GREMLIN Database
Q9HMW3 - Oligopeptide ABC permease
UniProt: Q9HMW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (301)
Sequences: 19142 (12317)
Seq/√Len: 710.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_V69_R3.2291.00
64_K72_N3.2141.00
64_K68_E3.2011.00
75_T79_T2.7531.00
71_V75_T2.7471.00
213_A240_V2.6301.00
58_E63_D2.6221.00
50_Q54_E2.6121.00
20_L70_Y2.6001.00
109_P194_S2.4311.00
226_K232_Q2.3891.00
102_Y273_I2.3831.00
234_R238_H2.3451.00
33_T57_R2.2981.00
278_L282_T2.2861.00
21_T70_Y2.2361.00
222_V240_V2.2231.00
216_Q221_F2.1991.00
67_T71_V2.0831.00
216_Q219_Q2.0741.00
3_W7_K2.0471.00
253_V310_E2.0361.00
95_A279_M2.0221.00
91_S94_A2.0191.00
121_L137_G2.0131.00
231_S234_R1.9821.00
53_R57_R1.9361.00
217_M240_V1.9161.00
88_R95_A1.9061.00
19_A300_V1.9001.00
167_I188_T1.8961.00
233_W237_I1.8941.00
49_A52_C1.8891.00
52_C55_Q1.8531.00
113_V198_L1.8491.00
134_D210_R1.8471.00
68_E72_N1.8261.00
116_I120_G1.8241.00
55_Q59_R1.8031.00
54_E57_R1.7721.00
167_I191_L1.7561.00
161_G169_T1.7531.00
90_Q94_A1.7451.00
249_T317_L1.7191.00
128_K131_T1.7091.00
54_E58_E1.6871.00
222_V235_L1.6671.00
132_K136_L1.6501.00
76_N81_N1.6491.00
230_A234_R1.6481.00
93_M97_S1.6411.00
92_V294_A1.6401.00
124_Y128_K1.6361.00
172_Q273_I1.6291.00
16_M301_F1.6141.00
224_V228_K1.6101.00
126_A213_A1.5781.00
128_K133_A1.5641.00
117_L120_G1.5451.00
127_Y236_M1.5431.00
133_A137_G1.5381.00
72_N75_T1.5361.00
313_S316_I1.5231.00
158_I163_H1.5101.00
123_L213_A1.5061.00
124_Y133_A1.4901.00
280_T295_T1.4801.00
250_T314_Y1.4791.00
105_Q172_Q1.4751.00
10_L14_V1.4611.00
156_L196_V1.4451.00
216_Q244_A1.4431.00
90_Q98_E1.4351.00
194_S198_L1.4231.00
221_F243_M1.4211.00
77_M82_W1.4201.00
220_E223_K1.4171.00
151_W155_V1.4161.00
102_Y172_Q1.4131.00
117_L202_L1.4111.00
114_S201_S1.4031.00
12_T304_I1.3981.00
186_N189_Q1.3871.00
216_Q222_V1.3821.00
17_W70_Y1.3801.00
56_Y60_Q1.3781.00
64_K67_T1.3661.00
68_E71_V1.3641.00
72_N76_N1.3601.00
17_W21_T1.3601.00
228_K239_H1.3361.00
159_L163_H1.3321.00
65_P68_E1.3221.00
283_A291_L1.3171.00
115_T252_F1.3121.00
61_N64_K1.3101.00
198_L202_L1.3011.00
130_Y134_D1.2971.00
159_L164_F1.2901.00
95_A291_L1.2841.00
56_Y59_R1.2811.00
279_M291_L1.2781.00
122_G126_A1.2671.00
118_G209_S1.2611.00
6_V10_L1.2551.00
118_G205_Q1.2511.00
82_W294_A1.2411.00
82_W93_M1.2291.00
111_L252_F1.2251.00
209_S248_L1.2211.00
90_Q95_A1.2201.00
127_Y232_Q1.2191.00
246_V314_Y1.2141.00
98_E101_P1.2131.00
216_Q240_V1.2091.00
210_R214_I1.1951.00
122_G209_S1.1951.00
36_T53_R1.1881.00
105_Q186_N1.1801.00
20_L73_Y1.1791.00
33_T36_T1.1791.00
84_W91_S1.1781.00
205_Q255_S1.1591.00
185_A188_T1.1531.00
105_Q109_P1.1521.00
102_Y105_Q1.1511.00
126_A217_M1.1461.00
208_Y251_S1.1441.00
105_Q190_L1.1361.00
144_G203_A1.1361.00
147_I152_F1.1361.00
295_T299_T1.1351.00
55_Q58_E1.1281.00
160_L164_F1.1271.00
185_A189_Q1.1231.00
137_G206_M1.1201.00
187_I191_L1.1051.00
281_F285_T1.0971.00
12_T308_L1.0921.00
21_T25_G1.0901.00
312_V316_I1.0881.00
125_S137_G1.0841.00
172_Q186_N1.0711.00
132_K135_Y1.0681.00
36_T39_V1.0641.00
5_I312_V1.0621.00
121_L206_M1.0621.00
306_G310_E1.0591.00
155_V159_L1.0591.00
126_A214_I1.0471.00
257_L306_G1.0331.00
61_N72_N1.0311.00
149_N267_I1.0291.00
97_S101_P1.0251.00
196_V200_A1.0231.00
25_G28_V1.0231.00
94_A98_E1.0221.00
95_A98_E1.0211.00
85_S288_D1.0181.00
9_V308_L1.0151.00
16_M304_I1.0091.00
156_L192_I1.0091.00
17_W74_V1.0071.00
51_Q55_Q1.0061.00
258_A303_A0.9941.00
76_N79_T0.9871.00
141_G206_M0.9851.00
28_V66_I0.9851.00
225_A235_L0.9821.00
232_Q235_L0.9741.00
14_V17_W0.9711.00
110_V198_L0.9681.00
32_D287_Q0.9641.00
4_Y315_T0.9591.00
94_A97_S0.9581.00
18_I22_L0.9551.00
191_L195_F0.9521.00
128_K232_Q0.9511.00
21_T66_I0.9471.00
190_L194_S0.9451.00
129_P218_N0.9441.00
282_T286_E0.9441.00
167_I192_I0.9421.00
153_A196_V0.9401.00
213_A244_A0.9341.00
58_E64_K0.9341.00
134_D214_I0.9321.00
309_I313_S0.9311.00
225_A230_A0.9281.00
107_A260_F0.9251.00
36_T40_M0.9251.00
130_Y135_Y0.9231.00
113_V194_S0.9191.00
78_A81_N0.9171.00
87_S286_E0.9111.00
209_S213_A0.9101.00
230_A235_L0.9061.00
280_T283_A0.9061.00
120_G123_L0.9051.00
84_W89_S0.9011.00
138_S206_M0.8971.00
40_M56_Y0.8971.00
37_K53_R0.8961.00
36_T41_S0.8951.00
99_A279_M0.8951.00
70_Y74_V0.8911.00
20_L297_M0.8891.00
249_T310_E0.8881.00
123_L236_M0.8851.00
108_I112_V0.8841.00
244_A247_P0.8751.00
108_I257_L0.8751.00
235_L240_V0.8731.00
111_L257_L0.8661.00
75_T78_A0.8651.00
279_M283_A0.8651.00
118_G122_G0.8611.00
51_Q54_E0.8601.00
315_T321_I0.8601.00
28_V289_T0.8601.00
105_Q108_I0.8591.00
226_K235_L0.8571.00
234_R237_I0.8561.00
140_V144_G0.8551.00
77_M297_M0.8541.00
25_G66_I0.8501.00
71_V74_V0.8501.00
195_F198_L0.8461.00
86_E290_T0.8421.00
160_L167_I0.8411.00
96_I294_A0.8401.00
136_L140_V0.8401.00
237_I240_V0.8311.00
103_T107_A0.8301.00
127_Y237_I0.8231.00
305_I309_I0.8211.00
50_Q53_R0.8181.00
122_G213_A0.8161.00
73_Y77_M0.8151.00
110_V197_L0.8141.00
120_G124_Y0.8121.00
314_Y321_I0.8121.00
172_Q185_A0.8111.00
135_Y138_S0.8071.00
202_L206_M0.8061.00
119_Y209_S0.8021.00
289_T293_L0.7991.00
160_L166_F0.7971.00
118_G206_M0.7971.00
153_A270_I0.7961.00
269_Q278_L0.7951.00
109_P273_I0.7891.00
121_L202_L0.7871.00
23_T296_T0.7861.00
264_S267_I0.7841.00
13_F17_W0.7771.00
110_V114_S0.7741.00
225_A239_H0.7741.00
129_P214_I0.7721.00
152_F199_T0.7711.00
119_Y248_L0.7701.00
282_T285_T0.7661.00
212_Q216_Q0.7621.00
133_A136_L0.7601.00
106_Y194_S0.7601.00
312_V315_T0.7571.00
212_Q244_A0.7561.00
115_T120_G0.7521.00
33_T37_K0.7491.00
163_H166_F0.7461.00
104_A108_I0.7461.00
117_L121_L0.7431.00
301_F305_I0.7411.00
96_I295_T0.7401.00
85_S90_Q0.7391.00
172_Q190_L0.7381.00
269_Q281_F0.7361.00
196_V267_I0.7341.00
149_N199_T0.7311.00
52_C56_Y0.7291.00
75_T80_L0.7251.00
74_V77_M0.7251.00
160_L192_I0.7231.00
191_L194_S0.7231.00
293_L296_T0.7211.00
201_S204_W0.7201.00
21_T67_T0.7191.00
315_T322_D0.7171.00
101_P104_A0.7161.00
123_L241_F0.7161.00
114_S198_L0.7131.00
74_V78_A0.7111.00
215_E219_Q0.7081.00
303_A307_N0.7021.00
144_G199_T0.7011.00
158_I162_T0.7001.00
171_Y189_Q0.6981.00
209_S212_Q0.6961.00
279_M295_T0.6911.00
232_Q236_M0.6911.00
209_S244_A0.6901.00
15_V304_I0.6891.00
117_L198_L0.6881.00
274_P278_L0.6861.00
157_I169_T0.6811.00
280_T299_T0.6791.00
170_Y272_S0.6781.00
209_S241_F0.6771.00
24_F28_V0.6741.00
14_V18_I0.6711.00
145_I203_A0.6711.00
92_V291_L0.6671.00
187_I190_L0.6651.00
225_A228_K0.6651.00
101_P105_Q0.6601.00
280_T284_I0.6571.00
54_E63_D0.6561.00
249_T313_S0.6501.00
168_S171_Y0.6471.00
36_T57_R0.6451.00
136_L139_F0.6441.00
137_G141_G0.6441.00
57_R63_D0.6441.00
38_S41_S0.6431.00
141_G203_A0.6431.00
109_P187_I0.6421.00
283_A292_V0.6411.00
23_T27_L0.6401.00
23_T28_V0.6391.00
198_L201_S0.6381.00
9_V13_F0.6371.00
100_W104_A0.6371.00
139_F143_F0.6361.00
299_T303_A0.6361.00
37_K41_S0.6301.00
95_A99_A0.6291.00
66_I69_R0.6281.00
97_S100_W0.6271.00
292_V296_T0.6251.00
223_K226_K0.6241.00
92_V279_M0.6231.00
99_A278_L0.6231.00
258_A302_L0.6231.00
10_L312_V0.6221.00
281_F284_I0.6221.00
109_P191_L0.6211.00
294_A298_I0.6191.00
147_I151_W0.6191.00
188_T191_L0.6181.00
265_V281_F0.6161.00
25_G29_A0.6151.00
269_Q282_T0.6131.00
212_Q215_E0.6111.00
156_L195_F0.6111.00
8_R311_D0.6091.00
107_A257_L0.6081.00
125_S134_D0.6071.00
27_L292_V0.6051.00
20_L74_V0.6041.00
149_N152_F0.6011.00
68_E75_T0.6001.00
310_E314_Y0.6001.00
28_V293_L0.6001.00
134_D138_S0.6001.00
204_W251_S0.5991.00
85_S88_R0.5961.00
230_A239_H0.5961.00
109_P113_V0.5961.00
203_A206_M0.5941.00
139_F142_F0.5941.00
164_F167_I0.5941.00
253_V306_G0.5901.00
293_L297_M0.5861.00
246_V321_I0.5861.00
204_W255_S0.5851.00
314_Y318_D0.5851.00
151_W154_L0.5841.00
115_T205_Q0.5811.00
302_L306_G0.5781.00
116_I119_Y0.5731.00
221_F225_A0.5731.00
251_S255_S0.5721.00
131_T134_D0.5711.00
265_V269_Q0.5691.00
205_Q251_S0.5681.00
319_P322_D0.5651.00
4_Y308_L0.5641.00
39_V56_Y0.5641.00
255_S259_I0.5631.00
245_A249_T0.5621.00
131_T135_Y0.5611.00
187_I194_S0.5601.00
205_Q209_S0.5581.00
57_R62_L0.5571.00
236_M240_V0.5551.00
88_R291_L0.5521.00
258_A306_G0.5511.00
291_L295_T0.5501.00
161_G192_I0.5501.00
245_A248_L0.5501.00
128_K134_D0.5491.00
205_Q248_L0.5491.00
125_S138_S0.5471.00
111_L115_T0.5471.00
27_L30_S0.5471.00
7_K11_W0.5451.00
105_Q273_I0.5431.00
149_N200_A0.5421.00
113_V195_F0.5421.00
112_V116_I0.5381.00
34_G289_T0.5351.00
109_P112_V0.5351.00
109_P190_L0.5351.00
127_Y217_M0.5341.00
192_I196_V0.5341.00
204_W208_Y0.5331.00
168_S189_Q0.5331.00
300_V304_I0.5321.00
37_K40_M0.5311.00
59_R89_S0.5291.00
7_K10_L0.5281.00
208_Y212_Q0.5261.00
107_A264_S0.5251.00
308_L312_V0.5231.00
80_L84_W0.5221.00
237_I242_R0.5221.00
149_N153_A0.5211.00
304_I307_N0.5211.00
231_S235_L0.5211.00
223_K227_A0.5201.00
123_L237_I0.5191.00
233_W236_M0.5191.00
96_I276_L0.5191.00
70_Y73_Y0.5171.00
161_G165_E0.5161.00
23_T30_S0.5151.00
66_I70_Y0.5141.00
107_A111_L0.5121.00
125_S210_R0.5111.00
106_Y268_E0.5080.99
290_T293_L0.5070.99
222_V226_K0.5070.99
230_A233_W0.5060.99
197_L264_S0.5060.99
141_G144_G0.5060.99
11_W14_V0.5060.99
135_Y139_F0.5050.99
200_A203_A0.5040.99
103_T268_E0.5040.99
8_R11_W0.5030.99
237_I241_F0.5010.99
131_T136_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6411 99.9 0.661 Contact Map
4tquM 1 0.8252 99.9 0.682 Contact Map
3rlfF 1 0.8374 99.9 0.686 Contact Map
4ymuD 2 0.6442 99.8 0.695 Contact Map
2onkC 2 0.7454 99.8 0.703 Contact Map
3d31C 2 0.7577 99.8 0.707 Contact Map
4tquN 1 0.7853 99.7 0.726 Contact Map
3rlfG 1 0.8067 99.7 0.736 Contact Map
1q16C 2 0.3681 13.3 0.959 Contact Map
2yevC 1 0.0951 4.9 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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