GREMLIN Database
Q9HMU1 - Uncharacterized protein
UniProt: Q9HMU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 113 (104)
Sequences: 10360 (8488)
Seq/√Len: 832.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_H97_K2.9011.00
54_A67_H2.6541.00
75_V107_L2.5841.00
58_G63_A2.4421.00
76_V104_I2.4211.00
68_A76_V2.1511.00
42_A53_T2.1471.00
96_E100_R2.0311.00
78_M98_V2.0001.00
56_I63_A1.9471.00
68_A103_P1.9101.00
80_T110_G1.8471.00
30_E33_R1.7641.00
102_S106_V1.7341.00
69_G103_P1.7071.00
31_H35_E1.6891.00
34_A38_V1.6871.00
41_T45_L1.6711.00
80_T108_T1.6221.00
63_A66_A1.6011.00
56_I67_H1.5981.00
76_V102_S1.5901.00
35_E39_R1.5891.00
76_V98_V1.5861.00
37_A41_T1.5401.00
65_V101_T1.5121.00
41_T44_G1.4211.00
32_E36_A1.3911.00
7_V63_A1.3701.00
27_A31_H1.3561.00
30_E34_A1.3191.00
5_V56_I1.2991.00
35_E53_T1.2771.00
78_M95_A1.2631.00
40_E43_A1.2451.00
65_V68_A1.2451.00
99_V108_T1.2111.00
97_K101_T1.2091.00
86_M90_L1.1961.00
34_A37_A1.1851.00
64_I98_V1.1761.00
96_E99_V1.1461.00
33_R37_A1.1391.00
6_S34_A1.1271.00
37_A40_E1.1221.00
34_A45_L1.1081.00
28_E32_E1.0911.00
20_G23_G1.0841.00
68_A104_I1.0821.00
33_R36_A1.0751.00
88_H96_E1.0741.00
22_A25_A1.0561.00
34_A55_V1.0461.00
24_D28_E1.0451.00
60_P94_V1.0391.00
5_V67_H1.0251.00
67_H73_A1.0071.00
39_R43_A0.9851.00
65_V102_S0.9761.00
39_R42_A0.9711.00
77_V107_L0.9691.00
38_V42_A0.9661.00
65_V98_V0.9561.00
80_T95_A0.9531.00
7_V60_P0.9411.00
25_A28_E0.9291.00
7_V58_G0.9201.00
61_H65_V0.9191.00
38_V53_T0.9121.00
95_A108_T0.9091.00
59_I62_E0.9071.00
77_V109_V0.8991.00
29_R32_E0.8831.00
68_A73_A0.8811.00
85_G88_H0.8731.00
58_G62_E0.8591.00
83_R87_D0.8521.00
24_D27_A0.8491.00
82_G93_S0.8481.00
85_G89_Y0.8481.00
23_G26_W0.8461.00
82_G91_V0.8421.00
80_T90_L0.8401.00
40_E44_G0.8241.00
32_E35_E0.8231.00
4_V38_V0.8151.00
63_A67_H0.8091.00
91_V95_A0.8081.00
82_G85_G0.7991.00
9_D12_N0.7951.00
79_G109_V0.7931.00
58_G66_A0.7871.00
99_V106_V0.7711.00
81_H95_A0.7561.00
28_E31_H0.7541.00
8_A57_E0.7511.00
61_H98_V0.7281.00
80_T83_R0.7251.00
10_E14_F0.7181.00
86_M89_Y0.7141.00
23_G27_A0.7131.00
27_A57_E0.6971.00
61_H101_T0.6791.00
10_E13_R0.6681.00
98_V106_V0.6601.00
78_M108_T0.6581.00
26_W29_R0.6531.00
39_R53_T0.6531.00
38_V41_T0.6491.00
64_I76_V0.6371.00
8_A34_A0.6351.00
69_G104_I0.6351.00
36_A40_E0.6341.00
90_L95_A0.6331.00
11_R14_F0.6221.00
82_G92_G0.6221.00
54_A57_E0.6141.00
26_W30_E0.6111.00
81_H84_T0.6111.00
4_V51_T0.6101.00
67_H72_G0.6071.00
12_N15_E0.6031.00
84_T88_H0.6021.00
17_P22_A0.6001.00
81_H94_V0.5971.00
36_A39_R0.5951.00
5_V64_I0.5941.00
68_A72_G0.5941.00
72_G103_P0.5891.00
10_E57_E0.5881.00
61_H94_V0.5861.00
64_I68_A0.5831.00
60_P64_I0.5781.00
29_R33_R0.5751.00
11_R17_P0.5621.00
45_L49_V0.5611.00
8_A55_V0.5591.00
44_G47_D0.5551.00
19_A22_A0.5541.00
35_E40_E0.5541.00
45_L48_V0.5521.00
76_V106_V0.5501.00
42_A45_L0.5401.00
4_V8_A0.5391.00
25_A29_R0.5381.00
16_S20_G0.5341.00
10_E15_E0.5331.00
85_G90_L0.5301.00
89_Y108_T0.5231.00
10_E27_A0.5211.00
4_V53_T0.5181.00
9_D14_F0.5131.00
94_V98_V0.5091.00
7_V10_E0.5061.00
45_L51_T0.5031.00
83_R90_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gm3A 2 0.8584 99.7 0.243 Contact Map
2dumA 2 0.9735 99.7 0.252 Contact Map
5ahwA 4 0.9912 99.7 0.255 Contact Map
4wnyA 2 0.8407 99.7 0.262 Contact Map
3tnjA 2 0.8584 99.7 0.263 Contact Map
3s3tA 4 0.9646 99.7 0.264 Contact Map
3mt0A 1 0.8673 99.7 0.269 Contact Map
1mjhA 2 0.9558 99.7 0.27 Contact Map
1tq8A 4 0.8142 99.7 0.274 Contact Map
4r2kA 2 0.9823 99.6 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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