GREMLIN Database
Q9HMW2 - Oligopeptide transport permease protein
UniProt: Q9HMW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (292)
Sequences: 2585 (1819)
Seq/√Len: 106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_V215_L6.0261.00
158_L171_V4.8751.00
94_W98_K4.4101.00
331_W359_T3.8781.00
282_A286_Y3.7241.00
203_A284_M3.6641.00
97_F366_V3.2031.00
214_L218_Y2.9981.00
315_E330_S2.9411.00
161_S165_Q2.9311.00
115_V119_L2.9281.00
175_M331_W2.9261.00
127_P130_Q2.8841.00
117_G175_M2.8181.00
158_L351_I2.7291.00
154_W157_P2.6421.00
116_V172_V2.5301.00
167_I334_T2.4871.00
108_G112_V2.4831.00
124_I169_T2.4811.00
158_L168_L2.2881.00
265_A292_L2.2131.00
98_K104_V2.1991.00
119_L122_L2.1911.00
188_F250_G2.0851.00
168_L172_V2.0791.00
103_A369_S2.0631.00
184_I246_I2.0601.00
201_A265_A2.0491.00
202_F284_M2.0461.00
198_A265_A1.9941.00
109_W358_L1.9891.00
217_R220_D1.9611.00
208_R212_D1.9021.00
331_W355_F1.9011.00
371_R375_D1.8961.00
268_R292_L1.8521.00
277_A291_H1.8431.00
212_D262_R1.8001.00
200_A216_M1.7941.00
210_R214_L1.7901.00
89_L93_Y1.7861.00
156_Y166_G1.7661.00
107_L111_A1.7641.00
274_I292_L1.7591.00
88_R91_A1.7271.00
268_R273_Y1.7241.00
87_P91_A1.7141.00
106_A362_S1.6571.00
105_V108_G1.6381.00
216_M220_D1.6291.00
203_A211_I1.6271.00
167_I348_I1.6191.00
350_T354_V1.6141.00
277_A287_I1.6091.00
283_N286_Y1.5901.00
171_V355_F1.5891.00
227_D231_L1.5321.00
185_A311_F1.5301.00
278_E284_M1.4391.00
216_M258_A1.4231.00
149_V152_G1.4181.00
107_L366_V1.4081.00
124_I172_V1.4041.00
153_T156_Y1.4021.00
90_R374_M1.4001.00
104_V108_G1.3881.00
120_G123_L1.3851.00
150_K153_T1.3731.00
120_G173_Y1.3731.00
272_E275_T1.3681.00
182_G312_I1.3591.00
120_G124_I1.3571.00
173_Y176_R1.3531.00
180_E246_I1.3350.99
265_A296_S1.3240.99
113_M359_T1.3220.99
309_P363_F1.3070.99
346_W350_T1.3050.99
285_L289_R1.3000.99
185_A250_G1.2990.99
249_F253_S1.2950.99
267_Q271_E1.2940.99
109_W362_S1.2880.99
198_A288_V1.2860.99
296_S299_S1.2820.99
331_W334_T1.2800.99
216_M219_V1.2650.99
210_R213_E1.2420.99
106_A365_Y1.2310.99
264_E267_Q1.2300.99
257_I307_G1.2230.99
275_T279_A1.2130.99
110_L363_F1.2070.99
305_T367_G1.2020.99
198_A293_I1.1960.99
302_I305_T1.1950.99
147_G152_G1.1930.99
90_R94_W1.1910.99
175_M359_T1.1790.99
94_W107_L1.1770.99
123_L168_L1.1750.99
200_A215_L1.1700.99
105_V109_W1.1580.98
335_I338_G1.1560.98
195_A289_R1.1470.98
121_P176_R1.1420.98
125_D169_T1.1390.98
351_I354_V1.1380.98
368_E372_D1.1380.98
100_N103_A1.1370.98
102_V106_A1.1310.98
278_E287_I1.1170.98
189_S307_G1.1030.98
196_V258_A1.0990.98
102_V365_Y1.0960.98
249_F314_G1.0930.98
156_Y160_T1.0920.98
165_Q170_L1.0890.98
215_L219_V1.0790.98
219_V258_A1.0670.97
202_F287_I1.0620.97
246_I250_G1.0610.97
152_G155_Q1.0570.97
91_A95_R1.0570.97
317_S321_L1.0520.97
200_A259_R1.0460.97
110_L362_S1.0450.97
227_D230_L1.0370.97
354_V358_L1.0360.97
203_A288_V1.0350.97
180_E184_I1.0340.97
353_G356_L1.0330.97
166_G169_T1.0330.97
106_A369_S1.0280.97
338_G348_I1.0280.97
111_A114_F1.0230.97
218_Y222_Q1.0050.96
75_I78_H1.0030.96
202_F288_V0.9940.96
248_L252_F0.9920.96
342_L350_T0.9890.96
196_V199_V0.9880.96
198_A296_S0.9870.96
327_T375_D0.9820.96
142_S145_V0.9800.96
201_A269_A0.9740.96
153_T157_P0.9720.96
309_P360_V0.9710.96
147_G150_K0.9700.95
178_S182_G0.9700.95
192_I195_A0.9700.95
355_F359_T0.9700.95
241_E244_M0.9650.95
78_H81_I0.9600.95
113_M358_L0.9560.95
216_M266_L0.9540.95
79_A82_P0.9520.95
126_P132_T0.9470.95
95_R98_K0.9440.95
97_F104_V0.9420.95
114_F118_V0.9400.95
90_R93_Y0.9330.94
87_P95_R0.9290.94
277_A282_A0.9200.94
256_G310_G0.9170.94
222_Q255_E0.9170.94
178_S315_E0.9090.94
253_S314_G0.9090.94
223_S255_E0.9070.94
189_S253_S0.9070.94
132_T156_Y0.8930.93
108_G111_A0.8910.93
100_N369_S0.8900.93
243_W246_I0.8890.93
217_R266_L0.8850.93
199_V203_A0.8840.93
368_E371_R0.8750.92
338_G349_A0.8720.92
145_V150_K0.8680.92
342_L345_A0.8640.92
220_D266_L0.8560.91
190_V304_A0.8510.91
268_R271_E0.8490.91
101_Q104_V0.8480.91
171_V334_T0.8470.91
364_Y368_E0.8450.91
254_W330_S0.8420.91
320_F339_Q0.8400.91
145_V148_V0.8390.91
167_I351_I0.8380.91
213_E217_R0.8370.91
151_T347_W0.8350.90
104_V107_L0.8350.90
199_V215_L0.8350.90
170_L327_T0.8290.90
256_G303_S0.8280.90
157_P168_L0.8260.90
97_F365_Y0.8230.90
220_D223_S0.8210.90
313_L353_G0.8210.90
230_L252_F0.8200.90
342_L346_W0.8180.89
112_V116_V0.8160.89
216_M259_R0.8160.89
260_T299_S0.8140.89
257_I303_S0.8120.89
264_E299_S0.8100.89
192_I254_W0.8080.89
243_W247_L0.8030.89
130_Q133_N0.8030.89
244_M248_L0.8010.88
163_K366_V0.7960.88
111_A115_V0.7910.88
333_R337_T0.7870.88
286_Y289_R0.7840.87
211_I214_L0.7810.87
119_L176_R0.7800.87
74_A77_F0.7780.87
240_S244_M0.7780.87
97_F103_A0.7760.87
286_Y290_Q0.7760.87
273_Y295_N0.7750.87
126_P156_Y0.7720.87
129_T133_N0.7690.86
115_V123_L0.7660.86
329_Y333_R0.7660.86
114_F183_L0.7630.86
120_G169_T0.7630.86
184_I187_I0.7610.86
128_T173_Y0.7590.86
220_D259_R0.7530.85
260_T303_S0.7510.85
312_I359_T0.7430.84
227_D314_G0.7420.84
109_W113_M0.7320.84
321_L347_W0.7310.84
118_V122_L0.7310.84
197_G201_A0.7300.83
128_T132_T0.7290.83
110_L366_V0.7280.83
180_E242_L0.7260.83
254_W315_E0.7240.83
128_T328_T0.7220.83
257_I315_E0.7210.83
247_L283_N0.7210.83
106_A361_L0.7210.83
128_T169_T0.7160.82
201_A361_L0.7150.82
80_V83_L0.7150.82
123_L169_T0.7120.82
253_S307_G0.7120.82
251_F279_A0.7100.82
124_I173_Y0.7050.81
229_M248_L0.7030.81
116_V120_G0.7030.81
361_L365_Y0.7020.81
145_V152_G0.7020.81
106_A109_W0.7010.81
353_G360_V0.6960.80
191_I194_S0.6940.80
151_T154_W0.6900.80
372_D375_D0.6900.80
305_T363_F0.6900.80
280_S365_Y0.6890.80
315_E319_A0.6870.80
275_T377_R0.6850.79
174_G334_T0.6810.79
215_L218_Y0.6780.79
102_V105_V0.6780.79
231_L248_L0.6760.78
113_M362_S0.6740.78
219_V255_E0.6740.78
182_G308_I0.6740.78
271_E275_T0.6730.78
88_R373_A0.6700.78
192_I196_V0.6700.78
309_P349_A0.6690.78
296_S300_I0.6620.77
148_V152_G0.6610.77
316_A336_A0.6590.77
186_T246_I0.6590.77
307_G311_F0.6580.77
146_G151_T0.6580.77
193_G197_G0.6570.76
261_V264_E0.6560.76
349_A353_G0.6560.76
212_D266_L0.6560.76
347_W351_I0.6530.76
244_M247_L0.6530.76
179_M183_L0.6530.76
252_F267_Q0.6500.76
319_A324_S0.6490.76
181_V315_E0.6490.76
229_M351_I0.6470.75
92_F96_R0.6470.75
181_V185_A0.6470.75
203_A283_N0.6460.75
152_G158_L0.6460.75
157_P351_I0.6430.75
203_A209_G0.6430.75
182_G229_M0.6390.74
158_L355_F0.6380.74
170_L333_R0.6380.74
193_G312_I0.6370.74
196_V219_V0.6340.74
182_G311_F0.6310.74
91_A94_W0.6300.73
193_G217_R0.6270.73
171_V351_I0.6270.73
245_I254_W0.6270.73
183_L187_I0.6260.73
191_I195_A0.6250.73
261_V291_H0.6200.72
325_D329_Y0.6190.72
91_A98_K0.6180.72
146_G152_G0.6180.72
238_F248_L0.6160.72
129_T132_T0.6150.72
375_D378_Q0.6140.72
264_E273_Y0.6130.71
245_I363_F0.6130.71
266_L270_S0.6120.71
335_I356_L0.6110.71
145_V149_V0.6110.71
338_G341_N0.6080.71
235_T241_E0.6070.71
245_I365_Y0.6060.71
154_W195_A0.6050.70
302_I368_E0.6040.70
292_L297_A0.6030.70
329_Y364_Y0.6000.70
224_V375_D0.6000.70
358_L362_S0.6000.70
327_T368_E0.5990.70
79_A192_I0.5980.70
109_W359_T0.5960.69
118_V176_R0.5960.69
172_V375_D0.5920.69
236_Y335_I0.5890.68
319_A330_S0.5890.68
232_L329_Y0.5880.68
274_I287_I0.5880.68
96_R373_A0.5860.68
264_E268_R0.5860.68
100_N372_D0.5840.68
274_I277_A0.5830.68
234_L339_Q0.5820.67
245_I320_F0.5820.67
200_A266_L0.5810.67
337_T340_V0.5800.67
161_S170_L0.5780.67
114_F179_M0.5770.67
363_F377_R0.5770.67
363_F366_V0.5760.67
309_P315_E0.5750.67
360_V364_Y0.5700.66
324_S330_S0.5700.66
186_T194_S0.5690.66
184_I279_A0.5680.66
254_W258_A0.5680.66
224_V368_E0.5670.65
265_A268_R0.5670.65
284_M288_V0.5670.65
92_F379_E0.5660.65
77_F80_V0.5640.65
187_I304_A0.5620.65
131_F163_K0.5580.64
194_S300_I0.5570.64
253_S310_G0.5560.64
283_N289_R0.5560.64
200_A220_D0.5550.64
234_L245_I0.5540.64
125_D128_T0.5530.64
368_E375_D0.5510.63
259_R324_S0.5470.63
188_F243_W0.5470.63
208_R269_A0.5450.62
128_T133_N0.5450.62
76_V79_A0.5440.62
227_D253_S0.5430.62
197_G212_D0.5410.62
162_A337_T0.5400.62
242_L246_I0.5400.62
222_Q254_W0.5400.62
313_L317_S0.5400.62
189_S311_F0.5390.62
189_S257_I0.5390.62
126_P155_Q0.5380.61
85_Q91_A0.5370.61
150_K156_Y0.5370.61
125_D168_L0.5360.61
231_L235_T0.5350.61
253_S257_I0.5340.61
156_Y169_T0.5320.61
119_L172_V0.5300.60
163_K234_L0.5290.60
215_L258_A0.5280.60
196_V211_I0.5280.60
323_F363_F0.5260.60
165_Q329_Y0.5260.60
181_V245_I0.5260.60
79_A83_L0.5250.60
299_S303_S0.5250.60
116_V355_F0.5230.59
80_V85_Q0.5230.59
96_R369_S0.5230.59
217_R367_G0.5220.59
311_F331_W0.5220.59
238_F247_L0.5210.59
275_T278_E0.5200.59
233_L236_Y0.5200.59
192_I315_E0.5170.58
110_L329_Y0.5140.58
142_S146_G0.5130.58
201_A292_L0.5130.58
122_L125_D0.5120.58
170_L375_D0.5110.58
235_T335_I0.5100.57
149_V348_I0.5100.57
343_A346_W0.5080.57
126_P130_Q0.5080.57
287_I377_R0.5080.57
118_V183_L0.5070.57
133_N145_V0.5060.57
181_V246_I0.5060.57
241_E252_F0.5060.57
258_A352_P0.5060.57
121_P225_F0.5050.57
132_T147_G0.5050.57
229_M360_V0.5040.57
237_L240_S0.5040.57
82_P85_Q0.5040.57
189_S250_G0.5030.56
76_V109_W0.5030.56
185_A189_S0.5020.56
302_I371_R0.5000.56
99_K111_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.6554 100 0.723 Contact Map
3tuiA 2 0.5259 99.9 0.747 Contact Map
3d31C 2 0.601 99.9 0.755 Contact Map
3rlfG 1 0.6736 99.9 0.763 Contact Map
3rlfF 1 0.886 99.9 0.766 Contact Map
2onkC 2 0.614 99.9 0.769 Contact Map
4tquN 1 0.6891 99.9 0.769 Contact Map
4ymuD 2 0.5415 99.9 0.775 Contact Map
2yevC 1 0.0881 20.2 0.97 Contact Map
3j9pD 4 0.772 20 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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