GREMLIN Database
Q9HMT0 - Uncharacterized protein
UniProt: Q9HMT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (177)
Sequences: 265 (215)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_G130_R4.5191.00
59_V118_I4.2851.00
30_V168_V3.9661.00
45_D169_H3.5741.00
149_L153_Q3.4360.99
30_V156_R3.0370.98
110_D113_G2.8990.98
152_L156_R2.8500.98
45_D132_S2.6820.97
132_S169_H2.5470.95
25_V31_A2.5310.95
112_D142_Y2.5000.95
116_A120_E2.4310.94
45_D167_L2.2250.91
132_S167_L2.1830.90
108_P142_Y2.1490.89
118_I131_V2.1200.88
153_Q186_A2.0740.87
122_L164_A2.0580.87
173_E179_A2.0060.85
115_L153_Q1.9670.84
159_V166_A1.8910.82
112_D116_A1.8580.81
65_A68_V1.8510.80
66_R163_D1.7610.77
120_E124_D1.7590.77
149_L182_R1.7280.75
116_A153_Q1.7090.75
40_A85_L1.7080.75
131_V191_V1.6550.72
116_A174_V1.6260.71
154_R182_R1.6110.70
154_R158_I1.5890.69
49_L95_S1.5640.68
144_D170_V1.5630.68
65_A86_D1.5480.67
53_T138_E1.5340.66
58_V166_A1.5270.66
30_V159_V1.4550.62
89_S113_G1.4230.60
55_H125_T1.3780.58
194_D197_G1.3770.57
30_V187_G1.3700.57
134_D193_L1.3600.56
43_R193_L1.3330.55
86_D166_A1.3280.55
137_T175_H1.3010.53
36_P105_V1.2760.52
119_D136_L1.2400.50
59_V84_I1.2180.48
150_D153_Q1.2150.48
31_A189_L1.2150.48
93_G104_Y1.1990.47
176_D195_A1.1960.47
167_L191_V1.1790.46
166_A189_L1.1720.46
110_D119_D1.1710.46
30_V154_R1.1470.44
60_S140_A1.1380.44
149_L195_A1.1130.42
86_D89_S1.1130.42
184_R190_V1.1080.42
125_T129_R1.1060.42
61_T86_D1.1010.41
140_A153_Q1.0880.41
153_Q156_R1.0870.41
130_R166_A1.0750.40
59_V158_I1.0740.40
86_D93_G1.0700.40
107_R142_Y1.0580.39
156_R187_G1.0520.39
134_D190_V1.0480.39
115_L149_L1.0430.38
150_D159_V1.0340.38
115_L119_D1.0260.37
139_L164_A1.0150.37
155_L177_E1.0010.36
32_L171_S1.0010.36
72_L184_R0.9930.36
33_L46_T0.9920.35
133_F179_A0.9890.35
148_A187_G0.9800.35
29_T189_L0.9790.35
47_D194_D0.9740.35
152_L182_R0.9700.34
119_D123_T0.9690.34
29_T108_P0.9620.34
101_H191_V0.9610.34
130_R164_A0.9600.34
62_R134_D0.9530.33
149_L187_G0.9500.33
102_I128_K0.9350.32
164_A193_L0.9350.32
50_K54_D0.9340.32
60_S120_E0.9310.32
90_V114_I0.9300.32
150_D182_R0.9270.32
133_F193_L0.9210.32
150_D186_A0.9180.32
33_L45_D0.9170.32
25_V54_D0.9130.31
42_D132_S0.9040.31
37_S61_T0.9020.31
151_A182_R0.9010.31
108_P112_D0.9010.31
72_L90_V0.9010.31
85_L159_V0.9000.31
100_S190_V0.8980.31
86_D135_S0.8880.30
27_G80_D0.8860.30
73_E197_G0.8800.30
175_H182_R0.8690.29
69_T153_Q0.8680.29
120_E123_T0.8620.29
117_S120_E0.8590.29
21_T114_I0.8530.28
149_L181_S0.8460.28
112_D115_L0.8460.28
170_V187_G0.8440.28
98_A103_R0.8420.28
27_G127_G0.8400.28
120_E139_L0.8380.28
112_D150_D0.8290.27
36_P44_M0.8290.27
172_A180_L0.8280.27
29_T119_D0.8170.27
65_A106_S0.8170.27
51_A57_L0.8160.27
170_V180_L0.8140.27
59_V79_E0.8100.26
37_S57_L0.8090.26
157_G184_R0.8040.26
51_A99_A0.8000.26
111_V148_A0.7990.26
39_G133_F0.7970.26
153_Q182_R0.7960.26
75_Y85_L0.7930.26
170_V177_E0.7820.25
132_S164_A0.7790.25
119_D157_G0.7770.25
118_I152_L0.7750.25
161_R191_V0.7690.25
28_G31_A0.7640.24
85_L171_S0.7590.24
66_R85_L0.7590.24
113_G185_D0.7570.24
88_L91_E0.7560.24
132_S194_D0.7560.24
39_G56_F0.7420.23
170_V173_E0.7410.23
31_A144_D0.7330.23
37_S156_R0.7280.23
113_G142_Y0.7260.23
145_E179_A0.7240.23
78_D127_G0.7240.23
122_L184_R0.7200.23
136_L162_H0.7170.22
140_A186_A0.7170.22
52_D59_V0.7160.22
70_Q95_S0.7150.22
123_T176_D0.7130.22
57_L197_G0.7100.22
149_L185_D0.7080.22
110_D182_R0.7080.22
123_T185_D0.7050.22
114_I180_L0.7020.22
115_L146_H0.6980.22
24_A197_G0.6960.22
59_V100_S0.6900.21
148_A190_V0.6900.21
146_H186_A0.6880.21
125_T164_A0.6880.21
61_T130_R0.6790.21
149_L179_A0.6780.21
28_G165_T0.6760.21
72_L185_D0.6750.21
130_R165_T0.6720.21
35_H41_T0.6720.21
38_T135_S0.6700.21
89_S104_Y0.6690.21
112_D119_D0.6650.20
109_G155_L0.6650.20
57_L121_F0.6580.20
52_D183_F0.6550.20
136_L172_A0.6540.20
55_H129_R0.6540.20
24_A127_G0.6510.20
48_F132_S0.6470.20
42_D46_T0.6450.20
150_D181_S0.6430.20
137_T149_L0.6410.20
86_D104_Y0.6370.19
72_L113_G0.6370.19
23_D120_E0.6360.19
27_G63_T0.6350.19
48_F197_G0.6330.19
32_L172_A0.6320.19
48_F137_T0.6320.19
168_V187_G0.6280.19
152_L168_V0.6230.19
33_L183_F0.6220.19
149_L186_A0.6180.19
168_V192_E0.6160.19
162_H190_V0.6120.18
117_S179_A0.6110.18
168_V195_A0.6060.18
36_P110_D0.6040.18
79_E92_H0.6020.18
76_D148_A0.6010.18
115_L185_D0.6010.18
84_I116_A0.6010.18
122_L195_A0.5980.18
23_D139_L0.5930.18
153_Q185_D0.5920.18
78_D130_R0.5900.18
163_D194_D0.5900.18
168_V171_S0.5880.18
100_S180_L0.5850.18
51_A155_L0.5840.18
56_F70_Q0.5760.17
176_D179_A0.5750.17
91_E144_D0.5740.17
145_E149_L0.5720.17
95_S173_E0.5720.17
74_Y85_L0.5670.17
21_T164_A0.5660.17
37_S193_L0.5620.17
102_I105_V0.5580.17
46_T131_V0.5550.17
38_T136_L0.5510.16
91_E191_V0.5510.16
60_S64_T0.5510.16
75_Y78_D0.5450.16
73_E184_R0.5450.16
112_D178_D0.5450.16
31_A120_E0.5350.16
64_T183_F0.5340.16
60_S168_V0.5330.16
36_P135_S0.5320.16
40_A142_Y0.5310.16
36_P137_T0.5300.16
60_S157_G0.5290.16
67_E70_Q0.5260.16
23_D33_L0.5220.16
29_T42_D0.5220.16
47_D196_D0.5210.15
151_A183_F0.5190.15
105_V118_I0.5180.15
111_V149_L0.5170.15
147_Q154_R0.5160.15
113_G162_H0.5150.15
21_T83_E0.5140.15
146_H180_L0.5140.15
119_D154_R0.5140.15
153_Q158_I0.5130.15
49_L57_L0.5120.15
150_D161_R0.5110.15
101_H181_S0.5110.15
108_P135_S0.5080.15
30_V150_D0.5070.15
66_R148_A0.5070.15
46_T193_L0.5060.15
75_Y196_D0.5040.15
69_T186_A0.5030.15
85_L96_R0.5010.15
101_H148_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.9163 99.5 0.747 Contact Map
4a8jA 1 0.8966 99.2 0.79 Contact Map
4bwyA 3 0.7734 98.1 0.853 Contact Map
2dr3A 3 0.9113 97.9 0.861 Contact Map
2cvhA 1 0.8424 97.3 0.875 Contact Map
2ekdA 5 0.8916 97 0.881 Contact Map
3io5A 2 0.7537 97 0.882 Contact Map
4blqA 3 0.7635 96.8 0.885 Contact Map
2w0mA 1 0.8621 96.7 0.886 Contact Map
2ztsA 3 0.867 96.6 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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