GREMLIN Database
Q9HMW5 - ATP-dependent RNA helicase homolog eIF-4A
UniProt: Q9HMW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 784 (694)
Sequences: 278 (196)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
611_V693_I4.9170.99
570_V693_I4.5850.99
216_Q475_R3.8760.96
259_Q263_N3.2280.89
27_L199_M3.0430.86
75_L78_Q3.0230.86
27_L49_V3.0090.85
463_Q470_R2.9220.84
463_Q467_R2.8780.83
688_D732_D2.8530.82
356_Q359_M2.8470.82
576_E585_L2.8290.82
492_I495_R2.7600.80
531_G534_E2.6930.78
447_D468_T2.6850.78
21_R35_H2.6600.77
23_Y35_H2.6430.77
72_T441_L2.6140.76
527_L530_F2.5670.75
43_G46_K2.5560.74
711_H725_Y2.4900.72
519_G522_G2.4810.72
454_P476_V2.4730.72
516_T520_G2.4650.71
42_T175_A2.4620.71
361_L373_V2.4350.70
24_Q46_K2.4170.70
527_L688_D2.3810.69
27_L38_V2.3600.68
711_H728_S2.3440.67
490_F494_R2.3260.67
45_G71_P2.2550.64
737_T740_S2.2300.63
575_R585_L2.2280.63
304_S379_S2.2110.63
376_F463_Q2.2110.63
613_R649_E2.1950.62
634_A678_L2.1940.62
68_L72_T2.1740.61
364_T371_D2.1720.61
376_F467_R2.1690.61
71_P401_G2.1510.60
453_E486_D2.1390.60
229_V245_R2.1310.60
515_E519_G2.1310.60
550_D557_V2.1060.59
24_Q45_G2.0970.58
526_A530_F2.0960.58
401_G463_Q2.0860.58
522_G525_Q2.0760.57
99_G126_D2.0510.56
37_L400_V2.0480.56
467_R470_R2.0310.56
416_Q442_D2.0110.55
664_A675_D2.0060.55
440_G470_R1.9910.54
523_A527_L1.9910.54
711_H730_I1.9810.54
555_E560_R1.9690.53
122_V372_R1.9510.53
74_P78_Q1.9420.52
497_E500_M1.9390.52
438_E442_D1.9360.52
175_A438_E1.9310.52
440_G467_R1.9190.51
450_L610_A1.9190.51
519_G524_Q1.9100.51
64_G372_R1.9020.51
45_G143_D1.8930.50
41_P468_T1.8900.50
380_R399_F1.8760.50
108_A535_A1.8630.49
27_L229_V1.8530.49
133_D300_V1.8440.48
605_V693_I1.8380.48
42_T438_E1.8370.48
266_R287_H1.8280.48
662_P666_R1.8240.48
109_A269_L1.8180.47
416_Q438_E1.8020.47
684_N688_D1.7950.46
515_E518_L1.7920.46
24_Q47_T1.7830.46
21_R191_L1.7820.46
46_K71_P1.7770.46
79_H82_F1.7750.46
175_A439_E1.7730.46
37_L145_C1.7700.45
83_Y115_V1.7610.45
173_M446_V1.7490.45
221_T733_V1.7480.45
155_T704_N1.7460.44
711_H724_E1.7340.44
146_H376_F1.7310.44
735_P740_S1.7190.43
694_E698_E1.7160.43
300_V731_T1.7130.43
300_V490_F1.7100.43
681_M684_N1.7070.43
43_G47_T1.7030.43
720_G732_D1.6920.42
146_H470_R1.6850.42
522_G531_G1.6840.42
605_V683_T1.6740.42
326_K329_Q1.6730.42
697_A701_Q1.6690.41
530_F535_A1.6650.41
45_G144_E1.6620.41
535_A538_E1.6570.41
401_G467_R1.6540.41
585_L606_S1.6500.41
140_C202_D1.6500.41
397_R422_E1.6480.41
47_T143_D1.6430.40
547_D551_G1.6400.40
231_D234_N1.6370.40
126_D447_D1.6360.40
409_D414_T1.6340.40
634_A672_L1.6150.39
143_D146_H1.6080.39
602_D614_K1.6070.39
606_S641_Y1.5980.39
71_P467_R1.5960.39
42_T78_Q1.5920.39
724_E728_S1.5810.38
440_G463_Q1.5770.38
146_H440_G1.5750.38
575_R606_S1.5730.38
729_S733_V1.5720.38
664_A668_A1.5710.38
175_A464_R1.5670.38
54_T269_L1.5670.38
528_D531_G1.5600.37
44_L47_T1.5470.37
71_P75_L1.5380.37
82_F86_A1.5340.36
554_T559_A1.5310.36
702_T720_G1.5290.36
642_T680_V1.5270.36
146_H467_R1.5180.36
576_E598_L1.5120.36
47_T71_P1.5070.35
547_D554_T1.4980.35
547_D550_D1.4970.35
80_A383_A1.4950.35
71_P463_Q1.4790.34
67_L449_V1.4770.34
551_G555_E1.4750.34
550_D556_G1.4750.34
377_T488_A1.4730.34
550_D553_D1.4600.34
541_A562_D1.4550.34
613_R619_F1.4550.34
390_L451_F1.4520.33
602_D612_E1.4520.33
549_S556_G1.4490.33
555_E558_A1.4440.33
373_V450_L1.4350.33
146_H431_L1.4330.33
439_E442_D1.4320.33
663_N666_R1.4280.33
176_S458_A1.4220.32
585_L649_E1.4220.32
144_E376_F1.4200.32
32_R53_V1.4170.32
78_Q466_G1.4150.32
516_T519_G1.4150.32
557_V560_R1.4110.32
35_H173_M1.4000.32
132_I256_D1.3990.32
522_G534_E1.3980.32
206_V442_D1.3970.32
444_P484_T1.3950.31
38_V172_A1.3920.31
113_A116_V1.3910.31
143_D177_P1.3900.31
376_F434_T1.3880.31
521_D524_Q1.3850.31
174_S504_L1.3820.31
618_D635_K1.3760.31
42_T466_G1.3750.31
663_N729_S1.3740.31
549_S559_A1.3720.31
442_D474_G1.3720.31
47_T144_E1.3660.31
527_L532_D1.3660.31
270_Q273_I1.3630.30
41_P469_G1.3580.30
522_G527_L1.3530.30
517_E522_G1.3530.30
42_T416_Q1.3520.30
724_E739_R1.3500.30
450_L674_V1.3440.30
48_T377_T1.3350.29
460_R464_R1.3340.29
702_T706_R1.3310.29
661_H737_T1.3310.29
576_E606_S1.3300.29
488_A492_I1.3280.29
435_S438_E1.3270.29
525_Q534_E1.3190.29
554_T557_V1.3140.29
146_H463_Q1.3080.29
286_V331_L1.3020.28
175_A466_G1.3010.28
714_K727_V1.3010.28
190_N446_V1.3000.28
618_D649_E1.2980.28
520_G536_A1.2970.28
41_P72_T1.2950.28
416_Q443_V1.2950.28
144_E470_R1.2930.28
42_T464_R1.2860.28
557_V561_V1.2820.28
52_L55_A1.2810.28
453_E458_A1.2720.27
530_F534_E1.2720.27
726_V733_V1.2700.27
23_Y40_L1.2680.27
605_V611_V1.2640.27
238_E245_R1.2640.27
71_P144_E1.2620.27
520_G523_A1.2620.27
516_T523_A1.2620.27
552_E555_E1.2600.27
32_R226_I1.2600.27
271_Q733_V1.2590.27
729_S734_G1.2590.27
42_T442_D1.2570.27
553_D557_V1.2550.27
711_H729_S1.2510.27
143_D353_K1.2440.27
516_T521_D1.2440.27
524_Q531_G1.2430.27
532_D535_A1.2400.26
551_G561_V1.2390.26
634_A692_M1.2380.26
43_G143_D1.2340.26
424_R471_Q1.2320.26
217_W377_T1.2310.26
175_A467_R1.2300.26
635_K676_W1.2290.26
691_E695_T1.2290.26
555_E561_V1.2280.26
556_G559_A1.2280.26
724_E735_P1.2260.26
524_Q528_D1.2140.26
570_V573_D1.2130.26
94_V105_D1.2120.26
71_P78_Q1.2120.26
298_E610_A1.2110.26
175_A442_D1.2080.25
157_V383_A1.2070.25
329_Q420_L1.2070.25
722_Q735_P1.2060.25
489_Y496_R1.2050.25
674_V736_V1.2050.25
436_V497_E1.2030.25
33_Q68_L1.2000.25
398_R484_T1.1990.25
606_S700_E1.1990.25
727_V737_T1.1970.25
551_G556_G1.1960.25
426_G464_R1.1910.25
492_I496_R1.1910.25
578_D611_V1.1840.25
522_G526_A1.1810.25
550_D558_A1.1770.25
245_R253_S1.1760.25
553_D561_V1.1740.24
35_H191_L1.1730.24
422_E744_T1.1670.24
174_S401_G1.1640.24
42_T75_L1.1590.24
644_P683_T1.1560.24
24_Q43_G1.1550.24
43_G71_P1.1540.24
245_R688_D1.1530.24
137_V142_F1.1490.24
431_L440_G1.1470.24
524_Q535_A1.1430.24
394_F409_D1.1430.24
549_S552_E1.1430.24
740_S744_T1.1390.23
28_A504_L1.1370.23
525_Q533_A1.1360.23
744_T747_S1.1360.23
142_F377_T1.1360.23
176_S453_E1.1360.23
74_P152_Y1.1340.23
416_Q457_T1.1340.23
127_L648_V1.1320.23
68_L155_T1.1320.23
74_P466_G1.1310.23
435_S486_D1.1290.23
416_Q474_G1.1280.23
576_E613_R1.1220.23
51_L117_V1.1210.23
237_I504_L1.1200.23
466_G474_G1.1200.23
690_T700_E1.1200.23
296_A461_S1.1180.23
357_A450_L1.1180.23
78_Q175_A1.1150.23
86_A372_R1.1130.23
24_Q143_D1.1120.23
503_E506_S1.1090.23
401_G470_R1.1080.23
523_A531_G1.1070.23
439_E474_G1.1050.23
523_A526_A1.1050.23
411_M466_G1.1040.22
144_E177_P1.1040.22
372_R623_L1.1010.22
142_F397_R1.0990.22
155_T158_A1.0990.22
517_E520_G1.0980.22
529_E538_E1.0980.22
31_A424_R1.0940.22
527_L536_A1.0940.22
42_T376_F1.0920.22
170_V478_V1.0890.22
173_M386_L1.0870.22
46_K143_D1.0870.22
47_T463_Q1.0850.22
552_E557_V1.0840.22
174_S467_R1.0830.22
98_T106_R1.0830.22
551_G554_T1.0830.22
21_R24_Q1.0820.22
42_T435_S1.0820.22
240_R734_G1.0820.22
556_G561_V1.0810.22
729_S741_L1.0800.22
177_P376_F1.0760.22
401_G437_A1.0760.22
436_V585_L1.0750.22
105_D421_A1.0730.22
108_A112_D1.0690.22
460_R466_G1.0680.22
447_D465_K1.0650.21
42_T72_T1.0630.21
70_A78_Q1.0630.21
377_T451_F1.0620.21
28_A49_V1.0580.21
376_F401_G1.0570.21
576_E619_F1.0560.21
694_E704_N1.0530.21
377_T383_A1.0520.21
518_L521_D1.0520.21
399_F466_G1.0510.21
240_R289_E1.0510.21
192_G432_V1.0480.21
123_V681_M1.0460.21
576_E622_T1.0460.21
261_D266_R1.0450.21
591_V694_E1.0430.21
566_E591_V1.0370.21
430_V435_S1.0340.21
183_E186_T1.0300.21
42_T49_V1.0300.21
93_D114_R1.0290.20
526_A535_A1.0290.20
576_E620_M1.0290.20
652_G656_A1.0280.20
193_V209_H1.0260.20
175_A474_G1.0230.20
250_T385_A1.0210.20
144_E353_K1.0200.20
515_E523_A1.0200.20
79_H456_P1.0190.20
209_H416_Q1.0190.20
550_D561_V1.0140.20
299_L483_D1.0090.20
371_D433_S1.0080.20
550_D555_E1.0080.20
24_Q144_E1.0080.20
239_D400_V1.0070.20
660_V677_G1.0070.20
701_Q706_R1.0050.20
41_P447_D1.0040.20
56_Y60_D1.0020.20
205_D244_L1.0010.20
361_L677_G0.9980.20
730_I740_S0.9970.20
21_R360_L0.9940.20
722_Q725_Y0.9930.20
71_P145_C0.9920.20
601_G618_D0.9900.20
529_E532_D0.9880.19
706_R732_D0.9880.19
576_E614_K0.9870.19
371_D378_E0.9860.19
175_A416_Q0.9850.19
548_V551_G0.9830.19
141_T173_M0.9830.19
175_A463_Q0.9830.19
46_K144_E0.9800.19
186_T214_D0.9790.19
43_G144_E0.9780.19
697_A734_G0.9760.19
618_D630_I0.9760.19
90_P357_A0.9750.19
434_T474_G0.9730.19
24_Q146_H0.9720.19
143_D376_F0.9720.19
46_K146_H0.9720.19
437_A476_V0.9700.19
435_S442_D0.9700.19
610_A641_Y0.9690.19
548_V557_V0.9680.19
71_P143_D0.9670.19
554_T558_A0.9650.19
64_G99_G0.9620.19
530_F536_A0.9600.19
266_R499_E0.9600.19
694_E732_D0.9590.19
558_A561_V0.9560.19
120_P416_Q0.9550.19
55_A386_L0.9540.19
714_K723_Q0.9530.19
42_T74_P0.9510.19
145_C191_L0.9510.19
637_L640_Q0.9500.19
438_E474_G0.9490.19
517_E527_L0.9490.19
725_Y728_S0.9490.19
304_S419_T0.9440.18
357_A427_D0.9440.18
574_Q595_L0.9420.18
21_R126_D0.9420.18
144_E467_R0.9420.18
431_L434_T0.9410.18
148_A152_Y0.9410.18
257_I489_Y0.9400.18
315_Q379_S0.9390.18
75_L175_A0.9390.18
711_H731_T0.9370.18
673_A692_M0.9340.18
516_T530_F0.9340.18
728_S735_P0.9330.18
733_V747_S0.9330.18
487_E494_R0.9310.18
298_E415_E0.9290.18
533_A537_G0.9270.18
143_D440_G0.9260.18
76_V125_N0.9240.18
434_T470_R0.9220.18
139_H171_T0.9210.18
441_L448_L0.9200.18
220_V476_V0.9170.18
447_D469_G0.9150.18
20_A458_A0.9140.18
99_G147_R0.9120.18
401_G474_G0.9120.18
432_V441_L0.9120.18
697_A738_A0.9120.18
298_E606_S0.9090.18
78_Q464_R0.9080.18
293_L307_S0.9050.17
45_G177_P0.9050.17
516_T538_E0.9020.17
299_L359_M0.9020.17
711_H723_Q0.9010.17
338_K357_A0.9000.17
623_L669_M0.9000.17
263_N266_R0.8990.17
380_R460_R0.8980.17
541_A554_T0.8970.17
113_A117_V0.8960.17
605_V696_I0.8940.17
719_Q723_Q0.8910.17
42_T474_G0.8890.17
439_E466_G0.8880.17
179_G266_R0.8870.17
357_A507_L0.8840.17
43_G292_K0.8840.17
575_R612_E0.8840.17
688_D737_T0.8830.17
339_R343_T0.8820.17
74_P438_E0.8800.17
112_D275_D0.8770.17
24_Q440_G0.8770.17
259_Q295_R0.8770.17
420_L424_R0.8740.17
329_Q610_A0.8710.17
74_P196_V0.8710.17
267_A696_I0.8680.17
227_L593_T0.8660.17
387_T432_V0.8660.17
420_L443_V0.8640.17
82_F711_H0.8630.17
441_L632_E0.8620.17
229_V266_R0.8620.17
683_T692_M0.8620.17
515_E524_Q0.8610.17
364_T378_E0.8610.17
689_T700_E0.8590.16
515_E522_G0.8570.16
142_F383_A0.8560.16
555_E562_D0.8560.16
516_T534_E0.8540.16
682_H695_T0.8520.16
110_W126_D0.8510.16
42_T439_E0.8510.16
334_E622_T0.8510.16
196_V469_G0.8500.16
115_V502_E0.8490.16
525_Q532_D0.8480.16
487_E490_F0.8470.16
548_V555_E0.8470.16
428_F443_V0.8470.16
46_K440_G0.8430.16
160_R583_R0.8420.16
724_E734_G0.8400.16
729_S740_S0.8400.16
70_A244_L0.8370.16
74_P205_D0.8360.16
490_F495_R0.8360.16
541_A549_S0.8360.16
574_Q601_G0.8350.16
47_T401_G0.8340.16
612_E647_V0.8340.16
35_H126_D0.8340.16
78_Q442_D0.8330.16
576_E680_V0.8320.16
72_T447_D0.8320.16
85_E141_T0.8320.16
521_D537_G0.8310.16
433_S482_E0.8310.16
430_V504_L0.8300.16
351_H466_G0.8290.16
77_E265_I0.8250.16
117_V172_A0.8250.16
576_E649_E0.8230.16
68_L83_Y0.8230.16
517_E537_G0.8220.16
174_S463_Q0.8190.16
94_V451_F0.8180.16
45_G75_L0.8180.16
331_L690_T0.8170.16
710_A729_S0.8150.16
678_L684_N0.8150.16
50_S78_Q0.8130.15
120_P148_A0.8100.15
44_L67_L0.8080.15
304_S413_Q0.8080.15
120_P466_G0.8080.15
515_E520_G0.8080.15
692_M702_T0.8070.15
685_G747_S0.8060.15
74_P399_F0.8040.15
49_V85_E0.8030.15
275_D681_M0.8020.15
335_P343_T0.8020.15
616_H661_H0.8010.15
172_A429_E0.7990.15
176_S376_F0.7990.15
71_P437_A0.7980.15
123_V493_S0.7980.15
522_G528_D0.7970.15
268_R747_S0.7960.15
24_Q376_F0.7950.15
728_S739_R0.7940.15
74_P98_T0.7930.15
519_G525_Q0.7930.15
479_L484_T0.7920.15
237_I300_V0.7920.15
439_E462_V0.7880.15
570_V619_F0.7880.15
78_Q380_R0.7860.15
74_P456_P0.7850.15
124_E450_L0.7840.15
37_L396_T0.7830.15
683_T729_S0.7830.15
177_P470_R0.7830.15
144_E401_G0.7830.15
142_F184_I0.7820.15
602_D619_F0.7810.15
78_Q439_E0.7800.15
97_F730_I0.7780.15
372_R739_R0.7770.15
202_D472_T0.7760.15
704_N722_Q0.7750.15
611_V623_L0.7750.15
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90_P615_S0.7750.15
125_N441_L0.7720.15
521_D528_D0.7710.15
41_P187_V0.7700.15
552_E558_A0.7690.15
383_A502_E0.7650.15
380_R466_G0.7640.14
640_Q646_L0.7630.14
173_M372_R0.7630.14
551_G559_A0.7620.14
326_K330_R0.7620.14
248_G256_D0.7620.14
662_P667_S0.7620.14
43_G476_V0.7620.14
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147_R174_S0.7590.14
144_E440_G0.7580.14
645_V696_I0.7580.14
495_R499_E0.7570.14
711_H717_K0.7570.14
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606_S613_R0.7550.14
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286_V677_G0.7490.14
547_D552_E0.7460.14
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70_A74_P0.7450.14
83_Y480_L0.7450.14
515_E521_D0.7430.14
534_E539_E0.7430.14
127_L233_I0.7400.14
23_Y42_T0.7400.14
98_T460_R0.7400.14
666_R670_A0.7390.14
573_D576_E0.7380.14
725_Y737_T0.7380.14
410_G414_T0.7380.14
444_P449_V0.7380.14
142_F217_W0.7370.14
226_I447_D0.7370.14
49_V86_A0.7370.14
42_T411_M0.7350.14
76_V95_V0.7350.14
143_D467_R0.7350.14
233_I241_L0.7340.14
434_T452_F0.7330.14
549_S554_T0.7320.14
177_P353_K0.7310.14
60_D233_I0.7300.14
434_T449_V0.7290.14
523_A534_E0.7290.14
450_L709_S0.7290.14
360_L477_V0.7270.14
707_A719_Q0.7250.14
721_E741_L0.7250.14
353_K401_G0.7250.14
612_E618_D0.7240.14
71_P470_R0.7240.14
75_L439_E0.7230.14
526_A532_D0.7230.14
434_T439_E0.7220.14
568_V591_V0.7210.14
31_A53_V0.7210.14
42_T45_G0.7200.14
269_L340_A0.7190.14
67_L423_F0.7190.14
130_G312_F0.7180.14
674_V704_N0.7170.14
424_R478_V0.7160.14
119_T436_V0.7150.14
605_V642_T0.7150.14
376_F440_G0.7150.14
205_D222_L0.7140.14
435_S444_P0.7130.14
552_E556_G0.7120.14
717_K729_S0.7110.13
671_S676_W0.7110.13
175_A460_R0.7090.13
709_S717_K0.7080.13
38_V41_P0.7070.13
529_E533_A0.7070.13
624_L637_L0.7070.13
75_L442_D0.7060.13
28_A53_V0.7050.13
162_H504_L0.7040.13
45_G353_K0.7030.13
670_A686_E0.7020.13
516_T522_G0.7020.13
631_F641_Y0.7000.13
669_M680_V0.7000.13
377_T452_F0.7000.13
202_D446_V0.6990.13
399_F442_D0.6990.13
554_T560_R0.6990.13
171_T490_F0.6990.13
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329_Q332_V0.6970.13
126_D191_L0.6960.13
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410_G413_Q0.6940.13
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597_T619_F0.6940.13
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553_D558_A0.6930.13
224_E553_D0.6920.13
229_V493_S0.6920.13
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536_A564_A0.6890.13
464_R474_G0.6870.13
265_I734_G0.6860.13
598_L606_S0.6850.13
238_E294_K0.6850.13
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116_V394_F0.6830.13
612_E643_R0.6820.13
250_T253_S0.6820.13
432_V627_E0.6820.13
606_S649_E0.6810.13
27_L472_T0.6790.13
707_A710_A0.6790.13
515_E526_A0.6780.13
186_T457_T0.6770.13
525_Q530_F0.6740.13
99_G191_L0.6740.13
532_D541_A0.6740.13
70_A417_R0.6730.13
145_C496_R0.6730.13
644_P650_G0.6730.13
172_A477_V0.6720.13
572_V630_I0.6700.13
45_G401_G0.6680.13
585_L613_R0.6680.13
176_S454_P0.6670.13
351_H399_F0.6640.13
75_L376_F0.6640.13
676_W726_V0.6630.13
177_P467_R0.6620.13
160_R330_R0.6610.13
72_T126_D0.6610.13
145_C467_R0.6610.13
399_F439_E0.6600.13
520_G530_F0.6590.13
317_N733_V0.6550.12
171_T375_V0.6550.12
263_N287_H0.6540.12
413_Q441_L0.6540.12
216_Q447_D0.6530.12
540_P563_G0.6530.12
315_Q318_A0.6530.12
220_V234_N0.6510.12
734_G740_S0.6510.12
548_V558_A0.6510.12
448_L468_T0.6490.12
489_Y492_I0.6490.12
78_Q460_R0.6490.12
171_T191_L0.6470.12
720_G740_S0.6460.12
531_G540_P0.6460.12
49_V148_A0.6450.12
41_P172_A0.6440.12
249_V450_L0.6440.12
378_E408_S0.6430.12
166_A329_Q0.6430.12
30_A195_N0.6420.12
548_V553_D0.6420.12
279_D282_Q0.6420.12
579_S614_K0.6410.12
697_A700_E0.6410.12
427_D450_L0.6410.12
548_V562_D0.6400.12
50_S75_L0.6390.12
518_L524_Q0.6390.12
401_G434_T0.6390.12
32_R458_A0.6380.12
351_H460_R0.6380.12
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326_K334_E0.6350.12
689_T693_I0.6350.12
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251_K386_L0.6340.12
573_D619_F0.6340.12
447_D493_S0.6330.12
263_N496_R0.6330.12
434_T467_R0.6330.12
206_V416_Q0.6330.12
121_Q460_R0.6330.12
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132_I157_V0.6310.12
98_T438_E0.6300.12
707_A739_R0.6300.12
79_H176_S0.6290.12
528_D533_A0.6290.12
721_E736_V0.6290.12
529_E565_G0.6290.12
711_H734_G0.6270.12
24_Q71_P0.6260.12
436_V442_D0.6260.12
384_E398_R0.6250.12
35_H379_S0.6240.12
527_L534_E0.6240.12
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175_A376_F0.6200.12
437_A472_T0.6200.12
75_L121_Q0.6200.12
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515_E525_Q0.6180.12
463_Q496_R0.6180.12
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118_A446_V0.6160.12
547_D555_E0.6160.12
286_V452_F0.6150.12
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298_E647_V0.6120.12
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51_L325_S0.6100.12
519_G530_F0.6100.12
80_A84_R0.6090.12
122_V125_N0.6090.12
276_D476_V0.6080.12
143_D401_G0.6080.12
369_D433_S0.6070.12
116_V594_R0.6070.12
48_T173_M0.6060.12
75_L401_G0.6060.12
187_V469_G0.6060.12
35_H190_N0.6060.12
96_V292_K0.6050.12
675_D679_S0.6050.12
215_V496_R0.6040.12
236_V243_K0.6040.12
454_P493_S0.6040.12
678_L682_H0.6030.12
42_T456_P0.6020.12
233_I376_F0.6020.12
257_I337_V0.6010.12
602_D613_R0.6010.12
71_P440_G0.5990.12
163_A293_L0.5950.11
66_A139_H0.5930.11
538_E566_E0.5920.11
421_A605_V0.5920.11
74_P121_Q0.5910.11
280_G283_G0.5910.11
172_A746_G0.5900.11
662_P673_A0.5900.11
437_A457_T0.5900.11
523_A536_A0.5890.11
491_W507_L0.5880.11
116_V362_A0.5880.11
711_H735_P0.5880.11
60_D83_Y0.5870.11
48_T419_T0.5860.11
531_G548_V0.5860.11
21_R110_W0.5850.11
638_A679_S0.5850.11
150_G399_F0.5850.11
620_M657_E0.5850.11
263_N492_I0.5840.11
71_P74_P0.5840.11
144_E463_Q0.5820.11
694_E746_G0.5820.11
526_A562_D0.5820.11
259_Q606_S0.5820.11
525_Q538_E0.5820.11
411_M438_E0.5810.11
172_A469_G0.5810.11
463_Q474_G0.5800.11
44_L71_P0.5800.11
142_F148_A0.5790.11
95_V293_L0.5790.11
463_Q466_G0.5780.11
438_E466_G0.5780.11
517_E524_Q0.5770.11
175_A399_F0.5750.11
296_A360_L0.5750.11
145_C463_Q0.5750.11
661_H666_R0.5740.11
581_I589_D0.5730.11
701_Q704_N0.5730.11
172_A336_A0.5730.11
290_V296_A0.5720.11
718_T736_V0.5710.11
75_L436_V0.5700.11
442_D456_P0.5680.11
380_R413_Q0.5680.11
517_E528_D0.5670.11
107_R115_V0.5660.11
178_G414_T0.5660.11
521_D527_L0.5660.11
416_Q466_G0.5660.11
329_Q643_R0.5630.11
637_L647_V0.5620.11
436_V456_P0.5600.11
651_D657_E0.5600.11
661_H714_K0.5590.11
96_V709_S0.5580.11
416_Q444_P0.5580.11
438_E444_P0.5570.11
667_S676_W0.5570.11
290_V740_S0.5560.11
657_E661_H0.5560.11
719_Q722_Q0.5560.11
494_R501_T0.5540.11
51_L57_R0.5530.11
256_D599_A0.5530.11
467_R496_R0.5510.11
658_R666_R0.5510.11
175_A206_V0.5500.11
178_G474_G0.5500.11
416_Q456_P0.5500.11
616_H623_L0.5490.11
206_V438_E0.5490.11
78_Q98_T0.5490.11
517_E530_F0.5490.11
724_E740_S0.5490.11
666_R673_A0.5490.11
23_Y126_D0.5480.11
573_D649_E0.5480.11
38_V72_T0.5480.11
193_V304_S0.5470.11
255_P476_V0.5470.11
618_D644_P0.5460.11
415_E418_E0.5430.11
706_R747_S0.5430.11
670_A703_T0.5430.11
185_R228_E0.5430.11
307_S318_A0.5420.11
696_I704_N0.5420.11
133_D138_V0.5410.11
156_Y382_T0.5400.11
707_A726_V0.5400.11
435_S500_M0.5400.11
424_R508_K0.5400.11
531_G536_A0.5400.11
333_S498_Q0.5390.11
728_S731_T0.5380.11
607_D706_R0.5380.11
196_V436_V0.5370.11
45_G440_G0.5370.11
551_G560_R0.5350.11
74_P469_G0.5350.11
55_A240_R0.5350.11
42_T206_V0.5340.11
724_E737_T0.5340.11
524_Q530_F0.5340.11
184_I372_R0.5330.11
49_V68_L0.5330.11
573_D612_E0.5330.11
589_D637_L0.5320.11
707_A718_T0.5320.11
520_G528_D0.5320.11
706_R731_T0.5310.11
215_V428_F0.5300.10
731_T737_T0.5290.10
556_G560_R0.5290.10
524_Q534_E0.5280.10
75_L430_V0.5270.10
646_L672_L0.5270.10
23_Y64_G0.5260.10
259_Q266_R0.5260.10
519_G531_G0.5260.10
704_N737_T0.5260.10
549_S560_R0.5250.10
177_P440_G0.5250.10
181_E228_E0.5240.10
612_E689_T0.5240.10
229_V736_V0.5240.10
411_M419_T0.5240.10
490_F621_D0.5240.10
176_S444_P0.5230.10
550_D559_A0.5230.10
174_S194_G0.5220.10
175_A435_S0.5220.10
273_I282_Q0.5220.10
40_L43_G0.5220.10
439_E460_R0.5210.10
722_Q732_D0.5210.10
434_T463_Q0.5210.10
70_A190_N0.5200.10
369_D482_E0.5190.10
75_L177_P0.5190.10
79_H444_P0.5190.10
121_Q399_F0.5190.10
178_G410_G0.5180.10
442_D457_T0.5180.10
459_I497_E0.5180.10
375_V665_V0.5180.10
235_D238_E0.5170.10
526_A539_E0.5170.10
526_A538_E0.5170.10
717_K736_V0.5170.10
601_G649_E0.5170.10
259_Q298_E0.5160.10
519_G527_L0.5160.10
184_I485_R0.5140.10
674_V677_G0.5140.10
531_G537_G0.5130.10
443_V457_T0.5130.10
75_L98_T0.5130.10
74_P150_G0.5120.10
367_I373_V0.5120.10
35_H457_T0.5110.10
118_A139_H0.5110.10
292_K318_A0.5110.10
178_G468_T0.5110.10
289_E734_G0.5100.10
54_T145_C0.5100.10
172_A454_P0.5090.10
295_R304_S0.5090.10
434_T440_G0.5080.10
242_A357_A0.5070.10
218_E605_V0.5070.10
535_A570_V0.5060.10
143_D470_R0.5060.10
612_E637_L0.5060.10
181_E336_A0.5050.10
118_A443_V0.5050.10
337_V605_V0.5050.10
527_L554_T0.5040.10
664_A667_S0.5040.10
353_K440_G0.5040.10
734_G744_T0.5010.10
42_T71_P0.5010.10
608_R611_V0.5010.10
173_M300_V0.5010.10
367_I529_E0.5010.10
523_A528_D0.5010.10
36_T190_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.6378 100 0.639 Contact Map
1wp9A 1 0.6084 100 0.647 Contact Map
1z63A 1 0.5651 100 0.663 Contact Map
1z3iX 4 0.7181 100 0.665 Contact Map
4a2pA 1 0.5599 100 0.694 Contact Map
4a2qA 1 0.5702 100 0.696 Contact Map
4a2wA 1 0.574 100 0.699 Contact Map
3tbkA 1 0.6148 100 0.702 Contact Map
2ykgA 1 0.7462 100 0.703 Contact Map
4gl2A 1 0.7117 100 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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