GREMLIN Database
Q9HMU7 - Uncharacterized protein
UniProt: Q9HMU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (82)
Sequences: 116 (74)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_M78_H4.5340.99
71_A75_R3.8640.97
9_L22_L2.8410.85
5_E31_H2.4780.76
74_M84_V2.4710.76
5_E52_A2.1560.65
6_R49_D2.1360.64
70_E73_R1.9470.56
53_D62_A1.7050.46
7_A56_D1.6290.43
65_D69_T1.6100.43
32_V37_R1.5640.41
16_D19_L1.5080.38
38_S52_A1.4930.38
72_S78_H1.4830.37
71_A74_M1.4790.37
58_V80_P1.4530.36
3_D84_V1.3930.34
43_D83_T1.3740.33
13_E44_P1.3640.33
59_E79_D1.3580.33
39_L44_P1.3320.32
17_K41_A1.3080.31
14_Y34_R1.2780.30
4_T76_D1.2760.30
60_D64_V1.2750.30
15_T36_Q1.2620.29
3_D40_N1.2430.29
60_D63_D1.2210.28
33_H54_D1.1920.27
18_G41_A1.1470.26
13_E41_A1.1450.25
15_T39_L1.1390.25
19_L77_E1.1310.25
27_P47_A1.1090.24
13_E16_D1.1030.24
24_Y29_G1.0580.23
19_L75_R1.0480.23
44_P56_D1.0420.22
31_H40_N1.0390.22
37_R44_P1.0060.21
6_R76_D1.0020.21
9_L28_D0.9860.21
41_A71_A0.9670.20
51_A65_D0.9590.20
13_E37_R0.9550.20
16_D41_A0.9460.20
17_K42_G0.9380.20
18_G32_V0.9370.19
4_T49_D0.9320.19
20_L55_L0.9310.19
32_V36_Q0.9240.19
27_P54_D0.9170.19
68_G84_V0.9140.19
28_D32_V0.9110.19
27_P49_D0.8980.18
13_E23_T0.8920.18
34_R54_D0.8720.18
50_V63_D0.8660.18
58_V63_D0.8540.17
7_A42_G0.8420.17
23_T30_E0.8330.17
23_T32_V0.8270.17
7_A55_L0.8220.17
35_K42_G0.8040.16
45_T49_D0.7850.16
23_T33_H0.7810.16
17_K44_P0.7780.16
33_H47_A0.7760.16
57_P76_D0.7690.15
42_G56_D0.7610.15
43_D59_E0.7550.15
66_R70_E0.7320.15
39_L56_D0.7240.15
36_Q82_D0.7200.14
65_D77_E0.7070.14
62_A84_V0.6980.14
15_T44_P0.6960.14
37_R43_D0.6930.14
13_E32_V0.6920.14
35_K44_P0.6860.14
11_F58_V0.6720.13
13_E18_G0.6610.13
17_K39_L0.6570.13
7_A39_L0.6500.13
62_A83_T0.6490.13
30_E58_V0.6470.13
21_S56_D0.6420.13
67_Y80_P0.6410.13
32_V41_A0.6360.13
21_S36_Q0.6350.13
7_A48_V0.6210.13
10_V70_E0.6150.12
27_P75_R0.6140.12
7_A21_S0.6120.12
41_A48_V0.6050.12
6_R51_A0.6050.12
33_H84_V0.6020.12
51_A69_T0.5960.12
39_L42_G0.5940.12
37_R42_G0.5920.12
63_D82_D0.5920.12
4_T55_L0.5820.12
45_T81_D0.5750.12
6_R34_R0.5690.12
34_R61_P0.5510.11
65_D76_D0.5490.11
14_Y52_A0.5440.11
50_V71_A0.5440.11
61_P82_D0.5330.11
77_E83_T0.5310.11
29_G68_G0.5280.11
24_Y68_G0.5280.11
52_A83_T0.5270.11
18_G40_N0.5240.11
18_G44_P0.5220.11
23_T38_S0.5220.11
20_L54_D0.5220.11
3_D54_D0.5090.11
24_Y46_A0.5090.11
29_G46_A0.5090.11
30_E57_P0.5030.11
21_S41_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w07A 2 0.5714 7.2 0.938 Contact Map
2olrA 1 1 7.1 0.938 Contact Map
1ytmA 1 0.9286 3.8 0.946 Contact Map
1qusA 1 0.9881 3.8 0.946 Contact Map
2gd9A 2 0.3214 3.5 0.946 Contact Map
3nvqA 2 0.3214 3.4 0.947 Contact Map
2affB 1 0.4048 3.3 0.947 Contact Map
4po6B 1 0.1429 3 0.948 Contact Map
1ik9A 2 0.9048 3 0.948 Contact Map
1tvcA 1 0.3571 2.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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