GREMLIN Database
Q9HMU4 - Ribonucleoside reductase small chain
UniProt: Q9HMU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (301)
Sequences: 2176 (770)
Seq/√Len: 44.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_E254_L5.8991.00
257_R273_A4.9651.00
253_Q277_E4.3021.00
281_D294_G4.1731.00
40_V110_T4.1311.00
56_D59_R4.0841.00
167_R240_E3.4771.00
136_A140_E3.3401.00
60_Q64_W3.3311.00
238_E290_D3.3011.00
246_R292_V3.2021.00
55_T58_E3.0221.00
249_V293_Y2.9551.00
175_I245_M2.9291.00
242_N292_V2.8301.00
170_V241_V2.6301.00
242_N284_F2.6161.00
253_Q273_A2.4701.00
249_V280_A2.4071.00
169_L221_L2.3561.00
243_S247_D2.3311.00
48_Q53_E2.3061.00
242_N290_D2.2981.00
242_N289_M2.2671.00
177_E211_E2.2581.00
239_A243_S2.1591.00
104_E177_E2.1251.00
222_I229_H2.0920.99
170_V287_L2.0760.99
246_R293_Y2.0430.99
133_P137_E2.0390.99
49_W59_R2.0230.99
211_E214_H2.0190.99
31_V36_T2.0000.99
235_A239_A1.9420.99
63_E119_G1.9200.99
241_V289_M1.8930.99
250_D254_L1.8810.99
73_E111_F1.8670.99
191_L197_M1.8510.99
42_M113_Y1.8280.99
15_I95_Q1.8180.99
242_N246_R1.7730.98
28_Q38_E1.7710.98
76_T146_T1.7620.98
110_T203_Q1.7450.98
30_G103_E1.7310.98
206_Y209_R1.7130.98
98_L105_A1.7100.98
104_E211_E1.7000.98
46_I50_Q1.6700.97
37_P110_T1.6570.97
98_L101_A1.6470.97
222_I289_M1.6100.97
277_E295_T1.6020.97
140_E144_G1.5780.96
22_W224_Q1.5700.96
96_Y217_F1.5580.96
238_E242_N1.5480.96
49_W63_E1.5270.96
144_G247_D1.5160.95
270_E274_D1.4920.95
20_Y90_A1.4690.95
271_Q274_D1.4690.95
77_A105_A1.4690.95
166_L222_I1.4580.94
99_R103_E1.4560.94
58_E196_K1.4540.94
285_Q291_P1.4370.94
59_R63_E1.4350.94
181_F207_I1.4300.94
31_V37_P1.4160.93
257_R269_S1.4160.93
246_R250_D1.3670.92
273_A277_E1.3650.92
163_R240_E1.3620.92
138_K252_E1.3560.92
30_G100_Q1.3510.92
107_H214_H1.3430.91
181_F185_F1.3380.91
114_C200_V1.3120.90
161_D164_D1.3020.90
181_F211_E1.2960.90
46_I117_S1.2960.90
69_F76_T1.2910.90
179_I245_M1.2850.89
312_T317_R1.2610.89
99_R102_Y1.2610.89
137_E247_D1.2580.88
313_N316_E1.2560.88
26_Y94_R1.2560.88
28_Q36_T1.2500.88
186_A301_W1.2430.88
140_E290_D1.2380.88
202_E320_S1.2380.88
192_K201_G1.2070.86
316_E319_V1.2010.86
37_P40_V1.2000.86
240_E243_S1.1950.86
235_A238_E1.1940.86
226_R238_E1.1930.86
61_L259_A1.1930.86
54_L197_M1.1880.85
193_R301_W1.1660.84
263_D270_E1.1620.84
186_A256_A1.1600.84
28_Q109_D1.1590.84
318_N324_Q1.1450.83
37_P106_V1.1430.83
238_E289_M1.1180.82
104_E181_F1.1100.81
62_V200_V1.1080.81
275_Y302_M1.1070.81
56_D270_E1.1040.81
68_F255_Y1.0890.80
37_P113_Y1.0880.80
164_D167_R1.0860.80
22_W25_E1.0860.80
44_G48_Q1.0850.80
57_A263_D1.0830.80
50_Q120_F1.0810.79
40_V206_Y1.0770.79
226_R233_W1.0730.79
127_G131_R1.0700.79
253_Q257_R1.0620.78
59_R123_E1.0610.78
299_F302_M1.0550.78
138_K255_Y1.0500.77
12_P17_P1.0480.77
188_M204_F1.0230.75
189_L208_M1.0230.75
95_Q105_A0.9950.73
172_F218_G0.9940.73
249_V277_E0.9910.73
47_S50_Q0.9900.73
21_D25_E0.9880.73
107_H210_D0.9870.73
290_D295_T0.9850.73
223_N226_R0.9810.72
215_L283_R0.9760.72
31_V106_V0.9720.72
40_V209_R0.9680.71
185_F322_Y0.9580.71
172_F215_L0.9540.70
94_R98_L0.9520.70
83_A86_E0.9400.69
81_V85_Y0.9310.68
250_D253_Q0.9310.68
185_F211_E0.9280.68
170_V245_M0.9280.68
281_D291_P0.9270.68
278_Y282_R0.9260.68
160_D163_R0.9210.68
23_A224_Q0.9190.67
24_R28_Q0.9190.67
73_E200_V0.9180.67
254_L257_R0.9170.67
50_Q243_S0.9150.67
138_K313_N0.9130.67
179_I183_A0.9090.66
98_L240_E0.9070.66
215_L282_R0.9050.66
177_E185_F0.9020.66
88_V165_F0.9010.66
22_W220_D0.9010.66
243_S250_D0.8990.66
184_G207_I0.8980.66
67_G125_M0.8970.65
310_T317_R0.8960.65
240_E244_L0.8930.65
95_Q98_L0.8930.65
219_V286_Q0.8830.64
113_Y116_D0.8820.64
279_V283_R0.8800.64
87_Y168_D0.8780.64
238_E270_E0.8730.63
69_F184_G0.8700.63
34_N99_R0.8680.63
140_E295_T0.8670.63
284_F292_V0.8660.63
173_Y218_G0.8660.63
274_D295_T0.8630.62
102_Y105_A0.8610.62
112_I116_D0.8540.62
298_P316_E0.8540.62
23_A220_D0.8530.62
183_A276_V0.8520.61
185_F214_H0.8480.61
41_A44_G0.8480.61
73_E214_H0.8460.61
178_G283_R0.8450.61
12_P16_L0.8440.61
208_M306_V0.8430.61
163_R236_D0.8420.60
107_H322_Y0.8420.60
270_E273_A0.8420.60
56_D246_R0.8410.60
28_Q32_A0.8410.60
48_Q191_L0.8390.60
277_E293_Y0.8350.60
42_M203_Q0.8340.60
310_T321_E0.8310.59
238_E243_S0.8290.59
99_R105_A0.8270.59
163_R234_T0.8250.59
27_Y109_D0.8210.59
26_Y216_N0.8160.58
242_N291_P0.8140.58
142_V176_M0.8120.58
291_P294_G0.8120.58
261_P265_L0.8070.57
42_M199_G0.8070.57
177_E214_H0.8060.57
177_E181_F0.8060.57
202_E206_Y0.8010.57
205_E310_T0.8010.57
24_R109_D0.7960.56
55_T273_A0.7960.56
140_E292_V0.7910.56
224_Q228_E0.7900.56
290_D294_G0.7890.56
256_A276_V0.7880.55
44_G47_S0.7780.54
165_F169_L0.7760.54
36_T106_V0.7700.54
140_E293_Y0.7700.54
214_H322_Y0.7700.54
249_V253_Q0.7680.54
220_D224_Q0.7640.53
312_T319_V0.7610.53
30_G33_N0.7600.53
166_L225_I0.7490.52
102_Y106_V0.7470.51
73_E210_D0.7420.51
43_Q46_I0.7420.51
277_E281_D0.7410.51
93_C221_L0.7370.51
273_A276_V0.7360.50
53_E290_D0.7360.50
30_G217_F0.7360.50
146_T182_Y0.7350.50
195_G320_S0.7340.50
53_E196_K0.7280.50
314_F319_V0.7250.49
100_Q181_F0.7250.49
19_D91_P0.7240.49
24_R27_Y0.7230.49
22_W37_P0.7170.49
54_L59_R0.7160.48
215_L278_Y0.7090.48
163_R237_F0.7080.48
73_E218_G0.7080.48
126_Y135_I0.7070.48
268_S271_Q0.7060.48
63_E123_E0.7040.47
67_G212_S0.7030.47
227_D289_M0.7030.47
23_A93_C0.7020.47
210_D214_H0.7010.47
56_D241_V0.6960.47
82_L85_Y0.6960.47
61_L187_M0.6950.46
14_K17_P0.6920.46
20_Y224_Q0.6900.46
192_K205_E0.6890.46
81_V86_E0.6860.46
237_F289_M0.6840.45
133_P242_N0.6830.45
239_A242_N0.6800.45
114_C182_Y0.6800.45
107_H185_F0.6800.45
107_H211_E0.6770.45
217_F221_L0.6760.45
41_A199_G0.6730.44
193_R202_E0.6720.44
50_Q57_A0.6720.44
232_V235_A0.6690.44
69_F313_N0.6660.44
42_M117_S0.6660.44
197_M203_Q0.6660.44
120_F123_E0.6650.44
141_F145_L0.6650.44
179_I280_A0.6650.44
203_Q308_L0.6640.44
39_E318_N0.6630.43
122_P131_R0.6620.43
137_E141_F0.6610.43
62_V69_F0.6610.43
281_D284_F0.6600.43
138_K251_L0.6570.43
202_E308_L0.6570.43
218_G276_V0.6570.43
34_N72_A0.6560.43
160_D164_D0.6550.43
56_D300_P0.6550.43
140_E243_S0.6550.43
77_A101_A0.6550.43
253_Q295_T0.6490.42
230_P233_W0.6490.42
30_G96_Y0.6490.42
81_V186_A0.6480.42
239_A294_G0.6470.42
35_W45_D0.6450.42
175_I248_A0.6450.42
63_E77_A0.6410.41
175_I179_I0.6400.41
92_E303_T0.6400.41
26_Y29_Q0.6390.41
230_P234_T0.6370.41
292_V295_T0.6360.41
229_H233_W0.6330.41
222_I287_L0.6330.41
256_A301_W0.6310.40
69_F172_F0.6280.40
176_M188_M0.6270.40
106_V259_A0.6250.40
75_L138_K0.6250.40
175_I244_L0.6240.40
104_E111_F0.6230.40
88_V169_L0.6220.40
71_T206_Y0.6210.39
263_D268_S0.6210.39
47_S254_L0.6200.39
171_G244_L0.6200.39
20_Y23_A0.6170.39
63_E124_H0.6170.39
56_D133_P0.6170.39
310_T320_S0.6150.39
211_E322_Y0.6140.39
234_T237_F0.6130.39
169_L278_Y0.6100.38
298_P303_T0.6090.38
104_E214_H0.6080.38
230_P236_D0.6070.38
207_I211_E0.6060.38
80_I100_Q0.6060.38
245_M280_A0.6060.38
212_S216_N0.6050.38
76_T176_M0.6030.38
111_F185_F0.6020.38
30_G213_L0.6010.38
256_A273_A0.6010.38
70_S115_C0.6000.38
30_G99_R0.5990.37
178_G215_L0.5970.37
106_V325_G0.5970.37
257_R263_D0.5950.37
17_P92_E0.5950.37
99_R106_V0.5940.37
142_V171_G0.5920.37
72_A76_T0.5900.37
35_W107_H0.5900.37
257_R276_V0.5890.37
112_I213_L0.5880.36
312_T318_N0.5870.36
131_R290_D0.5860.36
73_E255_Y0.5830.36
137_E251_L0.5830.36
225_I228_E0.5820.36
317_R323_Q0.5820.36
12_P173_Y0.5800.36
137_E143_V0.5800.36
145_L240_E0.5800.36
46_I263_D0.5800.36
73_E112_I0.5770.35
11_D130_D0.5760.35
133_P290_D0.5750.35
112_I324_Q0.5750.35
118_L200_V0.5750.35
289_M292_V0.5720.35
132_I258_D0.5720.35
104_E185_F0.5700.35
249_V276_V0.5680.35
308_L323_Q0.5680.35
26_Y49_W0.5650.34
134_S258_D0.5650.34
186_A276_V0.5640.34
85_Y101_A0.5630.34
312_T316_E0.5610.34
252_E255_Y0.5610.34
122_P134_S0.5610.34
138_K181_F0.5610.34
181_F214_H0.5600.34
26_Y217_F0.5600.34
178_G199_G0.5590.34
145_L171_G0.5590.34
111_F214_H0.5570.34
84_I168_D0.5570.34
87_Y165_F0.5570.34
73_E181_F0.5560.34
258_D309_N0.5560.34
19_D22_W0.5530.33
217_F220_D0.5530.33
185_F252_E0.5520.33
184_G188_M0.5510.33
141_F247_D0.5510.33
21_D85_Y0.5500.33
78_N105_A0.5500.33
43_Q123_E0.5480.33
34_N66_L0.5460.33
250_D277_E0.5430.33
73_E107_H0.5420.32
110_T176_M0.5410.32
115_C265_L0.5410.32
56_D239_A0.5390.32
305_Q309_N0.5390.32
58_E79_N0.5380.32
301_W305_Q0.5370.32
237_F272_F0.5370.32
72_A110_T0.5340.32
271_Q299_F0.5330.32
40_V199_G0.5320.32
227_D247_D0.5320.32
94_R319_V0.5320.32
323_Q326_G0.5310.32
21_D50_Q0.5310.32
133_P191_L0.5300.31
167_R237_F0.5300.31
73_E278_Y0.5300.31
232_V236_D0.5300.31
20_Y226_R0.5290.31
81_V224_Q0.5280.31
222_I290_D0.5270.31
134_S259_A0.5260.31
53_E56_D0.5260.31
114_C118_L0.5250.31
230_P239_A0.5220.31
313_N319_V0.5210.31
186_A272_F0.5210.31
267_M272_F0.5190.31
263_D269_S0.5190.31
66_L70_S0.5180.30
93_C217_F0.5170.30
190_A276_V0.5170.30
186_A299_F0.5160.30
76_T172_F0.5140.30
163_R167_R0.5110.30
15_I20_Y0.5070.30
195_G307_D0.5070.30
19_D106_V0.5070.30
25_E247_D0.5060.29
31_V99_R0.5050.29
285_Q289_M0.5040.29
192_K197_M0.5040.29
97_L218_G0.5040.29
39_E302_M0.5030.29
76_T80_I0.5020.29
219_V287_L0.5010.29
107_H181_F0.5010.29
164_D253_Q0.5010.29
144_G238_E0.5000.29
13_N16_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1syyA 2 0.9094 100 0.069 Contact Map
1mxrA 2 0.9154 100 0.074 Contact Map
2rccA 4 0.8912 100 0.096 Contact Map
1jk0A 1 0.855 100 0.107 Contact Map
1h0oA 2 0.8489 100 0.108 Contact Map
1jk0B 1 0.7583 100 0.109 Contact Map
2p1iA 2 0.7674 100 0.117 Contact Map
3n37A 2 0.8399 100 0.149 Contact Map
3dhzA 2 0.861 100 0.154 Contact Map
4bmoA 2 0.8701 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.