Q9HMT3 - HALSA - GREMLIN Contacts

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Q9HMT3 - Sulfate transport system ATP-binding protein

UniProt:	Q9HMT3	Sequences: MTSVELQGLVRAFGSTTTAVDDVSVSIADGEFFTLVGPSGCGKTTTLRLIAGFETPDRGEIVFGDRSVSGVPPEDRDVGIVFQSYALFPHMTVRENVAYGLRFREPPGGASTEERVSELLSLVDLAGTGDREPAALSGGQQQRVALARALAPGPSVLLLDEPMSALDARLRDRLRGTIKEIQRELDITTVYVTHDQAEALSISDRVAVMRDGAVVQVGTPEAVYREPSSRFVAEFVGENNVVSGTAVPLETGGSSVSVNGVTFEVSECVTGDVAVGLRPEALSFGSGGVGFDVTVERTAFRGDTYTVYCDWAGTELLVTTPDPPDRGPATVSVASGGIDVLPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	343 (268)
Sequences:	19105 (14130)
Seq/√Len:	863.1

ECOLI - MALK YCJV UGPC CYSA POTG POTA FBPC PROV YDCT METN DPPD SAPD DPPF MODC YEHX DDPD OPPD YADG OPPF ARAG YHES DDPF UUP GSIA RBSA MACB MLAF MDLB YECC MDLA CYDC TAUB YTFR FEPC LSRA MSBA NIKE LPTB HISP SAPF CYDD SSUB FHUC ETTA FECE YOJI PHNC GLNQ ZNUC YHDZ YPHE GLTL THIQ ALSA LIVG PHNK XYLG SUFC PSTB ARTP FTSE MGLA NIKD LIVF MODF LOLD BTUD FETA YBBA CCMA YDDA YEJF YNJD PHNL YBHF YBIT YHIH
BACSU - MSMX YURJ OPUBA OPUAA OPUCA YVRA METN OPPD DPPD APPD YKFD APPF TAGH YHCH YDBJ YFIL YXLF YCBN YHAQ YDIF YFMM YVFR YKPA RBSA YTRB OPPF YHEH FHUC YFMR YFMF ECFA1 YFIC YUSV SUNT YTLC YKNV ECSA BMRA YKNU SKFE BCEA YGAD YVCR TCYN YFIB YWJA CYDD YHEI YCLP ALBC YLMA MNTB ECFA2 YXDL SSUB SUFC YXEO FTSE PSTB1 CYDC ARTM TCYC NATA GLNQ ZNUC PSTB2 YTHP YKOD YCLH YJKB YVRO EXPZ YKNY YYBJ YHCG YUFO YYDI YTRE
HALSA - Q9HMT3 Q9HHQ5 Q9HNZ9 Q9HMW0 Q9HMX3 BTUDA Q9HR06 Q9HMX2 Q9HMU8 Q9HRJ6 PHNC Q9HMG1 Q9HRH8 Q9HSQ7 PSTB2 Q9HHM2 Q9HRV7 Q9HMG6 Q9HNY3 Q9HRZ9 Y1631 PSTB1 Y2317 Q9HHR7 Q9HR96 Q9HT03 Q9HS04 Q9HR21 Q9HQA8 Q9HMC1 Q9HMW1
SULSO - Q97UF2 Q97YY4 Q97UY8 Q97ZC0 Q97VC1 Q7LX64 Q97VF5 Q97UH3 Q97VK8 Q97YP3 Q97UD4 Q97VH6 Q97VK9 Q97YK2 Q97UJ9 Q97YP7 Q97X18 Q97VF4 Q97YP8 Q97YQ7 Q97Z03 Q980W0 Q97U54 Y1893 Y2030 Q97UH4 Q97V01 PSTB Q97W42 Q97V00 Q7LY07 Q7LXM4 Q97VY4 Q97VM2 Q7LX80 Q97Z56 Q97Z96 Q97UG5 Q97UC2 Q97YP4 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_G	22_D	4.438	1.00
31_E	205_R	4.163	1.00
200_L	221_E	4.002	1.00
18_T	21_D	3.963	1.00
6_L	9_L	3.609	1.00
7_Q	60_E	3.434	1.00
11_R	49_L	2.995	1.00
34_T	203_S	2.978	1.00
218_G	222_A	2.932	1.00
5_E	26_S	2.882	1.00
9_L	56_P	2.801	1.00
10_V	58_R	2.780	1.00
181_I	187_I	2.687	1.00
47_L	158_L	2.622	1.00
47_L	192_V	2.454	1.00
91_M	99_Y	2.429	1.00
219_T	222_A	2.363	1.00
90_H	134_A	2.354	1.00
128_T	131_R	2.353	1.00
33_F	207_A	2.339	1.00
28_A	31_E	2.310	1.00
94_R	98_A	2.281	1.00
21_D	213_A	2.236	1.00
11_R	54_E	2.155	1.00
11_R	57_D	2.140	1.00
10_V	22_D	2.124	1.00
27_I	33_F	1.982	1.00
179_K	201_S	1.955	1.00
48_R	53_F	1.941	1.00
131_R	135_A	1.921	1.00
5_E	62_V	1.909	1.00
222_A	226_E	1.886	1.00
34_T	199_A	1.878	1.00
91_M	95_E	1.870	1.00
10_V	18_T	1.848	1.00
7_Q	62_V	1.819	1.00
6_L	25_V	1.816	1.00
25_V	207_A	1.813	1.00
12_A	18_T	1.756	1.00
8_G	24_S	1.754	1.00
205_R	217_V	1.742	1.00
49_L	56_P	1.709	1.00
77_D	155_S	1.702	1.00
91_M	96_N	1.676	1.00
12_A	57_D	1.650	1.00
92_T	95_E	1.584	1.00
10_V	21_D	1.558	1.00
6_L	50_I	1.529	1.00
270_T	274_A	1.529	1.00
95_E	98_A	1.516	1.00
109_G	112_T	1.514	1.00
175_R	201_S	1.510	1.00
48_R	54_E	1.499	1.00
79_G	149_A	1.493	1.00
274_A	278_R	1.486	1.00
132_E	135_A	1.471	1.00
114_E	118_E	1.453	1.00
20_V	23_V	1.408	1.00
191_Y	203_S	1.392	1.00
220_P	224_Y	1.383	1.00
115_R	153_G	1.382	1.00
111_S	115_R	1.360	1.00
226_E	229_S	1.340	1.00
203_S	206_V	1.340	1.00
268_C	271_G	1.337	1.00
281_A	285_G	1.318	1.00
88_F	91_M	1.313	1.00
96_N	148_R	1.303	1.00
115_R	118_E	1.293	1.00
51_A	158_L	1.292	1.00
208_V	227_P	1.285	1.00
33_F	205_R	1.284	1.00
133_P	144_V	1.281	1.00
123_V	147_A	1.266	1.00
79_G	154_P	1.264	1.00
117_S	125_L	1.261	1.00
276_G	280_E	1.257	1.00
13_F	19_A	1.256	1.00
207_A	214_V	1.254	1.00
279_P	282_L	1.253	1.00
94_R	130_D	1.250	1.00
277_L	281_A	1.240	1.00
208_V	223_V	1.219	1.00
20_V	49_L	1.207	1.00
222_A	225_R	1.203	1.00
264_E	267_E	1.198	1.00
210_R	213_A	1.197	1.00
49_L	61_I	1.190	1.00
193_T	199_A	1.179	1.00
111_S	114_E	1.178	1.00
7_Q	24_S	1.178	1.00
113_E	117_S	1.158	1.00
8_G	58_R	1.154	1.00
53_F	82_F	1.150	1.00
89_P	134_A	1.141	1.00
31_E	204_D	1.137	1.00
153_G	187_I	1.134	1.00
27_I	188_T	1.133	1.00
96_N	133_P	1.116	1.00
277_L	280_E	1.112	1.00
166_L	174_L	1.109	1.00
259_N	262_T	1.104	1.00
255_S	258_V	1.103	1.00
274_A	281_A	1.102	1.00
101_L	104_R	1.098	1.00
98_A	116_V	1.098	1.00
233_A	237_G	1.084	1.00
87_L	96_N	1.082	1.00
38_P	41_C	1.081	1.00
271_G	274_A	1.080	1.00
269_V	273_V	1.079	1.00
121_S	126_A	1.070	1.00
221_E	225_R	1.067	1.00
41_C	209_M	1.058	1.00
260_G	264_E	1.057	1.00
50_I	190_V	1.056	1.00
120_L	129_G	1.051	1.00
234_E	238_E	1.048	1.00
30_G	188_T	1.046	1.00
260_G	263_F	1.043	1.00
281_A	284_F	1.040	1.00
51_A	80_I	1.029	1.00
176_G	180_E	1.022	1.00
259_N	264_E	1.019	1.00
94_R	129_G	1.019	1.00
278_R	281_A	1.018	1.00
210_R	215_V	1.016	1.00
267_E	270_T	1.000	1.00
270_T	273_V	0.994	1.00
254_S	258_V	0.993	1.00
266_S	270_T	0.993	1.00
117_S	129_G	0.991	1.00
182_Q	187_I	0.981	1.00
272_D	275_V	0.978	1.00
90_H	132_E	0.967	1.00
278_R	282_L	0.962	1.00
262_T	266_S	0.956	1.00
64_G	155_S	0.949	1.00
266_S	269_V	0.943	1.00
178_I	189_T	0.942	1.00
271_G	275_V	0.941	1.00
236_V	240_N	0.941	1.00
273_V	281_A	0.937	1.00
117_S	121_S	0.934	1.00
263_F	267_E	0.929	1.00
93_V	136_L	0.929	1.00
176_G	179_K	0.923	1.00
172_D	176_G	0.920	1.00
9_L	49_L	0.918	1.00
251_T	254_S	0.917	1.00
265_V	268_C	0.915	1.00
124_D	127_G	0.911	1.00
267_E	271_G	0.911	1.00
225_R	229_S	0.908	1.00
255_S	259_N	0.908	1.00
171_R	195_D	0.906	1.00
261_V	264_E	0.901	1.00
94_R	116_V	0.900	1.00
81_V	149_A	0.900	1.00
98_A	102_R	0.885	1.00
253_G	256_V	0.884	1.00
273_V	277_L	0.881	1.00
11_R	45_T	0.878	1.00
274_A	280_E	0.877	1.00
119_L	147_A	0.877	1.00
274_A	277_L	0.876	1.00
235_F	238_E	0.875	1.00
237_G	240_N	0.874	1.00
56_P	61_I	0.861	1.00
276_G	279_P	0.858	1.00
100_G	148_R	0.850	1.00
191_Y	202_I	0.845	1.00
281_A	287_G	0.845	1.00
197_A	201_S	0.844	1.00
28_A	205_R	0.840	1.00
262_T	265_V	0.839	1.00
35_L	46_T	0.839	1.00
136_L	144_V	0.836	1.00
92_T	96_N	0.835	1.00
245_T	248_P	0.834	1.00
77_D	152_P	0.830	1.00
63_F	76_R	0.828	1.00
270_T	278_R	0.828	1.00
280_E	284_F	0.826	1.00
52_G	55_T	0.826	1.00
6_L	61_I	0.826	1.00
273_V	276_G	0.820	1.00
284_F	287_G	0.819	1.00
33_F	190_V	0.818	1.00
257_S	260_G	0.817	1.00
275_V	279_P	0.816	1.00
118_E	121_S	0.812	1.00
258_V	263_F	0.812	1.00
279_P	283_S	0.810	1.00
239_N	243_S	0.809	1.00
99_Y	103_F	0.804	1.00
275_V	278_R	0.803	1.00
269_V	272_D	0.800	1.00
29_D	155_S	0.799	1.00
101_L	105_E	0.791	1.00
282_L	286_S	0.789	1.00
96_N	99_Y	0.786	1.00
107_P	110_A	0.784	1.00
156_V	188_T	0.780	1.00
44_T	48_R	0.779	1.00
32_F	189_T	0.778	1.00
207_A	217_V	0.777	1.00
256_V	259_N	0.776	1.00
259_N	263_F	0.774	1.00
223_V	227_P	0.774	1.00
268_C	273_V	0.774	1.00
12_A	15_S	0.773	1.00
205_R	215_V	0.772	1.00
260_G	267_E	0.769	1.00
238_E	242_V	0.769	1.00
258_V	262_T	0.768	1.00
94_R	97_V	0.766	1.00
240_N	244_G	0.765	1.00
248_P	252_G	0.764	1.00
32_F	191_Y	0.763	1.00
263_F	268_C	0.761	1.00
16_T	19_A	0.760	1.00
272_D	276_G	0.760	1.00
264_E	268_C	0.760	1.00
239_N	242_V	0.759	1.00
100_G	103_F	0.758	1.00
269_V	274_A	0.758	1.00
280_E	283_S	0.756	1.00
64_G	76_R	0.755	1.00
110_A	114_E	0.751	1.00
232_V	236_V	0.751	1.00
252_G	255_S	0.751	1.00
260_G	265_V	0.751	1.00
94_R	117_S	0.749	1.00
263_F	266_S	0.749	1.00
49_L	57_D	0.746	1.00
22_D	213_A	0.744	1.00
283_S	287_G	0.744	1.00
224_Y	228_S	0.741	1.00
49_L	54_E	0.740	1.00
93_V	96_N	0.734	1.00
129_G	132_E	0.733	1.00
210_R	214_V	0.733	1.00
97_V	100_G	0.731	1.00
256_V	260_G	0.731	1.00
262_T	267_E	0.727	1.00
80_I	83_Q	0.726	1.00
4_V	156_V	0.726	1.00
119_L	122_L	0.725	1.00
270_T	275_V	0.723	1.00
118_E	122_L	0.721	1.00
54_E	57_D	0.720	1.00
243_S	246_A	0.719	1.00
158_L	190_V	0.718	1.00
79_G	83_Q	0.716	1.00
219_T	223_V	0.712	1.00
20_V	46_T	0.712	1.00
280_E	287_G	0.711	1.00
120_L	125_L	0.709	1.00
12_A	16_T	0.703	1.00
64_G	75_D	0.695	1.00
13_F	45_T	0.693	1.00
256_V	261_V	0.686	1.00
234_E	237_G	0.685	1.00
9_L	61_I	0.684	1.00
250_E	254_S	0.681	1.00
236_V	239_N	0.680	1.00
269_V	276_G	0.678	1.00
112_T	116_V	0.677	1.00
232_V	235_F	0.672	1.00
224_Y	227_P	0.672	1.00
126_A	129_G	0.670	1.00
182_Q	189_T	0.670	1.00
22_D	58_R	0.669	1.00
282_L	285_G	0.666	1.00
277_L	282_L	0.666	1.00
159_L	189_T	0.666	1.00
146_L	159_L	0.664	1.00
275_V	281_A	0.663	1.00
246_A	250_E	0.663	1.00
255_S	262_T	0.660	1.00
81_V	142_Q	0.659	1.00
256_V	263_F	0.651	1.00
177_T	180_E	0.649	1.00
35_L	209_M	0.646	1.00
263_F	270_T	0.644	1.00
254_S	257_S	0.643	1.00
15_S	18_T	0.642	1.00
275_V	280_E	0.639	1.00
258_V	261_V	0.638	1.00
251_T	255_S	0.638	1.00
13_F	54_E	0.638	1.00
271_G	276_G	0.634	1.00
221_E	224_Y	0.633	1.00
257_S	262_T	0.631	1.00
133_P	141_Q	0.629	1.00
6_L	46_T	0.628	1.00
124_D	173_R	0.628	1.00
11_R	20_V	0.628	1.00
216_Q	226_E	0.627	1.00
267_E	274_A	0.626	1.00
12_A	58_R	0.623	1.00
227_P	232_V	0.623	1.00
119_L	151_A	0.622	1.00
220_P	223_V	0.621	1.00
98_A	103_F	0.621	1.00
21_D	212_G	0.620	1.00
25_V	46_T	0.618	1.00
241_V	244_G	0.617	1.00
275_V	285_G	0.617	1.00
244_G	247_V	0.616	1.00
264_E	269_V	0.616	1.00
248_P	251_T	0.614	1.00
46_T	209_M	0.610	1.00
109_G	113_E	0.607	1.00
270_T	280_E	0.607	1.00
251_T	256_V	0.607	1.00
273_V	280_E	0.606	1.00
238_E	241_V	0.606	1.00
282_L	287_G	0.606	1.00
27_I	156_V	0.605	1.00
23_V	214_V	0.604	1.00
199_A	203_S	0.604	1.00
107_P	111_S	0.603	1.00
179_K	202_I	0.602	1.00
233_A	236_V	0.600	1.00
12_A	19_A	0.599	1.00
7_Q	26_S	0.598	1.00
78_V	156_V	0.594	1.00
242_V	245_T	0.591	1.00
206_V	220_P	0.590	1.00
93_V	144_V	0.587	1.00
99_Y	102_R	0.585	1.00
229_S	234_E	0.585	1.00
52_G	63_F	0.584	1.00
261_V	267_E	0.581	1.00
225_R	228_S	0.579	1.00
235_F	239_N	0.578	1.00
255_S	260_G	0.578	1.00
245_T	249_L	0.577	1.00
269_V	275_V	0.577	1.00
253_G	257_S	0.577	1.00
168_A	172_D	0.576	1.00
96_N	100_G	0.576	1.00
192_V	195_D	0.575	1.00
23_V	46_T	0.572	1.00
10_V	20_V	0.570	1.00
181_I	189_T	0.566	1.00
280_E	285_G	0.566	1.00
257_S	270_T	0.566	1.00
249_L	252_G	0.565	1.00
216_Q	223_V	0.564	1.00
110_A	113_E	0.563	1.00
4_V	63_F	0.563	1.00
276_G	281_A	0.560	1.00
200_L	219_T	0.558	1.00
271_G	277_L	0.554	1.00
47_L	51_A	0.554	1.00
237_G	241_V	0.554	1.00
155_S	187_I	0.552	1.00
92_T	132_E	0.550	1.00
97_V	101_L	0.549	1.00
266_S	275_V	0.542	1.00
262_T	268_C	0.542	1.00
264_E	270_T	0.541	1.00
154_P	181_I	0.541	1.00
231_F	235_F	0.540	1.00
14_G	18_T	0.539	1.00
252_G	256_V	0.536	1.00
257_S	263_F	0.535	1.00
270_T	281_A	0.533	1.00
268_C	276_G	0.533	1.00
175_R	198_E	0.532	1.00
274_A	285_G	0.529	1.00
279_P	284_F	0.529	1.00
270_T	276_G	0.529	1.00
106_P	110_A	0.528	1.00
29_D	64_G	0.526	1.00
275_V	282_L	0.525	1.00
267_E	272_D	0.525	1.00
191_Y	199_A	0.525	1.00
266_S	271_G	0.524	1.00
259_N	265_V	0.524	1.00
256_V	262_T	0.522	1.00
277_L	284_F	0.521	1.00
240_N	243_S	0.520	1.00
259_N	267_E	0.520	1.00
254_S	261_V	0.519	1.00
261_V	268_C	0.518	1.00
274_A	283_S	0.518	1.00
209_M	214_V	0.516	1.00
97_V	151_A	0.515	1.00
283_S	286_S	0.513	1.00
278_R	285_G	0.513	1.00
270_T	279_P	0.512	1.00
36_V	208_V	0.510	1.00
257_S	261_V	0.509	1.00
50_I	158_L	0.508	1.00
272_D	279_P	0.505	1.00
270_T	277_L	0.505	1.00
261_V	265_V	0.504	1.00
87_L	133_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yyzA	1	0.9708	100	0.247	Contact Map
1v43A	2	0.965	100	0.248	Contact Map
2it1A	1	0.9942	100	0.25	Contact Map
1oxxK	1	0.9796	100	0.252	Contact Map
1g291	4	0.9942	100	0.253	Contact Map
1z47A	2	0.9883	100	0.253	Contact Map
3rlfA	2	0.9913	100	0.257	Contact Map
3tuiC	2	0.965	100	0.259	Contact Map
3fvqA	2	0.965	100	0.263	Contact Map
4yerA	2	0.8192	100	0.268	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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