GREMLIN Database
Q9HMT6 - Thiosulfate sulfurtransferase
UniProt: Q9HMT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (244)
Sequences: 4539 (3288)
Seq/√Len: 210.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_V11_W3.4261.00
78_T106_A3.4031.00
145_G148_A2.9391.00
194_K198_A2.8171.00
69_S131_T2.6911.00
166_P170_A2.6821.00
13_D119_H2.6451.00
28_A32_D2.6171.00
12_L108_L2.6051.00
21_R77_D2.5431.00
35_G116_V2.5261.00
114_A118_E2.5261.00
11_W15_Q2.3481.00
112_Y121_T2.3371.00
35_G123_T2.3231.00
64_W68_L2.2871.00
195_S198_A2.2671.00
8_T109_D2.2651.00
107_V229_V2.2321.00
60_P63_E2.1371.00
146_T252_A2.0911.00
166_P179_N2.0831.00
102_H133_Y2.0131.00
12_L22_V1.9091.00
228_F241_F1.9051.00
196_R200_E1.8931.00
8_T11_W1.8791.00
23_V73_V1.8581.00
194_K202_V1.8561.00
244_G248_A1.8521.00
65_A69_S1.8421.00
22_V37_V1.8161.00
74_E131_T1.8081.00
9_P118_E1.8031.00
9_P114_A1.7981.00
224_I241_F1.7671.00
122_T126_P1.7301.00
187_D192_G1.7231.00
91_A225_S1.7171.00
31_Y36_H1.7101.00
44_P47_A1.6961.00
75_R134_E1.6241.00
144_V149_V1.6231.00
158_A215_V1.6161.00
146_T150_A1.6011.00
200_E204_A1.5991.00
168_E223_R1.5981.00
69_S132_T1.5661.00
58_L96_T1.5641.00
9_P119_H1.5441.00
144_V240_S1.5401.00
43_V71_A1.5371.00
65_A135_P1.5321.00
23_V41_V1.5191.00
74_E77_D1.4931.00
64_W100_H1.4491.00
174_I177_A1.4481.00
68_L97_A1.4351.00
163_T227_T1.4331.00
144_V148_A1.4311.00
152_A215_V1.3961.00
21_R128_V1.3871.00
144_V215_V1.3831.00
143_F243_E1.3801.00
25_V81_A1.3761.00
10_D14_E1.3711.00
146_T248_A1.3671.00
66_A70_A1.3511.00
185_F199_I1.3371.00
114_A192_G1.3281.00
180_V202_V1.3271.00
6_V193_L1.3211.00
78_T104_D1.3161.00
189_D192_G1.2911.00
81_A93_F1.2831.00
180_V206_H1.2761.00
159_V212_D1.2561.00
228_F239_V1.2551.00
152_A158_A1.2551.00
98_L232_R1.2451.00
185_F203_L1.2431.00
216_L231_L1.2421.00
32_D125_T1.2311.00
209_T212_D1.2251.00
61_A65_A1.2191.00
73_V79_L1.2091.00
58_L99_Y1.1981.00
213_R240_S1.1931.00
196_R234_L1.1841.00
65_A134_E1.1731.00
74_E132_T1.1721.00
246_V250_T1.1471.00
213_R238_D1.1431.00
149_V215_V1.1361.00
46_D56_G1.1341.00
149_V152_A1.1241.00
139_G142_V1.1171.00
187_D190_T1.1131.00
216_L239_V1.1101.00
35_G121_T1.1051.00
31_Y126_P1.1011.00
103_D139_G1.1001.00
232_R237_T1.0981.00
214_V231_L1.0941.00
116_V121_T1.0891.00
21_R73_V1.0831.00
198_A201_D1.0771.00
64_W96_T1.0771.00
5_W233_W1.0761.00
174_I217_Y1.0551.00
187_D194_K1.0541.00
231_L236_F1.0481.00
7_V15_Q1.0421.00
149_V158_A1.0401.00
231_L239_V1.0381.00
15_Q20_V1.0381.00
230_V234_L1.0381.00
220_T247_R1.0301.00
64_W97_A1.0251.00
28_A47_A1.0231.00
63_E66_A1.0211.00
200_E210_R1.0161.00
193_L233_W1.0131.00
149_V153_A1.0091.00
99_Y138_R1.0081.00
160_V217_Y1.0031.00
168_E220_T1.0011.00
112_Y116_V0.9891.00
201_D205_E0.9851.00
20_V80_V0.9801.00
185_F227_T0.9801.00
29_W32_D0.9801.00
94_L228_F0.9711.00
193_L226_H0.9691.00
29_W34_I0.9631.00
48_F67_V0.9571.00
229_V233_W0.9561.00
5_W232_R0.9541.00
167_G170_A0.9480.99
91_A229_V0.9440.99
32_D124_G0.9440.99
28_A42_N0.9350.99
26_R84_D0.9350.99
38_P115_W0.9330.99
20_V78_T0.9280.99
88_V223_R0.9280.99
68_L73_V0.9280.99
236_F239_V0.9190.99
153_A176_D0.9140.99
242_Y248_A0.9120.99
152_A160_V0.9080.99
75_R133_Y0.9040.99
7_V106_A0.9020.99
48_F70_A0.8990.99
56_G168_E0.8990.99
168_E219_N0.8980.99
81_A97_A0.8980.99
149_V160_V0.8960.99
67_V70_A0.8950.99
75_R136_G0.8930.99
23_V93_F0.8910.99
75_R132_T0.8880.99
35_G112_Y0.8830.99
41_V128_V0.8810.99
99_Y142_V0.8800.99
180_V185_F0.8790.99
169_F173_H0.8780.99
185_F202_V0.8750.99
63_E67_V0.8750.99
184_A202_V0.8750.99
56_G220_T0.8740.99
210_R236_F0.8740.99
98_L228_F0.8710.99
81_A94_L0.8690.99
180_V203_L0.8660.99
218_C245_S0.8660.99
113_S117_R0.8650.99
144_V152_A0.8640.99
148_A152_A0.8640.99
73_V77_D0.8520.99
65_A131_T0.8480.99
66_A130_E0.8460.99
203_L231_L0.8450.99
83_D90_A0.8420.99
122_T125_T0.8400.99
165_D183_T0.8350.99
23_V43_V0.8330.99
21_R41_V0.8280.99
144_V158_A0.8280.99
94_L232_R0.8270.99
177_A217_Y0.8260.99
13_D120_E0.8240.99
19_S78_T0.8220.99
194_K199_I0.8200.99
6_V109_D0.8180.99
159_V178_V0.8160.98
70_A130_E0.8140.98
169_F177_A0.8080.98
86_H186_V0.8080.98
201_D204_A0.8050.98
166_P184_A0.8020.98
7_V12_L0.7940.98
165_D168_E0.7860.98
68_L133_Y0.7850.98
45_F222_R0.7850.98
152_A213_R0.7730.98
12_L20_V0.7720.98
41_V126_P0.7710.98
216_L228_F0.7690.98
41_V71_A0.7680.98
159_V209_T0.7670.98
185_F226_H0.7660.98
232_R238_D0.7650.98
69_S130_E0.7640.98
56_G222_R0.7630.98
94_L98_L0.7530.97
148_A151_D0.7520.97
159_V214_V0.7510.97
197_A200_E0.7500.97
30_E34_I0.7460.97
193_L230_V0.7450.97
87_G193_L0.7430.97
20_V77_D0.7360.97
248_A251_A0.7350.97
28_A44_P0.7300.97
75_R102_H0.7290.97
247_R250_T0.7290.97
23_V71_A0.7270.97
187_D198_A0.7230.97
61_A135_P0.7210.97
199_I203_L0.7120.96
199_I230_V0.7120.96
199_I202_V0.7070.96
87_G226_H0.7060.96
98_L103_D0.7030.96
87_G90_A0.7020.96
203_L227_T0.7010.96
196_R233_W0.7010.96
181_T184_A0.6980.96
232_R239_V0.6960.96
59_P92_R0.6840.96
108_L115_W0.6830.95
146_T153_A0.6820.95
219_N223_R0.6810.95
227_T230_V0.6810.95
31_Y124_G0.6810.95
173_H177_A0.6790.95
164_R177_A0.6760.95
94_L105_V0.6760.95
182_W186_V0.6760.95
87_G107_V0.6750.95
15_Q18_A0.6740.95
43_V93_F0.6710.95
37_V115_W0.6710.95
19_S76_G0.6660.95
86_H113_S0.6640.95
58_L143_F0.6620.95
15_Q78_T0.6590.95
198_A202_V0.6560.94
85_T113_S0.6550.94
113_S116_V0.6520.94
12_L80_V0.6430.94
73_V97_A0.6430.94
165_D223_R0.6420.94
9_P13_D0.6410.94
214_V236_F0.6410.94
36_H82_Y0.6400.94
242_Y245_S0.6390.94
31_Y40_A0.6380.94
84_D113_S0.6370.93
10_D119_H0.6360.93
6_V229_V0.6360.93
127_E130_E0.6340.93
49_R96_T0.6330.93
69_S74_E0.6310.93
79_L102_H0.6290.93
142_V240_S0.6270.93
57_M243_E0.6260.93
152_A155_S0.6220.93
225_S228_F0.6110.92
43_V67_V0.6110.92
82_Y112_Y0.6090.92
50_S53_G0.6090.92
147_E150_A0.6080.92
114_A117_R0.6070.92
37_V108_L0.6060.92
56_G219_N0.6060.92
202_V206_H0.6050.92
81_A105_V0.6040.92
87_G186_V0.6020.91
159_V213_R0.5980.91
83_D92_R0.5970.91
220_T223_R0.5950.91
164_R246_V0.5920.91
153_A160_V0.5890.91
225_S241_F0.5890.91
31_Y41_V0.5880.90
79_L97_A0.5860.90
208_I236_F0.5850.90
99_Y139_G0.5830.90
67_V71_A0.5810.90
43_V48_F0.5770.90
159_V208_I0.5770.90
19_S77_D0.5740.89
185_F230_V0.5730.89
117_R192_G0.5710.89
216_L227_T0.5690.89
150_A249_W0.5680.89
66_A69_S0.5670.89
173_H217_Y0.5670.89
16_D19_S0.5670.89
76_G131_T0.5630.88
100_H133_Y0.5630.88
68_L100_H0.5620.88
51_A63_E0.5610.88
220_T246_V0.5590.88
47_A70_A0.5580.88
114_A119_H0.5570.88
30_E84_D0.5570.88
115_W119_H0.5550.88
81_A107_V0.5540.88
148_A213_R0.5530.88
148_A240_S0.5530.88
51_A54_P0.5530.88
147_E151_D0.5520.88
38_P122_T0.5500.87
75_R131_T0.5490.87
34_I123_T0.5470.87
219_N222_R0.5470.87
10_D118_E0.5470.87
49_R56_G0.5450.87
98_L142_V0.5440.87
27_D42_N0.5440.87
146_T242_Y0.5440.87
83_D87_G0.5430.87
186_V226_H0.5420.87
106_A233_W0.5410.86
74_E133_Y0.5390.86
197_A201_D0.5370.86
75_R103_D0.5350.86
161_V227_T0.5330.86
173_H179_N0.5270.85
83_D168_E0.5270.85
5_W229_V0.5270.85
161_V180_V0.5260.85
85_T89_F0.5220.84
223_R226_H0.5190.84
111_D114_A0.5150.84
59_P96_T0.5140.84
5_W106_A0.5140.84
12_L115_W0.5130.83
45_F50_S0.5130.83
5_W78_T0.5110.83
36_H122_T0.5090.83
141_D240_S0.5090.83
99_Y143_F0.5080.83
48_F71_A0.5050.83
40_A82_Y0.5050.83
161_V214_V0.5040.82
68_L71_A0.5030.82
95_V225_S0.5030.82
49_R57_M0.5020.82
133_Y136_G0.5020.82
223_R241_F0.5010.82
36_H126_P0.5010.82
218_C221_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rhsA 1 0.9883 100 0.29 Contact Map
4jgtA 1 0.9767 100 0.292 Contact Map
1urhA 1 0.9416 100 0.292 Contact Map
1uarA 1 0.9883 100 0.294 Contact Map
1e0cA 1 0.9883 100 0.299 Contact Map
3aayA 1 0.9805 100 0.303 Contact Map
3utnX 1 0.9883 100 0.307 Contact Map
3hzuA 2 0.9728 100 0.315 Contact Map
1okgA 1 0.9494 100 0.328 Contact Map
2wlrA 1 0.9767 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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