GREMLIN Database
Q9HMW0 - Oligopeptide ABC transporter ATP-binding
UniProt: Q9HMW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (344)
Sequences: 643 (547)
Seq/√Len: 29.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_G234_C7.0901.00
167_L175_V5.8601.00
54_E236_R5.6751.00
21_G45_G5.5641.00
249_G254_V4.9711.00
19_V48_F4.4461.00
20_D83_S3.8481.00
18_R49_E3.7161.00
109_I190_A3.2501.00
126_S179_R3.1941.00
21_G47_S3.0691.00
127_V182_V2.8901.00
174_R197_L2.8221.00
19_V22_L2.7901.00
107_Q185_P2.7641.00
337_V340_L2.6741.00
192_E225_H2.6281.00
62_S197_L2.5830.99
105_E186_R2.5770.99
56_L238_A2.5490.99
238_A245_I2.5220.99
59_V239_V2.5040.99
179_R195_S2.4420.99
70_A189_V2.3300.99
90_D93_A2.2500.99
83_S90_D2.2240.98
171_Q179_R2.1160.98
109_I173_Q2.1100.98
23_K45_G2.1080.98
202_Q226_D2.1030.98
206_L229_V1.8770.95
62_S196_A1.7830.94
149_L182_V1.7580.94
66_K191_D1.7560.94
311_D316_E1.7540.93
325_N329_A1.7490.93
24_K72_S1.7440.93
50_V221_L1.7390.93
62_S192_E1.7380.93
53_G219_G1.7360.93
173_Q223_I1.7230.93
187_L219_G1.6880.92
75_R78_D1.6600.91
70_A223_I1.6580.91
66_K192_E1.6390.91
202_Q229_V1.5990.90
349_D353_S1.5910.90
126_S195_S1.5820.89
168_S198_D1.5550.88
147_R157_G1.5460.88
50_V187_L1.5230.87
172_K204_E1.5110.87
205_V208_L1.4980.86
59_V230_V1.4650.85
26_Y68_T1.4630.85
26_Y77_T1.4590.85
59_V107_Q1.4430.84
58_I187_L1.4350.84
159_D171_Q1.4340.84
286_G289_P1.4340.84
334_G348_D1.4310.84
75_R103_R1.4300.84
107_Q194_V1.4290.84
17_M187_L1.4110.83
50_V56_L1.4070.83
51_R54_E1.4020.83
177_L224_S1.3980.82
295_P298_C1.3910.82
126_S224_S1.3900.82
364_L368_H1.3880.82
58_I238_A1.3700.81
173_Q196_A1.3680.81
122_T125_E1.3670.81
150_L153_V1.3660.81
58_I221_L1.3610.81
110_F166_E1.3580.80
226_D229_V1.3430.80
161_A164_P1.3400.80
66_K111_Q1.3300.79
111_Q191_D1.3250.79
289_P300_F1.3180.78
66_K225_H1.3140.78
121_M125_E1.2960.77
169_G174_R1.2760.76
355_A359_A1.2670.76
365_R368_H1.2650.75
62_S173_Q1.2640.75
171_Q195_S1.2590.75
356_D362_A1.2590.75
73_V139_R1.2580.75
298_C303_R1.2510.75
265_A269_S1.2490.75
359_A362_A1.2420.74
64_C122_T1.2370.74
328_V332_R1.2370.74
27_P37_V1.2340.74
60_G63_G1.2240.73
46_V67_S1.2220.73
224_S234_C1.2170.73
42_A80_T1.2160.72
117_F192_E1.2060.72
361_K368_H1.2040.72
173_Q227_M1.2010.72
153_V171_Q1.1980.71
26_Y192_E1.1940.71
72_S201_V1.1830.70
187_L221_L1.1800.70
67_S235_D1.1770.70
335_V338_A1.1690.69
249_G253_D1.1630.69
171_Q175_V1.1600.69
340_L343_F1.1560.69
326_L331_E1.1520.68
298_C304_C1.1520.68
200_S242_L1.1510.68
109_I223_I1.1480.68
224_S230_V1.1470.68
67_S233_V1.1440.68
201_V205_V1.1440.68
171_Q231_R1.1400.67
110_F164_P1.1270.67
152_R211_D1.1210.66
356_D360_M1.1210.66
206_L226_D1.1190.66
130_P179_R1.1180.66
62_S174_R1.1160.66
46_V245_I1.1140.66
62_S166_E1.1130.66
75_R99_L1.1070.65
341_R344_V1.1030.65
87_D105_E1.1020.65
328_V331_E1.1020.65
60_G66_K1.0980.64
51_R236_R1.0970.64
293_D297_G1.0890.64
188_I194_V1.0830.63
145_I148_D1.0820.63
86_F187_L1.0800.63
354_P357_A1.0740.63
182_V192_E1.0720.63
22_L43_V1.0710.63
185_P192_E1.0700.62
314_D320_W1.0690.62
311_D318_A1.0630.62
173_Q247_E1.0630.62
290_P302_T1.0500.61
176_A179_R1.0420.60
60_G65_G1.0410.60
62_S164_P1.0370.60
349_D354_P1.0360.60
169_G198_D1.0360.60
325_N328_V1.0360.60
24_K155_M1.0340.60
43_V69_V1.0310.60
202_Q230_V1.0280.59
327_R336_D1.0250.59
227_M230_V1.0170.58
332_R337_V1.0160.58
221_L284_L1.0120.58
164_P196_A1.0120.58
145_I182_V1.0060.58
84_V220_V1.0060.58
164_P173_Q1.0060.58
213_Q220_V1.0000.57
359_A363_E0.9980.57
23_K81_A0.9890.56
125_E190_A0.9880.56
102_F106_A0.9860.56
234_C237_V0.9850.56
308_I311_D0.9830.56
172_K272_T0.9790.56
107_Q183_V0.9720.55
57_G199_V0.9720.55
306_E341_R0.9710.55
250_R253_D0.9700.55
46_V69_V0.9690.55
307_V324_M0.9690.55
316_E344_V0.9690.55
41_R44_D0.9610.54
145_I184_N0.9600.54
41_R244_E0.9580.54
349_D352_V0.9570.54
174_R196_A0.9530.53
124_G127_V0.9530.53
328_V334_G0.9490.53
14_E52_A0.9430.53
65_G198_D0.9400.52
202_Q239_V0.9390.52
174_R178_A0.9380.52
62_S109_I0.9370.52
324_M328_V0.9330.52
263_T266_L0.9290.52
341_R345_G0.9270.51
51_R87_D0.9270.51
59_V229_V0.9250.51
204_E209_L0.9180.51
18_R85_Y0.9140.50
39_R146_A0.9130.50
50_V219_G0.9120.50
59_V247_E0.9060.50
342_A346_V0.9050.50
311_D329_A0.9040.50
295_P303_R0.9030.50
148_D152_R0.9000.49
353_S356_D0.8930.49
326_L330_V0.8900.49
65_G191_D0.8890.48
55_T196_A0.8880.48
164_P195_S0.8880.48
169_G176_A0.8840.48
75_R84_V0.8830.48
300_F303_R0.8790.48
21_G81_A0.8760.47
138_P141_R0.8750.47
312_G319_H0.8750.47
186_R218_L0.8740.47
99_L103_R0.8730.47
343_F350_A0.8730.47
346_V353_S0.8720.47
74_L201_V0.8710.47
329_A332_R0.8710.47
193_P225_H0.8660.47
317_Q325_N0.8650.47
217_N268_R0.8610.46
357_A362_A0.8580.46
286_G291_P0.8560.46
64_C175_V0.8550.46
166_E196_A0.8530.46
340_L346_V0.8510.45
263_T270_I0.8490.45
227_M234_C0.8470.45
332_R335_V0.8460.45
358_D367_E0.8450.45
52_A186_R0.8450.45
286_G298_C0.8400.45
112_N167_L0.8390.45
72_S77_T0.8390.45
312_G315_F0.8330.44
311_D330_V0.8320.44
73_V249_G0.8300.44
126_S183_V0.8290.44
331_E336_D0.8290.44
272_T293_D0.8270.44
58_I69_V0.8270.44
76_L129_E0.8260.44
196_A199_V0.8250.43
360_M368_H0.8230.43
313_Y319_H0.8230.43
185_P225_H0.8220.43
195_S228_G0.8190.43
356_D361_K0.8190.43
237_V250_R0.8160.43
94_Y219_G0.8160.43
357_A363_E0.8160.43
350_A353_S0.8130.43
149_L202_Q0.8060.42
338_A351_S0.8040.42
17_M50_V0.8030.42
224_S232_E0.8020.42
81_A338_A0.8020.42
188_I192_E0.7990.41
297_G300_F0.7950.41
62_S225_H0.7950.41
24_K121_M0.7940.41
158_E161_A0.7910.41
224_S227_M0.7910.41
314_D327_R0.7910.41
82_G193_P0.7890.41
214_A253_D0.7870.41
68_T192_E0.7870.41
294_P302_T0.7870.41
330_V351_S0.7830.40
351_S356_D0.7810.40
24_K77_T0.7790.40
126_S164_P0.7770.40
336_D348_D0.7750.40
338_A350_A0.7720.39
141_R145_I0.7700.39
17_M149_L0.7680.39
59_V71_E0.7670.39
63_G66_K0.7670.39
238_A248_M0.7600.39
22_L72_S0.7600.39
316_E321_R0.7600.39
197_L226_D0.7590.38
173_Q177_L0.7570.38
346_V349_D0.7550.38
177_L182_V0.7520.38
48_F69_V0.7490.38
311_D320_W0.7480.38
197_L205_V0.7470.38
74_L196_A0.7470.38
126_S130_P0.7470.38
313_Y318_A0.7460.37
175_V201_V0.7440.37
337_V343_F0.7400.37
193_P227_M0.7400.37
131_L182_V0.7390.37
171_Q174_R0.7380.37
356_D365_R0.7380.37
348_D354_P0.7370.37
342_A350_A0.7340.37
362_A368_H0.7340.37
364_L367_E0.7320.36
354_P359_A0.7290.36
196_A223_I0.7260.36
22_L267_L0.7250.36
128_A132_K0.7250.36
309_Q320_W0.7240.36
315_F320_W0.7240.36
68_T171_Q0.7240.36
312_G316_E0.7240.36
60_G168_S0.7200.36
59_V226_D0.7200.36
227_M247_E0.7180.35
308_I330_V0.7110.35
146_A182_V0.7100.35
360_M365_R0.7100.35
358_D362_A0.7050.35
262_Y269_S0.7040.34
352_V358_D0.7040.34
193_P226_D0.7000.34
109_I179_R0.6970.34
193_P229_V0.6960.34
194_V229_V0.6930.34
223_I247_E0.6920.34
196_A229_V0.6920.34
357_A360_M0.6920.34
333_H339_G0.6910.34
268_R282_A0.6910.34
19_V84_V0.6910.34
70_A175_V0.6890.33
171_Q176_A0.6890.33
318_A327_R0.6870.33
320_W324_M0.6870.33
14_E329_A0.6860.33
362_A367_E0.6860.33
327_R341_R0.6810.33
356_D366_R0.6800.33
75_R224_S0.6790.33
322_G361_K0.6780.33
294_P297_G0.6740.32
120_R126_S0.6730.32
24_K68_T0.6690.32
196_A247_E0.6690.32
108_M209_L0.6680.32
46_V275_V0.6670.32
317_Q328_V0.6670.32
109_I116_S0.6670.32
62_S229_V0.6670.32
15_S87_D0.6650.32
202_Q206_L0.6650.32
309_Q341_R0.6640.32
183_V222_F0.6610.31
148_D337_V0.6610.31
295_P301_H0.6600.31
317_Q321_R0.6590.31
316_E323_V0.6550.31
138_P177_L0.6540.31
343_F353_S0.6530.31
263_T273_V0.6510.31
171_Q196_A0.6490.31
65_G170_G0.6490.31
68_T71_E0.6480.31
103_R111_Q0.6480.31
153_V208_L0.6440.30
347_E350_A0.6440.30
22_L192_E0.6430.30
304_C311_D0.6420.30
24_K136_V0.6350.30
303_R311_D0.6340.30
323_V337_V0.6320.30
323_V346_V0.6320.30
239_V247_E0.6300.29
57_G225_H0.6300.29
50_V88_G0.6290.29
223_I226_D0.6280.29
345_G348_D0.6280.29
178_A205_V0.6270.29
344_V348_D0.6250.29
36_E230_V0.6240.29
351_S354_P0.6240.29
53_G217_N0.6230.29
355_A362_A0.6220.29
316_E328_V0.6210.29
223_I239_V0.6200.29
95_D101_R0.6180.29
177_L204_E0.6170.29
276_E342_A0.6160.28
100_K216_F0.6150.28
26_Y172_K0.6140.28
170_G173_Q0.6140.28
358_D361_K0.6140.28
172_K176_A0.6140.28
155_M171_Q0.6130.28
115_S126_S0.6100.28
159_D224_S0.6100.28
323_V326_L0.6090.28
347_E351_S0.6080.28
131_L196_A0.6080.28
133_I136_V0.6080.28
55_T224_S0.6060.28
360_M366_R0.6060.28
309_Q315_F0.6050.28
218_L223_I0.6040.28
14_E187_L0.6020.28
111_Q249_G0.6010.28
363_E366_R0.6000.27
27_P36_E0.5980.27
227_M239_V0.5940.27
129_E206_L0.5940.27
152_R216_F0.5940.27
338_A346_V0.5940.27
149_L153_V0.5940.27
319_H347_E0.5930.27
61_E262_Y0.5920.27
293_D358_D0.5910.27
107_Q199_V0.5900.27
341_R346_V0.5900.27
286_G300_F0.5870.27
82_G225_H0.5860.27
118_D126_S0.5860.27
299_N302_T0.5860.27
76_L226_D0.5850.27
191_D225_H0.5850.27
88_G243_G0.5850.27
159_D231_R0.5840.26
27_P184_N0.5840.26
145_I149_L0.5830.26
358_D366_R0.5830.26
43_V239_V0.5810.26
126_S173_Q0.5800.26
309_Q318_A0.5790.26
361_K365_R0.5760.26
127_V146_A0.5740.26
293_D317_Q0.5740.26
309_Q312_G0.5730.26
46_V127_V0.5720.26
138_P188_I0.5710.26
265_A268_R0.5700.26
122_T244_E0.5680.25
319_H351_S0.5680.25
350_A354_P0.5670.25
291_P300_F0.5650.25
24_K135_G0.5650.25
345_G360_M0.5650.25
350_A355_A0.5650.25
60_G198_D0.5640.25
287_E323_V0.5630.25
227_M254_V0.5630.25
67_S108_M0.5630.25
359_A364_L0.5630.25
131_L146_A0.5620.25
313_Y327_R0.5620.25
87_D219_G0.5600.25
347_E359_A0.5600.25
67_S191_D0.5590.25
73_V333_H0.5590.25
155_M195_S0.5580.25
316_E325_N0.5570.25
76_L150_L0.5540.25
113_P227_M0.5530.25
126_S159_D0.5520.25
112_N164_P0.5510.24
181_L218_L0.5510.24
202_Q247_E0.5500.24
109_I154_G0.5500.24
199_V242_L0.5490.24
303_R321_R0.5450.24
336_D339_G0.5420.24
296_T301_H0.5420.24
113_P196_A0.5410.24
337_V342_A0.5410.24
69_V133_I0.5400.24
320_W323_V0.5400.24
295_P300_F0.5400.24
321_R337_V0.5390.24
340_L359_A0.5380.24
39_R190_A0.5380.24
176_A195_S0.5360.24
130_P171_Q0.5360.24
60_G191_D0.5350.24
247_E266_L0.5350.24
262_Y266_L0.5340.24
318_A328_V0.5320.23
64_C240_M0.5310.23
325_N333_H0.5280.23
322_G331_E0.5250.23
183_V229_V0.5250.23
126_S171_Q0.5230.23
353_S361_K0.5230.23
291_P294_P0.5230.23
172_K226_D0.5220.23
174_R238_A0.5210.23
327_R345_G0.5190.23
296_T305_P0.5190.23
334_G339_G0.5170.23
344_V347_E0.5160.23
111_Q169_G0.5160.23
102_F127_V0.5150.22
351_S355_A0.5140.22
48_F237_V0.5120.22
360_M367_E0.5110.22
343_F351_S0.5100.22
311_D324_M0.5100.22
226_D247_E0.5080.22
353_S357_A0.5080.22
115_S124_G0.5070.22
169_G223_I0.5060.22
188_I197_L0.5050.22
334_G344_V0.5040.22
113_P180_A0.5040.22
230_V237_V0.5030.22
256_N324_M0.5030.22
309_Q339_G0.5010.22
73_V306_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.7727 100 0.35 Contact Map
4fwiB 1 0.6864 100 0.353 Contact Map
4ry2A 2 0.5568 100 0.363 Contact Map
4f4cA 1 0.5455 100 0.366 Contact Map
1oxxK 1 0.7932 100 0.382 Contact Map
2it1A 1 0.8091 100 0.384 Contact Map
2yyzA 1 0.8 100 0.385 Contact Map
1g291 4 0.8227 100 0.387 Contact Map
1v43A 2 0.7841 100 0.39 Contact Map
4q9hA 1 0.5773 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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