GREMLIN Database
Q9HMT2 - 24-sterol C-methyltransferase
UniProt: Q9HMT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (191)
Sequences: 16655 (11474)
Seq/√Len: 830.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_T78_R3.0571.00
141_R191_L2.8261.00
86_P105_V2.7471.00
68_V79_G2.5471.00
139_E142_R2.5351.00
62_T81_G2.5211.00
80_Y118_I2.5091.00
140_I150_F2.3821.00
61_G126_A2.3341.00
119_D145_K2.3161.00
134_R188_G2.2941.00
82_L106_G2.1951.00
78_R102_A2.1481.00
55_D120_H2.1471.00
121_V140_I2.1381.00
113_F118_I2.1211.00
80_Y104_V2.1151.00
23_D85_A2.1051.00
89_A103_Y2.0951.00
58_L118_I2.0751.00
86_P90_A2.0741.00
89_A93_R2.0281.00
69_R96_T2.0251.00
92_A103_Y1.9701.00
60_L140_I1.9511.00
91_N94_T1.8611.00
144_L150_F1.8401.00
144_L148_G1.8161.00
134_R138_A1.8071.00
139_E143_V1.8001.00
52_E55_D1.7861.00
56_T80_Y1.7631.00
23_D87_E1.7551.00
89_A105_V1.7421.00
57_V71_L1.6981.00
178_D181_T1.6891.00
132_D135_E1.6881.00
121_V144_L1.6681.00
183_R187_R1.6601.00
134_R185_A1.6501.00
96_T103_Y1.6381.00
62_T68_V1.5551.00
133_P185_A1.4831.00
80_Y102_A1.4701.00
15_P107_D1.4691.00
130_A136_T1.4351.00
83_D89_A1.4341.00
68_V81_G1.4201.00
56_T145_K1.4061.00
87_E90_A1.3911.00
69_R95_Y1.3871.00
81_G103_Y1.3841.00
60_L108_F1.3841.00
56_T118_I1.3731.00
135_E138_A1.3571.00
94_T98_D1.3521.00
184_E188_G1.3481.00
57_V120_H1.3361.00
106_G112_P1.2871.00
115_D142_R1.2861.00
107_D110_S1.2781.00
144_L191_L1.2761.00
84_G107_D1.2641.00
126_A130_A1.2411.00
121_V143_V1.2371.00
33_G36_D1.2351.00
30_R64_S1.2321.00
44_D48_R1.2231.00
58_L121_V1.2181.00
114_A117_A1.2131.00
137_L186_F1.2021.00
108_F126_A1.1791.00
123_S126_A1.1771.00
90_A93_R1.1751.00
72_R100_D1.1691.00
43_K70_A1.1621.00
70_A74_R1.1481.00
48_R197_D1.1421.00
15_P109_G1.1301.00
104_V113_F1.1171.00
62_T92_A1.1151.00
82_L111_L1.1101.00
45_V151_Y1.0891.00
61_G123_S1.0661.00
184_E187_R1.0571.00
179_R198_L1.0521.00
134_R189_A1.0471.00
183_R196_Q1.0341.00
56_T119_D1.0321.00
164_H168_D1.0281.00
95_Y98_D1.0241.00
166_W170_I1.0231.00
70_A73_E1.0191.00
96_T101_L1.0181.00
168_D171_S1.0171.00
30_R95_Y1.0121.00
111_L143_V1.0071.00
67_A122_F1.0061.00
67_A124_F1.0041.00
43_K47_A1.0031.00
39_W43_K1.0031.00
108_F130_A0.9981.00
128_Y154_V0.9951.00
112_P139_E0.9951.00
94_T97_D0.9741.00
138_A189_A0.9641.00
90_A94_T0.9571.00
40_H43_K0.9531.00
38_H41_T0.9501.00
71_L122_F0.9451.00
69_R73_E0.9411.00
111_L139_E0.9381.00
83_D88_M0.9241.00
141_R189_A0.9211.00
65_G92_A0.9191.00
136_T140_I0.9171.00
82_L104_V0.9081.00
68_V101_L0.9071.00
51_V55_D0.8981.00
58_L143_V0.8941.00
85_A88_M0.8891.00
36_D39_W0.8871.00
44_D47_A0.8821.00
91_N95_Y0.8821.00
56_T117_A0.8811.00
57_V79_G0.8751.00
57_V122_F0.8711.00
138_A142_R0.8651.00
81_G92_A0.8651.00
55_D119_D0.8631.00
43_K74_R0.8631.00
44_D197_D0.8591.00
32_K40_H0.8591.00
140_I144_L0.8521.00
93_R102_A0.8511.00
181_T184_E0.8481.00
93_R97_D0.8421.00
22_F128_Y0.8421.00
36_D40_H0.8401.00
163_S166_W0.8361.00
135_E139_E0.8361.00
167_Q171_S0.8311.00
50_P149_T0.8281.00
127_F154_V0.8261.00
19_R23_D0.8241.00
109_G132_D0.8201.00
47_A74_R0.8131.00
34_M38_H0.8041.00
110_S135_E0.7951.00
166_W171_S0.7911.00
89_A92_A0.7901.00
137_L182_Y0.7861.00
141_R190_G0.7851.00
68_V103_Y0.7781.00
125_E128_Y0.7761.00
34_M37_R0.7761.00
120_H148_G0.7741.00
80_Y113_F0.7711.00
38_H42_A0.7691.00
115_D139_E0.7691.00
62_T83_D0.7671.00
37_R41_T0.7651.00
16_M19_R0.7611.00
163_S169_S0.7611.00
179_R196_Q0.7561.00
19_R105_V0.7531.00
16_M20_E0.7471.00
185_A189_A0.7461.00
125_E153_G0.7431.00
163_S167_Q0.7411.00
137_L189_A0.7411.00
54_D76_V0.7391.00
59_D129_Y0.7381.00
53_D76_V0.7331.00
66_Y70_A0.7331.00
65_G103_Y0.7321.00
39_W42_A0.7261.00
157_Y178_D0.7221.00
60_L121_V0.7221.00
111_L118_I0.7211.00
46_L74_R0.7161.00
59_D81_G0.7161.00
193_V196_Q0.7151.00
125_E129_Y0.7111.00
123_S130_A0.7081.00
150_F191_L0.7071.00
106_G111_L0.6971.00
64_S88_M0.6971.00
26_A88_M0.6871.00
34_M42_A0.6851.00
120_H149_T0.6811.00
26_A30_R0.6781.00
165_D169_S0.6761.00
127_F130_A0.6761.00
123_S152_C0.6751.00
27_A91_N0.6661.00
69_R72_R0.6641.00
37_R40_H0.6601.00
86_P93_R0.6591.00
127_F136_T0.6541.00
64_S95_Y0.6531.00
33_G37_R0.6531.00
117_A145_K0.6531.00
150_F186_F0.6511.00
167_Q170_I0.6511.00
22_F129_Y0.6511.00
25_W28_S0.6481.00
124_F153_G0.6451.00
24_E28_S0.6441.00
59_D62_T0.6411.00
46_L70_A0.6371.00
186_F189_A0.6351.00
165_D168_D0.6341.00
127_F182_Y0.6271.00
32_K36_D0.6221.00
35_E39_W0.6221.00
166_W169_S0.6191.00
59_D79_G0.6141.00
48_R195_A0.6131.00
179_R183_R0.6091.00
20_E24_E0.6031.00
46_L51_V0.6021.00
49_M151_Y0.6021.00
72_R101_L0.6021.00
17_S20_E0.5981.00
62_T103_Y0.5971.00
18_V22_F0.5951.00
116_D146_S0.5941.00
19_R86_P0.5931.00
19_R84_G0.5881.00
26_A87_E0.5861.00
67_A71_L0.5851.00
133_P177_W0.5841.00
99_D102_A0.5811.00
42_A46_L0.5791.00
162_H165_D0.5781.00
37_R42_A0.5771.00
109_G130_A0.5761.00
127_F152_C0.5751.00
93_R103_Y0.5741.00
36_D42_A0.5731.00
26_A29_G0.5701.00
78_R100_D0.5701.00
88_M125_E0.5651.00
115_D143_V0.5641.00
142_R145_K0.5591.00
127_F137_L0.5551.00
30_R91_N0.5551.00
116_D145_K0.5531.00
138_A188_G0.5521.00
46_L49_M0.5481.00
27_A87_E0.5471.00
185_A188_G0.5461.00
121_V148_G0.5441.00
45_V48_R0.5431.00
154_V182_Y0.5431.00
46_L71_L0.5421.00
81_G101_L0.5371.00
118_I143_V0.5331.00
35_E38_H0.5331.00
45_V49_M0.5301.00
157_Y181_T0.5291.00
109_G135_E0.5271.00
183_R193_V0.5251.00
15_P19_R0.5241.00
23_D86_P0.5211.00
128_Y155_N0.5201.00
69_R103_Y0.5191.00
199_I206_I0.5191.00
22_F29_G0.5181.00
137_L152_C0.5161.00
62_T82_L0.5161.00
55_D76_V0.5141.00
57_V75_G0.5131.00
68_V72_R0.5131.00
113_F143_V0.5111.00
93_R96_T0.5101.00
87_E91_N0.5091.00
123_S140_I0.5051.00
67_A128_Y0.5041.00
61_G130_A0.5041.00
34_M40_H0.5041.00
20_E23_D0.5011.00
22_F28_S0.5011.00
34_M41_T0.5001.00
152_C182_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pneA 2 0.9708 100 0.409 Contact Map
2fk8A 1 0.9125 100 0.426 Contact Map
2o57A 2 0.9542 100 0.436 Contact Map
4obxA 2 0.7875 100 0.439 Contact Map
3hemA 2 0.9458 100 0.439 Contact Map
4ineA 2 1 100 0.447 Contact Map
4kriA 1 0.9833 100 0.45 Contact Map
3bkxA 2 0.925 100 0.454 Contact Map
3kkzA 2 0.9375 100 0.454 Contact Map
3ujcA 1 0.9333 100 0.455 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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