GREMLIN Database
Q9HMU8 - Copper transport ATP-binding protein
UniProt: Q9HMU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (238)
Sequences: 75357 (45490)
Seq/√Len: 2948.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E198_H3.6061.00
77_R149_E3.2441.00
8_G21_D3.1821.00
5_E25_T3.0131.00
17_T20_T2.9911.00
7_S59_S2.9571.00
32_Y200_G2.8321.00
122_A125_R2.6951.00
33_G196_C2.6651.00
59_S66_D2.5151.00
198_H210_E2.5011.00
20_T206_T2.4631.00
27_D30_E2.4131.00
11_K48_I2.3911.00
5_E61_T2.3711.00
12_R17_T2.3471.00
212_S215_A2.2681.00
211_D215_A2.2251.00
10_S21_D2.1651.00
6_L9_V2.1641.00
200_G207_L2.1241.00
28_E149_E2.0431.00
10_S57_T2.0281.00
109_D147_D2.0061.00
10_S17_T1.9821.00
63_L149_E1.9541.00
174_E178_R1.8971.00
115_D120_P1.8911.00
93_A130_F1.8681.00
46_I185_S1.8671.00
7_S61_T1.8591.00
186_S192_V1.8231.00
102_D105_N1.8121.00
193_E214_D1.7821.00
109_D112_A1.7701.00
200_G210_E1.7541.00
111_D123_A1.7211.00
94_R123_A1.6891.00
116_R178_R1.6791.00
66_D69_A1.6601.00
13_Y44_T1.6571.00
113_L145_V1.6551.00
112_A116_R1.6551.00
116_R174_E1.6421.00
211_D216_L1.6161.00
173_T194_A1.6161.00
11_K56_T1.5901.00
147_D180_T1.5831.00
8_G23_N1.5801.00
107_T111_D1.5751.00
98_E106_A1.5711.00
46_I152_L1.5441.00
98_E110_P1.5441.00
94_R124_D1.5421.00
13_Y18_A1.5291.00
6_L24_I1.5061.00
11_K53_V1.4931.00
65_Y70_D1.4921.00
94_R98_E1.4881.00
125_R129_G1.4761.00
94_R107_T1.4571.00
114_L123_A1.4261.00
97_V114_L1.4251.00
12_R56_T1.4251.00
30_E197_D1.4031.00
175_E180_T1.3731.00
33_G192_V1.3611.00
173_T176_A1.3541.00
9_V55_P1.3501.00
63_L77_R1.3361.00
10_S20_T1.3321.00
32_Y210_E1.3231.00
70_D73_A1.3201.00
24_I200_G1.3141.00
71_S75_R1.2971.00
19_L48_I1.2921.00
26_V32_Y1.2791.00
122_A130_F1.2391.00
215_A219_A1.2361.00
94_R110_P1.2251.00
98_E107_T1.2241.00
7_S25_T1.2191.00
169_R191_Q1.2081.00
51_D54_R1.2021.00
6_L49_L1.1991.00
96_H142_I1.1901.00
108_N112_A1.1891.00
22_L45_A1.1811.00
92_T95_K1.1791.00
31_I176_A1.1741.00
12_R15_D1.1701.00
153_L182_V1.1601.00
83_E132_T1.1501.00
51_D71_S1.1401.00
48_I55_P1.1301.00
176_A197_D1.1261.00
91_L95_K1.1211.00
130_F138_L1.1181.00
27_D198_H1.1171.00
34_F183_F1.1141.00
7_S23_N1.0971.00
223_T226_L1.0911.00
111_D115_D1.0851.00
113_L141_A1.0841.00
24_I45_A1.0841.00
81_L153_L1.0771.00
34_F45_A1.0761.00
97_V145_V1.0731.00
118_G167_E1.0621.00
50_L80_V1.0571.00
160_L168_M1.0541.00
8_G57_T1.0531.00
32_Y198_H1.0531.00
94_R111_D1.0531.00
106_A110_P1.0431.00
61_T66_D1.0321.00
105_N108_N1.0271.00
79_G148_P1.0131.00
92_T124_D1.0131.00
151_L180_T1.0121.00
222_A225_T1.0111.00
28_E63_L0.9991.00
3_A63_L0.9941.00
47_N53_V0.9761.00
172_L182_V0.9741.00
104_K108_N0.9661.00
203_Q208_V0.9611.00
165_A191_Q0.9591.00
31_I182_V0.9531.00
214_D218_E0.9521.00
48_I60_A0.9521.00
113_L117_V0.9511.00
92_T126_K0.9291.00
223_T227_T0.9271.00
31_I196_C0.9181.00
215_A218_E0.9161.00
65_Y77_R0.9151.00
6_L60_A0.9111.00
117_V141_A0.9101.00
119_I122_A0.9091.00
151_L182_V0.9021.00
45_A202_L0.9011.00
112_A115_D0.8981.00
50_L152_L0.8981.00
101_I105_N0.8971.00
199_A213_I0.8971.00
28_E179_G0.8961.00
49_L183_F0.8941.00
81_L140_L0.8891.00
122_A134_M0.8871.00
103_S106_A0.8861.00
73_A76_Q0.8841.00
95_K98_E0.8821.00
165_A188_I0.8811.00
11_K44_T0.8811.00
127_A138_L0.8791.00
105_N109_D0.8781.00
166_R170_S0.8671.00
9_V48_I0.8661.00
12_R20_T0.8591.00
153_L172_L0.8531.00
226_L230_L0.8491.00
109_D113_L0.8491.00
203_Q227_T0.8451.00
106_A109_D0.8411.00
101_I109_D0.8391.00
34_F200_G0.8311.00
22_L207_L0.8281.00
155_E187_H0.8271.00
81_L143_A0.8151.00
91_L96_H0.8141.00
40_A202_L0.8131.00
115_D121_E0.8081.00
101_I106_A0.8061.00
118_G174_E0.8051.00
21_D206_T0.8021.00
176_A182_V0.8001.00
6_L45_A0.7961.00
93_A138_L0.7951.00
152_L183_F0.7931.00
171_I174_E0.7921.00
65_Y73_A0.7861.00
87_V135_R0.7861.00
100_A142_I0.7821.00
79_G143_A0.7781.00
4_I49_L0.7761.00
130_F134_M0.7671.00
97_V110_P0.7671.00
92_T96_H0.7671.00
19_L22_L0.7661.00
26_V150_M0.7651.00
90_R128_G0.7641.00
157_S168_M0.7631.00
32_Y183_F0.7621.00
27_D181_T0.7601.00
49_L60_A0.7581.00
91_L99_F0.7581.00
37_P203_Q0.7561.00
107_T123_A0.7501.00
209_A219_A0.7501.00
74_I78_I0.7461.00
78_I150_M0.7411.00
19_L45_A0.7411.00
208_V222_A0.7401.00
48_I53_V0.7381.00
47_N52_F0.7351.00
96_H127_A0.7341.00
113_L144_L0.7331.00
107_T110_P0.7321.00
12_R18_A0.7291.00
170_S174_E0.7251.00
100_A146_G0.7241.00
193_E213_I0.7161.00
132_T137_R0.7131.00
31_I173_T0.7131.00
31_I195_I0.7121.00
120_P123_A0.7121.00
126_K129_G0.7111.00
213_I217_R0.7081.00
90_R95_K0.7071.00
170_S194_A0.7041.00
224_T228_V0.7021.00
17_T21_D0.7011.00
3_A62_I0.7011.00
4_I62_I0.7001.00
26_V181_T0.7001.00
112_A147_D0.7001.00
173_T195_I0.6991.00
55_P68_Q0.6981.00
111_D121_E0.6961.00
170_S173_T0.6951.00
8_G11_K0.6921.00
4_I150_M0.6901.00
169_R194_A0.6901.00
108_N111_D0.6901.00
21_D57_T0.6871.00
13_Y53_V0.6861.00
113_L116_R0.6851.00
227_T230_L0.6831.00
189_L217_R0.6821.00
191_Q195_I0.6781.00
35_L192_V0.6771.00
147_D178_R0.6761.00
184_F196_C0.6731.00
173_T177_N0.6711.00
114_L119_I0.6691.00
150_M183_F0.6671.00
149_E180_T0.6641.00
207_L210_E0.6621.00
26_V183_F0.6561.00
184_F195_I0.6541.00
30_E210_E0.6531.00
225_T229_T0.6471.00
63_L150_M0.6401.00
11_K19_L0.6371.00
193_E217_R0.6371.00
111_D120_P0.6301.00
196_C199_A0.6291.00
150_M181_T0.6281.00
237_A240_A0.6271.00
220_T224_T0.6251.00
203_Q206_T0.6241.00
201_I216_L0.6221.00
225_T228_V0.6191.00
227_T231_D0.6151.00
29_G181_T0.6151.00
48_I56_T0.6151.00
209_A216_L0.6141.00
35_L201_I0.6121.00
12_R57_T0.6091.00
201_I220_T0.6071.00
31_I184_F0.6051.00
136_Q159_G0.6031.00
102_D106_A0.6021.00
204_N227_T0.5991.00
62_I150_M0.5981.00
110_P123_A0.5961.00
38_N155_E0.5961.00
59_S68_Q0.5951.00
54_R68_Q0.5951.00
120_P124_D0.5951.00
234_T237_A0.5941.00
40_A204_N0.5931.00
157_S191_Q0.5931.00
18_A44_T0.5921.00
167_E170_S0.5911.00
25_T210_E0.5891.00
196_C213_I0.5881.00
28_E181_T0.5881.00
79_G146_G0.5871.00
192_V199_A0.5861.00
9_V60_A0.5831.00
61_T64_G0.5831.00
125_R130_F0.5771.00
203_Q222_A0.5741.00
89_D135_R0.5721.00
85_F139_G0.5721.00
226_L229_T0.5711.00
103_S107_T0.5701.00
107_T124_D0.5661.00
216_L225_T0.5661.00
49_L152_L0.5641.00
62_I77_R0.5631.00
31_I197_D0.5631.00
38_N164_G0.5601.00
209_A220_T0.5581.00
231_D234_T0.5571.00
220_T223_T0.5571.00
235_D238_V0.5561.00
81_L139_G0.5531.00
88_Y91_L0.5521.00
88_Y96_H0.5511.00
47_N80_V0.5501.00
236_D239_A0.5491.00
140_L168_M0.5471.00
14_G17_T0.5471.00
6_L48_I0.5431.00
3_A150_M0.5421.00
50_L78_I0.5401.00
35_L189_L0.5381.00
16_V204_N0.5381.00
114_L120_P0.5381.00
208_V223_T0.5381.00
192_V196_C0.5381.00
186_S191_Q0.5381.00
73_A77_R0.5371.00
87_V138_L0.5371.00
65_Y74_I0.5371.00
62_I74_I0.5371.00
144_L180_T0.5371.00
71_S74_I0.5351.00
108_N115_D0.5331.00
190_G194_A0.5331.00
223_T230_L0.5321.00
94_R97_V0.5321.00
43_S47_N0.5291.00
222_A226_L0.5281.00
217_R220_T0.5271.00
131_S134_M0.5241.00
59_S69_A0.5231.00
67_A74_I0.5221.00
224_T227_T0.5211.00
52_F82_P0.5191.00
209_A221_D0.5191.00
24_I32_Y0.5181.00
85_F135_R0.5181.00
51_D68_Q0.5171.00
119_I134_M0.5151.00
10_S56_T0.5141.00
110_P145_V0.5121.00
111_D124_D0.5111.00
12_R16_V0.5111.00
3_A181_T0.5081.00
89_D128_G0.5061.00
20_T204_N0.5051.00
231_D235_D0.5011.00
88_Y99_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9013 100 0.121 Contact Map
3tuiC 2 0.9967 100 0.174 Contact Map
4rvcA 4 0.773 100 0.194 Contact Map
4u00A 1 0.7664 100 0.2 Contact Map
2oljA 2 0.7632 100 0.2 Contact Map
1vplA 2 0.7599 100 0.204 Contact Map
1b0uA 2 0.7796 100 0.206 Contact Map
2yyzA 1 0.9901 100 0.207 Contact Map
1g291 4 0.9013 100 0.207 Contact Map
4ymuJ 2 0.7599 100 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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