GREMLIN Database
Q9HMW8 - Uncharacterized protein
UniProt: Q9HMW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (215)
Sequences: 2638 (1405)
Seq/√Len: 95.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_G170_D4.1831.00
59_I204_W4.1121.00
251_Q255_D3.6341.00
223_Q227_E3.4141.00
244_R250_A3.1701.00
203_D207_E3.1701.00
77_T100_V3.0411.00
52_L212_V3.0151.00
141_T164_V2.9761.00
206_W237_V2.7341.00
233_M239_T2.6901.00
128_T132_G2.5071.00
58_L61_R2.4861.00
118_A128_T2.3601.00
227_E230_R2.3411.00
50_R212_V2.3041.00
198_A228_P2.2431.00
202_D232_F2.1831.00
81_T85_E2.1831.00
233_M259_E2.1391.00
84_P88_S2.0961.00
244_R249_A2.0861.00
78_T81_T2.0551.00
142_Y167_E2.0541.00
202_D213_G2.0321.00
252_T255_D2.0041.00
250_A254_L2.0041.00
79_Q107_E1.9511.00
88_S92_D1.9111.00
105_R170_D1.8661.00
146_P149_V1.8481.00
84_P127_D1.8051.00
129_D132_G1.8041.00
203_D235_S1.7901.00
152_R156_Y1.7751.00
104_E170_D1.7681.00
229_V241_T1.7481.00
143_E172_A1.7281.00
52_L214_S1.7181.00
213_G237_V1.7031.00
86_V110_V1.6991.00
149_V152_R1.6941.00
212_V240_V1.6741.00
232_F239_T1.6621.00
217_L225_P1.6501.00
55_R224_I1.6421.00
77_T86_V1.5821.00
77_T81_T1.5501.00
230_R234_T1.5131.00
141_T145_A1.5091.00
80_D129_D1.5031.00
247_R251_Q1.4941.00
83_V118_A1.4941.00
86_V90_M1.4901.00
85_E88_S1.4671.00
231_E235_S1.4671.00
77_T130_V1.4611.00
147_L151_E1.4281.00
200_D203_D1.4191.00
125_D128_T1.4130.99
124_A152_R1.4000.99
61_R65_D1.3850.99
139_N157_A1.3790.99
100_V130_V1.3630.99
110_V133_L1.3300.99
87_A126_G1.3290.99
197_M200_D1.3030.99
210_K237_V1.2700.99
80_D131_G1.2660.99
145_A149_V1.2550.99
227_E231_E1.2510.99
155_S158_N1.2370.99
199_A231_E1.2350.99
90_M98_V1.2330.99
102_E105_R1.2310.99
165_L169_G1.2260.99
82_T85_E1.2160.98
226_A230_R1.1870.98
215_R232_F1.1780.98
61_R64_E1.1760.98
238_V260_Q1.1630.98
200_D204_W1.1610.98
71_M76_T1.1580.98
181_I185_R1.1310.97
215_R229_V1.1280.97
231_E234_T1.1270.97
87_A91_V1.1220.97
239_T258_I1.1080.97
154_I162_S1.0980.97
228_P231_E1.0910.97
46_G67_L1.0710.97
241_T258_I1.0690.96
199_A202_D1.0570.96
215_R241_T1.0490.96
142_Y145_A1.0450.96
95_T98_V1.0430.96
79_Q131_G1.0390.96
75_P98_V1.0310.96
72_R194_G1.0130.95
78_T103_D1.0100.95
169_G172_A1.0030.95
94_G112_V0.9970.95
47_E186_V0.9830.94
229_V239_T0.9810.94
151_E183_V0.9770.94
201_D205_K0.9670.94
221_N252_T0.9660.94
84_P126_G0.9650.94
199_A235_S0.9630.94
202_D237_V0.9560.94
223_Q226_A0.9380.93
78_T107_E0.9330.93
102_E107_E0.9270.92
206_W210_K0.9230.92
143_E167_E0.9150.92
147_L180_I0.9140.92
226_A252_T0.9110.92
151_E180_I0.9090.92
251_Q254_L0.9040.91
78_T102_E0.9000.91
71_M164_V0.8950.91
142_Y149_V0.8930.91
226_A256_T0.8930.91
141_T163_V0.8850.91
75_P95_T0.8850.91
71_M75_P0.8790.90
250_A261_L0.8670.90
79_Q110_V0.8570.89
50_R260_Q0.8560.89
151_E158_N0.8510.89
87_A115_V0.8430.88
230_R255_D0.8390.88
224_I227_E0.8380.88
90_M115_V0.8330.88
118_A126_G0.8270.87
75_P100_V0.8240.87
83_V128_T0.8220.87
60_E200_D0.8190.87
63_E204_W0.8140.87
202_D206_W0.8130.86
64_E92_D0.8070.86
150_A174_M0.7990.86
83_V133_L0.7960.85
56_D99_P0.7840.84
78_T101_V0.7830.84
81_T130_V0.7810.84
229_V258_I0.7780.84
142_Y168_T0.7770.84
81_T98_V0.7700.83
89_L98_V0.7690.83
233_M258_I0.7690.83
47_E188_E0.7680.83
90_M95_T0.7670.83
128_T133_L0.7650.83
118_A125_D0.7620.83
233_M260_Q0.7610.83
248_D252_T0.7600.83
199_A203_D0.7580.82
150_A162_S0.7500.82
215_R225_P0.7480.82
201_D204_W0.7400.81
87_A98_V0.7400.81
99_P171_M0.7380.81
258_I261_L0.7330.80
67_L70_L0.7300.80
79_Q102_E0.7290.80
196_S200_D0.7280.80
196_S199_A0.7240.79
217_L224_I0.7220.79
115_V147_L0.7200.79
78_T131_G0.7180.79
229_V249_A0.7170.79
249_A252_T0.7130.78
118_A133_L0.7130.78
199_A228_P0.7130.78
69_L209_I0.7100.78
198_A202_D0.7100.78
102_E170_D0.7100.78
90_M162_S0.7020.77
229_V256_T0.6950.77
115_V126_G0.6940.76
51_G54_S0.6910.76
203_D206_W0.6870.76
257_D264_M0.6860.76
82_T129_D0.6850.76
66_Q69_L0.6850.76
118_A124_A0.6810.75
80_D88_S0.6790.75
198_A217_L0.6750.74
108_G114_D0.6750.74
217_L245_T0.6720.74
117_R155_S0.6700.74
230_R256_T0.6680.74
248_D255_D0.6660.73
46_G183_V0.6660.73
150_A158_N0.6650.73
192_N195_D0.6600.73
85_E130_V0.6590.73
138_I163_V0.6570.72
220_R244_R0.6560.72
237_V259_E0.6560.72
60_E204_W0.6550.72
167_E170_D0.6550.72
118_A155_S0.6540.72
102_E163_V0.6530.72
52_L237_V0.6530.72
79_Q101_V0.6510.72
47_E58_L0.6500.72
105_R168_T0.6440.71
242_G246_S0.6430.71
67_L93_S0.6420.71
60_E207_E0.6420.71
152_R155_S0.6410.71
190_E193_T0.6400.71
64_E69_L0.6370.70
224_I228_P0.6360.70
97_R161_Y0.6340.70
145_A164_V0.6320.70
214_S218_P0.6320.70
177_E181_I0.6320.70
218_P249_A0.6310.69
147_L183_V0.6280.69
248_D251_Q0.6250.69
69_L183_V0.6230.68
67_L186_V0.6210.68
87_A184_A0.6210.68
190_E194_G0.6200.68
46_G94_G0.6160.68
46_G163_V0.6160.68
254_L261_L0.6160.68
234_T255_D0.6130.67
74_V220_R0.6100.67
56_D217_L0.6060.66
90_M180_I0.6020.66
106_L161_Y0.6010.66
204_W207_E0.6010.66
96_R177_E0.6000.66
180_I184_A0.5960.65
213_G217_L0.5950.65
83_V130_V0.5950.65
216_Y219_T0.5950.65
84_P92_D0.5950.65
110_V177_E0.5940.65
86_V151_E0.5920.65
106_L154_I0.5910.64
158_N233_M0.5890.64
155_S164_V0.5880.64
244_R253_M0.5870.64
66_Q112_V0.5860.64
244_R261_L0.5860.64
69_L144_G0.5850.64
73_D171_M0.5850.64
66_Q155_S0.5840.64
113_T161_Y0.5820.63
82_T87_A0.5810.63
68_A191_D0.5810.63
147_L150_A0.5790.63
80_D102_E0.5790.63
160_P176_T0.5790.63
53_I57_D0.5780.63
62_P65_D0.5780.63
197_M228_P0.5770.63
117_R214_S0.5770.63
216_Y242_G0.5760.62
163_V171_M0.5740.62
210_K213_G0.5720.62
232_F237_V0.5700.62
85_E98_V0.5680.61
260_Q263_L0.5680.61
46_G185_R0.5670.61
227_E234_T0.5670.61
141_T153_S0.5670.61
217_L249_A0.5670.61
67_L94_G0.5650.61
211_A216_Y0.5650.61
74_V222_V0.5610.60
69_L194_G0.5560.60
50_R190_E0.5560.60
59_I63_E0.5540.59
212_V260_Q0.5530.59
181_I184_A0.5530.59
77_T89_L0.5490.59
125_D219_T0.5470.59
81_T131_G0.5460.58
98_V130_V0.5450.58
141_T154_I0.5400.58
242_G257_D0.5380.57
140_T165_L0.5380.57
93_S98_V0.5360.57
245_T249_A0.5360.57
67_L71_M0.5360.57
163_V169_G0.5350.57
141_T144_G0.5340.57
150_A175_V0.5330.57
154_I186_V0.5320.56
86_V93_S0.5320.56
181_I238_V0.5280.56
147_L153_S0.5220.55
112_V150_A0.5210.55
216_Y243_K0.5210.55
116_V164_V0.5210.55
65_D177_E0.5200.55
117_R245_T0.5160.54
114_D134_A0.5150.54
76_T98_V0.5140.54
223_Q230_R0.5120.54
148_T234_T0.5120.54
98_V177_E0.5120.54
86_V115_V0.5110.53
176_T263_L0.5100.53
243_K264_M0.5100.53
154_I214_S0.5100.53
219_T243_K0.5080.53
153_S255_D0.5060.53
238_V259_E0.5060.53
93_S112_V0.5040.52
226_A249_A0.5020.52
198_A215_R0.5010.52
143_E166_G0.5010.52
142_Y164_V0.5010.52
69_L130_V0.5010.52
115_V194_G0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.9719 100 0.548 Contact Map
4af0A 3 0.5825 100 0.553 Contact Map
1vrdA 3 0.6035 100 0.562 Contact Map
1jcnA 6 0.8351 100 0.565 Contact Map
1zfjA 4 0.9719 100 0.591 Contact Map
2cu0A 4 0.5754 100 0.597 Contact Map
5ahnA 3 0.5789 100 0.609 Contact Map
1me8A 3 0.586 100 0.609 Contact Map
4fxsA 3 0.9228 100 0.624 Contact Map
2qrdG 1 0.8772 100 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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