Q9HMW8 - HALSA - GREMLIN Contacts

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Q9HMW8 - Uncharacterized protein

UniProt:	Q9HMW8	Sequences: MNVADAMTPRDDVVTVELPGTRDDILEYLQERAFSAVPVVKASEDGERYRGLISRDDLIERPEEDQLALLMRDVPTTTQDTTVPEVASLMVDSGTRRVPVVEDERLEGIVTVTDVVRAIADGQADGDTDVGGLARRDINTTYEGAPLTVAERSISYANVPYSVVLGETGDMAGMVTEVDIIDVARVVEGEDNTGDSMAADDDDWKWESIKAVGSRYLPTRNVQIPAEPVREFMTSDVVTVTGKRTSRDAAQTMLDTDIEQLPLMSGDELTGIVRDVDLLAALTDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (215)
Sequences:	2638 (1405)
Seq/√Len:	95.8

ECOLI - IMDH
BACSU - IMDH
HALSA - Q9HMW8 IMDH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
166_G	170_D	4.183	1.00
59_I	204_W	4.112	1.00
251_Q	255_D	3.634	1.00
223_Q	227_E	3.414	1.00
244_R	250_A	3.170	1.00
203_D	207_E	3.170	1.00
77_T	100_V	3.041	1.00
52_L	212_V	3.015	1.00
141_T	164_V	2.976	1.00
206_W	237_V	2.734	1.00
233_M	239_T	2.690	1.00
128_T	132_G	2.507	1.00
58_L	61_R	2.486	1.00
118_A	128_T	2.360	1.00
227_E	230_R	2.341	1.00
50_R	212_V	2.304	1.00
198_A	228_P	2.243	1.00
202_D	232_F	2.183	1.00
81_T	85_E	2.183	1.00
233_M	259_E	2.139	1.00
84_P	88_S	2.096	1.00
244_R	249_A	2.086	1.00
78_T	81_T	2.055	1.00
142_Y	167_E	2.054	1.00
202_D	213_G	2.032	1.00
252_T	255_D	2.004	1.00
250_A	254_L	2.004	1.00
79_Q	107_E	1.951	1.00
88_S	92_D	1.911	1.00
105_R	170_D	1.866	1.00
146_P	149_V	1.848	1.00
84_P	127_D	1.805	1.00
129_D	132_G	1.804	1.00
203_D	235_S	1.790	1.00
152_R	156_Y	1.775	1.00
104_E	170_D	1.768	1.00
229_V	241_T	1.748	1.00
143_E	172_A	1.728	1.00
52_L	214_S	1.718	1.00
213_G	237_V	1.703	1.00
86_V	110_V	1.699	1.00
149_V	152_R	1.694	1.00
212_V	240_V	1.674	1.00
232_F	239_T	1.662	1.00
217_L	225_P	1.650	1.00
55_R	224_I	1.642	1.00
77_T	86_V	1.582	1.00
77_T	81_T	1.550	1.00
230_R	234_T	1.513	1.00
141_T	145_A	1.509	1.00
80_D	129_D	1.503	1.00
247_R	251_Q	1.494	1.00
83_V	118_A	1.494	1.00
86_V	90_M	1.490	1.00
85_E	88_S	1.467	1.00
231_E	235_S	1.467	1.00
77_T	130_V	1.461	1.00
147_L	151_E	1.428	1.00
200_D	203_D	1.419	1.00
125_D	128_T	1.413	0.99
124_A	152_R	1.400	0.99
61_R	65_D	1.385	0.99
139_N	157_A	1.379	0.99
100_V	130_V	1.363	0.99
110_V	133_L	1.330	0.99
87_A	126_G	1.329	0.99
197_M	200_D	1.303	0.99
210_K	237_V	1.270	0.99
80_D	131_G	1.266	0.99
145_A	149_V	1.255	0.99
227_E	231_E	1.251	0.99
155_S	158_N	1.237	0.99
199_A	231_E	1.235	0.99
90_M	98_V	1.233	0.99
102_E	105_R	1.231	0.99
165_L	169_G	1.226	0.99
82_T	85_E	1.216	0.98
226_A	230_R	1.187	0.98
215_R	232_F	1.178	0.98
61_R	64_E	1.176	0.98
238_V	260_Q	1.163	0.98
200_D	204_W	1.161	0.98
71_M	76_T	1.158	0.98
181_I	185_R	1.131	0.97
215_R	229_V	1.128	0.97
231_E	234_T	1.127	0.97
87_A	91_V	1.122	0.97
239_T	258_I	1.108	0.97
154_I	162_S	1.098	0.97
228_P	231_E	1.091	0.97
46_G	67_L	1.071	0.97
241_T	258_I	1.069	0.96
199_A	202_D	1.057	0.96
215_R	241_T	1.049	0.96
142_Y	145_A	1.045	0.96
95_T	98_V	1.043	0.96
79_Q	131_G	1.039	0.96
75_P	98_V	1.031	0.96
72_R	194_G	1.013	0.95
78_T	103_D	1.010	0.95
169_G	172_A	1.003	0.95
94_G	112_V	0.997	0.95
47_E	186_V	0.983	0.94
229_V	239_T	0.981	0.94
151_E	183_V	0.977	0.94
201_D	205_K	0.967	0.94
221_N	252_T	0.966	0.94
84_P	126_G	0.965	0.94
199_A	235_S	0.963	0.94
202_D	237_V	0.956	0.94
223_Q	226_A	0.938	0.93
78_T	107_E	0.933	0.93
102_E	107_E	0.927	0.92
206_W	210_K	0.923	0.92
143_E	167_E	0.915	0.92
147_L	180_I	0.914	0.92
226_A	252_T	0.911	0.92
151_E	180_I	0.909	0.92
251_Q	254_L	0.904	0.91
78_T	102_E	0.900	0.91
71_M	164_V	0.895	0.91
142_Y	149_V	0.893	0.91
226_A	256_T	0.893	0.91
141_T	163_V	0.885	0.91
75_P	95_T	0.885	0.91
71_M	75_P	0.879	0.90
250_A	261_L	0.867	0.90
79_Q	110_V	0.857	0.89
50_R	260_Q	0.856	0.89
151_E	158_N	0.851	0.89
87_A	115_V	0.843	0.88
230_R	255_D	0.839	0.88
224_I	227_E	0.838	0.88
90_M	115_V	0.833	0.88
118_A	126_G	0.827	0.87
75_P	100_V	0.824	0.87
83_V	128_T	0.822	0.87
60_E	200_D	0.819	0.87
63_E	204_W	0.814	0.87
202_D	206_W	0.813	0.86
64_E	92_D	0.807	0.86
150_A	174_M	0.799	0.86
83_V	133_L	0.796	0.85
56_D	99_P	0.784	0.84
78_T	101_V	0.783	0.84
81_T	130_V	0.781	0.84
229_V	258_I	0.778	0.84
142_Y	168_T	0.777	0.84
81_T	98_V	0.770	0.83
89_L	98_V	0.769	0.83
233_M	258_I	0.769	0.83
47_E	188_E	0.768	0.83
90_M	95_T	0.767	0.83
128_T	133_L	0.765	0.83
118_A	125_D	0.762	0.83
233_M	260_Q	0.761	0.83
248_D	252_T	0.760	0.83
199_A	203_D	0.758	0.82
150_A	162_S	0.750	0.82
215_R	225_P	0.748	0.82
201_D	204_W	0.740	0.81
87_A	98_V	0.740	0.81
99_P	171_M	0.738	0.81
258_I	261_L	0.733	0.80
67_L	70_L	0.730	0.80
79_Q	102_E	0.729	0.80
196_S	200_D	0.728	0.80
196_S	199_A	0.724	0.79
217_L	224_I	0.722	0.79
115_V	147_L	0.720	0.79
78_T	131_G	0.718	0.79
229_V	249_A	0.717	0.79
249_A	252_T	0.713	0.78
118_A	133_L	0.713	0.78
199_A	228_P	0.713	0.78
69_L	209_I	0.710	0.78
198_A	202_D	0.710	0.78
102_E	170_D	0.710	0.78
90_M	162_S	0.702	0.77
229_V	256_T	0.695	0.77
115_V	126_G	0.694	0.76
51_G	54_S	0.691	0.76
203_D	206_W	0.687	0.76
257_D	264_M	0.686	0.76
82_T	129_D	0.685	0.76
66_Q	69_L	0.685	0.76
118_A	124_A	0.681	0.75
80_D	88_S	0.679	0.75
198_A	217_L	0.675	0.74
108_G	114_D	0.675	0.74
217_L	245_T	0.672	0.74
117_R	155_S	0.670	0.74
230_R	256_T	0.668	0.74
248_D	255_D	0.666	0.73
46_G	183_V	0.666	0.73
150_A	158_N	0.665	0.73
192_N	195_D	0.660	0.73
85_E	130_V	0.659	0.73
138_I	163_V	0.657	0.72
220_R	244_R	0.656	0.72
237_V	259_E	0.656	0.72
60_E	204_W	0.655	0.72
167_E	170_D	0.655	0.72
118_A	155_S	0.654	0.72
102_E	163_V	0.653	0.72
52_L	237_V	0.653	0.72
79_Q	101_V	0.651	0.72
47_E	58_L	0.650	0.72
105_R	168_T	0.644	0.71
242_G	246_S	0.643	0.71
67_L	93_S	0.642	0.71
60_E	207_E	0.642	0.71
152_R	155_S	0.641	0.71
190_E	193_T	0.640	0.71
64_E	69_L	0.637	0.70
224_I	228_P	0.636	0.70
97_R	161_Y	0.634	0.70
145_A	164_V	0.632	0.70
214_S	218_P	0.632	0.70
177_E	181_I	0.632	0.70
218_P	249_A	0.631	0.69
147_L	183_V	0.628	0.69
248_D	251_Q	0.625	0.69
69_L	183_V	0.623	0.68
67_L	186_V	0.621	0.68
87_A	184_A	0.621	0.68
190_E	194_G	0.620	0.68
46_G	94_G	0.616	0.68
46_G	163_V	0.616	0.68
254_L	261_L	0.616	0.68
234_T	255_D	0.613	0.67
74_V	220_R	0.610	0.67
56_D	217_L	0.606	0.66
90_M	180_I	0.602	0.66
106_L	161_Y	0.601	0.66
204_W	207_E	0.601	0.66
96_R	177_E	0.600	0.66
180_I	184_A	0.596	0.65
213_G	217_L	0.595	0.65
83_V	130_V	0.595	0.65
216_Y	219_T	0.595	0.65
84_P	92_D	0.595	0.65
110_V	177_E	0.594	0.65
86_V	151_E	0.592	0.65
106_L	154_I	0.591	0.64
158_N	233_M	0.589	0.64
155_S	164_V	0.588	0.64
244_R	253_M	0.587	0.64
66_Q	112_V	0.586	0.64
244_R	261_L	0.586	0.64
69_L	144_G	0.585	0.64
73_D	171_M	0.585	0.64
66_Q	155_S	0.584	0.64
113_T	161_Y	0.582	0.63
82_T	87_A	0.581	0.63
68_A	191_D	0.581	0.63
147_L	150_A	0.579	0.63
80_D	102_E	0.579	0.63
160_P	176_T	0.579	0.63
53_I	57_D	0.578	0.63
62_P	65_D	0.578	0.63
197_M	228_P	0.577	0.63
117_R	214_S	0.577	0.63
216_Y	242_G	0.576	0.62
163_V	171_M	0.574	0.62
210_K	213_G	0.572	0.62
232_F	237_V	0.570	0.62
85_E	98_V	0.568	0.61
260_Q	263_L	0.568	0.61
46_G	185_R	0.567	0.61
227_E	234_T	0.567	0.61
141_T	153_S	0.567	0.61
217_L	249_A	0.567	0.61
67_L	94_G	0.565	0.61
211_A	216_Y	0.565	0.61
74_V	222_V	0.561	0.60
69_L	194_G	0.556	0.60
50_R	190_E	0.556	0.60
59_I	63_E	0.554	0.59
212_V	260_Q	0.553	0.59
181_I	184_A	0.553	0.59
77_T	89_L	0.549	0.59
125_D	219_T	0.547	0.59
81_T	131_G	0.546	0.58
98_V	130_V	0.545	0.58
141_T	154_I	0.540	0.58
242_G	257_D	0.538	0.57
140_T	165_L	0.538	0.57
93_S	98_V	0.536	0.57
245_T	249_A	0.536	0.57
67_L	71_M	0.536	0.57
163_V	169_G	0.535	0.57
141_T	144_G	0.534	0.57
150_A	175_V	0.533	0.57
154_I	186_V	0.532	0.56
86_V	93_S	0.532	0.56
181_I	238_V	0.528	0.56
147_L	153_S	0.522	0.55
112_V	150_A	0.521	0.55
216_Y	243_K	0.521	0.55
116_V	164_V	0.521	0.55
65_D	177_E	0.520	0.55
117_R	245_T	0.516	0.54
114_D	134_A	0.515	0.54
76_T	98_V	0.514	0.54
223_Q	230_R	0.512	0.54
148_T	234_T	0.512	0.54
98_V	177_E	0.512	0.54
86_V	115_V	0.511	0.53
176_T	263_L	0.510	0.53
243_K	264_M	0.510	0.53
154_I	214_S	0.510	0.53
219_T	243_K	0.508	0.53
153_S	255_D	0.506	0.53
238_V	259_E	0.506	0.53
93_S	112_V	0.504	0.52
226_A	249_A	0.502	0.52
198_A	215_R	0.501	0.52
143_E	166_G	0.501	0.52
142_Y	164_V	0.501	0.52
69_L	130_V	0.501	0.52
115_V	194_G	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3usbA	4	0.9719	100	0.548	Contact Map
4af0A	3	0.5825	100	0.553	Contact Map
1vrdA	3	0.6035	100	0.562	Contact Map
1jcnA	6	0.8351	100	0.565	Contact Map
1zfjA	4	0.9719	100	0.591	Contact Map
2cu0A	4	0.5754	100	0.597	Contact Map
5ahnA	3	0.5789	100	0.609	Contact Map
1me8A	3	0.586	100	0.609	Contact Map
4fxsA	3	0.9228	100	0.624	Contact Map
2qrdG	1	0.8772	100	0.63	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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