GREMLIN Database
Q9HMX0 - Dipeptide ABC transporter permease
UniProt: Q9HMX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (308)
Sequences: 16910 (10888)
Seq/√Len: 620.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_V71_V3.5821.00
30_Y72_Q3.4011.00
67_V75_N3.3871.00
78_V82_T2.9961.00
74_K78_V2.8631.00
22_L73_Y2.8271.00
55_I60_R2.7971.00
47_P51_R2.6921.00
249_V276_I2.5721.00
35_D54_E2.5381.00
114_W230_A2.4491.00
270_R274_K2.4001.00
262_K268_P2.4001.00
107_A308_I2.3931.00
313_N317_R2.3621.00
23_T73_Y2.3341.00
258_V276_I2.2861.00
60_R67_V2.2771.00
70_W74_K2.2261.00
21_G335_I2.1251.00
5_L9_K2.0631.00
100_M314_L2.0531.00
50_A54_E2.0311.00
96_P99_A2.0311.00
289_M345_Q2.0221.00
252_S257_Y1.9621.00
267_S270_R1.9301.00
253_L276_I1.9201.00
49_A52_N1.9011.00
118_V234_G1.8781.00
52_N56_S1.8701.00
285_L352_I1.8681.00
269_R273_V1.8531.00
93_R100_M1.8091.00
126_V142_A1.7951.00
171_L224_K1.7881.00
95_Q99_A1.7841.00
46_T49_A1.7731.00
166_T173_G1.7681.00
121_F125_P1.7681.00
252_S255_S1.7651.00
71_V75_N1.7631.00
51_R55_I1.7621.00
133_N136_S1.7581.00
18_L336_L1.7151.00
51_R54_E1.6961.00
79_N84_D1.6771.00
171_L227_L1.6741.00
260_T264_K1.6591.00
97_V329_S1.6491.00
75_N78_V1.6331.00
258_V271_I1.6091.00
139_D246_R1.6051.00
132_L272_I1.6041.00
348_L351_Y1.6031.00
137_W141_A1.5941.00
286_P349_Y1.5821.00
80_M85_F1.5661.00
14_G339_I1.5641.00
98_A102_V1.5341.00
129_Y138_S1.5051.00
315_F330_L1.5041.00
19_L73_Y1.5041.00
122_V125_P1.4921.00
266_V270_R1.4891.00
257_Y279_N1.4891.00
138_S142_A1.4881.00
129_Y133_N1.4851.00
163_G168_G1.4761.00
75_N79_N1.4631.00
176_D308_I1.4481.00
133_N138_S1.4471.00
95_Q103_G1.4401.00
131_G249_V1.4381.00
12_L16_P1.4351.00
156_W160_M1.4341.00
19_L23_T1.4231.00
161_L232_V1.4231.00
230_A234_G1.4121.00
252_S280_A1.4071.00
264_K275_H1.4071.00
318_A326_V1.3991.00
122_V238_M1.3981.00
119_A237_S1.3921.00
252_S258_V1.3841.00
164_L168_G1.3791.00
22_L76_F1.3791.00
37_V50_A1.3681.00
53_L57_L1.3651.00
128_L249_V1.3591.00
314_L326_V1.3501.00
256_E259_D1.3451.00
68_P71_V1.3431.00
234_G238_M1.3401.00
221_E225_W1.3381.00
53_L56_S1.3341.00
71_V74_K1.3311.00
100_M326_V1.3241.00
8_A12_L1.3111.00
110_W176_D1.2761.00
35_D38_L1.2681.00
123_G245_G1.2641.00
87_T96_P1.2561.00
282_I349_Y1.2411.00
120_L288_I1.2401.00
85_F329_S1.2371.00
58_G67_V1.2371.00
107_A176_D1.2291.00
127_G131_G1.2271.00
110_W222_A1.2241.00
152_M157_L1.2191.00
131_G250_L1.2101.00
245_G284_L1.2061.00
116_V288_I1.1981.00
178_L221_E1.1981.00
172_D175_G1.1981.00
19_L77_L1.1841.00
135_N139_D1.1721.00
127_G245_G1.1701.00
4_P7_I1.1701.00
95_Q100_M1.1691.00
103_G106_P1.1671.00
18_L339_I1.1661.00
160_M164_L1.1661.00
58_G75_N1.1581.00
23_T27_L1.1581.00
85_F98_A1.1531.00
14_G343_L1.1481.00
38_L50_A1.1451.00
67_V70_W1.1401.00
246_R250_L1.1351.00
161_L228_P1.1321.00
223_F227_L1.1301.00
41_L53_L1.1301.00
7_I347_V1.1271.00
88_S323_D1.1241.00
330_L334_F1.1231.00
149_W239_G1.1201.00
123_G241_E1.1191.00
110_W114_W1.1031.00
316_I320_F1.0931.00
252_S276_I1.0921.00
142_A242_V1.0911.00
107_A110_W1.0891.00
347_V351_Y1.0861.00
99_A103_G1.0831.00
221_E224_K1.0731.00
130_A142_A1.0711.00
11_L343_L1.0691.00
23_T69_L1.0681.00
341_F345_Q1.0641.00
34_I322_S1.0641.00
100_M103_G1.0571.00
244_I287_V1.0501.00
131_G253_L1.0501.00
22_L332_F1.0461.00
118_V230_A1.0391.00
317_R321_N1.0371.00
102_V106_P1.0331.00
171_L228_P1.0291.00
30_Y69_L1.0281.00
52_N55_I1.0201.00
268_P271_I1.0131.00
344_L348_L1.0121.00
110_W226_I1.0111.00
232_V236_S1.0091.00
241_E291_E1.0091.00
126_V242_V0.9961.00
293_Y338_Q0.9961.00
80_M332_F0.9931.00
266_V271_I0.9901.00
154_N302_V0.9881.00
227_L231_L0.9871.00
132_L268_P0.9821.00
27_L69_L0.9811.00
4_P8_A0.9751.00
178_L225_W0.9711.00
158_A232_V0.9671.00
99_A102_V0.9671.00
146_G242_V0.9621.00
78_V81_V0.9581.00
139_D250_L0.9571.00
113_F117_L0.9561.00
92_A321_N0.9501.00
55_I67_V0.9491.00
112_G295_L0.9441.00
137_W140_Y0.9441.00
41_L45_A0.9431.00
177_F225_W0.9401.00
27_L30_Y0.9381.00
262_K271_I0.9361.00
165_L170_V0.9271.00
158_A305_V0.9231.00
292_F341_F0.9221.00
314_L318_A0.9211.00
73_Y77_L0.9211.00
30_Y324_I0.9171.00
134_S254_R0.9161.00
115_S234_G0.9131.00
304_K313_N0.9131.00
226_I230_A0.9121.00
285_L345_Q0.9061.00
20_F24_L0.8991.00
87_T94_D0.8971.00
104_R314_L0.8921.00
128_L272_I0.8911.00
125_P128_L0.8871.00
245_G249_V0.8861.00
135_N140_Y0.8831.00
157_L235_S0.8831.00
248_A280_A0.8801.00
48_T52_N0.8801.00
145_G149_W0.8781.00
76_F80_M0.8621.00
89_W325_P0.8571.00
16_P19_L0.8551.00
123_G242_V0.8541.00
127_G249_V0.8511.00
74_K77_L0.8501.00
37_V53_L0.8491.00
132_L273_V0.8481.00
79_N82_T0.8481.00
273_V276_I0.8481.00
37_V41_L0.8461.00
261_A271_I0.8401.00
231_L234_G0.8401.00
116_V292_F0.8391.00
340_L344_L0.8371.00
108_T112_G0.8361.00
123_G127_G0.8301.00
270_R273_V0.8291.00
113_F292_F0.8291.00
25_T331_V0.8261.00
17_V339_I0.8241.00
47_P50_A0.8241.00
3_R7_I0.8221.00
299_S302_V0.8221.00
125_P129_Y0.8221.00
101_I330_L0.8201.00
78_V83_F0.8201.00
141_A145_G0.8191.00
165_L171_L0.8191.00
261_A266_V0.8181.00
336_L340_L0.8131.00
271_I276_I0.8131.00
315_F318_A0.8121.00
350_T356_I0.8121.00
6_Y350_T0.8101.00
115_S233_L0.8091.00
232_V302_V0.8071.00
114_W308_I0.8051.00
37_V54_E0.8021.00
126_V238_M0.8011.00
23_T70_W0.7971.00
134_S250_L0.7961.00
280_A283_P0.7961.00
109_I113_F0.7941.00
120_L125_P0.7931.00
110_W113_F0.7911.00
347_V350_T0.7901.00
154_N235_S0.7881.00
40_I53_L0.7861.00
124_I245_G0.7831.00
171_L174_Y0.7821.00
143_S242_V0.7821.00
106_P109_I0.7791.00
293_Y341_F0.7791.00
115_S119_A0.7761.00
161_L231_L0.7711.00
349_Y356_I0.7701.00
138_S141_A0.7671.00
140_Y143_S0.7641.00
101_I329_S0.7641.00
249_V280_A0.7621.00
285_L348_L0.7561.00
49_A53_L0.7561.00
48_T51_R0.7551.00
122_V126_V0.7541.00
45_A50_A0.7531.00
268_P272_I0.7471.00
238_M242_V0.7441.00
149_W235_S0.7431.00
119_A234_G0.7341.00
122_V234_G0.7321.00
77_L81_V0.7251.00
37_V57_L0.7251.00
304_K317_R0.7251.00
6_Y358_L0.7231.00
81_V84_D0.7201.00
324_I328_M0.7161.00
318_A327_M0.7141.00
328_M331_V0.7111.00
105_L109_I0.7091.00
165_L228_P0.7081.00
114_W118_V0.7041.00
27_L31_L0.7031.00
309_N313_N0.7021.00
176_D179_I0.7021.00
233_L299_S0.7021.00
304_K316_I0.7001.00
314_L330_L0.6991.00
29_L327_M0.6981.00
176_D222_A0.6981.00
77_L80_M0.6971.00
171_L175_G0.6911.00
114_W227_L0.6891.00
11_L15_V0.6891.00
163_G167_A0.6891.00
116_V120_L0.6881.00
165_L168_G0.6861.00
245_G280_A0.6841.00
104_R313_N0.6811.00
329_S333_I0.6801.00
142_A146_G0.6801.00
111_L230_A0.6781.00
300_V316_I0.6761.00
315_F334_F0.6761.00
245_G277_G0.6731.00
114_W226_I0.6721.00
141_A144_F0.6701.00
108_T299_S0.6701.00
227_L230_A0.6701.00
128_L277_G0.6691.00
124_I284_L0.6681.00
30_Y328_M0.6661.00
257_Y261_A0.6661.00
245_G248_A0.6641.00
16_P20_F0.6561.00
177_F222_A0.6541.00
118_V231_L0.6531.00
326_V330_L0.6501.00
261_A275_H0.6471.00
317_R320_F0.6471.00
130_A139_D0.6461.00
106_P110_W0.6401.00
237_S240_N0.6381.00
337_M341_F0.6381.00
261_A264_K0.6371.00
327_M331_V0.6351.00
272_I276_I0.6331.00
100_M104_R0.6311.00
154_N236_S0.6301.00
51_R60_R0.6291.00
248_A252_S0.6281.00
133_N139_D0.6271.00
15_V19_L0.6271.00
139_D143_S0.6261.00
350_T357_T0.6251.00
224_K227_L0.6251.00
112_G116_V0.6221.00
241_E287_V0.6211.00
345_Q349_Y0.6201.00
117_L121_F0.6171.00
338_Q342_N0.6161.00
170_V175_G0.6161.00
156_W159_V0.6151.00
282_I356_I0.6141.00
10_R346_D0.6131.00
177_F180_K0.6131.00
162_S173_G0.6131.00
177_F221_E0.6111.00
128_L273_V0.6111.00
144_F148_V0.6051.00
335_I339_I0.6031.00
136_S140_Y0.6001.00
289_M341_F0.6001.00
222_A225_W0.5971.00
334_F338_Q0.5961.00
69_L72_Q0.5961.00
174_Y307_S0.5951.00
175_G178_L0.5921.00
22_L77_L0.5911.00
93_R326_V0.5911.00
176_D226_I0.5911.00
240_N287_V0.5901.00
14_G18_L0.5891.00
293_Y337_M0.5881.00
281_V284_L0.5861.00
300_V304_K0.5851.00
36_P324_I0.5811.00
136_S141_A0.5811.00
101_I311_I0.5801.00
133_N268_P0.5791.00
26_F30_Y0.5761.00
14_G340_L0.5761.00
102_V105_L0.5721.00
343_L347_V0.5711.00
267_S271_I0.5701.00
136_S139_D0.5691.00
166_T169_G0.5691.00
71_V78_V0.5681.00
26_F69_L0.5661.00
152_M156_W0.5641.00
110_W308_I0.5631.00
146_G239_G0.5601.00
150_R239_G0.5591.00
131_G139_D0.5571.00
241_E245_G0.5551.00
273_V278_R0.5531.00
154_N157_L0.5521.00
37_V40_I0.5511.00
266_V275_H0.5491.00
54_E60_R0.5481.00
293_Y297_G0.5460.99
112_G292_F0.5450.99
10_R13_L0.5430.99
234_G237_S0.5420.99
119_A241_E0.5410.99
319_A327_M0.5410.99
240_N244_I0.5400.99
41_L49_A0.5390.99
133_N273_V0.5390.99
121_F124_I0.5390.99
128_L132_L0.5390.99
109_I296_I0.5380.99
339_I342_N0.5380.99
349_Y353_D0.5380.99
26_F72_Q0.5370.99
42_G45_A0.5340.99
56_S94_D0.5340.99
291_E294_L0.5340.99
281_V285_L0.5330.99
37_V45_A0.5330.99
354_P357_T0.5300.99
273_V277_G0.5290.99
241_E284_L0.5270.99
25_T30_Y0.5260.99
120_L124_I0.5240.99
258_V262_K0.5240.99
244_I248_A0.5240.99
112_G299_S0.5240.99
301_L305_V0.5230.99
293_Y345_Q0.5210.99
251_E255_S0.5200.99
147_I151_A0.5200.99
240_N291_E0.5190.99
45_A49_A0.5180.99
231_L235_S0.5160.99
256_E260_T0.5160.99
239_G242_V0.5160.99
297_G300_V0.5140.99
114_W234_G0.5140.99
228_P232_V0.5130.99
348_L352_I0.5130.99
325_P328_M0.5120.99
146_G149_W0.5120.99
130_A246_R0.5100.99
132_L253_L0.5100.99
6_Y343_L0.5100.99
38_L42_G0.5090.99
20_F23_T0.5090.99
178_L222_A0.5070.99
233_L302_V0.5070.99
97_V326_V0.5060.99
255_S260_T0.5060.99
111_L308_I0.5060.99
326_V329_S0.5040.99
237_S291_E0.5030.99
342_N345_Q0.5020.99
156_W305_V0.5010.99
13_L17_V0.5010.99
300_V315_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.5758 99.9 0.716 Contact Map
4tquM 1 0.7466 99.9 0.732 Contact Map
3rlfF 1 0.7383 99.9 0.732 Contact Map
2onkC 2 0.6639 99.8 0.742 Contact Map
3d31C 2 0.6777 99.8 0.745 Contact Map
4ymuD 2 0.5785 99.8 0.746 Contact Map
3rlfG 1 0.7713 99.8 0.757 Contact Map
4tquN 1 0.7163 99.8 0.76 Contact Map
4lz6A 1 0.2369 13.4 0.965 Contact Map
1q16C 2 0.3388 10.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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