GREMLIN Database
Q9HMU3 - Ribonucleoside reductase large chain
UniProt: Q9HMU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 804 (729)
Sequences: 2266 (804)
Seq/√Len: 29.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
341_E369_A8.3521.00
344_R745_E7.2471.00
497_E501_M5.0901.00
553_A603_R4.9971.00
545_I604_V4.8941.00
346_D391_D4.8551.00
546_G603_R4.4161.00
472_S546_G4.4031.00
348_Q391_D4.3231.00
566_W609_M4.2071.00
476_E550_D3.9181.00
510_V537_Q3.7431.00
350_T384_I3.7071.00
191_E473_E3.6351.00
664_R691_D3.5941.00
690_E694_E3.5721.00
259_A307_L3.5711.00
531_D535_A3.4691.00
352_F357_T3.4181.00
549_A603_R3.3921.00
348_Q389_R3.3581.00
114_D118_E3.2861.00
660_D696_Y3.2481.00
346_D393_T3.2291.00
235_D238_K3.1531.00
479_M506_V3.1481.00
462_D467_D3.1471.00
553_A607_H3.0711.00
341_E345_A3.0551.00
479_M614_T3.0071.00
674_K687_A2.9941.00
337_D419_V2.9591.00
128_L174_M2.9571.00
472_S542_Y2.9451.00
239_E495_N2.9001.00
254_W274_T2.8541.00
660_D695_L2.7831.00
384_I389_R2.7461.00
350_T376_E2.7131.00
476_E546_G2.6881.00
494_E497_E2.6751.00
24_E32_R2.6731.00
709_R746_L2.6561.00
521_R695_L2.6351.00
709_R742_T2.5971.00
190_I194_D2.5931.00
603_R607_H2.5680.99
570_V575_T2.5280.99
364_Y424_D2.5120.99
596_D599_D2.4920.99
453_G478_A2.4900.99
417_C439_T2.4860.99
131_A190_I2.4770.99
391_D394_D2.4740.99
350_T389_R2.4590.99
231_D238_K2.4560.99
447_T493_T2.4300.99
374_E381_D2.3910.99
561_Y605_A2.3390.99
310_P388_E2.3160.99
521_R660_D2.3090.99
472_S543_H2.3030.99
602_Q606_T2.2890.99
200_R470_Q2.2510.99
136_R197_S2.2450.99
761_Q764_K2.2220.98
480_R554_E2.2040.98
140_L169_W2.1950.98
338_L341_E2.1830.98
99_T103_F2.1640.98
571_F604_V2.1490.98
218_L488_L2.1420.98
549_A553_A2.1210.98
545_I609_M2.1120.98
535_A594_R2.1080.98
598_S601_R2.0970.98
366_S370_E2.0950.98
690_E693_Q2.0900.98
282_N328_D2.0550.97
351_L390_V2.0540.97
573_Q601_R2.0220.97
370_E374_E2.0130.97
352_F384_I2.0040.97
239_E447_T2.0010.97
498_R502_R1.9930.97
310_P390_V1.9860.97
523_P695_L1.9860.97
549_A607_H1.9650.97
205_T297_A1.9490.96
707_Q724_V1.9450.96
314_D398_T1.9440.96
127_R190_I1.9420.96
48_T51_E1.9390.96
49_T53_Y1.9280.96
675_L682_V1.9270.96
602_Q605_A1.9240.96
260_A311_A1.9170.96
471_L540_V1.8950.96
184_D187_E1.8890.96
525_A697_R1.8860.96
566_W571_F1.8670.95
49_T84_R1.8550.95
227_P232_G1.8420.95
342_R350_T1.8310.95
483_D555_R1.8150.95
335_I411_L1.7890.94
557_T561_Y1.7820.94
371_R374_E1.7820.94
309_F333_A1.7690.94
30_D46_D1.7650.94
541_A545_I1.7420.93
35_I52_R1.7380.93
278_L326_T1.7340.93
234_F280_I1.7130.93
457_L510_V1.7090.93
367_D370_E1.6960.92
79_R83_E1.6950.92
742_T746_L1.6840.92
369_A373_R1.6810.92
310_P398_T1.6810.92
278_L329_M1.6700.92
275_V315_L1.6570.92
359_D375_Y1.6560.92
729_P758_G1.6560.92
424_D568_R1.6460.91
342_R347_K1.6380.91
170_M189_A1.6190.91
131_A170_M1.6180.91
685_L688_V1.5960.90
170_M174_M1.5960.90
128_L186_E1.5940.90
234_F284_V1.5690.89
726_V743_A1.5670.89
447_T495_N1.5660.89
337_D744_W1.5650.89
24_E27_I1.5590.89
342_R376_E1.5530.89
510_V540_V1.5520.89
87_V96_D1.5460.88
524_M632_S1.5400.88
516_A536_L1.5380.88
705_R742_T1.5270.88
519_Q656_R1.5270.88
188_Y191_E1.5250.88
571_F601_R1.5210.88
27_I76_R1.5190.88
128_L170_M1.5090.87
27_I30_D1.5070.87
177_A192_F1.5010.87
238_K242_K1.4920.87
528_D531_D1.4900.86
424_D565_K1.4880.86
234_F241_A1.4880.86
364_Y419_V1.4850.86
34_R63_R1.4830.86
518_Q636_V1.4650.86
356_E385_Q1.4610.85
549_A604_V1.4570.85
199_L627_A1.4570.85
455_V475_V1.4500.85
131_A194_D1.4430.85
632_S727_F1.4380.84
460_H474_T1.4380.84
310_P395_L1.4380.84
522_V532_R1.4360.84
545_I571_F1.4360.84
50_D85_R1.4330.84
192_F481_M1.4280.84
86_L164_L1.4230.84
598_S602_Q1.4210.84
562_E567_D1.4180.84
726_V739_V1.4160.84
541_A615_M1.4090.83
414_K428_T1.4040.83
480_R547_A1.4010.83
660_D692_V1.3960.83
33_D37_T1.3810.82
525_A529_A1.3710.81
225_T253_D1.3690.81
366_S369_A1.3560.81
44_Y51_E1.3510.80
338_L369_A1.3450.80
139_R199_L1.3450.80
180_E484_N1.3420.80
103_F107_I1.3370.80
117_D121_G1.3290.79
679_D764_K1.3260.79
46_D49_T1.3210.79
566_W601_R1.3210.79
98_A101_Q1.3180.79
53_Y84_R1.3070.78
23_H27_I1.3070.78
400_L736_L1.3060.78
708_L726_V1.3010.78
413_F743_A1.2980.78
24_E73_V1.2970.78
156_E160_D1.2960.78
259_A353_S1.2840.77
494_E498_R1.2830.77
99_T112_D1.2680.76
99_T106_G1.2630.76
416_P419_V1.2610.76
285_T298_A1.2600.76
262_S355_K1.2590.75
304_C333_A1.2580.75
33_D36_L1.2540.75
221_C435_C1.2520.75
549_A600_V1.2490.75
340_M343_V1.2440.75
770_D773_D1.2440.75
186_E189_A1.2420.74
31_A34_R1.2370.74
457_L540_V1.2320.74
106_G112_D1.2280.74
175_G216_A1.2270.74
278_L315_L1.2260.74
22_D25_D1.2210.73
469_E472_S1.2070.72
194_D198_T1.2050.72
363_L371_R1.2010.72
117_D120_M1.2000.72
702_I706_H1.1990.72
542_Y600_V1.1980.72
226_V236_A1.1970.72
485_V489_N1.1880.71
342_R392_A1.1880.71
708_L712_A1.1880.71
128_L190_I1.1800.71
316_R331_T1.1800.71
358_G374_E1.1770.70
439_T721_S1.1770.70
107_I117_D1.1710.70
426_A560_S1.1690.70
478_A508_L1.1680.70
513_F533_A1.1680.70
24_E30_D1.1670.70
237_Y280_I1.1660.70
502_R560_S1.1650.70
664_R692_V1.1650.70
221_C452_L1.1560.69
390_V395_L1.1540.69
186_E190_I1.1540.69
601_R609_M1.1520.69
253_D431_S1.1510.69
48_T52_R1.1480.68
33_D49_T1.1450.68
485_V506_V1.1440.68
32_R46_D1.1440.68
468_R539_Y1.1430.68
75_G494_E1.1420.68
705_R709_R1.1340.67
422_P441_N1.1300.67
106_G111_L1.1260.67
542_Y596_D1.1260.67
136_R194_D1.1260.67
280_I283_D1.1230.67
666_L671_L1.1170.66
539_Y596_D1.1140.66
37_T41_R1.1120.66
301_Y332_A1.1100.66
39_A56_L1.1100.66
545_I566_W1.1070.66
561_Y566_W1.1070.66
544_A614_T1.1060.65
36_L43_A1.0990.65
206_P294_R1.0990.65
261_G265_E1.0990.65
81_R85_R1.0950.65
769_M772_Y1.0900.64
221_C249_G1.0850.64
525_A706_H1.0800.64
171_R212_G1.0770.63
248_G296_G1.0760.63
54_D81_R1.0720.63
624_S632_S1.0670.63
476_E603_R1.0590.62
30_D60_L1.0590.62
231_D235_D1.0580.62
708_L739_V1.0580.62
743_A751_T1.0580.62
435_C452_L1.0580.62
164_L167_P1.0560.62
572_P576_V1.0550.62
36_L45_D1.0540.62
315_L326_T1.0520.62
714_R722_Q1.0500.61
471_L536_L1.0490.61
704_P739_V1.0470.61
530_L713_R1.0470.61
461_L520_M1.0450.61
393_T397_R1.0450.61
600_V603_R1.0380.60
340_M413_F1.0350.60
359_D371_R1.0330.60
249_G433_N1.0330.60
708_L746_L1.0330.60
373_R377_A1.0310.60
459_R519_Q1.0260.60
193_Y197_S1.0250.59
103_F106_G1.0250.59
546_G600_V1.0240.59
237_Y284_V1.0210.59
363_L367_D1.0210.59
317_R325_R1.0200.59
550_D553_A1.0190.59
530_L706_H1.0190.59
708_L728_F1.0170.59
59_A62_G1.0160.59
99_T111_L1.0100.58
366_S419_V1.0090.58
338_L373_R1.0080.58
347_K391_D1.0080.58
484_N555_R1.0070.58
36_L53_Y1.0050.58
255_T361_Y1.0050.58
137_D166_Q1.0040.58
105_D109_R1.0040.58
545_I549_A1.0030.58
35_I63_R1.0030.58
472_S476_E1.0010.58
23_H32_R0.9980.57
502_R563_G0.9970.57
547_A550_D0.9960.57
344_R741_Q0.9890.57
221_C437_E0.9870.57
516_A532_R0.9870.57
134_P167_P0.9820.56
38_E44_Y0.9780.56
502_R559_E0.9780.56
38_E63_R0.9780.56
468_R532_R0.9760.56
249_G435_C0.9760.56
166_Q197_S0.9760.56
476_E547_A0.9760.56
195_A474_T0.9660.55
345_A599_D0.9590.54
630_T636_V0.9560.54
37_T48_T0.9560.54
30_D35_I0.9540.54
707_Q727_F0.9540.54
173_A211_A0.9520.54
686_D693_Q0.9460.53
206_P221_C0.9410.53
451_N486_V0.9380.53
437_E452_L0.9370.53
487_D491_Y0.9350.52
475_V543_H0.9350.52
82_L153_F0.9340.52
149_R153_F0.9330.52
168_F172_V0.9320.52
201_F453_G0.9320.52
206_P435_C0.9320.52
565_K570_V0.9290.52
341_E463_D0.9290.52
231_D242_K0.9290.52
60_L77_V0.9270.52
728_F739_V0.9270.52
345_A745_E0.9260.52
423_Q558_Y0.9260.52
249_G452_L0.9250.52
32_R36_L0.9210.51
37_T40_T0.9210.51
562_E606_T0.9210.51
206_P220_S0.9200.51
34_R66_R0.9180.51
235_D495_N0.9180.51
483_D610_R0.9180.51
304_C336_P0.9150.51
304_C309_F0.9150.51
245_K288_I0.9120.51
249_G437_E0.9120.51
28_D659_A0.9090.50
170_M190_I0.9070.50
539_Y595_L0.9070.50
686_D690_E0.9060.50
254_W281_S0.9040.50
203_H481_M0.9040.50
30_D37_T0.9010.50
174_M189_A0.9000.50
469_E595_L0.8990.50
46_D51_E0.8990.50
170_M193_Y0.8970.49
40_T44_Y0.8970.49
30_D56_L0.8960.49
83_E86_L0.8950.49
374_E377_A0.8950.49
38_E42_N0.8940.49
448_A505_P0.8940.49
309_F395_L0.8930.49
302_L312_F0.8900.49
128_L131_A0.8900.49
266_S285_T0.8890.49
542_Y599_D0.8880.49
229_D232_G0.8880.49
274_T278_L0.8880.49
49_T52_R0.8850.49
103_F113_A0.8850.49
103_F112_D0.8800.48
222_Y429_V0.8800.48
707_Q726_V0.8800.48
713_R716_V0.8790.48
433_N619_P0.8790.48
542_Y546_G0.8790.48
515_D629_T0.8740.48
249_G294_R0.8730.48
31_A43_A0.8720.47
416_P420_R0.8700.47
682_V688_V0.8690.47
103_F125_L0.8690.47
370_E377_A0.8690.47
104_R108_Q0.8680.47
599_D603_R0.8680.47
316_R408_H0.8680.47
553_A691_D0.8680.47
417_C721_S0.8680.47
421_S429_V0.8660.47
78_L145_M0.8650.47
557_T562_E0.8640.47
558_Y564_S0.8640.47
112_D117_D0.8640.47
485_V508_L0.8630.47
239_E494_E0.8630.47
461_L519_Q0.8590.46
240_H252_N0.8590.46
205_T220_S0.8580.46
570_V574_D0.8580.46
121_G124_D0.8540.46
106_G120_M0.8530.46
166_Q193_Y0.8520.46
221_C433_N0.8490.46
455_V540_V0.8490.46
26_D76_R0.8480.46
51_E54_D0.8480.46
297_A456_N0.8470.46
57_L77_V0.8460.45
673_D687_A0.8440.45
468_R535_A0.8430.45
155_R632_S0.8420.45
207_T485_V0.8410.45
669_E673_D0.8400.45
169_W202_V0.8390.45
210_H285_T0.8390.45
461_L470_Q0.8390.45
279_K283_D0.8390.45
738_E742_T0.8370.45
595_L599_D0.8350.45
535_A592_E0.8350.45
54_D58_G0.8340.45
37_T43_A0.8330.44
671_L685_L0.8330.44
43_A62_G0.8300.44
118_E123_Y0.8300.44
728_F735_K0.8290.44
31_A36_L0.8290.44
503_H560_S0.8290.44
502_R553_A0.8270.44
571_F609_M0.8270.44
36_L40_T0.8260.44
699_A727_F0.8240.44
525_A694_E0.8240.44
108_Q602_Q0.8220.44
22_D26_D0.8220.44
180_E188_Y0.8220.44
35_I75_G0.8190.43
88_D135_A0.8170.43
424_D574_D0.8160.43
185_R502_R0.8160.43
703_D739_V0.8160.43
550_D607_H0.8130.43
264_I308_D0.8120.43
44_Y49_T0.8110.43
422_P613_N0.8110.43
34_R40_T0.8110.43
39_A43_A0.8110.43
449_V500_N0.8110.43
259_A262_S0.8090.43
533_A714_R0.8080.42
106_G110_G0.8080.42
249_G619_P0.8070.42
294_R435_C0.8050.42
217_Q320_G0.8030.42
768_D772_Y0.8020.42
738_E741_Q0.8010.42
337_D416_P0.7990.42
370_E602_Q0.7980.42
155_R260_A0.7980.42
420_R575_T0.7980.42
26_D30_D0.7980.42
113_A118_E0.7970.42
217_Q489_N0.7970.42
272_T316_R0.7950.41
578_R591_R0.7920.41
21_T45_D0.7920.41
137_D193_Y0.7910.41
23_H77_V0.7900.41
305_W368_F0.7890.41
271_S276_P0.7890.41
28_D35_I0.7890.41
703_D707_Q0.7840.41
721_S770_D0.7820.40
550_D603_R0.7820.40
659_A663_E0.7820.40
21_T37_T0.7800.40
99_T117_D0.7800.40
53_Y81_R0.7780.40
453_G536_L0.7780.40
673_D772_Y0.7770.40
286_A328_D0.7740.40
472_S539_Y0.7740.40
45_D49_T0.7740.40
546_G549_A0.7730.40
534_D716_V0.7730.40
303_A414_K0.7720.40
82_L195_A0.7720.40
112_D120_M0.7720.40
25_D81_R0.7720.40
112_D115_L0.7710.40
50_D54_D0.7700.40
75_G79_R0.7700.40
83_E134_P0.7690.40
88_D130_D0.7680.39
675_L679_D0.7670.39
152_Y435_C0.7670.39
25_D133_T0.7670.39
245_K454_S0.7660.39
553_A606_T0.7650.39
461_L516_A0.7640.39
372_Y375_Y0.7620.39
541_A631_P0.7620.39
39_A44_Y0.7600.39
433_N452_L0.7600.39
205_T295_R0.7600.39
770_D774_D0.7600.39
505_P612_S0.7600.39
541_A573_Q0.7590.39
563_G567_D0.7590.39
237_Y346_D0.7590.39
86_L129_A0.7570.39
678_H684_E0.7570.39
402_R408_H0.7570.39
155_R161_P0.7560.39
315_L331_T0.7560.39
206_P407_G0.7550.38
36_L50_D0.7550.38
216_A266_S0.7550.38
237_Y281_S0.7550.38
341_E344_R0.7540.38
304_C343_V0.7540.38
44_Y47_A0.7530.38
682_V742_T0.7520.38
247_S266_S0.7520.38
574_D601_R0.7510.38
33_D40_T0.7510.38
330_N622_T0.7510.38
25_D88_D0.7500.38
425_H563_G0.7490.38
462_D465_D0.7480.38
218_L480_R0.7470.38
536_L540_V0.7440.38
196_L367_D0.7430.38
222_Y455_V0.7420.37
199_L459_R0.7410.37
228_D258_R0.7400.37
221_C294_R0.7400.37
377_A382_G0.7400.37
465_D520_M0.7400.37
127_R131_A0.7380.37
27_I32_R0.7370.37
565_K574_D0.7360.37
127_R187_E0.7360.37
191_E476_E0.7350.37
52_R84_R0.7350.37
200_R459_R0.7340.37
72_T81_R0.7340.37
88_D133_T0.7320.37
438_I616_A0.7310.37
53_Y86_L0.7310.37
35_I46_D0.7300.37
54_D88_D0.7290.37
187_E606_T0.7290.37
67_H82_L0.7270.36
604_V609_M0.7270.36
469_E562_E0.7270.36
332_A408_H0.7260.36
562_E605_A0.7260.36
47_A52_R0.7260.36
47_A55_A0.7250.36
304_C335_I0.7250.36
471_L475_V0.7240.36
576_V589_V0.7240.36
180_E480_R0.7240.36
71_K88_D0.7240.36
38_E41_R0.7230.36
170_M197_S0.7230.36
343_V393_T0.7220.36
732_D736_L0.7220.36
670_E673_D0.7210.36
542_Y597_W0.7190.36
103_F114_D0.7180.36
42_N55_A0.7180.36
32_R60_L0.7180.36
436_T449_V0.7170.36
22_D33_D0.7170.36
420_R576_V0.7170.36
107_I114_D0.7170.36
98_A114_D0.7160.36
24_E85_R0.7160.36
465_D745_E0.7150.35
373_R376_E0.7150.35
99_T105_D0.7150.35
71_K141_D0.7140.35
377_A472_S0.7130.35
35_I47_A0.7130.35
120_M124_D0.7120.35
39_A52_R0.7110.35
762_I767_L0.7110.35
467_D470_Q0.7110.35
24_E33_D0.7100.35
43_A769_M0.7090.35
697_R703_D0.7090.35
164_L238_K0.7080.35
290_R296_G0.7080.35
545_I719_D0.7080.35
502_R528_D0.7070.35
43_A66_R0.7060.35
72_T75_G0.7060.35
53_Y78_L0.7060.35
705_R738_E0.7050.35
341_E745_E0.7050.35
768_D771_E0.7020.35
28_D50_D0.7000.34
767_L772_Y0.7000.34
151_R622_T0.6990.34
35_I44_Y0.6980.34
148_L626_I0.6980.34
211_A508_L0.6960.34
626_I633_I0.6960.34
458_A519_Q0.6950.34
22_D88_D0.6950.34
463_D520_M0.6940.34
599_D602_Q0.6940.34
254_W300_A0.6930.34
576_V715_G0.6930.34
148_L241_A0.6920.34
517_L522_V0.6920.34
316_R438_I0.6910.34
32_R37_T0.6910.34
31_A47_A0.6900.34
452_L507_G0.6900.34
245_K651_T0.6900.34
512_G628_G0.6890.34
479_M544_A0.6880.34
80_E86_L0.6880.34
176_V488_L0.6870.33
358_G375_Y0.6870.33
99_T113_A0.6860.33
432_S438_I0.6860.33
112_D116_L0.6850.33
221_C619_P0.6850.33
425_H567_D0.6840.33
36_L41_R0.6840.33
54_D606_T0.6830.33
427_G558_Y0.6820.33
712_A746_L0.6820.33
314_D402_R0.6810.33
133_T194_D0.6810.33
297_A549_A0.6810.33
177_A189_A0.6800.33
113_A116_L0.6800.33
348_Q390_V0.6800.33
771_E774_D0.6800.33
106_G114_D0.6790.33
729_P757_L0.6790.33
60_L65_D0.6780.33
498_R559_E0.6780.33
769_M773_D0.6780.33
265_E295_R0.6760.33
22_D84_R0.6760.33
674_K678_H0.6750.33
741_Q745_E0.6750.33
81_R104_R0.6750.33
21_T31_A0.6720.32
49_T80_E0.6710.32
209_F293_K0.6710.32
456_N627_A0.6710.32
39_A42_N0.6700.32
152_Y221_C0.6700.32
207_T482_L0.6700.32
472_S603_R0.6690.32
98_A105_D0.6690.32
409_P427_G0.6690.32
277_F623_I0.6680.32
295_R651_T0.6680.32
244_S247_S0.6680.32
512_G515_D0.6670.32
98_A109_R0.6650.32
40_T53_Y0.6650.32
474_T477_T0.6650.32
226_V533_A0.6640.32
113_A178_L0.6640.32
99_T171_R0.6600.32
33_D45_D0.6600.32
22_D85_R0.6590.32
674_K686_D0.6580.31
84_R88_D0.6580.31
210_H245_K0.6570.31
682_V764_K0.6570.31
427_G563_G0.6550.31
499_S505_P0.6540.31
730_E758_G0.6540.31
21_T50_D0.6540.31
601_R605_A0.6530.31
274_T302_L0.6530.31
238_K495_N0.6510.31
454_S618_A0.6510.31
256_P430_R0.6510.31
31_A37_T0.6500.31
152_Y249_G0.6500.31
382_G385_Q0.6500.31
78_L82_L0.6490.31
525_A702_I0.6490.31
343_V392_A0.6490.31
370_E373_R0.6490.31
28_D41_R0.6480.31
703_D706_H0.6480.31
390_V602_Q0.6480.31
333_A399_M0.6470.31
342_R413_F0.6460.31
34_R37_T0.6460.31
571_F574_D0.6450.31
435_C450_C0.6450.31
32_R35_I0.6440.31
341_E348_Q0.6430.30
86_L162_F0.6430.30
360_L365_G0.6430.30
44_Y53_Y0.6420.30
47_A80_E0.6420.30
266_S288_I0.6410.30
24_E46_D0.6410.30
715_G722_Q0.6410.30
40_T43_A0.6390.30
609_M614_T0.6380.30
546_G550_D0.6380.30
472_S550_D0.6380.30
332_A410_W0.6380.30
207_T211_A0.6370.30
249_G297_A0.6360.30
446_E503_H0.6360.30
114_D562_E0.6350.30
115_L178_L0.6340.30
64_I205_T0.6340.30
98_A106_G0.6330.30
598_S605_A0.6320.30
176_V485_V0.6310.30
436_T507_G0.6310.30
294_R433_N0.6310.30
21_T32_R0.6300.30
253_D430_R0.6300.30
70_Y196_L0.6300.30
22_D80_E0.6280.29
36_L44_Y0.6280.29
141_D346_D0.6270.29
36_L55_A0.6270.29
22_D36_L0.6270.29
431_S621_A0.6270.29
274_T297_A0.6270.29
146_D149_R0.6260.29
206_P249_G0.6260.29
113_A117_D0.6250.29
33_D56_L0.6250.29
518_Q655_D0.6250.29
45_D729_P0.6250.29
28_D69_A0.6250.29
549_A561_Y0.6240.29
43_A52_R0.6240.29
369_A528_D0.6230.29
130_D133_T0.6220.29
234_F237_Y0.6220.29
233_I258_R0.6210.29
514_H636_V0.6210.29
590_P593_E0.6210.29
247_S292_G0.6200.29
23_H73_V0.6190.29
724_V739_V0.6180.29
277_F287_A0.6180.29
26_D69_A0.6180.29
206_P452_L0.6160.29
247_S646_M0.6150.29
673_D769_M0.6150.29
264_I296_G0.6150.29
34_R41_R0.6150.29
126_N130_D0.6150.29
50_D81_R0.6140.29
45_D48_T0.6140.29
372_Y376_E0.6140.29
26_D49_T0.6130.28
191_E477_T0.6130.28
433_N437_E0.6120.28
697_R706_H0.6120.28
103_F111_L0.6120.28
150_Q475_V0.6120.28
34_R59_A0.6100.28
265_E651_T0.6100.28
618_A740_Y0.6100.28
360_L372_Y0.6090.28
624_S729_P0.6090.28
23_H26_D0.6080.28
52_R130_D0.6080.28
28_D105_D0.6070.28
141_D295_R0.6060.28
188_Y192_F0.6050.28
365_G369_A0.6050.28
172_V208_L0.6050.28
253_D442_T0.6050.28
577_D591_R0.6040.28
736_L753_Y0.6040.28
207_T218_L0.6020.28
113_A120_M0.6020.28
357_T384_I0.6010.28
337_D340_M0.6010.28
511_M620_T0.6010.28
671_L677_Y0.6010.28
25_D33_D0.6010.28
37_T56_L0.6000.28
342_R368_F0.6000.28
290_R294_R0.6000.28
624_S633_I0.6000.28
440_L484_N0.5980.28
516_A520_M0.5980.28
545_I615_M0.5980.28
686_D771_E0.5970.27
767_L771_E0.5970.27
341_E497_E0.5950.27
326_T329_M0.5950.27
116_L212_G0.5950.27
243_L623_I0.5940.27
683_Q688_V0.5930.27
345_A463_D0.5930.27
440_L719_D0.5930.27
24_E71_K0.5920.27
572_P575_T0.5900.27
686_D743_A0.5890.27
263_L355_K0.5890.27
673_D771_E0.5890.27
46_D50_D0.5890.27
561_Y573_Q0.5880.27
760_S763_E0.5880.27
670_E728_F0.5880.27
640_L676_T0.5880.27
346_D669_E0.5880.27
252_N300_A0.5880.27
334_W412_T0.5870.27
33_D43_A0.5870.27
40_T377_A0.5860.27
31_A62_G0.5850.27
24_E36_L0.5850.27
367_D664_R0.5850.27
566_W575_T0.5840.27
31_A40_T0.5840.27
671_L674_K0.5840.27
414_K430_R0.5830.27
757_L761_Q0.5820.27
37_T62_G0.5810.26
407_G700_F0.5810.26
234_F401_T0.5810.26
53_Y63_R0.5810.26
557_T609_M0.5810.26
221_C450_C0.5800.26
377_A606_T0.5800.26
139_R198_T0.5800.26
768_D773_D0.5800.26
224_T239_E0.5800.26
294_R755_R0.5790.26
31_A45_D0.5790.26
253_D361_Y0.5790.26
300_A329_M0.5790.26
101_Q105_D0.5790.26
461_L465_D0.5780.26
22_D50_D0.5780.26
96_D99_T0.5770.26
500_N505_P0.5770.26
159_A347_K0.5770.26
269_V291_S0.5760.26
711_A724_V0.5760.26
666_L685_L0.5760.26
45_D52_R0.5760.26
483_D765_T0.5750.26
244_S289_N0.5750.26
21_T34_R0.5750.26
126_N366_S0.5730.26
210_H247_S0.5720.26
405_E427_G0.5720.26
675_L692_V0.5720.26
708_L748_L0.5720.26
678_H682_V0.5720.26
304_C395_L0.5710.26
737_S741_Q0.5710.26
340_M392_A0.5700.26
69_A90_Y0.5700.26
543_H546_G0.5700.26
124_D127_R0.5690.26
343_V351_L0.5680.26
36_L466_I0.5680.26
522_V528_D0.5680.26
102_A110_G0.5670.26
134_P164_L0.5660.26
654_N657_L0.5660.26
353_S356_E0.5650.26
79_R87_V0.5650.26
420_R572_P0.5640.25
534_D713_R0.5640.25
210_H454_S0.5640.25
539_Y543_H0.5630.25
443_S446_E0.5620.25
336_P343_V0.5620.25
100_R125_L0.5620.25
298_A630_T0.5620.25
24_E88_D0.5610.25
720_Q750_T0.5610.25
47_A130_D0.5600.25
452_L619_P0.5600.25
194_D592_E0.5580.25
133_T136_R0.5580.25
762_I766_T0.5580.25
89_D391_D0.5580.25
100_R104_R0.5570.25
43_A55_A0.5570.25
99_T120_M0.5560.25
25_D135_A0.5560.25
24_E81_R0.5560.25
131_A189_A0.5550.25
252_N298_A0.5550.25
58_G61_T0.5550.25
204_S330_N0.5540.25
204_S289_N0.5540.25
432_S750_T0.5530.25
148_L427_G0.5530.25
367_D494_E0.5530.25
670_E770_D0.5530.25
33_D48_T0.5520.25
216_A490_F0.5520.25
31_A35_I0.5520.25
54_D521_R0.5500.25
21_T377_A0.5500.25
362_E550_D0.5500.25
99_T109_R0.5500.25
461_L464_G0.5500.25
42_N59_A0.5490.25
297_A431_S0.5490.25
82_L86_L0.5480.24
221_C753_Y0.5480.24
36_L46_D0.5470.24
43_A54_D0.5450.24
469_E519_Q0.5450.24
403_L740_Y0.5440.24
223_L505_P0.5430.24
21_T25_D0.5430.24
532_R536_L0.5430.24
38_E45_D0.5420.24
257_L457_L0.5420.24
30_D69_A0.5420.24
573_Q591_R0.5420.24
298_A329_M0.5420.24
193_Y538_E0.5410.24
45_D85_R0.5400.24
558_Y563_G0.5400.24
34_R54_D0.5400.24
140_L145_M0.5400.24
464_G520_M0.5400.24
144_A524_M0.5390.24
544_A620_T0.5390.24
301_Y436_T0.5390.24
768_D774_D0.5390.24
133_T158_D0.5380.24
704_P736_L0.5380.24
418_N429_V0.5370.24
219_S451_N0.5370.24
341_E605_A0.5370.24
704_P727_F0.5370.24
261_G708_L0.5360.24
152_Y452_L0.5360.24
34_R50_D0.5360.24
152_Y433_N0.5360.24
23_H34_R0.5360.24
147_T621_A0.5350.24
217_Q318_N0.5340.24
57_L64_I0.5340.24
42_N51_E0.5340.24
557_T603_R0.5330.24
399_M411_L0.5330.24
83_E164_L0.5330.24
183_A539_Y0.5330.24
36_L49_T0.5330.24
46_D53_Y0.5330.24
409_P564_S0.5320.24
248_G449_V0.5320.24
441_N503_H0.5310.24
671_L676_T0.5310.24
37_T49_T0.5310.24
289_N319_T0.5310.24
674_K677_Y0.5310.24
257_L702_I0.5300.23
672_R676_T0.5300.23
434_L752_Y0.5290.23
334_W414_K0.5290.23
684_E693_Q0.5290.23
344_R550_D0.5290.23
232_G399_M0.5280.23
671_L760_S0.5280.23
534_D717_W0.5280.23
59_A86_L0.5280.23
119_R179_R0.5280.23
383_D568_R0.5280.23
538_E597_W0.5270.23
40_T50_D0.5270.23
433_N723_S0.5260.23
53_Y57_L0.5260.23
362_E365_G0.5250.23
301_Y432_S0.5250.23
434_L753_Y0.5230.23
21_T28_D0.5230.23
195_A200_R0.5230.23
366_S527_D0.5230.23
234_F758_G0.5230.23
25_D40_T0.5230.23
77_V410_W0.5220.23
151_R287_A0.5220.23
22_D45_D0.5220.23
56_L69_A0.5220.23
43_A47_A0.5220.23
45_D542_Y0.5210.23
314_D331_T0.5210.23
128_L136_R0.5200.23
269_V451_N0.5200.23
294_R452_L0.5200.23
56_L101_Q0.5190.23
311_A535_A0.5180.23
432_S505_P0.5180.23
46_D84_R0.5180.23
326_T331_T0.5180.23
669_E768_D0.5180.23
706_H716_V0.5180.23
533_A622_T0.5160.23
152_Y619_P0.5160.23
41_R47_A0.5150.23
34_R113_A0.5140.23
99_T108_Q0.5140.23
477_T502_R0.5140.23
359_D363_L0.5140.23
721_S774_D0.5140.23
25_D35_I0.5130.23
370_E531_D0.5130.23
435_C619_P0.5120.22
350_T353_S0.5120.22
673_D683_Q0.5110.22
28_D54_D0.5110.22
351_L395_L0.5110.22
32_R84_R0.5100.22
35_I73_V0.5100.22
102_A106_G0.5100.22
21_T63_R0.5100.22
437_E619_P0.5100.22
671_L675_L0.5090.22
188_Y554_E0.5090.22
89_D129_A0.5080.22
697_R746_L0.5080.22
127_R130_D0.5080.22
655_D675_L0.5080.22
25_D28_D0.5070.22
363_L375_Y0.5070.22
421_S441_N0.5070.22
260_A335_I0.5070.22
57_L60_L0.5070.22
647_S759_A0.5070.22
33_D81_R0.5060.22
659_A664_R0.5060.22
82_L164_L0.5060.22
465_D528_D0.5060.22
23_H28_D0.5050.22
53_Y80_E0.5050.22
562_E705_R0.5040.22
173_A266_S0.5040.22
720_Q752_Y0.5040.22
454_S623_I0.5030.22
123_Y126_N0.5030.22
22_D28_D0.5030.22
467_D502_R0.5020.22
34_R345_A0.5020.22
49_T55_A0.5010.22
313_C410_W0.5010.22
41_R54_D0.5010.22
319_T436_T0.5010.22
356_E384_I0.5000.22
337_D341_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hncA 2 0.908 100 0.117 Contact Map
3k8tA 2 0.7886 100 0.135 Contact Map
2xapA 4 0.8731 100 0.177 Contact Map
2wghA 2 0.8109 100 0.209 Contact Map
1peqA 2 0.7923 100 0.267 Contact Map
3o0qA 2 0.7102 100 0.307 Contact Map
1l1lA 1 0.6866 100 0.484 Contact Map
4u3eA 2 0.6629 99.9 0.919 Contact Map
1h7bA 2 0.5448 94.8 0.977 Contact Map
2g3qA 1 0.0535 16.9 0.989 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0176 seconds.