GREMLIN Database
Q9HMU9 - Nitrite/nitrate reduction protein
UniProt: Q9HMU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (239)
Sequences: 13627 (10120)
Seq/√Len: 654.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A106_A4.2311.00
141_F220_A4.1341.00
8_R12_S3.9761.00
6_I99_G3.9721.00
155_G255_I3.4731.00
10_D100_K3.2121.00
92_T95_D2.9371.00
147_L249_L2.8451.00
7_A102_V2.7731.00
142_A217_I2.6331.00
243_V247_A2.5451.00
4_A8_R2.4631.00
155_G252_V2.4041.00
9_K77_E2.3751.00
77_E100_K2.3661.00
203_G207_F2.2461.00
206_Q210_Q2.2351.00
108_M146_A2.1011.00
79_E163_T2.0951.00
9_K13_D2.0861.00
254_A258_W2.0831.00
113_F139_A2.0271.00
49_D52_D2.0231.00
239_W243_V1.9381.00
12_S15_V1.9351.00
49_D53_L1.8581.00
7_A99_G1.8371.00
109_L143_L1.8051.00
77_E82_T1.7831.00
160_A169_I1.7781.00
75_S166_S1.7731.00
145_L217_I1.7411.00
48_V51_L1.7051.00
151_S249_L1.6891.00
148_V249_L1.6791.00
248_W252_V1.6521.00
162_S165_R1.6221.00
209_N215_D1.6181.00
94_R98_I1.6071.00
99_G103_G1.6061.00
145_L149_Y1.5721.00
11_F106_A1.5671.00
219_T241_L1.5661.00
210_Q215_D1.5651.00
244_I247_A1.5611.00
148_V252_V1.5531.00
78_L83_S1.5121.00
94_R257_Y1.5021.00
136_L140_V1.4991.00
156_L160_A1.4911.00
105_S143_L1.4721.00
33_G37_G1.4601.00
144_L246_I1.4571.00
207_F211_I1.4501.00
117_M121_A1.4201.00
70_T153_G1.4051.00
240_V244_I1.3971.00
105_S147_L1.3821.00
47_A51_L1.3711.00
101_I154_V1.3601.00
155_G259_R1.3411.00
244_I248_W1.3351.00
11_F15_V1.3291.00
207_F210_Q1.3241.00
50_L53_L1.3141.00
249_L253_P1.3031.00
210_Q216_A1.2881.00
48_V52_D1.2861.00
255_I259_R1.2841.00
160_A165_R1.2561.00
152_I173_F1.2471.00
11_F103_G1.2441.00
234_L237_S1.2231.00
76_G79_E1.2231.00
247_A251_G1.2221.00
76_G80_S1.2181.00
7_A103_G1.2111.00
4_A7_A1.2091.00
71_I166_S1.2041.00
15_V18_K1.2021.00
204_R207_F1.2011.00
5_A8_R1.1971.00
223_G227_V1.1841.00
148_V248_W1.1781.00
156_L173_F1.1761.00
100_K104_R1.1751.00
158_A259_R1.1711.00
95_D99_G1.1661.00
87_L93_R1.1651.00
172_G176_L1.1621.00
204_R208_L1.1601.00
112_V142_A1.1431.00
52_D56_G1.1371.00
141_F242_L1.1351.00
255_I258_W1.1121.00
74_I158_A1.1011.00
86_L96_V1.0991.00
137_G140_V1.0991.00
151_S252_V1.0951.00
70_T104_R1.0901.00
219_T223_G1.0881.00
202_P206_Q1.0881.00
52_D55_S1.0851.00
220_A223_G1.0831.00
17_S20_L1.0821.00
240_V243_V1.0781.00
227_V232_A1.0751.00
216_A241_L1.0731.00
155_G158_A1.0691.00
236_T239_W1.0691.00
141_F224_F1.0601.00
159_L259_R1.0541.00
233_A237_S1.0471.00
66_A108_M1.0471.00
148_V245_A1.0461.00
78_L161_R1.0371.00
237_S240_V1.0341.00
140_V144_L1.0331.00
136_L139_A1.0291.00
217_I220_A1.0251.00
241_L245_A1.0231.00
137_G224_F1.0231.00
182_P187_V1.0211.00
46_T49_D1.0191.00
223_G226_S1.0111.00
203_G206_Q0.9991.00
97_V256_G0.9961.00
188_V209_N0.9881.00
91_H96_V0.9841.00
242_L246_I0.9811.00
215_D219_T0.9801.00
216_A219_T0.9791.00
151_S253_P0.9761.00
236_T240_V0.9721.00
10_D104_R0.9591.00
28_V31_M0.9561.00
235_A240_V0.9541.00
63_P67_L0.9531.00
251_G255_I0.9431.00
134_N137_G0.9431.00
154_V158_A0.9411.00
51_L55_S0.9401.00
72_H76_G0.9291.00
45_T49_D0.9271.00
18_K21_W0.9261.00
177_L212_P0.9251.00
210_Q213_P0.9231.00
104_R150_T0.9181.00
104_R154_V0.9121.00
47_A50_L0.9121.00
155_G256_G0.9111.00
173_F177_L0.9111.00
239_W242_L0.9091.00
25_A28_V0.9091.00
181_W184_I0.9031.00
216_A220_A0.8971.00
151_S256_G0.8961.00
258_W261_N0.8931.00
35_A39_G0.8881.00
158_A256_G0.8821.00
85_L88_S0.8801.00
246_I250_L0.8801.00
243_V246_I0.8801.00
58_V61_L0.8761.00
117_M120_G0.8721.00
202_P205_R0.8701.00
144_L249_L0.8651.00
124_F127_Y0.8611.00
174_Y178_S0.8601.00
212_P215_D0.8521.00
82_T86_L0.8511.00
114_I117_M0.8511.00
238_K241_L0.8491.00
101_I151_S0.8471.00
223_G233_A0.8451.00
61_L65_T0.8371.00
86_L91_H0.8291.00
10_D103_G0.8241.00
75_S78_L0.8161.00
51_L56_G0.8131.00
187_V191_T0.8121.00
182_P186_S0.8061.00
45_T48_V0.8031.00
206_Q209_N0.7991.00
116_V120_G0.7911.00
250_L254_A0.7901.00
49_D57_P0.7851.00
83_S96_V0.7841.00
47_A53_L0.7821.00
251_G254_A0.7811.00
209_N213_P0.7801.00
233_A236_T0.7721.00
7_A11_F0.7711.00
118_S122_Y0.7701.00
50_L55_S0.7641.00
184_I218_T0.7571.00
34_A37_G0.7561.00
234_L238_K0.7561.00
83_S87_L0.7541.00
12_S16_R0.7541.00
51_L54_L0.7531.00
123_V126_V0.7511.00
253_P257_Y0.7481.00
97_V257_Y0.7451.00
160_A166_S0.7451.00
157_S166_S0.7441.00
245_A248_W0.7441.00
188_V191_T0.7431.00
156_L169_I0.7341.00
47_A52_D0.7341.00
45_T52_D0.7341.00
62_I66_A0.7331.00
14_A107_V0.7311.00
19_A22_A0.7271.00
91_H95_D0.7251.00
37_G122_Y0.7201.00
28_V34_A0.7181.00
14_A24_T0.7151.00
105_S150_T0.7131.00
104_R108_M0.7121.00
85_L89_L0.7111.00
216_A244_I0.7101.00
224_F227_V0.7081.00
68_L167_T0.7031.00
252_V256_G0.7001.00
77_E84_K0.6991.00
247_A250_L0.6981.00
76_G163_T0.6961.00
98_I102_V0.6951.00
164_S168_I0.6951.00
246_I249_L0.6901.00
145_L245_A0.6891.00
212_P216_A0.6871.00
209_N212_P0.6831.00
237_S241_L0.6811.00
36_A123_V0.6771.00
63_P149_Y0.6751.00
205_R210_Q0.6741.00
218_T222_A0.6711.00
211_I216_A0.6691.00
254_A257_Y0.6681.00
49_D55_S0.6651.00
250_L253_P0.6561.00
146_A150_T0.6551.00
64_I67_L0.6491.00
66_A70_T0.6461.00
143_L146_A0.6451.00
129_T134_N0.6431.00
106_A110_I0.6421.00
57_P60_F0.6421.00
165_R169_I0.6391.00
234_L239_W0.6361.00
50_L56_G0.6361.00
144_L245_A0.6341.00
182_P189_A0.6331.00
72_H163_T0.6321.00
187_V190_Y0.6311.00
63_P70_T0.6301.00
142_A146_A0.6291.00
236_T241_L0.6241.00
49_D56_G0.6221.00
73_S100_K0.6201.00
152_I252_V0.6181.00
248_W251_G0.6161.00
86_L100_K0.6141.00
205_R209_N0.6131.00
219_T222_A0.6121.00
72_H101_I0.6101.00
223_G241_L0.6101.00
46_T51_L0.6101.00
101_I150_T0.6071.00
176_L179_F0.6051.00
220_A238_K0.6031.00
34_A38_Y0.5981.00
208_L212_P0.5961.00
82_T100_K0.5951.00
41_F190_Y0.5941.00
98_I257_Y0.5861.00
101_I105_S0.5851.00
238_K242_L0.5831.00
166_S177_L0.5831.00
181_W185_L0.5821.00
186_S191_T0.5821.00
256_G259_R0.5791.00
171_A175_T0.5781.00
79_E162_S0.5771.00
181_W186_S0.5771.00
111_A217_I0.5761.00
257_Y261_N0.5761.00
116_V135_Y0.5761.00
170_A174_Y0.5701.00
83_S260_F0.5701.00
37_G40_Y0.5681.00
71_I170_A0.5681.00
29_V118_S0.5671.00
19_A76_G0.5651.00
102_V106_A0.5651.00
36_A40_Y0.5641.00
135_Y139_A0.5621.00
75_S163_T0.5601.00
55_S58_V0.5591.00
57_P63_P0.5591.00
147_L151_S0.5581.00
226_S232_A0.5581.00
74_I97_V0.5581.00
101_I147_L0.5581.00
249_L254_A0.5571.00
63_P174_Y0.5561.00
222_A226_S0.5551.00
72_H167_T0.5551.00
48_V53_L0.5531.00
74_I154_V0.5531.00
29_V33_G0.5521.00
234_L240_V0.5521.00
186_S190_Y0.5501.00
165_R168_I0.5471.00
18_K22_A0.5431.00
9_K82_T0.5411.00
55_S59_N0.5411.00
14_A103_G0.5401.00
19_A72_H0.5401.00
116_V139_A0.5381.00
13_D77_E0.5331.00
252_V255_I0.5300.99
45_T51_L0.5300.99
22_A27_F0.5290.99
67_L170_A0.5290.99
156_L170_A0.5290.99
210_Q219_T0.5290.99
247_A254_A0.5280.99
22_A26_L0.5280.99
50_L57_P0.5270.99
188_V215_D0.5270.99
75_S79_E0.5260.99
188_V210_Q0.5230.99
241_L244_I0.5220.99
82_T96_V0.5220.99
99_G102_V0.5190.99
188_V206_Q0.5180.99
84_K88_S0.5180.99
183_L187_V0.5170.99
221_R224_F0.5160.99
67_L71_I0.5150.99
164_S167_T0.5150.99
186_S189_A0.5150.99
16_R78_L0.5150.99
52_D57_P0.5120.99
71_I75_S0.5120.99
65_T68_L0.5110.99
63_P145_L0.5100.99
236_T243_V0.5100.99
159_L255_I0.5100.99
167_T170_A0.5070.99
31_M35_A0.5050.99
59_N62_I0.5050.99
100_K103_G0.5040.99
10_D82_T0.5020.99
42_F46_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.3208 10.2 0.931 Contact Map
3ixzA 1 0.3358 4.6 0.941 Contact Map
1iijA 1 0.1321 4.5 0.942 Contact Map
2wswA 3 0.6264 4.2 0.942 Contact Map
2ks1B 1 0.1509 4 0.943 Contact Map
2zxeA 1 0.3358 3.5 0.944 Contact Map
2m20A 2 0.1208 3 0.946 Contact Map
2l2tA 2 0.1472 2.8 0.947 Contact Map
2ih3C 4 0.366 2.7 0.948 Contact Map
4xp4A 1 0.6377 2.3 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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