GREMLIN Database
Q9HMT7 - Probable thiosulfate sulfurtransferase
UniProt: Q9HMT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (267)
Sequences: 4460 (3206)
Seq/√Len: 196.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_T123_K3.6091.00
19_V23_W3.4801.00
163_Y166_D3.2341.00
225_K229_E2.8191.00
25_D137_Y2.7821.00
86_G149_T2.7711.00
47_T51_E2.7151.00
183_P187_S2.6761.00
131_Y135_N2.6661.00
24_V125_L2.6531.00
184_E190_I2.4961.00
53_S133_M2.4841.00
23_W27_H2.4531.00
129_R139_T2.4141.00
124_L260_F2.3951.00
53_S141_E2.3451.00
226_S229_E2.3161.00
81_F85_L2.3011.00
27_H30_Q2.3001.00
20_T126_D2.2941.00
77_D80_A2.2091.00
183_P211_N2.1551.00
184_E189_E2.1381.00
119_H151_Y2.1311.00
156_P159_G2.0271.00
32_R94_S1.9991.00
21_A131_Y1.9861.00
259_W273_N1.9101.00
164_R287_A1.8961.00
20_T23_W1.8901.00
227_A231_R1.8851.00
276_G280_E1.8771.00
91_T149_T1.8771.00
21_A135_N1.8751.00
225_K233_L1.8701.00
33_S55_A1.8421.00
82_E86_G1.8261.00
62_N65_T1.8071.00
108_A256_S1.7491.00
86_G150_D1.7441.00
255_S273_N1.7371.00
164_R284_L1.7281.00
21_A137_Y1.7001.00
140_S144_P1.6951.00
92_E152_D1.6931.00
175_L246_V1.6621.00
231_R235_A1.6361.00
284_L287_A1.6341.00
50_Y54_H1.6271.00
75_I113_Q1.6271.00
219_N223_T1.6201.00
170_A246_V1.5961.00
45_V49_A1.5911.00
162_A272_V1.5901.00
82_E153_A1.5781.00
22_D26_D1.5681.00
61_F88_H1.5561.00
263_H269_D1.5541.00
131_Y223_T1.5401.00
162_A167_V1.5341.00
164_R168_E1.5271.00
34_D90_I1.5151.00
162_A166_D1.5101.00
91_T94_S1.5081.00
81_F117_Y1.4961.00
212_I233_L1.4931.00
185_E254_R1.4811.00
161_R275_D1.4761.00
18_L224_F1.4611.00
206_I209_A1.4121.00
180_V258_A1.4031.00
95_T121_D1.3951.00
85_L114_F1.3881.00
162_A246_V1.3801.00
83_S87_S1.3741.00
164_R280_E1.3441.00
212_I237_Q1.3281.00
98_L110_A1.3121.00
170_A175_L1.3091.00
75_I116_Y1.3011.00
259_W271_T1.2931.00
240_D243_E1.2901.00
78_K82_E1.2901.00
176_P243_E1.2681.00
217_T234_Y1.2621.00
34_D59_I1.2621.00
247_S262_L1.2501.00
168_E287_A1.2491.00
51_E143_P1.2491.00
90_I96_V1.2361.00
244_T272_V1.2291.00
115_K263_H1.2151.00
167_V246_V1.1871.00
82_E152_D1.1861.00
217_T230_L1.1751.00
229_E232_S1.1721.00
167_V170_A1.1691.00
91_T150_D1.1691.00
219_N225_K1.1611.00
247_S271_T1.1601.00
244_T270_N1.1601.00
227_A266_L1.1511.00
19_V27_H1.1441.00
262_L271_T1.1431.00
24_V33_S1.1411.00
245_T262_L1.1371.00
261_A266_L1.1271.00
202_R282_G1.1171.00
191_L203_G1.1171.00
53_S139_T1.1121.00
50_Y144_P1.1081.00
120_D156_P1.1061.00
39_R101_D1.1041.00
202_R289_V1.1011.00
133_M139_T1.0991.00
47_T65_T1.0931.00
81_F113_Q1.0921.00
32_R90_I1.0891.00
129_R133_M1.0711.00
80_A83_S1.0621.00
278_W282_G1.0491.00
64_E73_R1.0471.00
201_Q282_G1.0411.00
42_E48_E1.0321.00
108_A260_F1.0291.00
231_R241_G1.0281.00
206_I248_Y1.0241.00
36_P98_L1.0211.00
177_L248_Y1.0211.00
232_S236_D1.0201.00
262_L268_Y1.0191.00
17_V263_H1.0071.00
59_I146_F1.0021.00
167_V175_L0.9961.00
167_V177_L0.9961.00
51_E142_E0.9951.00
182_S190_I0.9931.00
48_E52_E0.9921.00
224_F257_I0.9861.00
251_I279_T0.9851.00
66_Q84_L0.9830.99
216_A233_L0.9740.99
111_Y259_W0.9730.99
92_E151_Y0.9700.99
225_K230_L0.9680.99
81_F114_F0.9630.99
260_F265_L0.9610.99
217_T258_A0.9570.99
19_V123_K0.9570.99
90_I94_S0.9550.99
56_P132_W0.9530.99
116_Y160_I0.9520.99
85_L90_I0.9510.99
48_E51_E0.9490.99
241_G268_Y0.9470.99
92_E150_D0.9370.99
66_Q87_S0.9350.99
83_S148_A0.9350.99
53_S129_R0.9270.99
105_W254_R0.9270.99
217_T233_L0.9230.99
98_L114_F0.9200.99
31_F95_T0.9120.99
185_E251_I0.9110.99
84_L87_S0.9100.99
92_E154_S0.9050.99
27_H31_F0.8960.99
224_F265_L0.8960.99
274_Y280_E0.8930.99
86_G148_A0.8840.99
234_Y262_L0.8810.99
162_A175_L0.8750.99
268_Y271_T0.8730.99
18_L126_D0.8720.99
25_D138_P0.8690.99
31_F97_V0.8690.99
59_I144_P0.8690.99
176_P240_D0.8560.99
18_L260_F0.8540.99
82_E149_T0.8490.99
130_D134_D0.8460.98
249_C277_S0.8460.98
27_H95_T0.8430.98
202_R287_A0.8430.98
111_Y263_H0.8420.98
212_I217_T0.8420.98
230_L234_Y0.8410.98
232_S235_A0.8380.98
186_F205_H0.8380.98
170_A177_L0.8380.98
98_L111_Y0.8370.98
39_R43_V0.8360.98
100_G107_A0.8310.98
80_A84_L0.8300.98
212_I234_Y0.8260.98
68_Q71_T0.8240.98
162_A170_A0.8240.98
166_D170_A0.8220.98
24_V97_V0.8210.98
19_V24_V0.8170.98
104_N224_F0.8160.98
73_R251_I0.8160.98
85_L151_Y0.8160.98
63_W253_E0.8140.98
115_K259_W0.8130.98
59_I88_H0.8100.98
228_D231_R0.8040.98
185_E250_R0.7940.98
182_S215_A0.7900.98
140_S143_P0.7890.98
87_S148_A0.7890.98
166_D169_N0.7870.98
76_L109_Y0.7840.98
217_T257_I0.7810.97
183_P216_A0.7800.97
37_D101_D0.7770.97
282_G289_V0.7720.97
234_Y258_A0.7680.97
38_H60_G0.7680.97
34_D110_A0.7680.97
230_L233_L0.7660.97
176_P210_E0.7600.97
209_A248_Y0.7580.97
247_S259_W0.7570.97
47_T60_G0.7550.97
44_D49_A0.7540.97
224_F261_A0.7520.97
184_E187_S0.7510.97
103_S218_V0.7460.97
61_F84_L0.7400.96
213_S216_A0.7400.96
167_V171_I0.7380.96
176_P245_T0.7380.96
67_L113_Q0.7370.96
55_A132_W0.7370.96
50_Y59_I0.7360.96
205_H209_A0.7350.96
182_S185_E0.7310.96
111_Y115_K0.7290.96
278_W289_V0.7290.96
61_F110_A0.7280.96
186_F209_A0.7260.96
73_R253_E0.7260.96
92_E119_H0.7250.96
170_A244_T0.7210.96
280_E283_N0.7210.96
49_A52_E0.7180.96
73_R185_E0.7150.96
256_S273_N0.7130.96
171_I177_L0.7130.96
75_I161_R0.7120.96
104_N257_I0.7110.96
50_Y58_A0.7030.95
16_D123_K0.6990.95
219_N229_E0.6990.95
115_K120_D0.6950.95
206_I290_E0.6900.95
258_A261_A0.6890.95
156_P160_I0.6890.95
102_N130_D0.6820.94
130_D133_M0.6810.94
263_H271_T0.6800.94
278_W288_P0.6780.94
98_L122_V0.6780.94
90_I114_F0.6760.94
229_E233_L0.6750.94
245_T268_Y0.6730.94
55_A125_L0.6700.94
22_D137_Y0.6700.94
86_G91_T0.6670.94
93_D149_T0.6660.94
233_L237_Q0.6660.94
160_I272_V0.6660.94
39_R49_A0.6640.94
17_V260_F0.6610.94
31_F94_S0.6610.94
27_H35_D0.6600.93
178_V245_T0.6570.93
25_D29_D0.6570.93
214_W218_V0.6570.93
111_Y122_V0.6500.93
185_E193_P0.6500.93
274_Y277_S0.6480.93
92_E149_T0.6480.93
69_D80_A0.6470.93
47_T62_N0.6460.93
78_K153_A0.6430.93
181_R209_A0.6420.93
164_R171_I0.6400.92
171_I208_G0.6380.92
256_S259_W0.6360.92
191_L199_T0.6350.92
74_D275_D0.6340.92
159_G272_V0.6330.92
50_Y142_E0.6330.92
263_H270_N0.6220.91
279_T282_G0.6220.91
84_L88_H0.6210.91
101_D130_D0.6190.91
41_V44_D0.6180.91
216_A237_Q0.6180.91
96_V119_H0.6160.91
18_L265_L0.6150.91
200_A282_G0.6150.91
100_G109_Y0.6130.91
54_H99_Y0.6130.91
103_S130_D0.6100.90
182_S254_R0.6090.90
91_T151_Y0.6080.90
98_L124_L0.6080.90
96_V114_F0.6070.90
85_L117_Y0.6070.90
239_I268_Y0.6050.90
165_D168_E0.6050.90
131_Y134_D0.6030.90
172_D175_L0.6000.90
92_E120_D0.5950.89
166_D244_T0.5950.89
17_V265_L0.5930.89
168_E288_P0.5930.89
52_E141_E0.5920.89
230_L261_A0.5920.89
125_L132_W0.5920.89
131_Y137_Y0.5910.89
188_G204_G0.5880.89
117_Y153_A0.5880.89
54_H140_S0.5880.89
39_R42_E0.5870.89
83_S86_G0.5840.89
165_D169_N0.5830.88
155_G158_E0.5820.88
104_N124_L0.5810.88
178_V212_I0.5790.88
17_V123_K0.5790.88
65_T87_S0.5780.88
99_Y129_R0.5750.88
38_H64_E0.5750.88
104_N107_A0.5740.88
132_W137_Y0.5730.88
227_A265_L0.5710.87
86_G151_Y0.5690.87
199_T203_G0.5690.87
176_P239_I0.5690.87
115_K160_I0.5680.87
22_D135_N0.5670.87
42_E49_A0.5630.87
116_Y155_G0.5630.87
250_R254_R0.5620.87
166_D272_V0.5610.86
111_Y260_F0.5610.86
21_A25_D0.5580.86
39_R45_V0.5570.86
32_R146_F0.5550.86
104_N218_V0.5530.86
66_Q69_D0.5500.85
251_I278_W0.5470.85
73_R193_P0.5460.85
40_L43_V0.5450.85
82_E151_Y0.5440.85
76_L113_Q0.5440.85
34_D88_H0.5430.85
231_R269_D0.5400.84
217_T261_A0.5400.84
205_H211_N0.5390.84
247_S258_A0.5390.84
24_V132_W0.5390.84
178_V258_A0.5370.84
128_G131_Y0.5350.84
254_R257_I0.5320.83
73_R250_R0.5300.83
176_P244_T0.5290.83
78_K155_G0.5280.83
95_T98_L0.5280.83
179_D209_A0.5270.83
178_V239_I0.5270.83
54_H58_A0.5230.82
67_L74_D0.5230.82
69_D72_T0.5230.82
58_A99_Y0.5220.82
24_V28_L0.5210.82
117_Y151_Y0.5180.82
181_R278_W0.5170.82
190_I193_P0.5170.82
85_L88_H0.5160.82
168_E281_W0.5150.81
164_R274_Y0.5140.81
191_L200_A0.5130.81
100_G185_E0.5120.81
218_V257_I0.5110.81
109_Y251_I0.5080.81
78_K117_Y0.5080.81
205_H248_Y0.5070.80
251_I254_R0.5050.80
49_A101_D0.5040.80
24_V55_A0.5040.80
200_A279_T0.5030.80
246_V272_V0.5020.80
28_L33_S0.5020.80
75_I112_W0.5000.80
133_M136_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uarA 1 0.9249 100 0.317 Contact Map
1urhA 1 0.8532 100 0.318 Contact Map
3aayA 1 0.942 100 0.321 Contact Map
1rhsA 1 0.9488 100 0.325 Contact Map
3hzuA 2 0.9659 100 0.327 Contact Map
1e0cA 1 0.9147 100 0.332 Contact Map
3utnX 1 0.9283 100 0.348 Contact Map
1okgA 1 0.9215 100 0.349 Contact Map
4jgtA 1 0.901 100 0.352 Contact Map
2wlrA 1 0.9727 100 0.356 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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