Q9HMU3 - HALSA - GREMLIN Contacts

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Q9HMU3 - Ribonucleoside reductase large chain

UniProt:	Q9HMU3	Sequences: MTHATSATSDMVAAALDRALTDHEDDIDSDARDRILTEATRNAYDDATTDERYDALLGALTGRIDRHPAYKTVAGRVLRERLERRLVDDYDPATRDAATRQAFRDGIQRGLDADLLDERMGDYDLNRLADAITPARDDRLDYMAMDTLRQRYFLREPDADPFELPQPFWMRVAMGVALREDPADREEYAIEFYDALSTLRFVHSTPTLFHAGTTHAQLSSCYLTTVPDDLDGIFDAYKEHAKLSKWSGGLGNDWTPLRAAGSLIESTGVESTGTVPFLKISNDVTAAINRSGKRRGAAAAYLACWHLDFPAFCDLRRNTGDERRRTHDMNTAAWIPDLFMERVRADKQWTLFSPKETGDLYELYGSDFAERYREYEAMADDGDIQRFERVDATDLWRTMLTRLFETGHPWLTFKDPCNVRSPQDHAGTVRSSNLCTEITLNTSEEETAVCNLGSVNLARHLDDGDIDREQLSETVETAMRMLDNVVDLNFYPTENAERSNMRHRPVGLGVMGFHDALQQMRVPMASDDALDRADALQEYVAYHAIGASADLAAERGTYESYEGSKWDRDVFPQDTVDRLESERGREIPVPREERLDWSDVRQRVATHGMRNSNTMAVAPTATISTIAGTTPSIEPVYSNLYVKSNMSGDFTVVNDRLVADLEERDLWTEELRDKLTYHDGSVQELDAVPEDVQELYRTAFEIDPRHQLRLAARRGVWIDQSQSVNVFFPETDGSKLSEVYQTAWELGLKTTYYLRTLGASQIEKTTLDMDEYDDTQFRGDDDGEDADGDGDLPSVEDPTCEVCQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	804 (729)
Sequences:	2266 (804)
Seq/√Len:	29.8

ECOLI - RIR1 RIR3
BACSU - RIR1 NRDEB
HALSA - Q9HMU3 Q9HPG8
SULSO - Q97ZH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
341_E	369_A	8.352	1.00
344_R	745_E	7.247	1.00
497_E	501_M	5.090	1.00
553_A	603_R	4.997	1.00
545_I	604_V	4.894	1.00
346_D	391_D	4.855	1.00
546_G	603_R	4.416	1.00
472_S	546_G	4.403	1.00
348_Q	391_D	4.323	1.00
566_W	609_M	4.207	1.00
476_E	550_D	3.918	1.00
510_V	537_Q	3.743	1.00
350_T	384_I	3.707	1.00
191_E	473_E	3.635	1.00
664_R	691_D	3.594	1.00
690_E	694_E	3.572	1.00
259_A	307_L	3.571	1.00
531_D	535_A	3.469	1.00
352_F	357_T	3.418	1.00
549_A	603_R	3.392	1.00
348_Q	389_R	3.358	1.00
114_D	118_E	3.286	1.00
660_D	696_Y	3.248	1.00
346_D	393_T	3.229	1.00
235_D	238_K	3.153	1.00
479_M	506_V	3.148	1.00
462_D	467_D	3.147	1.00
553_A	607_H	3.071	1.00
341_E	345_A	3.055	1.00
479_M	614_T	3.007	1.00
674_K	687_A	2.994	1.00
337_D	419_V	2.959	1.00
128_L	174_M	2.957	1.00
472_S	542_Y	2.945	1.00
239_E	495_N	2.900	1.00
254_W	274_T	2.854	1.00
660_D	695_L	2.783	1.00
384_I	389_R	2.746	1.00
350_T	376_E	2.713	1.00
476_E	546_G	2.688	1.00
494_E	497_E	2.675	1.00
24_E	32_R	2.673	1.00
709_R	746_L	2.656	1.00
521_R	695_L	2.635	1.00
709_R	742_T	2.597	1.00
190_I	194_D	2.593	1.00
603_R	607_H	2.568	0.99
570_V	575_T	2.528	0.99
364_Y	424_D	2.512	0.99
596_D	599_D	2.492	0.99
453_G	478_A	2.490	0.99
417_C	439_T	2.486	0.99
131_A	190_I	2.477	0.99
391_D	394_D	2.474	0.99
350_T	389_R	2.459	0.99
231_D	238_K	2.456	0.99
447_T	493_T	2.430	0.99
374_E	381_D	2.391	0.99
561_Y	605_A	2.339	0.99
310_P	388_E	2.316	0.99
521_R	660_D	2.309	0.99
472_S	543_H	2.303	0.99
602_Q	606_T	2.289	0.99
200_R	470_Q	2.251	0.99
136_R	197_S	2.245	0.99
761_Q	764_K	2.222	0.98
480_R	554_E	2.204	0.98
140_L	169_W	2.195	0.98
338_L	341_E	2.183	0.98
99_T	103_F	2.164	0.98
571_F	604_V	2.149	0.98
218_L	488_L	2.142	0.98
549_A	553_A	2.121	0.98
545_I	609_M	2.112	0.98
535_A	594_R	2.108	0.98
598_S	601_R	2.097	0.98
366_S	370_E	2.095	0.98
690_E	693_Q	2.090	0.98
282_N	328_D	2.055	0.97
351_L	390_V	2.054	0.97
573_Q	601_R	2.022	0.97
370_E	374_E	2.013	0.97
352_F	384_I	2.004	0.97
239_E	447_T	2.001	0.97
498_R	502_R	1.993	0.97
310_P	390_V	1.986	0.97
523_P	695_L	1.986	0.97
549_A	607_H	1.965	0.97
205_T	297_A	1.949	0.96
707_Q	724_V	1.945	0.96
314_D	398_T	1.944	0.96
127_R	190_I	1.942	0.96
48_T	51_E	1.939	0.96
49_T	53_Y	1.928	0.96
675_L	682_V	1.927	0.96
602_Q	605_A	1.924	0.96
260_A	311_A	1.917	0.96
471_L	540_V	1.895	0.96
184_D	187_E	1.889	0.96
525_A	697_R	1.886	0.96
566_W	571_F	1.867	0.95
49_T	84_R	1.855	0.95
227_P	232_G	1.842	0.95
342_R	350_T	1.831	0.95
483_D	555_R	1.815	0.95
335_I	411_L	1.789	0.94
557_T	561_Y	1.782	0.94
371_R	374_E	1.782	0.94
309_F	333_A	1.769	0.94
30_D	46_D	1.765	0.94
541_A	545_I	1.742	0.93
35_I	52_R	1.738	0.93
278_L	326_T	1.734	0.93
234_F	280_I	1.713	0.93
457_L	510_V	1.709	0.93
367_D	370_E	1.696	0.92
79_R	83_E	1.695	0.92
742_T	746_L	1.684	0.92
369_A	373_R	1.681	0.92
310_P	398_T	1.681	0.92
278_L	329_M	1.670	0.92
275_V	315_L	1.657	0.92
359_D	375_Y	1.656	0.92
729_P	758_G	1.656	0.92
424_D	568_R	1.646	0.91
342_R	347_K	1.638	0.91
170_M	189_A	1.619	0.91
131_A	170_M	1.618	0.91
685_L	688_V	1.596	0.90
170_M	174_M	1.596	0.90
128_L	186_E	1.594	0.90
234_F	284_V	1.569	0.89
726_V	743_A	1.567	0.89
447_T	495_N	1.566	0.89
337_D	744_W	1.565	0.89
24_E	27_I	1.559	0.89
342_R	376_E	1.553	0.89
510_V	540_V	1.552	0.89
87_V	96_D	1.546	0.88
524_M	632_S	1.540	0.88
516_A	536_L	1.538	0.88
705_R	742_T	1.527	0.88
519_Q	656_R	1.527	0.88
188_Y	191_E	1.525	0.88
571_F	601_R	1.521	0.88
27_I	76_R	1.519	0.88
128_L	170_M	1.509	0.87
27_I	30_D	1.507	0.87
177_A	192_F	1.501	0.87
238_K	242_K	1.492	0.87
528_D	531_D	1.490	0.86
424_D	565_K	1.488	0.86
234_F	241_A	1.488	0.86
364_Y	419_V	1.485	0.86
34_R	63_R	1.483	0.86
518_Q	636_V	1.465	0.86
356_E	385_Q	1.461	0.85
549_A	604_V	1.457	0.85
199_L	627_A	1.457	0.85
455_V	475_V	1.450	0.85
131_A	194_D	1.443	0.85
632_S	727_F	1.438	0.84
460_H	474_T	1.438	0.84
310_P	395_L	1.438	0.84
522_V	532_R	1.436	0.84
545_I	571_F	1.436	0.84
50_D	85_R	1.433	0.84
192_F	481_M	1.428	0.84
86_L	164_L	1.423	0.84
598_S	602_Q	1.421	0.84
562_E	567_D	1.418	0.84
726_V	739_V	1.416	0.84
541_A	615_M	1.409	0.83
414_K	428_T	1.404	0.83
480_R	547_A	1.401	0.83
660_D	692_V	1.396	0.83
33_D	37_T	1.381	0.82
525_A	529_A	1.371	0.81
225_T	253_D	1.369	0.81
366_S	369_A	1.356	0.81
44_Y	51_E	1.351	0.80
338_L	369_A	1.345	0.80
139_R	199_L	1.345	0.80
180_E	484_N	1.342	0.80
103_F	107_I	1.337	0.80
117_D	121_G	1.329	0.79
679_D	764_K	1.326	0.79
46_D	49_T	1.321	0.79
566_W	601_R	1.321	0.79
98_A	101_Q	1.318	0.79
53_Y	84_R	1.307	0.78
23_H	27_I	1.307	0.78
400_L	736_L	1.306	0.78
708_L	726_V	1.301	0.78
413_F	743_A	1.298	0.78
24_E	73_V	1.297	0.78
156_E	160_D	1.296	0.78
259_A	353_S	1.284	0.77
494_E	498_R	1.283	0.77
99_T	112_D	1.268	0.76
99_T	106_G	1.263	0.76
416_P	419_V	1.261	0.76
285_T	298_A	1.260	0.76
262_S	355_K	1.259	0.75
304_C	333_A	1.258	0.75
33_D	36_L	1.254	0.75
221_C	435_C	1.252	0.75
549_A	600_V	1.249	0.75
340_M	343_V	1.244	0.75
770_D	773_D	1.244	0.75
186_E	189_A	1.242	0.74
31_A	34_R	1.237	0.74
457_L	540_V	1.232	0.74
106_G	112_D	1.228	0.74
175_G	216_A	1.227	0.74
278_L	315_L	1.226	0.74
22_D	25_D	1.221	0.73
469_E	472_S	1.207	0.72
194_D	198_T	1.205	0.72
363_L	371_R	1.201	0.72
117_D	120_M	1.200	0.72
702_I	706_H	1.199	0.72
542_Y	600_V	1.198	0.72
226_V	236_A	1.197	0.72
485_V	489_N	1.188	0.71
342_R	392_A	1.188	0.71
708_L	712_A	1.188	0.71
128_L	190_I	1.180	0.71
316_R	331_T	1.180	0.71
358_G	374_E	1.177	0.70
439_T	721_S	1.177	0.70
107_I	117_D	1.171	0.70
426_A	560_S	1.169	0.70
478_A	508_L	1.168	0.70
513_F	533_A	1.168	0.70
24_E	30_D	1.167	0.70
237_Y	280_I	1.166	0.70
502_R	560_S	1.165	0.70
664_R	692_V	1.165	0.70
221_C	452_L	1.156	0.69
390_V	395_L	1.154	0.69
186_E	190_I	1.154	0.69
601_R	609_M	1.152	0.69
253_D	431_S	1.151	0.69
48_T	52_R	1.148	0.68
33_D	49_T	1.145	0.68
485_V	506_V	1.144	0.68
32_R	46_D	1.144	0.68
468_R	539_Y	1.143	0.68
75_G	494_E	1.142	0.68
705_R	709_R	1.134	0.67
422_P	441_N	1.130	0.67
106_G	111_L	1.126	0.67
542_Y	596_D	1.126	0.67
136_R	194_D	1.126	0.67
280_I	283_D	1.123	0.67
666_L	671_L	1.117	0.66
539_Y	596_D	1.114	0.66
37_T	41_R	1.112	0.66
301_Y	332_A	1.110	0.66
39_A	56_L	1.110	0.66
545_I	566_W	1.107	0.66
561_Y	566_W	1.107	0.66
544_A	614_T	1.106	0.65
36_L	43_A	1.099	0.65
206_P	294_R	1.099	0.65
261_G	265_E	1.099	0.65
81_R	85_R	1.095	0.65
769_M	772_Y	1.090	0.64
221_C	249_G	1.085	0.64
525_A	706_H	1.080	0.64
171_R	212_G	1.077	0.63
248_G	296_G	1.076	0.63
54_D	81_R	1.072	0.63
624_S	632_S	1.067	0.63
476_E	603_R	1.059	0.62
30_D	60_L	1.059	0.62
231_D	235_D	1.058	0.62
708_L	739_V	1.058	0.62
743_A	751_T	1.058	0.62
435_C	452_L	1.058	0.62
164_L	167_P	1.056	0.62
572_P	576_V	1.055	0.62
36_L	45_D	1.054	0.62
315_L	326_T	1.052	0.62
714_R	722_Q	1.050	0.61
471_L	536_L	1.049	0.61
704_P	739_V	1.047	0.61
530_L	713_R	1.047	0.61
461_L	520_M	1.045	0.61
393_T	397_R	1.045	0.61
600_V	603_R	1.038	0.60
340_M	413_F	1.035	0.60
359_D	371_R	1.033	0.60
249_G	433_N	1.033	0.60
708_L	746_L	1.033	0.60
373_R	377_A	1.031	0.60
459_R	519_Q	1.026	0.60
193_Y	197_S	1.025	0.59
103_F	106_G	1.025	0.59
546_G	600_V	1.024	0.59
237_Y	284_V	1.021	0.59
363_L	367_D	1.021	0.59
317_R	325_R	1.020	0.59
550_D	553_A	1.019	0.59
530_L	706_H	1.019	0.59
708_L	728_F	1.017	0.59
59_A	62_G	1.016	0.59
99_T	111_L	1.010	0.58
366_S	419_V	1.009	0.58
338_L	373_R	1.008	0.58
347_K	391_D	1.008	0.58
484_N	555_R	1.007	0.58
36_L	53_Y	1.005	0.58
255_T	361_Y	1.005	0.58
137_D	166_Q	1.004	0.58
105_D	109_R	1.004	0.58
545_I	549_A	1.003	0.58
35_I	63_R	1.003	0.58
472_S	476_E	1.001	0.58
23_H	32_R	0.998	0.57
502_R	563_G	0.997	0.57
547_A	550_D	0.996	0.57
344_R	741_Q	0.989	0.57
221_C	437_E	0.987	0.57
516_A	532_R	0.987	0.57
134_P	167_P	0.982	0.56
38_E	44_Y	0.978	0.56
502_R	559_E	0.978	0.56
38_E	63_R	0.978	0.56
468_R	532_R	0.976	0.56
249_G	435_C	0.976	0.56
166_Q	197_S	0.976	0.56
476_E	547_A	0.976	0.56
195_A	474_T	0.966	0.55
345_A	599_D	0.959	0.54
630_T	636_V	0.956	0.54
37_T	48_T	0.956	0.54
30_D	35_I	0.954	0.54
707_Q	727_F	0.954	0.54
173_A	211_A	0.952	0.54
686_D	693_Q	0.946	0.53
206_P	221_C	0.941	0.53
451_N	486_V	0.938	0.53
437_E	452_L	0.937	0.53
487_D	491_Y	0.935	0.52
475_V	543_H	0.935	0.52
82_L	153_F	0.934	0.52
149_R	153_F	0.933	0.52
168_F	172_V	0.932	0.52
201_F	453_G	0.932	0.52
206_P	435_C	0.932	0.52
565_K	570_V	0.929	0.52
341_E	463_D	0.929	0.52
231_D	242_K	0.929	0.52
60_L	77_V	0.927	0.52
728_F	739_V	0.927	0.52
345_A	745_E	0.926	0.52
423_Q	558_Y	0.926	0.52
249_G	452_L	0.925	0.52
32_R	36_L	0.921	0.51
37_T	40_T	0.921	0.51
562_E	606_T	0.921	0.51
206_P	220_S	0.920	0.51
34_R	66_R	0.918	0.51
235_D	495_N	0.918	0.51
483_D	610_R	0.918	0.51
304_C	336_P	0.915	0.51
304_C	309_F	0.915	0.51
245_K	288_I	0.912	0.51
249_G	437_E	0.912	0.51
28_D	659_A	0.909	0.50
170_M	190_I	0.907	0.50
539_Y	595_L	0.907	0.50
686_D	690_E	0.906	0.50
254_W	281_S	0.904	0.50
203_H	481_M	0.904	0.50
30_D	37_T	0.901	0.50
174_M	189_A	0.900	0.50
469_E	595_L	0.899	0.50
46_D	51_E	0.899	0.50
170_M	193_Y	0.897	0.49
40_T	44_Y	0.897	0.49
30_D	56_L	0.896	0.49
83_E	86_L	0.895	0.49
374_E	377_A	0.895	0.49
38_E	42_N	0.894	0.49
448_A	505_P	0.894	0.49
309_F	395_L	0.893	0.49
302_L	312_F	0.890	0.49
128_L	131_A	0.890	0.49
266_S	285_T	0.889	0.49
542_Y	599_D	0.888	0.49
229_D	232_G	0.888	0.49
274_T	278_L	0.888	0.49
49_T	52_R	0.885	0.49
103_F	113_A	0.885	0.49
103_F	112_D	0.880	0.48
222_Y	429_V	0.880	0.48
707_Q	726_V	0.880	0.48
713_R	716_V	0.879	0.48
433_N	619_P	0.879	0.48
542_Y	546_G	0.879	0.48
515_D	629_T	0.874	0.48
249_G	294_R	0.873	0.48
31_A	43_A	0.872	0.47
416_P	420_R	0.870	0.47
682_V	688_V	0.869	0.47
103_F	125_L	0.869	0.47
370_E	377_A	0.869	0.47
104_R	108_Q	0.868	0.47
599_D	603_R	0.868	0.47
316_R	408_H	0.868	0.47
553_A	691_D	0.868	0.47
417_C	721_S	0.868	0.47
421_S	429_V	0.866	0.47
78_L	145_M	0.865	0.47
557_T	562_E	0.864	0.47
558_Y	564_S	0.864	0.47
112_D	117_D	0.864	0.47
485_V	508_L	0.863	0.47
239_E	494_E	0.863	0.47
461_L	519_Q	0.859	0.46
240_H	252_N	0.859	0.46
205_T	220_S	0.858	0.46
570_V	574_D	0.858	0.46
121_G	124_D	0.854	0.46
106_G	120_M	0.853	0.46
166_Q	193_Y	0.852	0.46
221_C	433_N	0.849	0.46
455_V	540_V	0.849	0.46
26_D	76_R	0.848	0.46
51_E	54_D	0.848	0.46
297_A	456_N	0.847	0.46
57_L	77_V	0.846	0.45
673_D	687_A	0.844	0.45
468_R	535_A	0.843	0.45
155_R	632_S	0.842	0.45
207_T	485_V	0.841	0.45
669_E	673_D	0.840	0.45
169_W	202_V	0.839	0.45
210_H	285_T	0.839	0.45
461_L	470_Q	0.839	0.45
279_K	283_D	0.839	0.45
738_E	742_T	0.837	0.45
595_L	599_D	0.835	0.45
535_A	592_E	0.835	0.45
54_D	58_G	0.834	0.45
37_T	43_A	0.833	0.44
671_L	685_L	0.833	0.44
43_A	62_G	0.830	0.44
118_E	123_Y	0.830	0.44
728_F	735_K	0.829	0.44
31_A	36_L	0.829	0.44
503_H	560_S	0.829	0.44
502_R	553_A	0.827	0.44
571_F	609_M	0.827	0.44
36_L	40_T	0.826	0.44
699_A	727_F	0.824	0.44
525_A	694_E	0.824	0.44
108_Q	602_Q	0.822	0.44
22_D	26_D	0.822	0.44
180_E	188_Y	0.822	0.44
35_I	75_G	0.819	0.43
88_D	135_A	0.817	0.43
424_D	574_D	0.816	0.43
185_R	502_R	0.816	0.43
703_D	739_V	0.816	0.43
550_D	607_H	0.813	0.43
264_I	308_D	0.812	0.43
44_Y	49_T	0.811	0.43
422_P	613_N	0.811	0.43
34_R	40_T	0.811	0.43
39_A	43_A	0.811	0.43
449_V	500_N	0.811	0.43
259_A	262_S	0.809	0.43
533_A	714_R	0.808	0.42
106_G	110_G	0.808	0.42
249_G	619_P	0.807	0.42
294_R	435_C	0.805	0.42
217_Q	320_G	0.803	0.42
768_D	772_Y	0.802	0.42
738_E	741_Q	0.801	0.42
337_D	416_P	0.799	0.42
370_E	602_Q	0.798	0.42
155_R	260_A	0.798	0.42
420_R	575_T	0.798	0.42
26_D	30_D	0.798	0.42
113_A	118_E	0.797	0.42
217_Q	489_N	0.797	0.42
272_T	316_R	0.795	0.41
578_R	591_R	0.792	0.41
21_T	45_D	0.792	0.41
137_D	193_Y	0.791	0.41
23_H	77_V	0.790	0.41
305_W	368_F	0.789	0.41
271_S	276_P	0.789	0.41
28_D	35_I	0.789	0.41
703_D	707_Q	0.784	0.41
721_S	770_D	0.782	0.40
550_D	603_R	0.782	0.40
659_A	663_E	0.782	0.40
21_T	37_T	0.780	0.40
99_T	117_D	0.780	0.40
53_Y	81_R	0.778	0.40
453_G	536_L	0.778	0.40
673_D	772_Y	0.777	0.40
286_A	328_D	0.774	0.40
472_S	539_Y	0.774	0.40
45_D	49_T	0.774	0.40
546_G	549_A	0.773	0.40
534_D	716_V	0.773	0.40
303_A	414_K	0.772	0.40
82_L	195_A	0.772	0.40
112_D	120_M	0.772	0.40
25_D	81_R	0.772	0.40
112_D	115_L	0.771	0.40
50_D	54_D	0.770	0.40
75_G	79_R	0.770	0.40
83_E	134_P	0.769	0.40
88_D	130_D	0.768	0.39
675_L	679_D	0.767	0.39
152_Y	435_C	0.767	0.39
25_D	133_T	0.767	0.39
245_K	454_S	0.766	0.39
553_A	606_T	0.765	0.39
461_L	516_A	0.764	0.39
372_Y	375_Y	0.762	0.39
541_A	631_P	0.762	0.39
39_A	44_Y	0.760	0.39
433_N	452_L	0.760	0.39
205_T	295_R	0.760	0.39
770_D	774_D	0.760	0.39
505_P	612_S	0.760	0.39
541_A	573_Q	0.759	0.39
563_G	567_D	0.759	0.39
237_Y	346_D	0.759	0.39
86_L	129_A	0.757	0.39
678_H	684_E	0.757	0.39
402_R	408_H	0.757	0.39
155_R	161_P	0.756	0.39
315_L	331_T	0.756	0.39
206_P	407_G	0.755	0.38
36_L	50_D	0.755	0.38
216_A	266_S	0.755	0.38
237_Y	281_S	0.755	0.38
341_E	344_R	0.754	0.38
304_C	343_V	0.754	0.38
44_Y	47_A	0.753	0.38
682_V	742_T	0.752	0.38
247_S	266_S	0.752	0.38
574_D	601_R	0.751	0.38
33_D	40_T	0.751	0.38
330_N	622_T	0.751	0.38
25_D	88_D	0.750	0.38
425_H	563_G	0.749	0.38
462_D	465_D	0.748	0.38
218_L	480_R	0.747	0.38
536_L	540_V	0.744	0.38
196_L	367_D	0.743	0.38
222_Y	455_V	0.742	0.37
199_L	459_R	0.741	0.37
228_D	258_R	0.740	0.37
221_C	294_R	0.740	0.37
377_A	382_G	0.740	0.37
465_D	520_M	0.740	0.37
127_R	131_A	0.738	0.37
27_I	32_R	0.737	0.37
565_K	574_D	0.736	0.37
127_R	187_E	0.736	0.37
191_E	476_E	0.735	0.37
52_R	84_R	0.735	0.37
200_R	459_R	0.734	0.37
72_T	81_R	0.734	0.37
88_D	133_T	0.732	0.37
438_I	616_A	0.731	0.37
53_Y	86_L	0.731	0.37
35_I	46_D	0.730	0.37
54_D	88_D	0.729	0.37
187_E	606_T	0.729	0.37
67_H	82_L	0.727	0.36
604_V	609_M	0.727	0.36
469_E	562_E	0.727	0.36
332_A	408_H	0.726	0.36
562_E	605_A	0.726	0.36
47_A	52_R	0.726	0.36
47_A	55_A	0.725	0.36
304_C	335_I	0.725	0.36
471_L	475_V	0.724	0.36
576_V	589_V	0.724	0.36
180_E	480_R	0.724	0.36
71_K	88_D	0.724	0.36
38_E	41_R	0.723	0.36
170_M	197_S	0.723	0.36
343_V	393_T	0.722	0.36
732_D	736_L	0.722	0.36
670_E	673_D	0.721	0.36
542_Y	597_W	0.719	0.36
103_F	114_D	0.718	0.36
42_N	55_A	0.718	0.36
32_R	60_L	0.718	0.36
436_T	449_V	0.717	0.36
22_D	33_D	0.717	0.36
420_R	576_V	0.717	0.36
107_I	114_D	0.717	0.36
98_A	114_D	0.716	0.36
24_E	85_R	0.716	0.36
465_D	745_E	0.715	0.35
373_R	376_E	0.715	0.35
99_T	105_D	0.715	0.35
71_K	141_D	0.714	0.35
377_A	472_S	0.713	0.35
35_I	47_A	0.713	0.35
120_M	124_D	0.712	0.35
39_A	52_R	0.711	0.35
762_I	767_L	0.711	0.35
467_D	470_Q	0.711	0.35
24_E	33_D	0.710	0.35
43_A	769_M	0.709	0.35
697_R	703_D	0.709	0.35
164_L	238_K	0.708	0.35
290_R	296_G	0.708	0.35
545_I	719_D	0.708	0.35
502_R	528_D	0.707	0.35
43_A	66_R	0.706	0.35
72_T	75_G	0.706	0.35
53_Y	78_L	0.706	0.35
705_R	738_E	0.705	0.35
341_E	745_E	0.705	0.35
768_D	771_E	0.702	0.35
28_D	50_D	0.700	0.34
767_L	772_Y	0.700	0.34
151_R	622_T	0.699	0.34
35_I	44_Y	0.698	0.34
148_L	626_I	0.698	0.34
211_A	508_L	0.696	0.34
626_I	633_I	0.696	0.34
458_A	519_Q	0.695	0.34
22_D	88_D	0.695	0.34
463_D	520_M	0.694	0.34
599_D	602_Q	0.694	0.34
254_W	300_A	0.693	0.34
576_V	715_G	0.693	0.34
148_L	241_A	0.692	0.34
517_L	522_V	0.692	0.34
316_R	438_I	0.691	0.34
32_R	37_T	0.691	0.34
31_A	47_A	0.690	0.34
452_L	507_G	0.690	0.34
245_K	651_T	0.690	0.34
512_G	628_G	0.689	0.34
479_M	544_A	0.688	0.34
80_E	86_L	0.688	0.34
176_V	488_L	0.687	0.33
358_G	375_Y	0.687	0.33
99_T	113_A	0.686	0.33
432_S	438_I	0.686	0.33
112_D	116_L	0.685	0.33
221_C	619_P	0.685	0.33
425_H	567_D	0.684	0.33
36_L	41_R	0.684	0.33
54_D	606_T	0.683	0.33
427_G	558_Y	0.682	0.33
712_A	746_L	0.682	0.33
314_D	402_R	0.681	0.33
133_T	194_D	0.681	0.33
297_A	549_A	0.681	0.33
177_A	189_A	0.680	0.33
113_A	116_L	0.680	0.33
348_Q	390_V	0.680	0.33
771_E	774_D	0.680	0.33
106_G	114_D	0.679	0.33
729_P	757_L	0.679	0.33
60_L	65_D	0.678	0.33
498_R	559_E	0.678	0.33
769_M	773_D	0.678	0.33
265_E	295_R	0.676	0.33
22_D	84_R	0.676	0.33
674_K	678_H	0.675	0.33
741_Q	745_E	0.675	0.33
81_R	104_R	0.675	0.33
21_T	31_A	0.672	0.32
49_T	80_E	0.671	0.32
209_F	293_K	0.671	0.32
456_N	627_A	0.671	0.32
39_A	42_N	0.670	0.32
152_Y	221_C	0.670	0.32
207_T	482_L	0.670	0.32
472_S	603_R	0.669	0.32
98_A	105_D	0.669	0.32
409_P	427_G	0.669	0.32
277_F	623_I	0.668	0.32
295_R	651_T	0.668	0.32
244_S	247_S	0.668	0.32
512_G	515_D	0.667	0.32
98_A	109_R	0.665	0.32
40_T	53_Y	0.665	0.32
474_T	477_T	0.665	0.32
226_V	533_A	0.664	0.32
113_A	178_L	0.664	0.32
99_T	171_R	0.660	0.32
33_D	45_D	0.660	0.32
22_D	85_R	0.659	0.32
674_K	686_D	0.658	0.31
84_R	88_D	0.658	0.31
210_H	245_K	0.657	0.31
682_V	764_K	0.657	0.31
427_G	563_G	0.655	0.31
499_S	505_P	0.654	0.31
730_E	758_G	0.654	0.31
21_T	50_D	0.654	0.31
601_R	605_A	0.653	0.31
274_T	302_L	0.653	0.31
238_K	495_N	0.651	0.31
454_S	618_A	0.651	0.31
256_P	430_R	0.651	0.31
31_A	37_T	0.650	0.31
152_Y	249_G	0.650	0.31
382_G	385_Q	0.650	0.31
78_L	82_L	0.649	0.31
525_A	702_I	0.649	0.31
343_V	392_A	0.649	0.31
370_E	373_R	0.649	0.31
28_D	41_R	0.648	0.31
703_D	706_H	0.648	0.31
390_V	602_Q	0.648	0.31
333_A	399_M	0.647	0.31
342_R	413_F	0.646	0.31
34_R	37_T	0.646	0.31
571_F	574_D	0.645	0.31
435_C	450_C	0.645	0.31
32_R	35_I	0.644	0.31
341_E	348_Q	0.643	0.30
86_L	162_F	0.643	0.30
360_L	365_G	0.643	0.30
44_Y	53_Y	0.642	0.30
47_A	80_E	0.642	0.30
266_S	288_I	0.641	0.30
24_E	46_D	0.641	0.30
715_G	722_Q	0.641	0.30
40_T	43_A	0.639	0.30
609_M	614_T	0.638	0.30
546_G	550_D	0.638	0.30
472_S	550_D	0.638	0.30
332_A	410_W	0.638	0.30
207_T	211_A	0.637	0.30
249_G	297_A	0.636	0.30
446_E	503_H	0.636	0.30
114_D	562_E	0.635	0.30
115_L	178_L	0.634	0.30
64_I	205_T	0.634	0.30
98_A	106_G	0.633	0.30
598_S	605_A	0.632	0.30
176_V	485_V	0.631	0.30
436_T	507_G	0.631	0.30
294_R	433_N	0.631	0.30
21_T	32_R	0.630	0.30
253_D	430_R	0.630	0.30
70_Y	196_L	0.630	0.30
22_D	80_E	0.628	0.29
36_L	44_Y	0.628	0.29
141_D	346_D	0.627	0.29
36_L	55_A	0.627	0.29
22_D	36_L	0.627	0.29
431_S	621_A	0.627	0.29
274_T	297_A	0.627	0.29
146_D	149_R	0.626	0.29
206_P	249_G	0.626	0.29
113_A	117_D	0.625	0.29
33_D	56_L	0.625	0.29
518_Q	655_D	0.625	0.29
45_D	729_P	0.625	0.29
28_D	69_A	0.625	0.29
549_A	561_Y	0.624	0.29
43_A	52_R	0.624	0.29
369_A	528_D	0.623	0.29
130_D	133_T	0.622	0.29
234_F	237_Y	0.622	0.29
233_I	258_R	0.621	0.29
514_H	636_V	0.621	0.29
590_P	593_E	0.621	0.29
247_S	292_G	0.620	0.29
23_H	73_V	0.619	0.29
724_V	739_V	0.618	0.29
277_F	287_A	0.618	0.29
26_D	69_A	0.618	0.29
206_P	452_L	0.616	0.29
247_S	646_M	0.615	0.29
673_D	769_M	0.615	0.29
264_I	296_G	0.615	0.29
34_R	41_R	0.615	0.29
126_N	130_D	0.615	0.29
50_D	81_R	0.614	0.29
45_D	48_T	0.614	0.29
372_Y	376_E	0.614	0.29
26_D	49_T	0.613	0.28
191_E	477_T	0.613	0.28
433_N	437_E	0.612	0.28
697_R	706_H	0.612	0.28
103_F	111_L	0.612	0.28
150_Q	475_V	0.612	0.28
34_R	59_A	0.610	0.28
265_E	651_T	0.610	0.28
618_A	740_Y	0.610	0.28
360_L	372_Y	0.609	0.28
624_S	729_P	0.609	0.28
23_H	26_D	0.608	0.28
52_R	130_D	0.608	0.28
28_D	105_D	0.607	0.28
141_D	295_R	0.606	0.28
188_Y	192_F	0.605	0.28
365_G	369_A	0.605	0.28
172_V	208_L	0.605	0.28
253_D	442_T	0.605	0.28
577_D	591_R	0.604	0.28
736_L	753_Y	0.604	0.28
207_T	218_L	0.602	0.28
113_A	120_M	0.602	0.28
357_T	384_I	0.601	0.28
337_D	340_M	0.601	0.28
511_M	620_T	0.601	0.28
671_L	677_Y	0.601	0.28
25_D	33_D	0.601	0.28
37_T	56_L	0.600	0.28
342_R	368_F	0.600	0.28
290_R	294_R	0.600	0.28
624_S	633_I	0.600	0.28
440_L	484_N	0.598	0.28
516_A	520_M	0.598	0.28
545_I	615_M	0.598	0.28
686_D	771_E	0.597	0.27
767_L	771_E	0.597	0.27
341_E	497_E	0.595	0.27
326_T	329_M	0.595	0.27
116_L	212_G	0.595	0.27
243_L	623_I	0.594	0.27
683_Q	688_V	0.593	0.27
345_A	463_D	0.593	0.27
440_L	719_D	0.593	0.27
24_E	71_K	0.592	0.27
572_P	575_T	0.590	0.27
686_D	743_A	0.589	0.27
263_L	355_K	0.589	0.27
673_D	771_E	0.589	0.27
46_D	50_D	0.589	0.27
561_Y	573_Q	0.588	0.27
760_S	763_E	0.588	0.27
670_E	728_F	0.588	0.27
640_L	676_T	0.588	0.27
346_D	669_E	0.588	0.27
252_N	300_A	0.588	0.27
334_W	412_T	0.587	0.27
33_D	43_A	0.587	0.27
40_T	377_A	0.586	0.27
31_A	62_G	0.585	0.27
24_E	36_L	0.585	0.27
367_D	664_R	0.585	0.27
566_W	575_T	0.584	0.27
31_A	40_T	0.584	0.27
671_L	674_K	0.584	0.27
414_K	430_R	0.583	0.27
757_L	761_Q	0.582	0.27
37_T	62_G	0.581	0.26
407_G	700_F	0.581	0.26
234_F	401_T	0.581	0.26
53_Y	63_R	0.581	0.26
557_T	609_M	0.581	0.26
221_C	450_C	0.580	0.26
377_A	606_T	0.580	0.26
139_R	198_T	0.580	0.26
768_D	773_D	0.580	0.26
224_T	239_E	0.580	0.26
294_R	755_R	0.579	0.26
31_A	45_D	0.579	0.26
253_D	361_Y	0.579	0.26
300_A	329_M	0.579	0.26
101_Q	105_D	0.579	0.26
461_L	465_D	0.578	0.26
22_D	50_D	0.578	0.26
96_D	99_T	0.577	0.26
500_N	505_P	0.577	0.26
159_A	347_K	0.577	0.26
269_V	291_S	0.576	0.26
711_A	724_V	0.576	0.26
666_L	685_L	0.576	0.26
45_D	52_R	0.576	0.26
483_D	765_T	0.575	0.26
244_S	289_N	0.575	0.26
21_T	34_R	0.575	0.26
126_N	366_S	0.573	0.26
210_H	247_S	0.572	0.26
405_E	427_G	0.572	0.26
675_L	692_V	0.572	0.26
708_L	748_L	0.572	0.26
678_H	682_V	0.572	0.26
304_C	395_L	0.571	0.26
737_S	741_Q	0.571	0.26
340_M	392_A	0.570	0.26
69_A	90_Y	0.570	0.26
543_H	546_G	0.570	0.26
124_D	127_R	0.569	0.26
343_V	351_L	0.568	0.26
36_L	466_I	0.568	0.26
522_V	528_D	0.568	0.26
102_A	110_G	0.567	0.26
134_P	164_L	0.566	0.26
654_N	657_L	0.566	0.26
353_S	356_E	0.565	0.26
79_R	87_V	0.565	0.26
420_R	572_P	0.564	0.25
534_D	713_R	0.564	0.25
210_H	454_S	0.564	0.25
539_Y	543_H	0.563	0.25
443_S	446_E	0.562	0.25
336_P	343_V	0.562	0.25
100_R	125_L	0.562	0.25
298_A	630_T	0.562	0.25
24_E	88_D	0.561	0.25
720_Q	750_T	0.561	0.25
47_A	130_D	0.560	0.25
452_L	619_P	0.560	0.25
194_D	592_E	0.558	0.25
133_T	136_R	0.558	0.25
762_I	766_T	0.558	0.25
89_D	391_D	0.558	0.25
100_R	104_R	0.557	0.25
43_A	55_A	0.557	0.25
99_T	120_M	0.556	0.25
25_D	135_A	0.556	0.25
24_E	81_R	0.556	0.25
131_A	189_A	0.555	0.25
252_N	298_A	0.555	0.25
58_G	61_T	0.555	0.25
204_S	330_N	0.554	0.25
204_S	289_N	0.554	0.25
432_S	750_T	0.553	0.25
148_L	427_G	0.553	0.25
367_D	494_E	0.553	0.25
670_E	770_D	0.553	0.25
33_D	48_T	0.552	0.25
216_A	490_F	0.552	0.25
31_A	35_I	0.552	0.25
54_D	521_R	0.550	0.25
21_T	377_A	0.550	0.25
362_E	550_D	0.550	0.25
99_T	109_R	0.550	0.25
461_L	464_G	0.550	0.25
42_N	59_A	0.549	0.25
297_A	431_S	0.549	0.25
82_L	86_L	0.548	0.24
221_C	753_Y	0.548	0.24
36_L	46_D	0.547	0.24
43_A	54_D	0.545	0.24
469_E	519_Q	0.545	0.24
403_L	740_Y	0.544	0.24
223_L	505_P	0.543	0.24
21_T	25_D	0.543	0.24
532_R	536_L	0.543	0.24
38_E	45_D	0.542	0.24
257_L	457_L	0.542	0.24
30_D	69_A	0.542	0.24
573_Q	591_R	0.542	0.24
298_A	329_M	0.542	0.24
193_Y	538_E	0.541	0.24
45_D	85_R	0.540	0.24
558_Y	563_G	0.540	0.24
34_R	54_D	0.540	0.24
140_L	145_M	0.540	0.24
464_G	520_M	0.540	0.24
144_A	524_M	0.539	0.24
544_A	620_T	0.539	0.24
301_Y	436_T	0.539	0.24
768_D	774_D	0.539	0.24
133_T	158_D	0.538	0.24
704_P	736_L	0.538	0.24
418_N	429_V	0.537	0.24
219_S	451_N	0.537	0.24
341_E	605_A	0.537	0.24
704_P	727_F	0.537	0.24
261_G	708_L	0.536	0.24
152_Y	452_L	0.536	0.24
34_R	50_D	0.536	0.24
152_Y	433_N	0.536	0.24
23_H	34_R	0.536	0.24
147_T	621_A	0.535	0.24
217_Q	318_N	0.534	0.24
57_L	64_I	0.534	0.24
42_N	51_E	0.534	0.24
557_T	603_R	0.533	0.24
399_M	411_L	0.533	0.24
83_E	164_L	0.533	0.24
183_A	539_Y	0.533	0.24
36_L	49_T	0.533	0.24
46_D	53_Y	0.533	0.24
409_P	564_S	0.532	0.24
248_G	449_V	0.532	0.24
441_N	503_H	0.531	0.24
671_L	676_T	0.531	0.24
37_T	49_T	0.531	0.24
289_N	319_T	0.531	0.24
674_K	677_Y	0.531	0.24
257_L	702_I	0.530	0.23
672_R	676_T	0.530	0.23
434_L	752_Y	0.529	0.23
334_W	414_K	0.529	0.23
684_E	693_Q	0.529	0.23
344_R	550_D	0.529	0.23
232_G	399_M	0.528	0.23
671_L	760_S	0.528	0.23
534_D	717_W	0.528	0.23
59_A	86_L	0.528	0.23
119_R	179_R	0.528	0.23
383_D	568_R	0.528	0.23
538_E	597_W	0.527	0.23
40_T	50_D	0.527	0.23
433_N	723_S	0.526	0.23
53_Y	57_L	0.526	0.23
362_E	365_G	0.525	0.23
301_Y	432_S	0.525	0.23
434_L	753_Y	0.523	0.23
21_T	28_D	0.523	0.23
195_A	200_R	0.523	0.23
366_S	527_D	0.523	0.23
234_F	758_G	0.523	0.23
25_D	40_T	0.523	0.23
77_V	410_W	0.522	0.23
151_R	287_A	0.522	0.23
22_D	45_D	0.522	0.23
56_L	69_A	0.522	0.23
43_A	47_A	0.522	0.23
45_D	542_Y	0.521	0.23
314_D	331_T	0.521	0.23
128_L	136_R	0.520	0.23
269_V	451_N	0.520	0.23
294_R	452_L	0.520	0.23
56_L	101_Q	0.519	0.23
311_A	535_A	0.518	0.23
432_S	505_P	0.518	0.23
46_D	84_R	0.518	0.23
326_T	331_T	0.518	0.23
669_E	768_D	0.518	0.23
706_H	716_V	0.518	0.23
533_A	622_T	0.516	0.23
152_Y	619_P	0.516	0.23
41_R	47_A	0.515	0.23
34_R	113_A	0.514	0.23
99_T	108_Q	0.514	0.23
477_T	502_R	0.514	0.23
359_D	363_L	0.514	0.23
721_S	774_D	0.514	0.23
25_D	35_I	0.513	0.23
370_E	531_D	0.513	0.23
435_C	619_P	0.512	0.22
350_T	353_S	0.512	0.22
673_D	683_Q	0.511	0.22
28_D	54_D	0.511	0.22
351_L	395_L	0.511	0.22
32_R	84_R	0.510	0.22
35_I	73_V	0.510	0.22
102_A	106_G	0.510	0.22
21_T	63_R	0.510	0.22
437_E	619_P	0.510	0.22
671_L	675_L	0.509	0.22
188_Y	554_E	0.509	0.22
89_D	129_A	0.508	0.22
697_R	746_L	0.508	0.22
127_R	130_D	0.508	0.22
655_D	675_L	0.508	0.22
25_D	28_D	0.507	0.22
363_L	375_Y	0.507	0.22
421_S	441_N	0.507	0.22
260_A	335_I	0.507	0.22
57_L	60_L	0.507	0.22
647_S	759_A	0.507	0.22
33_D	81_R	0.506	0.22
659_A	664_R	0.506	0.22
82_L	164_L	0.506	0.22
465_D	528_D	0.506	0.22
23_H	28_D	0.505	0.22
53_Y	80_E	0.505	0.22
562_E	705_R	0.504	0.22
173_A	266_S	0.504	0.22
720_Q	752_Y	0.504	0.22
454_S	623_I	0.503	0.22
123_Y	126_N	0.503	0.22
22_D	28_D	0.503	0.22
467_D	502_R	0.502	0.22
34_R	345_A	0.502	0.22
49_T	55_A	0.501	0.22
313_C	410_W	0.501	0.22
41_R	54_D	0.501	0.22
319_T	436_T	0.501	0.22
356_E	384_I	0.500	0.22
337_D	341_E	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hncA	2	0.908	100	0.117	Contact Map
3k8tA	2	0.7886	100	0.135	Contact Map
2xapA	4	0.8731	100	0.177	Contact Map
2wghA	2	0.8109	100	0.209	Contact Map
1peqA	2	0.7923	100	0.267	Contact Map
3o0qA	2	0.7102	100	0.307	Contact Map
1l1lA	1	0.6866	100	0.484	Contact Map
4u3eA	2	0.6629	99.9	0.919	Contact Map
1h7bA	2	0.5448	94.8	0.977	Contact Map
2g3qA	1	0.0535	16.9	0.989	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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