Q9HMU8 - HALSA - GREMLIN Contacts

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Q9HMU8 - Copper transport ATP-binding protein

UniProt:	Q9HMU8	Sequences: MPAIELSGVSKRYGDVTALTDLNITVDEGEIYGFLGPNGAGKSTAINILLDFVRPTTGSATILGYDAQADSQAIRQRIGVLPEGFSVYDRLTARKHVEFAIDSKNATNDPDALLDRVGIPEAADRKAGGFSTGMRQRLGLAIALVGDPEMLLLDEPSSGLDPNGAREMRSILTEEANRGTTVFFSSHILGQVEAICDHAGILQNGTLVAEDSIDALREATDATTTLTVTLDAVTDDAVAAANAIPGVSEVSVDASDLVVRTGDASKTDVLDAIESTGATVQDFATEDASLDDVFSAYTTEEMPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (238)
Sequences:	75357 (45490)
Seq/√Len:	2948.7

ECOLI - YADG UGPC MALK YCJV METN PROV POTA FBPC POTG CYSA YDCT MODC YEHX SAPD DPPD MACB ARAG DPPF RBSA OPPF OPPD YHES DDPD YECC UUP MLAF DDPF GSIA HISP FEPC LPTB TAUB LSRA FECE SSUB YTFR FHUC MDLB SAPF MDLA GLNQ CYDC PHNC NIKE YOJI GLTL YHDZ MSBA ZNUC YPHE CYDD BTUD ARTP XYLG PHNK ALSA LIVG SUFC LIVF MODF MGLA PSTB CCMA FTSE THIQ ETTA LOLD NIKD FETA YBBA YDDA PHNL YNJD YEJF YBHF YBIT YHIH
BACSU - YFIL YCBN YVFR YDBJ YVRA YHCH YURJ YXLF OPUCA MSMX OPUBA YHAQ METN TAGH OPUAA OPPD YTRB YFMM YKFD APPF RBSA DPPD FHUC APPD OPPF ECSA YKPA YFMF YFMR YUSV ECFA1 SKFE YDIF TCYN YCLP YHEH SUNT ALBC BCEA YLMA YFIC YTLC YFIB YVCR YXEO BMRA NATA SUFC TCYC YGAD GLNQ ECFA2 MNTB YKOD YWJA YKNV ARTM YHEI YKNU YXDL CYDD FTSE YJKB SSUB CYDC PSTB1 YVRO ZNUC PSTB2 YTHP YCLH YYBJ YKNY YUFO YHCG EXPZ YYDI YTRE
HALSA - Q9HMU8 Q9HHQ5 Q9HRJ6 BTUDA Q9HMX3 Q9HNZ9 Q9HMT3 Q9HMW0 Q9HR06 Q9HRH8 Q9HMX2 PHNC Q9HMG1 PSTB2 Q9HSQ7 Q9HHM2 Q9HMG6 Y1631 Q9HRV7 Q9HNY3 Y2317 Q9HRZ9 PSTB1 Q9HS04 Q9HHR7 Q9HR96 Q9HT03 Q9HR21 Q9HQA8 Q9HMC1 Q9HMW1
SULSO - Q7LX64 Q97UF2 Q97YY4 Q97X18 Q97YK2 Q97UY8 Q97VH6 Q97ZC0 Q97UD4 Q97VK9 Q97VC1 Q97YQ7 Q97VK8 Q97VF5 Q97UH3 Q97YP7 Q97YP3 Q97YP8 Q97UJ9 Q97VF4 Q97Z03 Q97U54 Y1893 Q97UH4 Q980W0 Q7LY07 Y2030 Q97V00 Q97V01 PSTB Q97W42 Q97VM2 Q7LXM4 Q7LX80 Q97VY4 Q97Z56 Q97UC2 Q97Z96 Q97UG5 Q97YP4 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_E	198_H	3.606	1.00
77_R	149_E	3.244	1.00
8_G	21_D	3.182	1.00
5_E	25_T	3.013	1.00
17_T	20_T	2.991	1.00
7_S	59_S	2.957	1.00
32_Y	200_G	2.832	1.00
122_A	125_R	2.695	1.00
33_G	196_C	2.665	1.00
59_S	66_D	2.515	1.00
198_H	210_E	2.501	1.00
20_T	206_T	2.463	1.00
27_D	30_E	2.413	1.00
11_K	48_I	2.391	1.00
5_E	61_T	2.371	1.00
12_R	17_T	2.347	1.00
212_S	215_A	2.268	1.00
211_D	215_A	2.225	1.00
10_S	21_D	2.165	1.00
6_L	9_V	2.164	1.00
200_G	207_L	2.124	1.00
28_E	149_E	2.043	1.00
10_S	57_T	2.028	1.00
109_D	147_D	2.006	1.00
10_S	17_T	1.982	1.00
63_L	149_E	1.954	1.00
174_E	178_R	1.897	1.00
115_D	120_P	1.891	1.00
93_A	130_F	1.868	1.00
46_I	185_S	1.867	1.00
7_S	61_T	1.859	1.00
186_S	192_V	1.823	1.00
102_D	105_N	1.812	1.00
193_E	214_D	1.782	1.00
109_D	112_A	1.770	1.00
200_G	210_E	1.754	1.00
111_D	123_A	1.721	1.00
94_R	123_A	1.689	1.00
116_R	178_R	1.679	1.00
66_D	69_A	1.660	1.00
13_Y	44_T	1.657	1.00
113_L	145_V	1.655	1.00
112_A	116_R	1.655	1.00
116_R	174_E	1.642	1.00
211_D	216_L	1.616	1.00
173_T	194_A	1.616	1.00
11_K	56_T	1.590	1.00
147_D	180_T	1.583	1.00
8_G	23_N	1.580	1.00
107_T	111_D	1.575	1.00
98_E	106_A	1.571	1.00
46_I	152_L	1.544	1.00
98_E	110_P	1.544	1.00
94_R	124_D	1.542	1.00
13_Y	18_A	1.529	1.00
6_L	24_I	1.506	1.00
11_K	53_V	1.493	1.00
65_Y	70_D	1.492	1.00
94_R	98_E	1.488	1.00
125_R	129_G	1.476	1.00
94_R	107_T	1.457	1.00
114_L	123_A	1.426	1.00
97_V	114_L	1.425	1.00
12_R	56_T	1.425	1.00
30_E	197_D	1.403	1.00
175_E	180_T	1.373	1.00
33_G	192_V	1.361	1.00
173_T	176_A	1.354	1.00
9_V	55_P	1.350	1.00
63_L	77_R	1.336	1.00
10_S	20_T	1.332	1.00
32_Y	210_E	1.323	1.00
70_D	73_A	1.320	1.00
24_I	200_G	1.314	1.00
71_S	75_R	1.297	1.00
19_L	48_I	1.292	1.00
26_V	32_Y	1.279	1.00
122_A	130_F	1.239	1.00
215_A	219_A	1.236	1.00
94_R	110_P	1.225	1.00
98_E	107_T	1.224	1.00
7_S	25_T	1.219	1.00
169_R	191_Q	1.208	1.00
51_D	54_R	1.202	1.00
6_L	49_L	1.199	1.00
96_H	142_I	1.190	1.00
108_N	112_A	1.189	1.00
22_L	45_A	1.181	1.00
92_T	95_K	1.179	1.00
31_I	176_A	1.174	1.00
12_R	15_D	1.170	1.00
153_L	182_V	1.160	1.00
83_E	132_T	1.150	1.00
51_D	71_S	1.140	1.00
48_I	55_P	1.130	1.00
176_A	197_D	1.126	1.00
91_L	95_K	1.121	1.00
130_F	138_L	1.118	1.00
27_D	198_H	1.117	1.00
34_F	183_F	1.114	1.00
7_S	23_N	1.097	1.00
223_T	226_L	1.091	1.00
111_D	115_D	1.085	1.00
113_L	141_A	1.084	1.00
24_I	45_A	1.084	1.00
81_L	153_L	1.077	1.00
34_F	45_A	1.076	1.00
97_V	145_V	1.073	1.00
118_G	167_E	1.062	1.00
50_L	80_V	1.057	1.00
160_L	168_M	1.054	1.00
8_G	57_T	1.053	1.00
32_Y	198_H	1.053	1.00
94_R	111_D	1.053	1.00
106_A	110_P	1.043	1.00
61_T	66_D	1.032	1.00
105_N	108_N	1.027	1.00
79_G	148_P	1.013	1.00
92_T	124_D	1.013	1.00
151_L	180_T	1.012	1.00
222_A	225_T	1.011	1.00
28_E	63_L	0.999	1.00
3_A	63_L	0.994	1.00
47_N	53_V	0.976	1.00
172_L	182_V	0.974	1.00
104_K	108_N	0.966	1.00
203_Q	208_V	0.961	1.00
165_A	191_Q	0.959	1.00
31_I	182_V	0.953	1.00
214_D	218_E	0.952	1.00
48_I	60_A	0.952	1.00
113_L	117_V	0.951	1.00
92_T	126_K	0.929	1.00
223_T	227_T	0.927	1.00
31_I	196_C	0.918	1.00
215_A	218_E	0.916	1.00
65_Y	77_R	0.915	1.00
6_L	60_A	0.911	1.00
117_V	141_A	0.910	1.00
119_I	122_A	0.909	1.00
151_L	182_V	0.902	1.00
45_A	202_L	0.901	1.00
112_A	115_D	0.898	1.00
50_L	152_L	0.898	1.00
101_I	105_N	0.897	1.00
199_A	213_I	0.897	1.00
28_E	179_G	0.896	1.00
49_L	183_F	0.894	1.00
81_L	140_L	0.889	1.00
122_A	134_M	0.887	1.00
103_S	106_A	0.886	1.00
73_A	76_Q	0.884	1.00
95_K	98_E	0.882	1.00
165_A	188_I	0.881	1.00
11_K	44_T	0.881	1.00
127_A	138_L	0.879	1.00
105_N	109_D	0.878	1.00
166_R	170_S	0.867	1.00
9_V	48_I	0.866	1.00
12_R	20_T	0.859	1.00
153_L	172_L	0.853	1.00
226_L	230_L	0.849	1.00
109_D	113_L	0.849	1.00
203_Q	227_T	0.845	1.00
106_A	109_D	0.841	1.00
101_I	109_D	0.839	1.00
34_F	200_G	0.831	1.00
22_L	207_L	0.828	1.00
155_E	187_H	0.827	1.00
81_L	143_A	0.815	1.00
91_L	96_H	0.814	1.00
40_A	202_L	0.813	1.00
115_D	121_E	0.808	1.00
101_I	106_A	0.806	1.00
118_G	174_E	0.805	1.00
21_D	206_T	0.802	1.00
176_A	182_V	0.800	1.00
6_L	45_A	0.796	1.00
93_A	138_L	0.795	1.00
152_L	183_F	0.793	1.00
171_I	174_E	0.792	1.00
65_Y	73_A	0.786	1.00
87_V	135_R	0.786	1.00
100_A	142_I	0.782	1.00
79_G	143_A	0.778	1.00
4_I	49_L	0.776	1.00
130_F	134_M	0.767	1.00
97_V	110_P	0.767	1.00
92_T	96_H	0.767	1.00
19_L	22_L	0.766	1.00
26_V	150_M	0.765	1.00
90_R	128_G	0.764	1.00
157_S	168_M	0.763	1.00
32_Y	183_F	0.762	1.00
27_D	181_T	0.760	1.00
49_L	60_A	0.758	1.00
91_L	99_F	0.758	1.00
37_P	203_Q	0.756	1.00
107_T	123_A	0.750	1.00
209_A	219_A	0.750	1.00
74_I	78_I	0.746	1.00
78_I	150_M	0.741	1.00
19_L	45_A	0.741	1.00
208_V	222_A	0.740	1.00
48_I	53_V	0.738	1.00
47_N	52_F	0.735	1.00
96_H	127_A	0.734	1.00
113_L	144_L	0.733	1.00
107_T	110_P	0.732	1.00
12_R	18_A	0.729	1.00
170_S	174_E	0.725	1.00
100_A	146_G	0.724	1.00
193_E	213_I	0.716	1.00
132_T	137_R	0.713	1.00
31_I	173_T	0.713	1.00
31_I	195_I	0.712	1.00
120_P	123_A	0.712	1.00
126_K	129_G	0.711	1.00
213_I	217_R	0.708	1.00
90_R	95_K	0.707	1.00
170_S	194_A	0.704	1.00
224_T	228_V	0.702	1.00
17_T	21_D	0.701	1.00
3_A	62_I	0.701	1.00
4_I	62_I	0.700	1.00
26_V	181_T	0.700	1.00
112_A	147_D	0.700	1.00
173_T	195_I	0.699	1.00
55_P	68_Q	0.698	1.00
111_D	121_E	0.696	1.00
170_S	173_T	0.695	1.00
8_G	11_K	0.692	1.00
4_I	150_M	0.690	1.00
169_R	194_A	0.690	1.00
108_N	111_D	0.690	1.00
21_D	57_T	0.687	1.00
13_Y	53_V	0.686	1.00
113_L	116_R	0.685	1.00
227_T	230_L	0.683	1.00
189_L	217_R	0.682	1.00
191_Q	195_I	0.678	1.00
35_L	192_V	0.677	1.00
147_D	178_R	0.676	1.00
184_F	196_C	0.673	1.00
173_T	177_N	0.671	1.00
114_L	119_I	0.669	1.00
150_M	183_F	0.667	1.00
149_E	180_T	0.664	1.00
207_L	210_E	0.662	1.00
26_V	183_F	0.656	1.00
184_F	195_I	0.654	1.00
30_E	210_E	0.653	1.00
225_T	229_T	0.647	1.00
63_L	150_M	0.640	1.00
11_K	19_L	0.637	1.00
193_E	217_R	0.637	1.00
111_D	120_P	0.630	1.00
196_C	199_A	0.629	1.00
150_M	181_T	0.628	1.00
237_A	240_A	0.627	1.00
220_T	224_T	0.625	1.00
203_Q	206_T	0.624	1.00
201_I	216_L	0.622	1.00
225_T	228_V	0.619	1.00
227_T	231_D	0.615	1.00
29_G	181_T	0.615	1.00
48_I	56_T	0.615	1.00
209_A	216_L	0.614	1.00
35_L	201_I	0.612	1.00
12_R	57_T	0.609	1.00
201_I	220_T	0.607	1.00
31_I	184_F	0.605	1.00
136_Q	159_G	0.603	1.00
102_D	106_A	0.602	1.00
204_N	227_T	0.599	1.00
62_I	150_M	0.598	1.00
110_P	123_A	0.596	1.00
38_N	155_E	0.596	1.00
59_S	68_Q	0.595	1.00
54_R	68_Q	0.595	1.00
120_P	124_D	0.595	1.00
234_T	237_A	0.594	1.00
40_A	204_N	0.593	1.00
157_S	191_Q	0.593	1.00
18_A	44_T	0.592	1.00
167_E	170_S	0.591	1.00
25_T	210_E	0.589	1.00
196_C	213_I	0.588	1.00
28_E	181_T	0.588	1.00
79_G	146_G	0.587	1.00
192_V	199_A	0.586	1.00
9_V	60_A	0.583	1.00
61_T	64_G	0.583	1.00
125_R	130_F	0.577	1.00
203_Q	222_A	0.574	1.00
89_D	135_R	0.572	1.00
85_F	139_G	0.572	1.00
226_L	229_T	0.571	1.00
103_S	107_T	0.570	1.00
107_T	124_D	0.566	1.00
216_L	225_T	0.566	1.00
49_L	152_L	0.564	1.00
62_I	77_R	0.563	1.00
31_I	197_D	0.563	1.00
38_N	164_G	0.560	1.00
209_A	220_T	0.558	1.00
231_D	234_T	0.557	1.00
220_T	223_T	0.557	1.00
235_D	238_V	0.556	1.00
81_L	139_G	0.553	1.00
88_Y	91_L	0.552	1.00
88_Y	96_H	0.551	1.00
47_N	80_V	0.550	1.00
236_D	239_A	0.549	1.00
140_L	168_M	0.547	1.00
14_G	17_T	0.547	1.00
6_L	48_I	0.543	1.00
3_A	150_M	0.542	1.00
50_L	78_I	0.540	1.00
35_L	189_L	0.538	1.00
16_V	204_N	0.538	1.00
114_L	120_P	0.538	1.00
208_V	223_T	0.538	1.00
192_V	196_C	0.538	1.00
186_S	191_Q	0.538	1.00
73_A	77_R	0.537	1.00
87_V	138_L	0.537	1.00
65_Y	74_I	0.537	1.00
62_I	74_I	0.537	1.00
144_L	180_T	0.537	1.00
71_S	74_I	0.535	1.00
108_N	115_D	0.533	1.00
190_G	194_A	0.533	1.00
223_T	230_L	0.532	1.00
94_R	97_V	0.532	1.00
43_S	47_N	0.529	1.00
222_A	226_L	0.528	1.00
217_R	220_T	0.527	1.00
131_S	134_M	0.524	1.00
59_S	69_A	0.523	1.00
67_A	74_I	0.522	1.00
224_T	227_T	0.521	1.00
52_F	82_P	0.519	1.00
209_A	221_D	0.519	1.00
24_I	32_Y	0.518	1.00
85_F	135_R	0.518	1.00
51_D	68_Q	0.517	1.00
119_I	134_M	0.515	1.00
10_S	56_T	0.514	1.00
110_P	145_V	0.512	1.00
111_D	124_D	0.511	1.00
12_R	16_V	0.511	1.00
3_A	181_T	0.508	1.00
89_D	128_G	0.506	1.00
20_T	204_N	0.505	1.00
231_D	235_D	0.501	1.00
88_Y	99_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yerA	2	0.9013	100	0.121	Contact Map
3tuiC	2	0.9967	100	0.174	Contact Map
4rvcA	4	0.773	100	0.194	Contact Map
4u00A	1	0.7664	100	0.2	Contact Map
2oljA	2	0.7632	100	0.2	Contact Map
1vplA	2	0.7599	100	0.204	Contact Map
1b0uA	2	0.7796	100	0.206	Contact Map
2yyzA	1	0.9901	100	0.207	Contact Map
1g291	4	0.9013	100	0.207	Contact Map
4ymuJ	2	0.7599	100	0.207	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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