GREMLIN Database
HELS - ATP-dependent DNA helicase Hel308
UniProt: Q9HMV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 783 (624)
Sequences: 3671 (2338)
Seq/√Len: 93.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_V186_A6.8381.00
151_V175_L4.3141.00
291_A314_A4.2391.00
78_G149_S4.2241.00
318_A341_V3.7351.00
239_S242_Q3.4621.00
41_A204_E3.2481.00
259_V343_A3.1991.00
240_G247_V3.1841.00
45_A56_I3.1391.00
483_L499_L3.0661.00
106_S123_D3.0381.00
93_K96_E2.9921.00
445_I492_V2.9391.00
502_T505_G2.9261.00
289_R338_D2.9151.00
501_A505_G2.8141.00
239_S243_T2.8111.00
63_S67_E2.7771.00
239_S246_V2.7611.00
625_M655_A2.6571.00
153_A172_L2.6201.00
239_S244_A2.6071.00
627_D641_Y2.5591.00
106_S125_D2.5401.00
469_T474_R2.5371.00
240_G243_T2.5271.00
412_L415_L2.4341.00
292_D296_E2.4321.00
60_A64_A2.3631.00
452_T455_G2.3451.00
40_G63_S2.3361.00
135_D139_R2.3281.00
190_T386_Q2.3001.00
334_E338_D2.2951.00
217_T384_V2.2941.00
517_S525_L2.2831.00
172_L201_L2.2771.00
240_G244_A2.2701.00
157_H386_Q2.2421.00
476_R482_V2.2271.00
216_R399_Y2.2081.00
59_L62_L2.2051.00
507_L510_R2.1641.00
620_K623_R2.1421.00
155_E390_R2.1331.00
272_R308_E2.1201.00
353_G390_R2.0881.00
289_R292_D2.0781.00
515_P518_A2.0711.00
564_L568_H2.0531.00
359_R397_D2.0471.00
307_D311_D2.0201.00
169_E200_W1.9971.00
320_H349_T1.9721.00
242_Q246_V1.9701.00
505_G508_V1.9331.00
288_E292_D1.9291.00
566_L573_T1.8891.00
246_V249_D1.8881.00
476_R480_G1.8711.00
94_A98_E1.8431.00
132_E349_T1.8421.00
242_Q247_V1.8391.00
484_R488_R1.8231.00
464_L468_Q1.8101.00
478_V482_V1.8021.00
483_L490_G1.7931.00
702_G705_R1.7861.00
508_V518_A1.7851.00
525_L528_A1.7781.00
290_L293_I1.7751.00
30_A34_E1.7741.00
386_Q390_R1.7641.00
49_T389_G1.7561.00
221_Y225_L1.7531.00
83_I129_A1.7531.00
659_L684_V1.7521.00
390_R393_R1.7501.00
243_T247_V1.7451.00
165_G169_E1.7431.00
61_M80_A1.7421.00
504_T508_V1.7401.00
298_R302_D1.7361.00
286_E342_K1.7291.00
49_T155_E1.7231.00
59_L64_A1.7111.00
240_G246_V1.7041.00
242_Q245_A1.6961.00
560_E564_L1.6781.00
49_T89_L1.6761.00
566_L569_L1.6641.00
320_H333_E1.6421.00
517_S520_T1.6401.00
218_G401_E1.6021.00
600_L605_P1.6001.00
88_A132_E1.5991.00
505_G513_V1.5961.00
347_T390_R1.5961.00
475_L483_L1.5961.00
479_T483_L1.5951.00
627_D632_L1.5881.00
485_Y489_N1.5811.00
332_V341_V1.5651.00
310_A314_A1.5641.00
301_S304_E1.5621.00
244_A248_A1.5481.00
701_V706_A1.5481.00
211_R215_L1.5441.00
289_R293_I1.5401.00
597_E600_L1.5381.00
485_Y488_R1.5381.00
483_L494_R1.5341.00
365_D371_G1.5291.00
61_M65_I1.5191.00
367_Q376_M1.5111.00
289_R296_E1.5091.00
295_A310_A1.5091.00
303_T306_S1.4921.00
505_G515_P1.4861.00
221_Y224_S1.4831.00
619_L622_A1.4811.00
331_L335_A1.4711.00
239_S249_D1.4681.00
293_I296_E1.4671.00
524_G528_A1.4611.00
436_A440_H1.4561.00
504_T518_A1.4551.00
65_I105_L1.4511.00
361_V364_R1.4511.00
701_V709_L1.4511.00
291_A295_A1.4511.00
505_G518_A1.4471.00
86_L352_A1.4411.00
705_R710_Y1.4310.99
491_F494_R1.4230.99
511_L515_P1.4160.99
295_A298_R1.4150.99
504_T507_L1.4050.99
155_E353_G1.4050.99
412_L416_F1.4030.99
164_R349_T1.4030.99
44_V186_A1.3990.99
703_R707_R1.3960.99
475_L478_V1.3910.99
93_K97_F1.3910.99
263_S266_N1.3870.99
510_R514_D1.3820.99
508_V525_L1.3820.99
659_L680_A1.3810.99
499_L505_G1.3730.99
522_I528_A1.3720.99
384_V402_A1.3690.99
54_T97_F1.3660.99
582_R585_D1.3640.99
480_G483_L1.3620.99
459_F462_G1.3570.99
429_S463_T1.3550.99
241_S246_V1.3530.99
590_T600_L1.3530.99
479_T487_D1.3530.99
475_L482_V1.3510.99
596_H600_L1.3500.99
302_D305_T1.3490.99
222_G225_L1.3490.99
502_T509_S1.3460.99
87_R113_N1.3450.99
481_D484_R1.3440.99
193_N196_E1.3380.99
333_E349_T1.3280.99
502_T507_L1.3240.99
388_F402_A1.3230.99
591_E594_Y1.3220.99
84_V90_A1.3190.99
506_Q510_R1.3190.99
490_G493_E1.3170.99
484_R487_D1.3170.99
157_H321_H1.3150.99
264_R323_G1.3100.99
705_R713_G1.3060.99
567_Y571_S1.3030.99
454_D458_E1.3010.99
477_S481_D1.3010.99
617_S620_K1.3010.99
354_V404_L1.2990.99
511_L518_A1.2970.99
453_E480_G1.2840.99
60_A65_I1.2830.99
294_A297_I1.2790.99
347_T392_G1.2780.99
501_A512_Y1.2730.99
565_G568_H1.2690.99
242_Q250_T1.2660.99
25_L33_V1.2640.99
91_G94_A1.2570.99
108_G124_N1.2550.99
291_A294_A1.2490.99
451_T455_G1.2470.99
484_R497_A1.2450.99
583_S586_R1.2450.99
490_G494_R1.2450.99
431_L440_H1.2430.99
469_T489_N1.2420.99
501_A506_Q1.2400.99
112_G130_T1.2390.99
94_A109_V1.2340.98
249_D253_D1.2330.98
312_A319_F1.2330.98
514_D518_A1.2310.98
502_T506_Q1.2290.98
370_D375_G1.2240.98
63_S66_A1.2230.98
97_F126_I1.2230.98
508_V511_L1.2230.98
505_G509_S1.2140.98
482_V485_Y1.2120.98
291_A296_E1.2080.98
507_L511_L1.2040.98
49_T392_G1.2020.98
58_Q387_M1.2020.98
284_S287_R1.2010.98
695_L698_V1.1990.98
667_G674_G1.1960.98
217_T385_H1.1940.98
501_A507_L1.1900.98
45_A187_L1.1900.98
494_R498_A1.1890.98
320_H355_N1.1870.98
709_L713_G1.1830.98
523_D527_D1.1810.98
515_P519_A1.1790.98
428_R468_Q1.1770.98
83_I134_V1.1770.98
487_D493_E1.1760.98
132_E164_R1.1730.98
129_A134_V1.1720.98
196_E468_Q1.1710.98
57_A187_L1.1680.98
389_G400_G1.1660.98
501_A504_T1.1650.98
24_E30_A1.1630.98
88_A350_L1.1600.98
442_L446_A1.1590.98
164_R355_N1.1540.98
513_V517_S1.1510.98
274_L345_S1.1480.98
487_D490_G1.1470.98
318_A335_A1.1460.98
60_A63_S1.1460.98
482_V486_L1.1440.97
153_A168_L1.1440.97
299_G304_E1.1430.97
505_G511_L1.1430.97
370_D377_Q1.1410.97
477_S482_V1.1350.97
491_F518_A1.1350.97
164_R169_E1.1320.97
330_E334_E1.1300.97
483_L489_N1.1300.97
270_S345_S1.1290.97
81_L127_V1.1270.97
155_E386_Q1.1260.97
378_P410_D1.1260.97
267_A321_H1.1260.97
371_G375_G1.1250.97
460_L465_Y1.1150.97
247_V360_R1.1120.97
590_T604_T1.1110.97
613_E616_L1.1100.97
688_V693_L1.1100.97
707_R710_Y1.1090.97
309_L319_F1.1030.97
577_Y594_Y1.1030.97
301_S306_S1.1000.97
484_R490_G1.1000.97
61_M64_A1.0980.97
273_R277_V1.0980.97
510_R515_P1.0960.97
244_A249_D1.0930.97
264_R322_A1.0900.97
47_V51_S1.0870.97
508_V521_I1.0850.97
512_Y517_S1.0850.97
278_T287_R1.0840.97
150_C183_Q1.0820.96
241_S248_A1.0810.96
525_L529_A1.0790.96
247_V250_T1.0760.96
86_L132_E1.0750.96
360_R403_V1.0710.96
597_E601_L1.0700.96
260_F387_M1.0690.96
49_T357_P1.0660.96
239_S248_A1.0660.96
463_T466_A1.0650.96
508_V513_V1.0650.96
674_G677_V1.0630.96
164_R333_E1.0620.96
353_G393_R1.0590.96
33_V59_L1.0560.96
384_V388_F1.0540.96
459_F463_T1.0530.96
309_L332_V1.0490.96
593_A596_H1.0470.96
287_R290_L1.0420.96
285_A292_D1.0420.96
320_H392_G1.0370.96
487_D494_R1.0370.96
291_A297_I1.0350.95
582_R590_T1.0340.95
511_L519_A1.0340.95
579_L582_R1.0340.95
516_M520_T1.0320.95
188_S191_V1.0280.95
510_R518_A1.0270.95
164_R320_H1.0270.95
157_H323_G1.0270.95
354_V358_A1.0270.95
189_A393_R1.0260.95
37_V63_S1.0220.95
366_W369_Y1.0170.95
659_L681_R1.0170.95
458_E462_G1.0130.95
630_S689_R1.0120.95
255_G359_R1.0090.95
302_D306_S1.0090.95
115_E118_G1.0080.95
299_G302_D1.0080.95
518_A522_I1.0070.95
413_E416_F1.0060.95
489_N492_V1.0060.95
645_P649_R1.0030.95
560_E575_D1.0000.95
212_P215_L0.9990.94
499_L504_T0.9980.94
397_D400_G0.9980.94
270_S364_R0.9920.94
683_R690_E0.9920.94
62_L66_A0.9900.94
495_D498_A0.9870.94
266_N270_S0.9870.94
247_V255_G0.9860.94
49_T53_K0.9860.94
297_I306_S0.9850.94
243_T248_A0.9840.94
176_R202_D0.9810.94
663_E678_R0.9780.94
222_G226_H0.9770.94
492_V499_L0.9770.94
242_Q249_D0.9750.94
511_L514_D0.9740.94
583_S589_Y0.9710.94
514_D521_I0.9690.94
58_Q96_E0.9690.94
507_L517_S0.9690.94
48_P392_G0.9670.93
707_R713_G0.9650.93
504_T522_I0.9640.93
30_A33_V0.9630.93
441_V450_T0.9630.93
526_R529_A0.9610.93
300_V303_T0.9600.93
246_V254_D0.9600.93
80_A126_I0.9580.93
609_Q613_E0.9570.93
483_L487_D0.9570.93
258_L274_L0.9560.93
461_G465_Y0.9550.93
478_V483_L0.9540.93
503_A506_Q0.9540.93
84_V344_V0.9540.93
500_R505_G0.9510.93
586_R590_T0.9500.93
463_T467_T0.9500.93
189_A392_G0.9500.93
359_R364_R0.9500.93
505_G521_I0.9460.93
195_G199_A0.9450.93
58_Q97_F0.9410.93
691_E710_Y0.9400.92
258_L346_A0.9400.92
508_V515_P0.9380.92
608_E611_E0.9380.92
710_Y713_G0.9360.92
502_T517_S0.9270.92
151_V172_L0.9250.92
257_T362_V0.9250.92
501_A510_R0.9230.92
83_I482_V0.9220.92
610_A620_K0.9220.92
706_A709_L0.9220.92
573_T582_R0.9220.92
708_R711_N0.9210.92
132_E350_L0.9200.92
88_A349_T0.9150.91
320_H350_L0.9150.91
357_P392_G0.9150.91
486_L490_G0.9120.91
582_R592_V0.9120.91
509_S517_S0.9070.91
520_T527_D0.9070.91
81_L148_L0.9070.91
299_G303_T0.9060.91
333_E392_G0.9050.91
292_D295_A0.9040.91
211_R214_E0.9030.91
576_M579_L0.9030.91
483_L486_L0.9020.91
518_A523_D0.9020.91
561_P585_D0.9010.91
59_L63_S0.9000.91
479_T482_V0.8970.91
625_M684_V0.8960.91
189_A192_G0.8960.91
189_A389_G0.8950.91
298_R301_S0.8890.90
591_E600_L0.8870.90
123_D144_W0.8870.90
90_A109_V0.8860.90
224_S229_D0.8850.90
54_T58_Q0.8840.90
117_D124_N0.8830.90
675_P678_R0.8830.90
296_E300_V0.8830.90
510_R521_I0.8820.90
519_A523_D0.8810.90
493_E500_R0.8780.90
598_D604_T0.8780.90
611_E615_W0.8780.90
256_S262_N0.8780.90
565_G569_L0.8770.90
674_G681_R0.8720.89
329_R333_E0.8690.89
439_T443_A0.8670.89
589_Y599_E0.8650.89
28_P47_V0.8650.89
349_T355_N0.8620.89
49_T54_T0.8590.89
392_G400_G0.8570.89
475_L479_T0.8570.89
389_G392_G0.8550.88
135_D394_P0.8540.88
609_Q612_F0.8540.88
702_G707_R0.8530.88
80_A152_V0.8530.88
49_T390_R0.8520.88
500_R506_Q0.8500.88
347_T355_N0.8460.88
476_R492_V0.8460.88
290_L300_V0.8450.88
507_L512_Y0.8440.88
298_R314_A0.8440.88
212_P391_A0.8410.88
323_G386_Q0.8410.88
586_R589_Y0.8370.87
102_R105_L0.8370.87
592_V596_H0.8360.87
291_A299_G0.8360.87
481_D487_D0.8340.87
662_A677_V0.8330.87
86_L382_L0.8320.87
346_A356_T0.8300.87
27_P31_E0.8290.87
503_A523_D0.8290.87
294_A310_A0.8280.87
480_G487_D0.8260.87
92_E350_L0.8250.87
225_L228_D0.8240.87
504_T511_L0.8230.86
592_V600_L0.8230.86
165_G320_H0.8210.86
616_L623_R0.8190.86
274_L343_A0.8190.86
647_D654_T0.8180.86
157_H190_T0.8170.86
589_Y600_L0.8160.86
521_I529_A0.8150.86
333_E350_L0.8150.86
301_S305_T0.8140.86
490_G501_A0.8130.86
333_E357_P0.8130.86
601_L605_P0.8130.86
40_G183_Q0.8130.86
524_G527_D0.8130.86
464_L467_T0.8120.86
450_T456_L0.8110.86
708_R713_G0.8090.86
92_E164_R0.8080.85
157_H352_A0.8070.85
505_G512_Y0.8050.85
378_P381_V0.8040.85
300_V304_E0.8010.85
271_A317_A0.8000.85
656_E685_Q0.8000.85
617_S623_R0.7980.85
349_T393_R0.7970.85
321_H392_G0.7970.85
513_V521_I0.7960.85
484_R494_R0.7960.85
261_V267_A0.7960.85
487_D492_V0.7940.84
704_K710_Y0.7940.84
488_R492_V0.7930.84
587_E594_Y0.7920.84
160_D380_D0.7910.84
95_Q330_E0.7910.84
696_A706_A0.7900.84
600_L604_T0.7850.84
478_V481_D0.7830.84
49_T92_E0.7830.84
494_R497_A0.7810.83
666_A673_C0.7800.83
289_R294_A0.7800.83
244_A250_T0.7770.83
674_G678_R0.7750.83
522_I529_A0.7710.83
575_D582_R0.7700.83
329_R350_L0.7680.82
688_V697_G0.7670.82
463_T468_Q0.7670.82
689_R697_G0.7660.82
516_M521_I0.7640.82
581_L588_Q0.7640.82
588_Q591_E0.7630.82
288_E291_A0.7630.82
285_A289_R0.7610.82
624_L648_I0.7590.82
506_Q514_D0.7580.82
290_L294_A0.7570.82
83_I151_V0.7560.81
499_L514_D0.7540.81
239_S251_L0.7540.81
564_L571_S0.7510.81
87_R320_H0.7500.81
333_E355_N0.7500.81
358_A361_V0.7500.81
504_T514_D0.7490.81
505_G510_R0.7490.81
508_V529_A0.7480.81
580_Y583_S0.7440.80
193_N200_W0.7440.80
504_T512_Y0.7430.80
316_G320_H0.7420.80
88_A351_A0.7420.80
584_G588_Q0.7410.80
49_T324_L0.7400.80
600_L603_A0.7400.80
676_A679_E0.7390.80
677_V680_A0.7390.80
569_L572_R0.7390.80
601_L604_T0.7390.80
650_G654_T0.7390.80
566_L571_S0.7380.80
704_K708_R0.7380.80
694_G697_G0.7370.80
164_R350_L0.7360.80
624_L641_Y0.7360.80
425_E428_R0.7350.80
517_S573_T0.7320.79
509_S512_Y0.7320.79
240_G250_T0.7320.79
590_T597_E0.7300.79
566_L570_V0.7300.79
479_T486_L0.7290.79
247_V251_L0.7290.79
89_L155_E0.7280.79
489_N515_P0.7270.79
159_V460_L0.7270.79
507_L513_V0.7250.79
308_E312_A0.7250.79
560_E566_L0.7240.79
582_R588_Q0.7230.78
89_L353_G0.7230.78
578_E595_E0.7220.78
239_S247_V0.7220.78
191_V425_E0.7220.78
159_V186_A0.7210.78
474_R478_V0.7210.78
502_T512_Y0.7210.78
272_R311_D0.7210.78
628_W631_E0.7200.78
50_A322_A0.7200.78
489_N496_G0.7200.78
347_T353_G0.7190.78
351_A357_P0.7190.78
92_E348_P0.7180.78
49_T351_A0.7180.78
48_P350_L0.7140.78
88_A92_E0.7130.78
87_R349_T0.7130.78
57_A152_V0.7130.78
605_P610_A0.7130.78
508_V512_Y0.7120.77
241_S247_V0.7120.77
599_E605_P0.7110.77
492_V496_G0.7110.77
223_Q227_Y0.7110.77
243_T249_D0.7110.77
189_A386_Q0.7090.77
88_A355_N0.7060.77
591_E595_E0.7040.77
321_H386_Q0.7040.77
483_L493_E0.7030.77
322_A357_P0.7020.76
568_H572_R0.7010.76
246_V250_T0.7010.76
521_I662_A0.7000.76
610_A621_T0.7000.76
367_Q378_P0.7000.76
569_L573_T0.6990.76
304_E313_V0.6980.76
93_K400_G0.6980.76
648_I654_T0.6980.76
134_V175_L0.6970.76
307_D310_A0.6950.76
245_A249_D0.6930.75
510_R523_D0.6930.75
507_L522_I0.6920.75
517_S658_L0.6910.75
294_A314_A0.6900.75
594_Y601_L0.6900.75
501_A508_V0.6890.75
199_A467_T0.6870.75
469_T476_R0.6860.75
135_D170_V0.6850.75
92_E353_G0.6840.75
92_E355_N0.6830.74
58_Q93_K0.6830.74
347_T357_P0.6820.74
267_A271_A0.6810.74
100_F126_I0.6790.74
521_I524_G0.6780.74
576_M580_Y0.6770.74
459_F468_Q0.6770.74
311_D314_A0.6760.74
505_G517_S0.6760.74
92_E389_G0.6740.73
592_V595_E0.6730.73
244_A247_V0.6720.73
296_E302_D0.6720.73
702_G708_R0.6690.73
296_E303_T0.6690.73
513_V525_L0.6680.73
309_L312_A0.6670.73
296_E299_G0.6660.73
199_A259_V0.6650.72
441_V456_L0.6650.72
354_V396_L0.6630.72
626_A630_S0.6630.72
692_L707_R0.6630.72
576_M582_R0.6630.72
349_T354_V0.6630.72
201_L215_L0.6590.72
243_T246_V0.6590.72
87_R392_G0.6580.72
177_Q462_G0.6580.72
135_D167_T0.6570.72
569_L585_D0.6560.71
224_S227_Y0.6550.71
508_V517_S0.6550.71
132_E333_E0.6540.71
598_D602_G0.6520.71
247_V253_D0.6500.71
486_L491_F0.6500.71
127_V131_S0.6500.71
300_V305_T0.6500.71
585_D592_V0.6490.71
353_G386_Q0.6480.71
695_L700_N0.6460.70
164_R357_P0.6450.70
615_W621_T0.6450.70
489_N493_E0.6440.70
291_A300_V0.6430.70
681_R685_Q0.6430.70
615_W618_A0.6430.70
132_E391_A0.6430.70
509_S522_I0.6410.70
155_E190_T0.6390.69
350_L355_N0.6390.69
680_A687_G0.6380.69
518_A525_L0.6360.69
59_L65_I0.6360.69
561_P683_R0.6350.69
357_P389_G0.6350.69
520_T526_R0.6350.69
455_G463_T0.6340.69
248_A252_A0.6340.69
566_L576_M0.6340.69
271_A324_L0.6330.69
265_R268_E0.6330.69
502_T523_D0.6320.69
475_L494_R0.6310.69
288_E299_G0.6310.69
577_Y580_Y0.6290.68
169_E429_S0.6280.68
589_Y593_A0.6280.68
105_L125_D0.6270.68
256_S261_V0.6270.68
49_T386_Q0.6270.68
692_L710_Y0.6270.68
241_S244_A0.6260.68
499_L502_T0.6250.68
164_R392_G0.6250.68
457_H465_Y0.6240.68
29_Q52_G0.6240.68
132_E320_H0.6240.68
250_T360_R0.6230.68
287_R296_E0.6230.68
92_E349_T0.6210.67
465_Y468_Q0.6180.67
520_T524_G0.6180.67
206_V211_R0.6170.67
565_G573_T0.6150.67
687_G692_L0.6150.67
134_V139_R0.6140.66
51_S212_P0.6140.66
657_W661_A0.6140.66
524_G529_A0.6140.66
294_A301_S0.6120.66
648_I657_W0.6110.66
288_E293_I0.6100.66
499_L508_V0.6100.66
502_T521_I0.6090.66
169_E211_R0.6080.66
320_H329_R0.6080.66
297_I300_V0.6070.66
296_E301_S0.6070.66
133_K349_T0.6060.65
82_Y113_N0.6050.65
593_A598_D0.6050.65
87_R111_T0.6050.65
627_D640_R0.6050.65
261_V345_S0.6030.65
88_A157_H0.6020.65
683_R688_V0.6020.65
457_H461_G0.6010.65
505_G524_G0.6000.65
692_L713_G0.6000.65
484_R495_D0.5990.65
284_S291_A0.5990.65
48_P88_A0.5990.65
246_V251_L0.5980.64
475_L493_E0.5980.64
320_H357_P0.5970.64
285_A288_E0.5970.64
206_V210_W0.5970.64
48_P348_P0.5960.64
437_L443_A0.5950.64
619_L623_R0.5950.64
261_V270_S0.5940.64
586_R597_E0.5940.64
647_D651_K0.5920.64
561_P564_L0.5910.63
503_A508_V0.5910.63
85_P392_G0.5900.63
705_R709_L0.5900.63
476_R493_E0.5900.63
49_T189_A0.5880.63
58_Q256_S0.5880.63
501_A518_A0.5870.63
26_Y30_A0.5870.63
89_L389_G0.5870.63
359_R362_V0.5850.63
291_A306_S0.5830.62
349_T357_P0.5830.62
692_L698_V0.5830.62
291_A307_D0.5820.62
691_E709_L0.5820.62
249_D255_G0.5820.62
679_E683_R0.5820.62
675_P679_E0.5810.62
99_A102_R0.5810.62
394_P397_D0.5810.62
359_R394_P0.5810.62
220_H223_Q0.5790.62
132_E392_G0.5780.62
165_G333_E0.5770.62
286_E290_L0.5770.62
703_R711_N0.5770.62
688_V692_L0.5760.62
562_T575_D0.5750.61
169_E173_A0.5750.61
320_H347_T0.5750.61
583_S600_L0.5750.61
563_P566_L0.5750.61
362_V667_G0.5740.61
702_G709_L0.5740.61
496_G525_L0.5730.61
355_N396_L0.5730.61
324_L389_G0.5730.61
83_I131_S0.5720.61
457_H460_L0.5710.61
132_E358_A0.5710.61
489_N498_A0.5700.61
358_A386_Q0.5700.61
441_V444_A0.5690.61
349_T392_G0.5680.60
132_E323_G0.5680.60
54_T390_R0.5670.60
298_R306_S0.5670.60
139_R174_K0.5670.60
169_E316_G0.5670.60
124_N127_V0.5660.60
240_G248_A0.5660.60
515_P523_D0.5650.60
336_F358_A0.5650.60
285_A301_S0.5640.60
26_Y47_V0.5640.60
244_A255_G0.5640.60
517_S528_A0.5630.60
633_D636_R0.5620.60
93_K387_M0.5620.60
49_T350_L0.5620.60
159_V377_Q0.5610.59
92_E356_T0.5600.59
486_L496_G0.5580.59
199_A285_A0.5580.59
651_K656_E0.5580.59
306_S310_A0.5570.59
132_E355_N0.5560.59
521_I528_A0.5560.59
669_L674_G0.5550.59
627_D631_E0.5540.59
287_R314_A0.5510.58
32_A93_K0.5500.58
191_V200_W0.5500.58
564_L572_R0.5490.58
311_D315_S0.5480.58
584_G600_L0.5480.58
680_A683_R0.5460.57
439_T442_L0.5460.57
499_L515_P0.5460.57
510_R513_V0.5450.57
89_L349_T0.5430.57
190_T390_R0.5430.57
290_L295_A0.5430.57
88_A386_Q0.5420.57
284_S290_L0.5420.57
285_A297_I0.5410.57
507_L518_A0.5410.57
111_T397_D0.5410.57
634_E638_A0.5400.57
680_A684_V0.5400.57
504_T513_V0.5390.56
654_T657_W0.5390.56
584_G591_E0.5380.56
650_G653_E0.5370.56
26_Y51_S0.5360.56
169_E193_N0.5350.56
589_Y604_T0.5350.56
279_G343_A0.5350.56
251_L343_A0.5350.56
453_E494_R0.5340.56
46_S381_V0.5340.56
83_I171_T0.5340.56
113_N329_R0.5330.56
239_S250_T0.5330.56
135_D138_V0.5330.56
166_P201_L0.5330.56
613_E622_A0.5330.56
424_P428_R0.5320.56
132_E357_P0.5320.56
453_E462_G0.5320.56
631_E692_L0.5310.55
242_Q248_A0.5300.55
585_D593_A0.5290.55
240_G255_G0.5280.55
170_V173_A0.5280.55
164_R167_T0.5270.55
355_N393_R0.5270.55
585_D589_Y0.5270.55
504_T521_I0.5260.55
491_F495_D0.5260.55
506_Q522_I0.5260.55
358_A391_A0.5250.55
85_P390_R0.5250.55
215_L400_G0.5240.54
130_T133_K0.5240.54
686_Y691_E0.5230.54
499_L513_V0.5230.54
621_T624_L0.5220.54
487_D495_D0.5220.54
189_A357_P0.5220.54
469_T477_S0.5220.54
302_D310_A0.5210.54
518_A524_G0.5210.54
492_V595_E0.5210.54
349_T356_T0.5210.54
92_E133_K0.5200.54
288_E311_D0.5200.54
696_A710_Y0.5200.54
448_G451_T0.5190.54
679_E682_K0.5190.54
612_F672_E0.5190.54
687_G691_E0.5190.54
152_V187_L0.5180.54
49_T52_G0.5180.54
664_R668_E0.5170.53
476_R495_D0.5160.53
366_W378_P0.5150.53
389_G393_R0.5150.53
517_S521_I0.5150.53
218_G403_V0.5150.53
489_N494_R0.5140.53
482_V492_V0.5140.53
48_P111_T0.5130.53
194_A205_L0.5130.53
224_S228_D0.5130.53
570_V684_V0.5130.53
266_N269_A0.5120.53
260_F351_A0.5100.52
303_T310_A0.5100.52
565_G572_R0.5090.52
165_G350_L0.5090.52
615_W619_L0.5090.52
590_T594_Y0.5080.52
44_V191_V0.5070.52
510_R524_G0.5070.52
322_A392_G0.5070.52
418_R423_D0.5060.52
595_E598_D0.5050.52
316_G321_H0.5050.52
86_L349_T0.5040.52
284_S288_E0.5040.52
167_T170_V0.5040.52
627_D643_V0.5040.52
521_I573_T0.5040.52
701_V708_R0.5030.51
90_A128_V0.5030.51
49_T400_G0.5020.51
489_N500_R0.5020.51
616_L619_L0.5020.51
576_M592_V0.5020.51
450_T455_G0.5010.51
288_E295_A0.5010.51
505_G525_L0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zj8A 2 0.8863 100 0.292 Contact Map
2p6rA 1 0.8697 100 0.303 Contact Map
2va8A 1 0.8723 100 0.312 Contact Map
5agaA 4 0.9349 100 0.327 Contact Map
4f92B 1 0.9119 100 0.349 Contact Map
4bgdA 1 0.9055 100 0.384 Contact Map
4bujA 1 0.7957 100 0.448 Contact Map
4qu4A 1 0.8148 100 0.478 Contact Map
4u4cA 1 0.8442 100 0.482 Contact Map
4a4zA 1 0.8352 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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