Q9HMV1 - HALSA - GREMLIN Contacts

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Q9HMV1 - Aspartokinase

UniProt:	Q9HMV1	Sequences: MGNTTDELLDDITFDADEPDRAEIVSMGERTSVRMLKAALAARGVDATFLEPGTTDWPIVTNERGEVDADATAAGVDRLAGRLGDTVPVITGFLAEDPQGNVTTLGRGGSDTTAVMLGRYLDADEVVIVTDVEGIMTGDPQVVEGARNVGRITVDELRNLSFRGAEVIAPSALSFKDDALDVRVIHYQHGDLLSGGTRIEGTFESMIDMRDSPLACLTVAGRAIRNRPGITSALSTALSDSDINVDAVASGMDSMTFYVDESVAERAENILHQEVIAVSELSSVTVTDDIAAIRVLGGELPNRPGVLCRIIDPLADRNINVIDIISSATSVAVFVSWADREPALDVVQNGFGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	353 (337)
Sequences:	4677 (2718)
Seq/√Len:	148.1

ECOLI - AK1H AK2H AK3
BACSU - AK2 AK3 AK1
HALSA - Q9HMV1
SULSO - Q97ZL7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_V	87_V	5.061	1.00
46_D	86_T	4.456	1.00
97_D	101_N	4.333	1.00
309_R	350_G	4.302	1.00
339_D	342_P	4.040	1.00
90_I	117_L	3.807	1.00
118_G	126_V	3.609	1.00
160_L	296_L	3.369	1.00
312_D	316_D	3.202	1.00
50_L	82_R	2.998	1.00
151_R	194_S	2.871	1.00
125_E	183_R	2.835	1.00
210_R	340_R	2.807	1.00
133_E	189_H	2.770	1.00
215_A	261_E	2.720	1.00
37_K	47_A	2.690	1.00
289_D	337_W	2.649	1.00
48_T	86_T	2.643	1.00
268_E	272_H	2.612	1.00
183_R	192_L	2.590	1.00
293_I	347_V	2.544	1.00
33_V	91_T	2.510	1.00
236_T	240_D	2.329	1.00
155_D	177_D	2.268	1.00
212_S	341_E	2.222	1.00
300_L	305_G	2.199	1.00
145_G	349_N	2.144	1.00
127_V	183_R	2.102	1.00
61_T	103_T	2.098	1.00
63_E	97_D	2.064	1.00
264_A	286_V	2.044	1.00
176_K	182_V	2.029	1.00
117_L	121_L	2.029	1.00
179_A	195_G	2.019	1.00
26_S	102_V	2.013	1.00
22_A	67_V	2.013	1.00
212_S	337_W	2.006	1.00
41_A	46_D	1.999	1.00
76_V	80_A	1.965	1.00
77_D	81_G	1.961	1.00
115_V	126_V	1.902	1.00
336_S	339_D	1.895	1.00
317_R	342_P	1.893	1.00
149_V	152_I	1.888	1.00
342_P	345_D	1.862	1.00
48_T	88_P	1.858	1.00
314_L	343_A	1.813	1.00
316_D	350_G	1.803	1.00
78_R	82_R	1.781	1.00
39_A	43_R	1.761	1.00
272_H	276_I	1.741	1.00
231_T	255_M	1.717	1.00
21_R	25_V	1.705	1.00
130_T	184_V	1.694	1.00
261_E	288_D	1.678	1.00
73_A	76_V	1.640	1.00
208_D	344_L	1.636	1.00
133_E	136_M	1.600	1.00
232_S	239_S	1.578	1.00
268_E	286_V	1.576	1.00
310_I	333_V	1.573	1.00
71_A	116_M	1.534	1.00
291_A	340_R	1.531	1.00
138_G	210_R	1.524	1.00
261_E	337_W	1.524	1.00
19_P	101_N	1.515	1.00
75_G	80_A	1.485	1.00
217_L	267_A	1.468	1.00
40_L	45_V	1.466	1.00
76_V	79_L	1.455	1.00
53_G	102_V	1.455	1.00
247_A	334_F	1.452	1.00
50_L	88_P	1.448	1.00
127_V	185_I	1.445	1.00
61_T	95_A	1.416	1.00
317_R	346_V	1.414	1.00
293_I	343_A	1.403	1.00
24_I	34_R	1.399	1.00
9_L	21_R	1.391	1.00
310_I	347_V	1.389	1.00
224_I	229_G	1.383	1.00
52_P	57_W	1.378	1.00
293_I	344_L	1.377	1.00
215_A	264_A	1.366	1.00
9_L	13_T	1.360	1.00
133_E	186_H	1.360	1.00
320_N	324_I	1.355	1.00
281_L	284_V	1.353	1.00
269_N	273_Q	1.349	1.00
27_M	31_T	1.337	1.00
75_G	79_L	1.335	1.00
78_R	81_G	1.334	1.00
51_E	58_P	1.326	1.00
265_E	288_D	1.323	1.00
63_E	99_Q	1.311	1.00
79_L	88_P	1.309	1.00
126_V	176_K	1.305	1.00
137_T	348_Q	1.305	1.00
233_A	278_V	1.299	1.00
81_G	84_G	1.299	1.00
151_R	192_L	1.297	1.00
276_I	281_L	1.293	1.00
213_P	261_E	1.285	1.00
12_I	24_I	1.247	1.00
79_L	83_L	1.247	1.00
152_I	206_M	1.245	1.00
119_R	180_L	1.237	1.00
168_I	193_L	1.233	1.00
38_A	41_A	1.233	1.00
218_T	256_T	1.232	1.00
219_V	234_L	1.228	1.00
60_V	98_P	1.226	1.00
10_D	13_T	1.225	1.00
18_E	67_V	1.220	1.00
125_E	192_L	1.213	1.00
66_E	69_A	1.201	1.00
142_V	344_L	1.199	1.00
313_P	346_V	1.198	1.00
313_P	350_G	1.197	1.00
53_G	96_E	1.192	1.00
216_C	322_I	1.180	1.00
341_E	345_D	1.173	1.00
289_D	336_S	1.165	1.00
7_E	11_D	1.141	1.00
138_G	344_L	1.140	1.00
69_A	103_T	1.135	0.99
37_K	49_F	1.134	0.99
33_V	49_F	1.129	0.99
37_K	41_A	1.122	0.99
246_D	258_Y	1.121	0.99
66_E	97_D	1.109	0.99
80_A	84_G	1.105	0.99
59_I	113_T	1.105	0.99
9_L	12_I	1.089	0.99
215_A	288_D	1.087	0.99
291_A	337_W	1.087	0.99
48_T	82_R	1.085	0.99
312_D	350_G	1.085	0.99
293_I	335_V	1.082	0.99
80_A	83_L	1.080	0.99
240_D	274_E	1.078	0.99
269_N	272_H	1.071	0.99
217_L	259_V	1.068	0.99
26_S	30_R	1.066	0.99
319_I	343_A	1.063	0.99
40_L	89_V	1.057	0.99
52_P	91_T	1.052	0.99
229_G	320_N	1.048	0.99
36_L	89_V	1.048	0.99
62_N	69_A	1.046	0.99
36_L	40_L	1.044	0.99
132_V	167_V	1.030	0.99
231_T	250_S	1.028	0.99
220_A	283_S	1.024	0.99
294_R	332_A	1.023	0.99
41_A	47_A	1.019	0.99
238_L	245_V	1.015	0.99
300_L	306_V	1.010	0.99
322_I	336_S	1.008	0.99
12_I	21_R	1.008	0.99
246_D	292_A	1.008	0.99
295_V	310_I	1.007	0.99
234_L	255_M	1.002	0.99
22_A	104_T	1.000	0.99
60_V	96_E	0.999	0.99
81_G	85_D	0.997	0.99
51_E	91_T	0.985	0.99
53_G	58_P	0.982	0.99
138_G	143_V	0.970	0.98
72_T	98_P	0.970	0.98
210_R	344_L	0.963	0.98
212_S	340_R	0.961	0.98
211_D	214_L	0.961	0.98
290_I	334_F	0.959	0.98
136_M	168_I	0.955	0.98
295_V	331_V	0.954	0.98
52_P	90_I	0.954	0.98
287_T	322_I	0.953	0.98
237_A	241_S	0.949	0.98
163_R	294_R	0.949	0.98
265_E	268_E	0.946	0.98
82_R	88_P	0.938	0.98
305_G	328_A	0.938	0.98
247_A	332_A	0.937	0.98
231_T	248_V	0.936	0.98
23_E	49_F	0.935	0.98
97_D	103_T	0.933	0.98
18_E	266_R	0.929	0.98
113_T	117_L	0.929	0.98
241_S	273_Q	0.925	0.98
170_P	175_F	0.921	0.98
307_L	311_I	0.921	0.98
237_A	274_E	0.921	0.98
8_L	11_D	0.911	0.98
74_A	78_R	0.907	0.98
33_V	89_V	0.907	0.98
301_P	328_A	0.906	0.98
111_D	131_D	0.903	0.97
314_L	319_I	0.902	0.97
16_A	42_A	0.901	0.97
221_G	282_S	0.900	0.97
224_I	230_I	0.897	0.97
51_E	57_W	0.897	0.97
60_V	75_G	0.889	0.97
142_V	210_R	0.879	0.97
173_L	182_V	0.874	0.97
8_L	12_I	0.869	0.97
308_C	315_A	0.867	0.97
143_V	344_L	0.862	0.97
75_G	78_R	0.859	0.97
247_A	325_I	0.858	0.97
34_R	38_A	0.857	0.97
22_A	95_A	0.851	0.96
144_E	345_D	0.849	0.96
52_P	58_P	0.848	0.96
232_S	236_T	0.846	0.96
168_I	182_V	0.846	0.96
241_S	270_I	0.845	0.96
171_S	174_S	0.843	0.96
82_R	86_T	0.842	0.96
186_H	189_H	0.841	0.96
212_S	291_A	0.840	0.96
153_T	156_E	0.840	0.96
292_A	332_A	0.839	0.96
73_A	77_D	0.836	0.96
256_T	323_D	0.835	0.96
289_D	338_A	0.832	0.96
317_R	339_D	0.829	0.96
234_L	271_L	0.827	0.96
136_M	146_A	0.826	0.96
68_D	263_V	0.826	0.96
168_I	172_A	0.823	0.96
230_I	255_M	0.820	0.96
10_D	14_F	0.816	0.95
235_S	245_V	0.815	0.95
310_I	331_V	0.815	0.95
204_E	306_V	0.814	0.95
263_V	266_R	0.810	0.95
11_D	15_D	0.806	0.95
241_S	266_R	0.805	0.95
151_R	197_T	0.798	0.95
66_E	71_A	0.796	0.95
135_I	167_V	0.794	0.95
319_I	342_P	0.793	0.95
217_L	264_A	0.793	0.95
235_S	255_M	0.791	0.95
40_L	87_V	0.790	0.95
319_I	346_V	0.789	0.94
47_A	89_V	0.785	0.94
238_L	243_I	0.784	0.94
287_T	336_S	0.783	0.94
313_P	317_R	0.778	0.94
64_R	68_D	0.775	0.94
37_K	89_V	0.774	0.94
178_D	203_F	0.774	0.94
238_L	267_A	0.771	0.94
234_L	284_V	0.770	0.94
237_A	270_I	0.769	0.94
207_I	296_L	0.769	0.94
287_T	290_I	0.767	0.94
130_T	167_V	0.765	0.94
215_A	259_V	0.765	0.94
49_F	91_T	0.765	0.94
30_R	33_V	0.764	0.94
11_D	35_M	0.764	0.94
30_R	102_V	0.764	0.94
272_H	283_S	0.761	0.93
46_D	85_D	0.760	0.93
243_I	267_A	0.759	0.93
151_R	198_R	0.759	0.93
292_A	334_F	0.758	0.93
335_V	343_A	0.755	0.93
309_R	313_P	0.754	0.93
260_D	263_V	0.753	0.93
128_I	167_V	0.750	0.93
220_A	285_T	0.750	0.93
151_R	196_G	0.749	0.93
238_L	257_F	0.749	0.93
109_G	131_D	0.748	0.93
153_T	195_G	0.748	0.93
243_I	270_I	0.740	0.92
68_D	71_A	0.739	0.92
305_G	320_N	0.737	0.92
235_S	244_N	0.735	0.92
173_L	193_L	0.733	0.92
113_T	175_F	0.733	0.92
172_A	175_F	0.732	0.92
290_I	322_I	0.732	0.92
270_I	273_Q	0.731	0.92
47_A	87_V	0.723	0.92
213_P	337_W	0.721	0.91
229_G	250_S	0.721	0.91
21_R	67_V	0.719	0.91
231_T	245_V	0.716	0.91
276_I	285_T	0.716	0.91
135_I	157_L	0.716	0.91
236_T	312_D	0.715	0.91
138_G	208_D	0.711	0.91
62_N	70_D	0.709	0.91
315_A	320_N	0.708	0.91
268_E	274_E	0.707	0.91
300_L	328_A	0.707	0.91
27_M	30_R	0.705	0.90
335_V	340_R	0.703	0.90
80_A	122_D	0.703	0.90
128_I	166_E	0.702	0.90
135_I	191_D	0.701	0.90
216_C	256_T	0.700	0.90
226_N	253_D	0.698	0.90
231_T	320_N	0.697	0.90
93_F	110_S	0.692	0.90
137_T	147_R	0.692	0.90
130_T	187_Y	0.689	0.89
235_S	248_V	0.685	0.89
57_W	60_V	0.684	0.89
214_L	258_Y	0.678	0.89
39_A	42_A	0.678	0.89
63_E	98_P	0.678	0.89
228_P	231_T	0.675	0.88
77_D	80_A	0.674	0.88
147_R	151_R	0.673	0.88
73_A	79_L	0.670	0.88
51_E	102_V	0.669	0.88
78_R	101_N	0.668	0.88
72_T	75_G	0.667	0.88
213_P	262_S	0.667	0.88
220_A	253_D	0.665	0.88
136_M	148_N	0.665	0.88
88_P	91_T	0.664	0.88
112_T	172_A	0.661	0.87
52_P	94_L	0.660	0.87
343_A	346_V	0.659	0.87
63_E	69_A	0.658	0.87
93_F	107_R	0.657	0.87
249_A	325_I	0.654	0.87
312_D	315_A	0.651	0.87
30_R	51_E	0.650	0.87
142_V	212_S	0.649	0.86
138_G	348_Q	0.647	0.86
51_E	96_E	0.646	0.86
214_L	260_D	0.646	0.86
266_R	269_N	0.646	0.86
217_L	268_E	0.646	0.86
238_L	264_A	0.645	0.86
105_L	131_D	0.643	0.86
300_L	331_V	0.640	0.86
311_I	321_V	0.637	0.85
221_G	224_I	0.637	0.85
169_A	175_F	0.636	0.85
323_D	326_S	0.635	0.85
316_D	338_A	0.634	0.85
205_S	208_D	0.634	0.85
224_I	254_S	0.633	0.85
336_S	346_V	0.631	0.85
305_G	308_C	0.629	0.85
210_R	291_A	0.629	0.85
33_V	37_K	0.629	0.85
67_V	71_A	0.628	0.85
346_V	350_G	0.627	0.85
62_N	68_D	0.625	0.84
208_D	347_V	0.624	0.84
270_I	274_E	0.624	0.84
62_N	66_E	0.624	0.84
306_V	331_V	0.621	0.84
31_T	34_R	0.621	0.84
60_V	97_D	0.620	0.84
281_L	285_T	0.620	0.84
265_E	269_N	0.617	0.84
108_G	172_A	0.616	0.84
194_S	197_T	0.613	0.83
112_T	169_A	0.611	0.83
40_L	43_R	0.610	0.83
48_T	85_D	0.609	0.83
72_T	76_V	0.609	0.83
317_R	343_A	0.605	0.82
311_I	320_N	0.605	0.82
105_L	109_G	0.605	0.82
127_V	186_H	0.604	0.82
227_R	230_I	0.604	0.82
228_P	320_N	0.602	0.82
147_R	203_F	0.602	0.82
262_S	265_E	0.600	0.82
206_M	209_M	0.600	0.82
16_A	21_R	0.599	0.82
234_L	257_F	0.599	0.82
60_V	73_A	0.599	0.82
66_E	103_T	0.598	0.82
24_I	38_A	0.594	0.81
323_D	334_F	0.594	0.81
58_P	61_T	0.593	0.81
29_E	107_R	0.593	0.81
33_V	51_E	0.589	0.81
74_A	81_G	0.589	0.81
181_D	192_L	0.587	0.80
338_A	342_P	0.587	0.80
229_G	244_N	0.585	0.80
14_F	17_D	0.585	0.80
12_I	38_A	0.583	0.80
268_E	288_D	0.583	0.80
15_D	42_A	0.583	0.80
265_E	272_H	0.581	0.80
154_V	177_D	0.581	0.80
342_P	346_V	0.581	0.80
308_C	312_D	0.580	0.80
7_E	10_D	0.580	0.80
321_V	324_I	0.579	0.80
71_A	74_A	0.579	0.80
150_G	266_R	0.578	0.79
159_N	311_I	0.577	0.79
116_M	171_S	0.577	0.79
297_G	300_L	0.574	0.79
276_I	279_S	0.574	0.79
172_A	176_K	0.572	0.79
61_T	66_E	0.572	0.79
108_G	166_E	0.571	0.79
157_L	163_R	0.569	0.78
169_A	182_V	0.569	0.78
307_L	324_I	0.568	0.78
231_T	324_I	0.567	0.78
259_V	267_A	0.567	0.78
88_P	209_M	0.567	0.78
60_V	100_G	0.565	0.78
79_L	117_L	0.564	0.78
317_R	349_N	0.564	0.78
112_T	115_V	0.563	0.78
62_N	103_T	0.559	0.77
261_E	289_D	0.559	0.77
214_L	246_D	0.559	0.77
274_E	278_V	0.558	0.77
20_D	49_F	0.557	0.77
263_V	270_I	0.556	0.77
218_T	285_T	0.556	0.77
314_L	333_V	0.555	0.77
174_S	178_D	0.555	0.77
311_I	324_I	0.554	0.77
216_C	287_T	0.553	0.76
36_L	88_P	0.553	0.76
320_N	325_I	0.553	0.76
114_A	126_V	0.552	0.76
203_F	206_M	0.552	0.76
43_R	87_V	0.551	0.76
128_I	135_I	0.551	0.76
235_S	246_D	0.550	0.76
30_R	49_F	0.549	0.76
227_R	233_A	0.548	0.76
243_I	266_R	0.546	0.76
226_N	231_T	0.546	0.76
58_P	96_E	0.545	0.75
80_A	121_L	0.544	0.75
317_R	338_A	0.544	0.75
320_N	326_S	0.544	0.75
23_E	102_V	0.543	0.75
63_E	179_A	0.543	0.75
30_R	94_L	0.543	0.75
319_I	339_D	0.543	0.75
158_R	250_S	0.542	0.75
159_N	162_F	0.541	0.75
195_G	199_I	0.540	0.75
165_A	168_I	0.540	0.75
136_M	139_D	0.539	0.75
345_D	349_N	0.539	0.75
154_V	181_D	0.538	0.74
74_A	79_L	0.536	0.74
161_S	290_I	0.536	0.74
82_R	85_D	0.536	0.74
153_T	205_S	0.535	0.74
117_L	120_Y	0.535	0.74
28_G	107_R	0.533	0.74
112_T	175_F	0.533	0.74
266_R	270_I	0.533	0.74
229_G	255_M	0.532	0.74
76_V	83_L	0.531	0.74
78_R	100_G	0.529	0.73
316_D	349_N	0.529	0.73
60_V	72_T	0.528	0.73
12_I	16_A	0.524	0.73
91_T	102_V	0.523	0.72
137_T	146_A	0.519	0.72
73_A	80_A	0.519	0.72
131_D	167_V	0.517	0.72
168_I	184_V	0.517	0.72
54_T	82_R	0.516	0.71
106_G	348_Q	0.516	0.71
160_L	195_G	0.514	0.71
226_N	229_G	0.513	0.71
54_T	96_E	0.513	0.71
217_L	284_V	0.512	0.71
219_V	284_V	0.512	0.71
27_M	33_V	0.511	0.71
235_S	250_S	0.510	0.71
22_A	103_T	0.510	0.71
243_I	263_V	0.510	0.71
130_T	207_I	0.509	0.70
276_I	283_S	0.507	0.70
162_F	170_P	0.507	0.70
50_L	86_T	0.507	0.70
115_V	176_K	0.507	0.70
271_L	276_I	0.505	0.70
221_G	253_D	0.503	0.70
128_I	165_A	0.503	0.70
129_V	157_L	0.502	0.69
156_E	305_G	0.502	0.69
240_D	277_A	0.501	0.69
18_E	22_A	0.501	0.69
308_C	313_P	0.501	0.69
237_A	279_S	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j0wA	2	0.983	100	0.26	Contact Map
2cdqA	2	0.9858	100	0.265	Contact Map
3l76A	2	0.9603	100	0.285	Contact Map
3ab4A	7	0.9207	100	0.287	Contact Map
3c1mA	3	0.9887	100	0.292	Contact Map
3tviA	2	0.9688	100	0.314	Contact Map
4ab7A	3	0.8612	100	0.689	Contact Map
4go7X	2	0.4363	99.9	0.751	Contact Map
3s1tA	2	0.4221	99.9	0.751	Contact Map
2dt9A	2	0.4136	99.9	0.752	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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