GREMLIN Database
TNAA - Probable tryptophanase
UniProt: Q9HMV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (440)
Sequences: 480 (288)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
427_E445_Q6.4051.00
174_V200_A6.2821.00
197_A201_D5.7721.00
59_A301_V5.3831.00
371_G412_T4.2241.00
160_R202_D4.0811.00
4_H314_E4.0731.00
208_V246_A3.8251.00
163_V167_G3.6800.99
87_Q266_H3.6460.99
190_I228_Y3.6070.99
417_C420_G3.5550.99
191_E195_E3.5000.99
111_D172_P3.4940.99
163_V205_A3.4430.99
349_A420_G3.3070.98
24_L365_C3.1990.98
160_R164_D3.0550.97
138_V148_A3.0420.97
24_L369_R3.0360.97
114_L172_P2.9980.97
223_Q320_Q2.9310.97
31_V364_V2.9220.97
79_A304_R2.9010.96
176_L193_T2.8080.96
108_S111_D2.6920.95
82_D304_R2.6850.95
231_D235_A2.6780.94
6_A402_G2.6780.94
156_V199_F2.6760.94
178_I240_Q2.6470.94
227_G231_D2.5980.93
17_R21_E2.5880.93
139_D158_R2.5190.92
322_L410_A2.4530.91
323_A337_A2.4170.91
222_Q309_P2.3900.90
349_A417_C2.3560.89
366_E419_R2.3480.89
127_A133_P2.3290.89
228_Y231_D2.3280.89
190_I221_V2.3050.88
147_D335_Q2.2690.88
113_V172_P2.2550.87
226_P229_E2.1750.85
327_T335_Q2.1690.85
222_Q236_I2.1570.85
100_N129_N2.1560.85
36_S66_A2.1500.84
320_Q324_D2.1430.84
7_T10_D2.0990.83
228_Y239_E2.0930.83
26_D38_D2.0890.83
28_G443_A2.0690.82
59_A72_S2.0580.82
259_V292_S2.0120.80
327_T333_I1.9870.79
344_I413_A1.9150.77
55_D62_Q1.9130.77
381_F444_L1.8910.76
380_R390_D1.8800.75
325_A407_D1.8560.74
194_R239_E1.8380.74
195_E198_A1.8220.73
35_A38_D1.7990.72
204_D331_V1.7270.69
123_R135_D1.7220.68
239_E242_S1.7190.68
163_V171_V1.7170.68
156_V195_E1.7050.68
111_D170_A1.6560.65
57_W258_N1.6540.65
329_R414_A1.6500.65
114_L162_V1.6390.64
211_A241_L1.6210.64
120_D439_H1.6130.63
414_A418_E1.6100.63
378_L382_A1.5950.62
337_A342_V1.5840.62
144_P348_A1.5830.62
52_M298_A1.5610.61
72_S301_V1.5600.61
52_M258_N1.5520.60
75_D297_A1.5420.60
291_M296_M1.5380.59
218_A240_Q1.5360.59
220_F339_G1.5340.59
80_A89_I1.5330.59
140_G153_N1.5300.59
29_H446_P1.5150.58
221_V240_Q1.5120.58
37_D71_A1.4930.57
59_A257_V1.4890.57
72_S75_D1.4780.56
23_A34_L1.4670.56
103_Y173_V1.4640.55
167_G205_A1.4560.55
161_R165_D1.4510.55
88_H268_D1.4480.55
193_T197_A1.4190.53
86_F244_A1.4130.53
16_S19_D1.3920.52
154_F199_F1.3830.51
124_A281_L1.3700.50
23_A38_D1.3400.49
204_D330_D1.3390.49
258_N298_A1.3350.49
32_F44_L1.2950.46
105_A275_C1.2930.46
31_V375_A1.2900.46
258_N295_D1.2880.46
215_A237_A1.2860.46
163_V168_A1.2810.46
90_I97_G1.2740.45
59_A75_D1.2720.45
50_G400_T1.2620.45
232_S235_A1.2590.45
160_R203_I1.2440.44
83_V163_V1.2390.43
215_A312_V1.2380.43
52_M57_W1.2380.43
163_V199_F1.2350.43
114_L126_V1.2200.42
123_R180_N1.2180.42
233_V237_A1.2170.42
115_N212_C1.2070.42
112_T134_V1.2050.42
101_V278_R1.2030.42
346_A363_F1.1960.41
73_F77_A1.1950.41
125_H282_Y1.1950.41
65_E293_G1.1920.41
76_L272_H1.1880.41
331_V413_A1.1800.40
35_A74_E1.1790.40
233_V307_V1.1790.40
241_L255_G1.1770.40
215_A255_G1.1750.40
84_M307_V1.1710.40
110_G392_V1.1620.39
53_S399_R1.1590.39
87_Q268_D1.1570.39
22_A26_D1.1520.39
375_A394_L1.1480.39
358_F389_R1.1370.38
251_G299_F1.1370.38
384_P387_D1.1370.38
415_A418_E1.1310.38
370_E419_R1.1310.38
166_V169_D1.1290.38
193_T196_V1.1270.38
120_D177_T1.1190.37
257_V299_F1.1170.37
255_G306_A1.1130.37
409_V413_A1.1120.37
55_D301_V1.1110.37
4_H441_S1.1010.36
350_L362_A1.1000.36
70_S400_T1.0930.36
81_E87_Q1.0880.36
364_V392_V1.0860.36
150_F263_V1.0810.35
80_A264_G1.0800.35
171_V198_A1.0770.35
143_D348_A1.0750.35
57_W295_D1.0730.35
190_I240_Q1.0690.35
107_L131_A1.0640.35
102_L248_V1.0400.33
183_M383_F1.0360.33
190_I227_G1.0300.33
345_D348_A1.0240.33
111_D114_L1.0230.33
238_R304_R1.0220.33
191_E229_E1.0200.32
194_R227_G1.0200.32
103_Y439_H1.0140.32
226_P320_Q1.0140.32
112_T166_V1.0120.32
209_I244_A1.0060.32
112_T162_V0.9980.31
413_A420_G0.9970.31
378_L439_H0.9970.31
429_V445_Q0.9940.31
34_L38_D0.9940.31
214_F237_A0.9920.31
403_P407_D0.9900.31
280_I395_A0.9890.31
237_A255_G0.9860.31
163_V166_V0.9830.31
174_V205_A0.9820.31
190_I242_S0.9800.31
430_S443_A0.9740.30
419_R422_D0.9720.30
75_D79_A0.9680.30
25_A229_E0.9630.30
177_T214_F0.9630.30
294_R298_A0.9630.30
205_A407_D0.9620.30
15_T23_A0.9610.30
79_A255_G0.9610.30
382_A439_H0.9600.30
59_A297_A0.9600.30
259_V291_M0.9580.30
115_N126_V0.9520.29
101_V444_L0.9500.29
317_A403_P0.9480.29
118_H175_V0.9450.29
325_A411_D0.9430.29
153_N191_E0.9420.29
221_V248_V0.9390.29
365_C371_G0.9380.29
211_A247_C0.9350.29
325_A410_A0.9330.28
120_D378_L0.9320.28
88_H272_H0.9320.28
332_P373_V0.9310.28
166_V172_P0.9310.28
206_T373_V0.9300.28
53_S305_E0.9280.28
154_F176_L0.9280.28
177_T439_H0.9270.28
50_G256_L0.9270.28
193_T207_F0.9220.28
216_E315_R0.9190.28
100_N282_Y0.9180.28
371_G408_H0.9150.28
22_A25_A0.9100.27
254_D315_R0.9080.27
321_R407_D0.9050.27
344_I392_V0.9020.27
137_P141_A0.8990.27
408_H412_T0.8980.27
22_A168_A0.8940.27
396_L406_L0.8910.27
168_A421_T0.8900.27
212_C299_F0.8870.27
66_A124_A0.8860.26
85_G410_A0.8850.26
219_H326_L0.8830.26
178_I207_F0.8790.26
190_I239_E0.8770.26
271_L329_R0.8750.26
16_S373_V0.8750.26
373_V376_V0.8730.26
10_D63_G0.8650.26
197_A207_F0.8610.25
233_V313_A0.8610.25
197_A243_Y0.8600.25
221_V228_Y0.8570.25
37_D268_D0.8560.25
88_H317_A0.8540.25
157_E202_D0.8530.25
298_A332_P0.8510.25
413_A416_V0.8500.25
97_G426_L0.8470.25
173_V207_F0.8420.25
235_A310_P0.8410.25
57_W294_R0.8370.24
28_G430_S0.8300.24
21_E369_R0.8290.24
58_A72_S0.8290.24
354_P357_Q0.8290.24
292_S295_D0.8270.24
112_T163_V0.8270.24
33_E443_A0.8270.24
76_L89_I0.8260.24
74_E78_V0.8250.24
15_T372_G0.8190.24
108_S207_F0.8170.24
410_A414_A0.8150.24
213_R340_H0.8150.24
150_F225_E0.8130.24
285_F380_R0.8080.23
83_V307_V0.8070.23
247_C264_G0.8060.23
77_A276_R0.8050.23
218_A237_A0.8010.23
7_T63_G0.7980.23
101_V408_H0.7980.23
313_A427_E0.7980.23
118_H126_V0.7980.23
115_N383_F0.7970.23
156_V196_V0.7940.23
213_R315_R0.7900.23
140_G148_A0.7900.23
344_I423_V0.7890.23
267_D270_R0.7880.23
194_R232_S0.7870.23
33_E163_V0.7860.22
107_L173_V0.7860.22
145_D348_A0.7860.22
194_R228_Y0.7840.22
6_A11_R0.7840.22
233_V312_V0.7840.22
112_T171_V0.7840.22
367_L392_V0.7810.22
100_N125_H0.7800.22
396_L414_A0.7790.22
396_L409_V0.7780.22
190_I231_D0.7740.22
172_P281_L0.7740.22
6_A10_D0.7720.22
366_E369_R0.7690.22
15_T19_D0.7680.22
276_R423_V0.7680.22
353_L423_V0.7670.22
193_T243_Y0.7660.22
286_S441_S0.7630.22
36_S218_A0.7610.22
24_L419_R0.7580.21
312_V316_V0.7560.21
239_E243_Y0.7560.21
170_A232_S0.7550.21
118_H133_P0.7550.21
118_H136_C0.7540.21
83_V304_R0.7530.21
163_V414_A0.7520.21
331_V375_A0.7520.21
131_A348_A0.7510.21
237_A241_L0.7480.21
81_E109_A0.7480.21
213_R254_D0.7430.21
298_A345_D0.7400.21
222_Q235_A0.7390.21
317_A324_D0.7370.21
268_D423_V0.7360.21
251_G378_L0.7340.21
17_R370_E0.7320.21
344_I367_L0.7320.21
63_G293_G0.7310.20
42_D47_S0.7300.20
28_G196_V0.7300.20
182_S439_H0.7300.20
177_T180_N0.7290.20
167_G171_V0.7270.20
173_V176_L0.7250.20
341_A350_L0.7250.20
275_C400_T0.7240.20
42_D46_D0.7240.20
117_A408_H0.7220.20
5_T14_D0.7210.20
72_S395_A0.7200.20
76_L90_I0.7180.20
52_M294_R0.7180.20
57_W61_L0.7170.20
323_A342_V0.7170.20
350_L423_V0.7150.20
258_N294_R0.7100.20
351_P421_T0.7080.20
120_D376_V0.7080.20
272_H276_R0.7060.20
84_M241_L0.7050.20
22_A170_A0.7050.20
195_E274_Q0.7040.20
7_T342_V0.7040.20
190_I328_D0.7020.19
69_G346_A0.7010.19
342_V373_V0.7000.19
227_G348_A0.6990.19
367_L413_A0.6980.19
308_E364_V0.6980.19
362_A423_V0.6970.19
207_F244_A0.6960.19
171_V206_T0.6960.19
355_R380_R0.6930.19
72_S216_E0.6920.19
25_A427_E0.6910.19
59_A347_N0.6900.19
212_C383_F0.6900.19
345_D371_G0.6890.19
332_P345_D0.6890.19
211_A392_V0.6880.19
110_G150_F0.6850.19
52_M56_Q0.6850.19
242_S266_H0.6830.19
236_I339_G0.6820.19
230_H357_Q0.6810.19
230_H433_E0.6800.19
274_Q418_E0.6790.19
230_H427_E0.6770.19
134_V396_L0.6770.19
93_H283_E0.6740.19
118_H285_F0.6740.19
36_S364_V0.6740.19
57_W65_E0.6720.19
263_V275_C0.6710.18
131_A156_V0.6710.18
256_L311_Y0.6700.18
353_L421_T0.6660.18
320_Q337_A0.6640.18
57_W298_A0.6630.18
331_V418_E0.6630.18
231_D239_E0.6610.18
52_M332_P0.6590.18
238_R242_S0.6590.18
114_L154_F0.6580.18
8_M143_D0.6570.18
318_Q406_L0.6560.18
246_A263_V0.6550.18
104_G128_A0.6550.18
180_N212_C0.6550.18
169_D274_Q0.6550.18
161_R170_A0.6540.18
180_N207_F0.6540.18
15_T37_D0.6530.18
198_A418_E0.6530.18
126_V173_V0.6530.18
197_A200_A0.6520.18
141_A394_L0.6520.18
90_I272_H0.6500.18
84_M275_C0.6500.18
256_L259_V0.6490.18
36_S139_D0.6490.18
179_T216_E0.6480.18
247_C444_L0.6480.18
141_A383_F0.6480.18
85_G247_C0.6480.18
120_D182_S0.6480.18
49_T200_A0.6480.18
14_D208_V0.6470.18
5_T219_H0.6470.18
212_C266_H0.6440.18
132_T385_D0.6440.18
395_A406_L0.6440.18
179_T341_A0.6430.18
50_G200_A0.6410.18
103_Y378_L0.6410.18
190_I413_A0.6410.18
346_A390_D0.6410.18
361_Q381_F0.6400.17
157_E161_R0.6400.17
347_N355_R0.6390.17
79_A242_S0.6380.17
133_P439_H0.6370.17
403_P406_L0.6370.17
41_V433_E0.6360.17
321_R403_P0.6360.17
86_F441_S0.6360.17
21_E25_A0.6360.17
346_A352_H0.6350.17
370_E412_T0.6350.17
241_L311_Y0.6340.17
78_V153_N0.6340.17
101_V137_P0.6340.17
168_A203_I0.6330.17
326_L345_D0.6330.17
182_S378_L0.6320.17
103_Y396_L0.6320.17
120_D382_A0.6310.17
120_D180_N0.6310.17
230_H445_Q0.6310.17
341_A441_S0.6300.17
351_P437_L0.6300.17
103_Y120_D0.6290.17
25_A433_E0.6290.17
78_V199_F0.6280.17
115_N408_H0.6280.17
247_C262_F0.6270.17
365_C369_R0.6270.17
73_F373_V0.6240.17
300_A322_L0.6240.17
8_M60_M0.6240.17
53_S68_A0.6220.17
212_C376_V0.6210.17
377_E392_V0.6200.17
316_V319_V0.6180.17
79_A83_V0.6170.17
183_M343_Y0.6170.17
188_V311_Y0.6170.17
92_A221_V0.6160.17
375_A392_V0.6160.17
113_V370_E0.6160.17
176_L196_V0.6160.17
73_F370_E0.6160.17
258_N342_V0.6150.17
15_T39_V0.6140.17
29_H444_L0.6140.17
227_G331_V0.6130.17
97_G395_A0.6130.17
5_T10_D0.6130.17
175_V212_C0.6120.17
143_D146_T0.6120.17
364_V375_A0.6120.17
367_L412_T0.6120.17
97_G159_A0.6100.17
147_D232_S0.6090.17
111_D262_F0.6090.17
274_Q277_Q0.6080.17
212_C434_L0.6080.17
198_A227_G0.6070.16
12_I26_D0.6070.16
58_A198_A0.6060.16
318_Q396_L0.6050.16
329_R409_V0.6050.16
101_V430_S0.6040.16
186_Q379_G0.6030.16
246_A265_L0.6020.16
352_H362_A0.6000.16
200_A207_F0.6000.16
154_F207_F0.5980.16
179_T405_H0.5960.16
45_T345_D0.5960.16
219_H223_Q0.5960.16
40_A54_N0.5960.16
278_R394_L0.5950.16
164_D194_R0.5950.16
333_I337_A0.5940.16
199_F369_R0.5930.16
92_A391_L0.5920.16
13_E40_A0.5910.16
319_V396_L0.5900.16
159_A196_V0.5900.16
271_L394_L0.5890.16
312_V439_H0.5880.16
228_Y240_Q0.5880.16
212_C382_A0.5850.16
65_E252_K0.5840.16
295_D323_A0.5840.16
191_E226_P0.5840.16
7_T323_A0.5830.16
219_H239_E0.5820.16
212_C392_V0.5820.16
334_Y391_L0.5780.16
120_D280_I0.5780.16
168_A171_V0.5780.16
159_A184_A0.5750.16
194_R243_Y0.5750.16
72_S135_D0.5750.16
237_A307_V0.5750.16
136_C162_V0.5740.16
76_L282_Y0.5730.16
192_N290_G0.5730.16
177_T378_L0.5720.15
24_L39_V0.5720.15
333_I380_R0.5710.15
18_A195_E0.5700.15
315_R340_H0.5700.15
175_V208_V0.5700.15
82_D238_R0.5690.15
249_M405_H0.5690.15
319_V403_P0.5680.15
226_P444_L0.5680.15
73_F265_L0.5660.15
10_D65_E0.5660.15
56_Q305_E0.5650.15
165_D169_D0.5650.15
325_A328_D0.5650.15
50_G341_A0.5650.15
128_A432_P0.5640.15
154_F234_A0.5630.15
252_K258_N0.5630.15
133_P378_L0.5630.15
32_F379_G0.5620.15
376_V439_H0.5610.15
164_D419_R0.5600.15
292_S368_Y0.5590.15
117_A355_R0.5590.15
349_A421_T0.5580.15
78_V81_E0.5580.15
66_A431_E0.5570.15
89_I135_D0.5570.15
109_A230_H0.5570.15
66_A280_I0.5560.15
228_Y354_P0.5550.15
305_E399_R0.5550.15
149_P224_R0.5540.15
180_N439_H0.5540.15
73_F131_A0.5540.15
349_A355_R0.5540.15
113_V126_V0.5540.15
314_E441_S0.5540.15
16_S272_H0.5530.15
45_T368_Y0.5520.15
274_Q324_D0.5520.15
92_A277_Q0.5520.15
344_I434_L0.5480.15
49_T216_E0.5480.15
198_A274_Q0.5480.15
120_D312_V0.5450.15
261_G294_R0.5450.15
25_A29_H0.5430.15
140_G150_F0.5420.15
198_A273_E0.5400.15
177_T312_V0.5400.15
263_V422_D0.5390.15
358_F380_R0.5390.15
134_V166_V0.5380.15
252_K293_G0.5370.15
362_A434_L0.5360.14
43_L340_H0.5360.14
141_A363_F0.5360.14
120_D212_C0.5360.14
93_H399_R0.5350.14
103_Y221_V0.5350.14
172_P383_F0.5340.14
8_M421_T0.5340.14
161_R227_G0.5330.14
146_T219_H0.5320.14
328_D418_E0.5310.14
157_E160_R0.5310.14
352_H359_P0.5310.14
39_V45_T0.5300.14
126_V420_G0.5290.14
343_Y383_F0.5290.14
140_G146_T0.5280.14
14_D310_P0.5270.14
173_V197_A0.5270.14
108_S421_T0.5260.14
214_F306_A0.5250.14
147_D324_D0.5240.14
165_D198_A0.5240.14
66_A241_L0.5240.14
86_F209_I0.5230.14
26_D170_A0.5230.14
276_R286_S0.5230.14
65_E258_N0.5220.14
331_V373_V0.5200.14
139_D201_D0.5200.14
25_A74_E0.5190.14
254_D340_H0.5170.14
337_A395_A0.5160.14
112_T170_A0.5150.14
37_D171_V0.5150.14
26_D226_P0.5140.14
244_A434_L0.5130.14
223_Q274_Q0.5130.14
246_A279_G0.5130.14
212_C262_F0.5110.14
115_N180_N0.5100.14
58_A388_R0.5100.14
112_T203_I0.5100.14
302_G398_R0.5100.14
112_T353_L0.5090.14
105_A274_Q0.5080.14
212_C380_R0.5080.14
252_K315_R0.5080.14
18_A21_E0.5080.14
230_H320_Q0.5070.14
178_I188_V0.5070.14
57_W345_D0.5070.14
326_L339_G0.5070.14
246_A311_Y0.5060.14
104_G247_C0.5050.14
357_Q427_E0.5040.14
135_D180_N0.5040.14
157_E169_D0.5040.14
61_L232_S0.5030.14
388_R418_E0.5030.14
70_S431_E0.5030.14
148_A153_N0.5030.14
14_D40_A0.5020.14
191_E223_Q0.5020.14
4_H8_M0.5020.14
138_V153_N0.5010.14
214_F218_A0.5010.14
75_D301_V0.5010.14
188_V241_L0.5000.14
69_G390_D0.5000.14
314_E349_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ez2A 4 0.9911 100 0.685 Contact Map
2oqxA 4 0.9844 100 0.694 Contact Map
1ax4A 4 0.9911 100 0.752 Contact Map
4iw7A 2 0.7143 100 0.861 Contact Map
1jg8A 4 0.7411 100 0.865 Contact Map
4lnjA 4 0.7165 99.9 0.885 Contact Map
1v72A 4 0.7277 99.9 0.888 Contact Map
3wgcA 4 0.7143 99.9 0.888 Contact Map
3b46A 2 0.8571 99.9 0.889 Contact Map
1svvA 4 0.7277 99.9 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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