GREMLIN Database
Q9HMW1 - Oligopeptide ABC transporter ATP-binding
UniProt: Q9HMW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (218)
Sequences: 24928 (17182)
Seq/√Len: 1163.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_R102_D3.8401.00
152_R164_T3.6061.00
154_V161_V3.3741.00
66_K132_H3.3051.00
166_T169_D3.0381.00
59_Q62_D2.8711.00
75_R78_D2.7501.00
66_K131_E2.7431.00
127_D131_E2.6591.00
165_G170_I2.6351.00
63_L98_A2.5751.00
52_P55_P2.5001.00
61_V76_V2.4321.00
59_Q100_D2.2861.00
154_V164_T2.2801.00
78_D82_E2.2531.00
147_S168_E2.2251.00
34_Y38_R2.1901.00
213_S224_R2.1581.00
222_A227_D2.1201.00
140_T146_V1.8841.00
41_G60_V1.8811.00
62_D66_K1.8771.00
37_G76_V1.8441.00
71_E74_A1.8231.00
45_R56_V1.8181.00
61_V71_E1.8181.00
219_A224_R1.7761.00
11_L15_R1.7711.00
37_G77_D1.7231.00
75_R83_F1.7191.00
160_K228_Q1.7171.00
122_L145_V1.6481.00
70_P74_A1.6341.00
57_Q76_V1.6131.00
125_L136_I1.5961.00
35_T77_D1.5921.00
57_Q61_V1.5731.00
165_G169_D1.5581.00
100_D132_H1.5371.00
37_G41_G1.5071.00
14_V19_I1.4971.00
169_D173_N1.4881.00
106_A136_I1.4871.00
40_I64_L1.4871.00
210_C216_C1.4851.00
128_L134_M1.4711.00
219_A223_C1.4551.00
74_A78_D1.4461.00
22_I106_A1.4361.00
41_G56_V1.4341.00
35_T38_R1.4281.00
180_R218_H1.4241.00
38_R41_G1.4221.00
33_V81_H1.4201.00
126_E148_E1.4171.00
221_E225_S1.4041.00
41_G57_Q1.4001.00
216_C223_C1.3911.00
48_D59_Q1.3891.00
211_R228_Q1.3821.00
40_I98_A1.3771.00
34_Y42_E1.3501.00
66_K127_D1.3251.00
54_V58_R1.3161.00
180_R184_D1.3151.00
44_I98_A1.3121.00
58_R62_D1.3071.00
41_G45_R1.2941.00
83_F91_V1.2741.00
153_V167_V1.2711.00
221_E224_R1.2571.00
126_E129_Q1.2511.00
39_Q95_M1.2501.00
138_F149_I1.2381.00
70_P75_R1.2371.00
168_E172_R1.2161.00
188_G191_G1.2131.00
64_L76_V1.2131.00
152_R163_E1.2121.00
208_A213_S1.2061.00
19_I103_L1.2031.00
37_G57_Q1.2021.00
160_K211_R1.1771.00
62_D65_D1.1711.00
48_D51_D1.1571.00
113_L121_I1.1511.00
118_Q142_D1.1491.00
213_S219_A1.1251.00
170_I179_T1.1141.00
34_Y39_Q1.1121.00
56_V60_V1.1101.00
216_C220_T1.0981.00
104_L136_I1.0931.00
61_V65_D1.0861.00
67_T94_A1.0771.00
20_S96_A1.0771.00
211_R214_P1.0731.00
129_Q136_I1.0701.00
206_P211_R1.0671.00
104_L134_M1.0621.00
57_Q77_D1.0551.00
31_N34_Y1.0551.00
103_L137_I1.0541.00
126_E149_I1.0491.00
30_L88_K1.0341.00
36_V91_V1.0321.00
202_D205_D1.0291.00
53_E56_V1.0271.00
231_L234_V1.0171.00
203_V206_P1.0141.00
55_P58_R1.0121.00
100_D134_M1.0071.00
17_K48_D1.0031.00
51_D55_P1.0021.00
197_E217_E1.0011.00
51_D56_V0.9991.00
220_T224_R0.9931.00
106_A125_L0.9851.00
212_F216_C0.9831.00
44_I48_D0.9811.00
65_D71_E0.9791.00
71_E75_R0.9761.00
118_Q145_V0.9731.00
63_L94_A0.9721.00
68_G127_D0.9641.00
169_D172_R0.9631.00
11_L14_V0.9581.00
138_F150_A0.9571.00
60_V76_V0.9471.00
222_A225_S0.9411.00
40_I60_V0.9411.00
209_G213_S0.9261.00
161_V164_T0.9241.00
41_G76_V0.9151.00
228_Q231_L0.9021.00
63_L66_K0.8991.00
79_Y82_E0.8981.00
129_Q151_D0.8911.00
206_P209_G0.8901.00
181_A185_C0.8851.00
210_C223_C0.8781.00
43_A95_M0.8701.00
227_D230_P0.8651.00
47_H99_C0.8651.00
214_P217_E0.8641.00
210_C217_E0.8611.00
69_I87_M0.8601.00
52_P56_V0.8561.00
207_P213_S0.8551.00
228_Q232_W0.8531.00
189_R193_M0.8521.00
83_F87_M0.8471.00
105_I137_I0.8451.00
22_I93_I0.8421.00
108_E141_H0.8421.00
171_F174_P0.8351.00
157_Y162_M0.8331.00
100_D131_E0.8331.00
20_S101_P0.8311.00
198_G201_P0.8251.00
198_G203_V0.8141.00
207_P214_P0.8121.00
59_Q63_L0.8111.00
110_T145_V0.8081.00
199_S203_V0.8041.00
37_G60_V0.8031.00
30_L39_Q0.7981.00
205_D209_G0.7921.00
210_C215_R0.7881.00
218_H221_E0.7871.00
217_E220_T0.7831.00
125_L138_F0.7781.00
75_R87_M0.7771.00
179_T183_M0.7741.00
203_V207_P0.7701.00
54_V57_Q0.7671.00
25_N28_N0.7641.00
209_G212_F0.7631.00
65_D70_P0.7571.00
216_C219_A0.7561.00
93_I121_I0.7561.00
210_C213_S0.7551.00
69_I75_R0.7481.00
190_G193_M0.7451.00
191_G194_D0.7441.00
219_A222_A0.7431.00
173_N176_H0.7411.00
162_M211_R0.7401.00
145_V149_I0.7331.00
45_R53_E0.7321.00
227_D232_W0.7311.00
155_V174_P0.7281.00
84_S87_M0.7251.00
143_L171_F0.7241.00
119_G123_R0.7231.00
204_T207_P0.7191.00
220_T223_C0.7181.00
48_D100_D0.7151.00
209_G216_C0.7141.00
68_G120_Q0.7101.00
182_L185_C0.7101.00
213_S216_C0.7091.00
150_A167_V0.7041.00
36_V64_L0.7001.00
43_A46_I0.6951.00
207_P211_R0.6901.00
211_R215_R0.6901.00
63_L97_L0.6861.00
28_N88_K0.6841.00
58_R61_V0.6811.00
229_P232_W0.6801.00
39_Q80_P0.6781.00
40_I43_A0.6761.00
212_F215_R0.6761.00
180_R183_M0.6701.00
146_V150_A0.6701.00
97_L134_M0.6701.00
199_S202_D0.6691.00
44_I51_D0.6691.00
169_D235_D0.6651.00
165_G171_F0.6621.00
201_P205_D0.6601.00
150_A153_V0.6571.00
208_A212_F0.6561.00
53_E57_Q0.6531.00
214_P224_R0.6521.00
43_A99_C0.6461.00
178_Y182_L0.6451.00
181_A184_D0.6381.00
30_L91_V0.6321.00
230_P233_G0.6311.00
58_R65_D0.6271.00
74_A77_D0.6271.00
78_D83_F0.6231.00
167_V171_F0.6231.00
167_V178_Y0.6221.00
140_T150_A0.6211.00
80_P91_V0.6181.00
22_I89_Q0.6181.00
51_D59_Q0.6181.00
123_R127_D0.6161.00
174_P179_T0.6161.00
232_W235_D0.6141.00
181_A196_I0.6141.00
201_P206_P0.6141.00
200_L203_V0.6111.00
216_C224_R0.6091.00
40_I91_V0.6091.00
35_T39_Q0.6061.00
43_A98_A0.6061.00
124_L127_D0.6001.00
215_R219_A0.6001.00
156_M161_V0.5991.00
35_T79_Y0.5961.00
139_V142_D0.5941.00
106_A109_P0.5921.00
173_N177_P0.5911.00
201_P207_P0.5901.00
206_P210_C0.5901.00
217_E223_C0.5881.00
147_S171_F0.5861.00
210_C214_P0.5851.00
205_D208_A0.5841.00
155_V170_I0.5831.00
201_P204_T0.5821.00
215_R218_H0.5821.00
40_I95_M0.5821.00
220_T232_W0.5721.00
55_P59_Q0.5701.00
44_I50_G0.5681.00
204_T209_G0.5671.00
44_I99_C0.5661.00
183_M186_L0.5641.00
85_G90_R0.5641.00
199_S206_P0.5631.00
177_P180_R0.5631.00
198_G202_D0.5621.00
174_P183_M0.5601.00
39_Q43_A0.5601.00
102_D134_M0.5601.00
37_G40_I0.5581.00
103_L135_G0.5571.00
167_V170_I0.5571.00
207_P210_C0.5561.00
12_Q46_I0.5551.00
60_V98_A0.5511.00
125_L149_I0.5511.00
160_K164_T0.5491.00
215_R223_C0.5481.00
136_I149_I0.5481.00
115_V119_G0.5461.00
217_E221_E0.5461.00
202_D206_P0.5451.00
186_L189_R0.5421.00
39_Q42_E0.5411.00
26_P29_G0.5401.00
89_Q112_A0.5391.00
42_E46_I0.5381.00
207_P212_F0.5381.00
32_P81_H0.5371.00
122_L148_E0.5371.00
203_V210_C0.5351.00
122_L138_F0.5341.00
56_V61_V0.5341.00
122_L149_I0.5321.00
140_T144_G0.5311.00
44_I59_Q0.5291.00
140_T145_V0.5291.00
29_G92_L0.5261.00
211_R216_C0.5251.00
218_H222_A0.5241.00
196_I199_S0.5231.00
63_L67_T0.5191.00
223_C229_P0.5181.00
36_V40_I0.5171.00
175_S234_V0.5161.00
22_I96_A0.5151.00
48_D56_V0.5141.00
206_P214_P0.5051.00
36_V83_F0.5031.00
29_G32_P0.5031.00
202_D207_P0.5011.00
223_C228_Q0.5001.00
142_D145_V0.5001.00
92_L95_M0.5001.00
196_I200_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.6704 100 0.3 Contact Map
4f4cA 1 0.6217 100 0.308 Contact Map
3tuiC 2 0.97 100 0.322 Contact Map
4q9hA 1 0.6704 100 0.322 Contact Map
4huqB 1 0.794 100 0.33 Contact Map
4mkiB 2 0.8052 100 0.332 Contact Map
4a82A 2 0.6667 100 0.337 Contact Map
2onkA 2 0.6891 100 0.337 Contact Map
4fwiB 1 0.8914 100 0.338 Contact Map
4huqA 1 0.8052 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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