GREMLIN Database
Q9HMV1 - Aspartokinase
UniProt: Q9HMV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (337)
Sequences: 4677 (2718)
Seq/√Len: 148.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_V87_V5.0611.00
46_D86_T4.4561.00
97_D101_N4.3331.00
309_R350_G4.3021.00
339_D342_P4.0401.00
90_I117_L3.8071.00
118_G126_V3.6091.00
160_L296_L3.3691.00
312_D316_D3.2021.00
50_L82_R2.9981.00
151_R194_S2.8711.00
125_E183_R2.8351.00
210_R340_R2.8071.00
133_E189_H2.7701.00
215_A261_E2.7201.00
37_K47_A2.6901.00
289_D337_W2.6491.00
48_T86_T2.6431.00
268_E272_H2.6121.00
183_R192_L2.5901.00
293_I347_V2.5441.00
33_V91_T2.5101.00
236_T240_D2.3291.00
155_D177_D2.2681.00
212_S341_E2.2221.00
300_L305_G2.1991.00
145_G349_N2.1441.00
127_V183_R2.1021.00
61_T103_T2.0981.00
63_E97_D2.0641.00
264_A286_V2.0441.00
176_K182_V2.0291.00
117_L121_L2.0291.00
179_A195_G2.0191.00
26_S102_V2.0131.00
22_A67_V2.0131.00
212_S337_W2.0061.00
41_A46_D1.9991.00
76_V80_A1.9651.00
77_D81_G1.9611.00
115_V126_V1.9021.00
336_S339_D1.8951.00
317_R342_P1.8931.00
149_V152_I1.8881.00
342_P345_D1.8621.00
48_T88_P1.8581.00
314_L343_A1.8131.00
316_D350_G1.8031.00
78_R82_R1.7811.00
39_A43_R1.7611.00
272_H276_I1.7411.00
231_T255_M1.7171.00
21_R25_V1.7051.00
130_T184_V1.6941.00
261_E288_D1.6781.00
73_A76_V1.6401.00
208_D344_L1.6361.00
133_E136_M1.6001.00
232_S239_S1.5781.00
268_E286_V1.5761.00
310_I333_V1.5731.00
71_A116_M1.5341.00
291_A340_R1.5311.00
138_G210_R1.5241.00
261_E337_W1.5241.00
19_P101_N1.5151.00
75_G80_A1.4851.00
217_L267_A1.4681.00
40_L45_V1.4661.00
76_V79_L1.4551.00
53_G102_V1.4551.00
247_A334_F1.4521.00
50_L88_P1.4481.00
127_V185_I1.4451.00
61_T95_A1.4161.00
317_R346_V1.4141.00
293_I343_A1.4031.00
24_I34_R1.3991.00
9_L21_R1.3911.00
310_I347_V1.3891.00
224_I229_G1.3831.00
52_P57_W1.3781.00
293_I344_L1.3771.00
215_A264_A1.3661.00
9_L13_T1.3601.00
133_E186_H1.3601.00
320_N324_I1.3551.00
281_L284_V1.3531.00
269_N273_Q1.3491.00
27_M31_T1.3371.00
75_G79_L1.3351.00
78_R81_G1.3341.00
51_E58_P1.3261.00
265_E288_D1.3231.00
63_E99_Q1.3111.00
79_L88_P1.3091.00
126_V176_K1.3051.00
137_T348_Q1.3051.00
233_A278_V1.2991.00
81_G84_G1.2991.00
151_R192_L1.2971.00
276_I281_L1.2931.00
213_P261_E1.2851.00
12_I24_I1.2471.00
79_L83_L1.2471.00
152_I206_M1.2451.00
119_R180_L1.2371.00
168_I193_L1.2331.00
38_A41_A1.2331.00
218_T256_T1.2321.00
219_V234_L1.2281.00
60_V98_P1.2261.00
10_D13_T1.2251.00
18_E67_V1.2201.00
125_E192_L1.2131.00
66_E69_A1.2011.00
142_V344_L1.1991.00
313_P346_V1.1981.00
313_P350_G1.1971.00
53_G96_E1.1921.00
216_C322_I1.1801.00
341_E345_D1.1731.00
289_D336_S1.1651.00
7_E11_D1.1411.00
138_G344_L1.1401.00
69_A103_T1.1350.99
37_K49_F1.1340.99
33_V49_F1.1290.99
37_K41_A1.1220.99
246_D258_Y1.1210.99
66_E97_D1.1090.99
80_A84_G1.1050.99
59_I113_T1.1050.99
9_L12_I1.0890.99
215_A288_D1.0870.99
291_A337_W1.0870.99
48_T82_R1.0850.99
312_D350_G1.0850.99
293_I335_V1.0820.99
80_A83_L1.0800.99
240_D274_E1.0780.99
269_N272_H1.0710.99
217_L259_V1.0680.99
26_S30_R1.0660.99
319_I343_A1.0630.99
40_L89_V1.0570.99
52_P91_T1.0520.99
229_G320_N1.0480.99
36_L89_V1.0480.99
62_N69_A1.0460.99
36_L40_L1.0440.99
132_V167_V1.0300.99
231_T250_S1.0280.99
220_A283_S1.0240.99
294_R332_A1.0230.99
41_A47_A1.0190.99
238_L245_V1.0150.99
300_L306_V1.0100.99
322_I336_S1.0080.99
12_I21_R1.0080.99
246_D292_A1.0080.99
295_V310_I1.0070.99
234_L255_M1.0020.99
22_A104_T1.0000.99
60_V96_E0.9990.99
81_G85_D0.9970.99
51_E91_T0.9850.99
53_G58_P0.9820.99
138_G143_V0.9700.98
72_T98_P0.9700.98
210_R344_L0.9630.98
212_S340_R0.9610.98
211_D214_L0.9610.98
290_I334_F0.9590.98
136_M168_I0.9550.98
295_V331_V0.9540.98
52_P90_I0.9540.98
287_T322_I0.9530.98
237_A241_S0.9490.98
163_R294_R0.9490.98
265_E268_E0.9460.98
82_R88_P0.9380.98
305_G328_A0.9380.98
247_A332_A0.9370.98
231_T248_V0.9360.98
23_E49_F0.9350.98
97_D103_T0.9330.98
18_E266_R0.9290.98
113_T117_L0.9290.98
241_S273_Q0.9250.98
170_P175_F0.9210.98
307_L311_I0.9210.98
237_A274_E0.9210.98
8_L11_D0.9110.98
74_A78_R0.9070.98
33_V89_V0.9070.98
301_P328_A0.9060.98
111_D131_D0.9030.97
314_L319_I0.9020.97
16_A42_A0.9010.97
221_G282_S0.9000.97
224_I230_I0.8970.97
51_E57_W0.8970.97
60_V75_G0.8890.97
142_V210_R0.8790.97
173_L182_V0.8740.97
8_L12_I0.8690.97
308_C315_A0.8670.97
143_V344_L0.8620.97
75_G78_R0.8590.97
247_A325_I0.8580.97
34_R38_A0.8570.97
22_A95_A0.8510.96
144_E345_D0.8490.96
52_P58_P0.8480.96
232_S236_T0.8460.96
168_I182_V0.8460.96
241_S270_I0.8450.96
171_S174_S0.8430.96
82_R86_T0.8420.96
186_H189_H0.8410.96
212_S291_A0.8400.96
153_T156_E0.8400.96
292_A332_A0.8390.96
73_A77_D0.8360.96
256_T323_D0.8350.96
289_D338_A0.8320.96
317_R339_D0.8290.96
234_L271_L0.8270.96
136_M146_A0.8260.96
68_D263_V0.8260.96
168_I172_A0.8230.96
230_I255_M0.8200.96
10_D14_F0.8160.95
235_S245_V0.8150.95
310_I331_V0.8150.95
204_E306_V0.8140.95
263_V266_R0.8100.95
11_D15_D0.8060.95
241_S266_R0.8050.95
151_R197_T0.7980.95
66_E71_A0.7960.95
135_I167_V0.7940.95
319_I342_P0.7930.95
217_L264_A0.7930.95
235_S255_M0.7910.95
40_L87_V0.7900.95
319_I346_V0.7890.94
47_A89_V0.7850.94
238_L243_I0.7840.94
287_T336_S0.7830.94
313_P317_R0.7780.94
64_R68_D0.7750.94
37_K89_V0.7740.94
178_D203_F0.7740.94
238_L267_A0.7710.94
234_L284_V0.7700.94
237_A270_I0.7690.94
207_I296_L0.7690.94
287_T290_I0.7670.94
130_T167_V0.7650.94
215_A259_V0.7650.94
49_F91_T0.7650.94
30_R33_V0.7640.94
11_D35_M0.7640.94
30_R102_V0.7640.94
272_H283_S0.7610.93
46_D85_D0.7600.93
243_I267_A0.7590.93
151_R198_R0.7590.93
292_A334_F0.7580.93
335_V343_A0.7550.93
309_R313_P0.7540.93
260_D263_V0.7530.93
128_I167_V0.7500.93
220_A285_T0.7500.93
151_R196_G0.7490.93
238_L257_F0.7490.93
109_G131_D0.7480.93
153_T195_G0.7480.93
243_I270_I0.7400.92
68_D71_A0.7390.92
305_G320_N0.7370.92
235_S244_N0.7350.92
173_L193_L0.7330.92
113_T175_F0.7330.92
172_A175_F0.7320.92
290_I322_I0.7320.92
270_I273_Q0.7310.92
47_A87_V0.7230.92
213_P337_W0.7210.91
229_G250_S0.7210.91
21_R67_V0.7190.91
231_T245_V0.7160.91
276_I285_T0.7160.91
135_I157_L0.7160.91
236_T312_D0.7150.91
138_G208_D0.7110.91
62_N70_D0.7090.91
315_A320_N0.7080.91
268_E274_E0.7070.91
300_L328_A0.7070.91
27_M30_R0.7050.90
335_V340_R0.7030.90
80_A122_D0.7030.90
128_I166_E0.7020.90
135_I191_D0.7010.90
216_C256_T0.7000.90
226_N253_D0.6980.90
231_T320_N0.6970.90
93_F110_S0.6920.90
137_T147_R0.6920.90
130_T187_Y0.6890.89
235_S248_V0.6850.89
57_W60_V0.6840.89
214_L258_Y0.6780.89
39_A42_A0.6780.89
63_E98_P0.6780.89
228_P231_T0.6750.88
77_D80_A0.6740.88
147_R151_R0.6730.88
73_A79_L0.6700.88
51_E102_V0.6690.88
78_R101_N0.6680.88
72_T75_G0.6670.88
213_P262_S0.6670.88
220_A253_D0.6650.88
136_M148_N0.6650.88
88_P91_T0.6640.88
112_T172_A0.6610.87
52_P94_L0.6600.87
343_A346_V0.6590.87
63_E69_A0.6580.87
93_F107_R0.6570.87
249_A325_I0.6540.87
312_D315_A0.6510.87
30_R51_E0.6500.87
142_V212_S0.6490.86
138_G348_Q0.6470.86
51_E96_E0.6460.86
214_L260_D0.6460.86
266_R269_N0.6460.86
217_L268_E0.6460.86
238_L264_A0.6450.86
105_L131_D0.6430.86
300_L331_V0.6400.86
311_I321_V0.6370.85
221_G224_I0.6370.85
169_A175_F0.6360.85
323_D326_S0.6350.85
316_D338_A0.6340.85
205_S208_D0.6340.85
224_I254_S0.6330.85
336_S346_V0.6310.85
305_G308_C0.6290.85
210_R291_A0.6290.85
33_V37_K0.6290.85
67_V71_A0.6280.85
346_V350_G0.6270.85
62_N68_D0.6250.84
208_D347_V0.6240.84
270_I274_E0.6240.84
62_N66_E0.6240.84
306_V331_V0.6210.84
31_T34_R0.6210.84
60_V97_D0.6200.84
281_L285_T0.6200.84
265_E269_N0.6170.84
108_G172_A0.6160.84
194_S197_T0.6130.83
112_T169_A0.6110.83
40_L43_R0.6100.83
48_T85_D0.6090.83
72_T76_V0.6090.83
317_R343_A0.6050.82
311_I320_N0.6050.82
105_L109_G0.6050.82
127_V186_H0.6040.82
227_R230_I0.6040.82
228_P320_N0.6020.82
147_R203_F0.6020.82
262_S265_E0.6000.82
206_M209_M0.6000.82
16_A21_R0.5990.82
234_L257_F0.5990.82
60_V73_A0.5990.82
66_E103_T0.5980.82
24_I38_A0.5940.81
323_D334_F0.5940.81
58_P61_T0.5930.81
29_E107_R0.5930.81
33_V51_E0.5890.81
74_A81_G0.5890.81
181_D192_L0.5870.80
338_A342_P0.5870.80
229_G244_N0.5850.80
14_F17_D0.5850.80
12_I38_A0.5830.80
268_E288_D0.5830.80
15_D42_A0.5830.80
265_E272_H0.5810.80
154_V177_D0.5810.80
342_P346_V0.5810.80
308_C312_D0.5800.80
7_E10_D0.5800.80
321_V324_I0.5790.80
71_A74_A0.5790.80
150_G266_R0.5780.79
159_N311_I0.5770.79
116_M171_S0.5770.79
297_G300_L0.5740.79
276_I279_S0.5740.79
172_A176_K0.5720.79
61_T66_E0.5720.79
108_G166_E0.5710.79
157_L163_R0.5690.78
169_A182_V0.5690.78
307_L324_I0.5680.78
231_T324_I0.5670.78
259_V267_A0.5670.78
88_P209_M0.5670.78
60_V100_G0.5650.78
79_L117_L0.5640.78
317_R349_N0.5640.78
112_T115_V0.5630.78
62_N103_T0.5590.77
261_E289_D0.5590.77
214_L246_D0.5590.77
274_E278_V0.5580.77
20_D49_F0.5570.77
263_V270_I0.5560.77
218_T285_T0.5560.77
314_L333_V0.5550.77
174_S178_D0.5550.77
311_I324_I0.5540.77
216_C287_T0.5530.76
36_L88_P0.5530.76
320_N325_I0.5530.76
114_A126_V0.5520.76
203_F206_M0.5520.76
43_R87_V0.5510.76
128_I135_I0.5510.76
235_S246_D0.5500.76
30_R49_F0.5490.76
227_R233_A0.5480.76
243_I266_R0.5460.76
226_N231_T0.5460.76
58_P96_E0.5450.75
80_A121_L0.5440.75
317_R338_A0.5440.75
320_N326_S0.5440.75
23_E102_V0.5430.75
63_E179_A0.5430.75
30_R94_L0.5430.75
319_I339_D0.5430.75
158_R250_S0.5420.75
159_N162_F0.5410.75
195_G199_I0.5400.75
165_A168_I0.5400.75
136_M139_D0.5390.75
345_D349_N0.5390.75
154_V181_D0.5380.74
74_A79_L0.5360.74
161_S290_I0.5360.74
82_R85_D0.5360.74
153_T205_S0.5350.74
117_L120_Y0.5350.74
28_G107_R0.5330.74
112_T175_F0.5330.74
266_R270_I0.5330.74
229_G255_M0.5320.74
76_V83_L0.5310.74
78_R100_G0.5290.73
316_D349_N0.5290.73
60_V72_T0.5280.73
12_I16_A0.5240.73
91_T102_V0.5230.72
137_T146_A0.5190.72
73_A80_A0.5190.72
131_D167_V0.5170.72
168_I184_V0.5170.72
54_T82_R0.5160.71
106_G348_Q0.5160.71
160_L195_G0.5140.71
226_N229_G0.5130.71
54_T96_E0.5130.71
217_L284_V0.5120.71
219_V284_V0.5120.71
27_M33_V0.5110.71
235_S250_S0.5100.71
22_A103_T0.5100.71
243_I263_V0.5100.71
130_T207_I0.5090.70
276_I283_S0.5070.70
162_F170_P0.5070.70
50_L86_T0.5070.70
115_V176_K0.5070.70
271_L276_I0.5050.70
221_G253_D0.5030.70
128_I165_A0.5030.70
129_V157_L0.5020.69
156_E305_G0.5020.69
240_D277_A0.5010.69
18_E22_A0.5010.69
308_C313_P0.5010.69
237_A279_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.983 100 0.26 Contact Map
2cdqA 2 0.9858 100 0.265 Contact Map
3l76A 2 0.9603 100 0.285 Contact Map
3ab4A 7 0.9207 100 0.287 Contact Map
3c1mA 3 0.9887 100 0.292 Contact Map
3tviA 2 0.9688 100 0.314 Contact Map
4ab7A 3 0.8612 100 0.689 Contact Map
4go7X 2 0.4363 99.9 0.751 Contact Map
3s1tA 2 0.4221 99.9 0.751 Contact Map
2dt9A 2 0.4136 99.9 0.752 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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