_H0.5161.00
29_R32_H0.5151.00
307_P324_S0.5141.00
232_V236_I0.5131.00
144_T147_A0.5121.00
70_G103_R0.5121.00
26_T29_R0.5111.00
273_I276_T0.5111.00
43_L51_L0.5111.00
258_F261_P0.5101.00
140_G144_T0.5091.00
316_V320_H0.5071.00
296_P300_C0.5071.00
124_V128_I0.5061.00
294_N298_T0.5061.00
227_T237_S0.5061.00
110_I176_Q0.5021.00
254_V265_Y0.5021.00
298_T304_P0.5011.00
138_I146_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9146 100 0.27 Contact Map
4ry2A 2 0.6804 100 0.281 Contact Map
4f4cA 1 0.6722 100 0.285 Contact Map
4ymuJ 2 0.6612 100 0.291 Contact Map
2oljA 2 0.6667 100 0.292 Contact Map
4u00A 1 0.6639 100 0.294 Contact Map
1b0uA 2 0.6804 100 0.296 Contact Map
2yyzA 1 0.7603 100 0.296 Contact Map
4q9hA 1 0.708 100 0.297 Contact Map
4mkiB 2 0.7851 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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