GREMLIN Database
Q9HMS7 - DNA damage-inducible protein
UniProt: Q9HMS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 513 (425)
Sequences: 18342 (13883)
Seq/√Len: 673.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_D105_G4.7251.00
162_F224_A3.9281.00
70_E295_A3.3381.00
151_A213_V3.2971.00
95_S320_G3.1891.00
361_A372_T3.0941.00
356_A359_P3.0871.00
256_S260_R2.9771.00
133_D150_A2.9661.00
327_D330_E2.8831.00
178_D181_T2.7881.00
131_Y134_S2.6291.00
133_D137_G2.6291.00
252_W256_S2.5241.00
192_T225_V2.5061.00
90_T113_S2.5021.00
155_V213_V2.4901.00
56_M201_I2.4571.00
199_V204_I2.4161.00
150_A154_R2.4041.00
401_D453_P2.4021.00
97_F105_G2.3891.00
64_T144_E2.3141.00
56_M198_A2.3001.00
68_A148_L2.2721.00
30_E34_D2.1951.00
108_F251_D2.1881.00
189_T226_A2.1841.00
315_S338_T2.1621.00
155_V216_A2.1161.00
185_V229_V2.1041.00
142_N288_H2.0831.00
431_I434_G2.0281.00
336_W340_R2.0271.00
148_L151_A2.0261.00
53_D219_T2.0061.00
357_A377_R1.9871.00
159_T220_A1.9861.00
165_W227_G1.9691.00
293_A371_L1.9551.00
40_M310_G1.9331.00
213_V217_W1.9181.00
57_V215_A1.9121.00
201_I215_A1.9101.00
374_T433_A1.9011.00
322_Q330_E1.9011.00
210_L217_W1.8961.00
97_F102_D1.8871.00
147_E151_A1.8701.00
358_G373_V1.8631.00
117_A168_T1.8361.00
56_M197_N1.8311.00
62_G65_A1.8291.00
37_V41_V1.7801.00
357_A373_V1.7301.00
180_R184_Y1.7221.00
132_A150_A1.7201.00
185_V230_F1.6971.00
97_F100_A1.6951.00
155_V217_W1.6931.00
323_L399_A1.6901.00
228_I232_A1.6851.00
137_G146_I1.6841.00
191_P195_A1.6721.00
158_L161_V1.6701.00
199_V203_G1.6691.00
204_I209_E1.6541.00
251_D254_V1.6541.00
318_L334_Y1.6531.00
162_F227_G1.6431.00
385_G444_S1.6391.00
354_F377_R1.6361.00
36_A314_A1.6341.00
333_A336_W1.6341.00
203_G209_E1.6261.00
333_A337_Q1.6241.00
335_G392_L1.6131.00
332_A336_W1.5681.00
93_V109_A1.5641.00
358_G362_S1.5521.00
60_A202_F1.5481.00
342_A387_S1.5411.00
323_L331_A1.5401.00
128_T157_M1.5381.00
197_N215_A1.5361.00
52_A194_I1.5221.00
125_T161_V1.5171.00
322_Q327_D1.5161.00
134_S137_G1.5111.00
196_L218_G1.4981.00
198_A204_I1.4791.00
198_A202_F1.4781.00
155_V220_A1.4711.00
146_I150_A1.4701.00
200_L204_I1.4651.00
350_G354_F1.4611.00
132_A154_R1.4591.00
143_P147_E1.4551.00
144_E147_E1.4551.00
335_G395_A1.4501.00
53_D193_N1.4491.00
359_P362_S1.4471.00
401_D404_W1.4451.00
430_I434_G1.4391.00
452_T455_I1.4281.00
329_D333_A1.4271.00
195_A199_V1.4261.00
373_V377_R1.4211.00
133_D147_E1.4171.00
169_A230_F1.4141.00
72_G153_L1.4021.00
378_I437_V1.4021.00
448_G452_T1.4001.00
29_G337_Q1.3991.00
105_G108_F1.3991.00
137_G143_P1.3971.00
340_R344_A1.3961.00
136_I146_I1.3951.00
195_A198_A1.3941.00
184_Y188_I1.3921.00
451_T455_I1.3921.00
232_A236_S1.3731.00
28_R318_L1.3731.00
192_T196_L1.3681.00
103_H107_N1.3641.00
67_A292_A1.3621.00
97_F109_A1.3531.00
99_G324_G1.3531.00
213_V216_A1.3451.00
96_R100_A1.3391.00
104_A108_F1.3361.00
41_V183_M1.3271.00
57_V69_L1.3221.00
200_L210_L1.3181.00
144_E288_H1.3161.00
354_F380_G1.2951.00
359_P363_A1.2951.00
45_L187_L1.2891.00
328_P332_A1.2881.00
98_K321_Q1.2791.00
65_A148_L1.2771.00
362_S369_F1.2701.00
416_V445_L1.2641.00
423_L427_P1.2641.00
96_R320_G1.2611.00
63_S367_E1.2581.00
98_K106_A1.2561.00
411_I415_I1.2531.00
134_S138_L1.2531.00
26_R30_E1.2511.00
133_D146_I1.2471.00
196_L221_I1.2461.00
105_G254_V1.2411.00
404_W453_P1.2391.00
253_G256_S1.2391.00
54_F299_R1.2371.00
342_A391_T1.2341.00
452_T456_A1.2251.00
430_I437_V1.2241.00
403_R407_Y1.2181.00
351_A355_V1.2141.00
112_Q250_W1.2141.00
370_S374_T1.2121.00
185_V233_V1.2121.00
197_N218_G1.2071.00
361_A369_F1.2061.00
29_G341_V1.1881.00
129_W154_R1.1861.00
422_F426_D1.1821.00
96_R400_G1.1801.00
125_T129_W1.1651.00
94_V175_G1.1641.00
434_G438_I1.1631.00
290_V432_S1.1581.00
300_V360_I1.1571.00
263_L267_G1.1541.00
453_P456_A1.1501.00
112_Q255_A1.1411.00
282_V286_F1.1381.00
63_S289_Q1.1381.00
244_S247_G1.1321.00
68_A145_I1.1251.00
54_F66_V1.1221.00
250_W255_A1.1211.00
200_L221_I1.1201.00
198_A201_I1.1121.00
193_N219_T1.1111.00
69_L212_V1.1101.00
312_S394_G1.1081.00
319_V331_A1.1071.00
64_T148_L1.1041.00
424_A430_I1.1031.00
297_G375_F1.1001.00
53_D197_N1.0991.00
178_D182_P1.0981.00
371_L374_T1.0921.00
369_F372_T1.0841.00
281_F285_L1.0841.00
188_I229_V1.0831.00
32_A338_T1.0791.00
344_A348_I1.0791.00
407_Y411_I1.0781.00
136_I149_G1.0761.00
419_P423_L1.0721.00
110_I172_A1.0701.00
116_L255_A1.0671.00
64_T288_H1.0621.00
203_G210_L1.0551.00
27_R30_E1.0541.00
335_G454_T1.0491.00
99_G325_A1.0471.00
198_A203_G1.0451.00
192_T222_A1.0411.00
181_T233_V1.0391.00
415_I419_P1.0381.00
389_A443_H1.0331.00
200_L203_G1.0251.00
177_G321_Q1.0241.00
118_L165_W1.0231.00
113_S258_I1.0211.00
337_Q341_V1.0121.00
117_A164_F1.0111.00
392_L454_T1.0021.00
358_G370_S0.9821.00
33_F37_V0.9801.00
61_T65_A0.9771.00
154_R158_L0.9771.00
408_G450_V0.9771.00
442_V446_S0.9741.00
347_L351_A0.9741.00
257_E260_R0.9681.00
396_L453_P0.9671.00
130_V134_S0.9671.00
427_P430_I0.9661.00
370_S373_V0.9651.00
187_L191_P0.9641.00
109_A254_V0.9631.00
322_Q334_Y0.9611.00
217_W220_A0.9541.00
220_A224_A0.9531.00
169_A227_G0.9511.00
98_K176_A0.9501.00
111_K248_K0.9451.00
96_R323_L0.9441.00
108_F254_V0.9431.00
310_G314_A0.9391.00
107_N247_G0.9381.00
300_V353_L0.9351.00
55_F58_S0.9311.00
125_T158_L0.9301.00
132_A153_L0.9291.00
369_F373_V0.9271.00
197_N219_T0.9271.00
289_Q371_L0.9241.00
39_A313_T0.9231.00
378_I433_A0.9201.00
129_W133_D0.9201.00
438_I442_V0.9181.00
375_F432_S0.9171.00
130_V154_R0.9131.00
204_I210_L0.9131.00
225_V229_V0.9111.00
348_I351_A0.9091.00
385_G447_V0.9071.00
98_K103_H0.9051.00
339_L388_V0.9011.00
296_I372_T0.8981.00
31_E34_D0.8981.00
296_I364_F0.8971.00
119_L123_P0.8961.00
115_W250_W0.8941.00
260_R403_R0.8911.00
354_F358_G0.8871.00
178_D237_G0.8871.00
151_A154_R0.8861.00
290_V371_L0.8851.00
331_A399_A0.8821.00
271_S410_L0.8801.00
331_A335_G0.8781.00
90_T94_V0.8781.00
178_D233_V0.8741.00
56_M202_F0.8721.00
217_W221_I0.8651.00
319_V398_G0.8641.00
184_Y187_L0.8631.00
224_A228_I0.8621.00
76_Y156_V0.8621.00
196_L200_L0.8601.00
319_V395_A0.8591.00
50_R73_F0.8591.00
283_L432_S0.8571.00
52_A190_L0.8551.00
158_L220_A0.8551.00
348_I352_L0.8541.00
193_N197_N0.8541.00
148_L212_V0.8501.00
433_A437_V0.8501.00
355_V359_P0.8501.00
52_A193_N0.8501.00
173_L234_L0.8491.00
96_R257_E0.8461.00
35_L179_T0.8431.00
127_G131_Y0.8381.00
143_P146_I0.8341.00
229_V232_A0.8331.00
169_A234_L0.8311.00
420_L441_T0.8281.00
421_A425_L0.8271.00
378_I440_A0.8261.00
322_Q325_A0.8251.00
282_V285_L0.8231.00
83_A164_F0.8231.00
434_G437_V0.8211.00
267_G406_L0.8191.00
64_T145_I0.8171.00
357_A376_I0.8161.00
299_R364_F0.8161.00
333_A340_R0.8161.00
183_M187_L0.8101.00
308_A346_Q0.8091.00
293_A372_T0.8081.00
155_V158_L0.8071.00
115_W248_K0.8071.00
354_F357_A0.8061.00
132_A157_M0.7991.00
361_A373_V0.7941.00
123_P127_G0.7941.00
412_G446_S0.7901.00
45_L190_L0.7901.00
67_A145_I0.7891.00
166_G226_A0.7891.00
294_Y436_W0.7881.00
61_T209_E0.7871.00
424_A434_G0.7841.00
231_F235_L0.7811.00
416_V419_P0.7801.00
93_V261_V0.7801.00
136_I153_L0.7801.00
311_Y338_T0.7801.00
293_A375_F0.7791.00
31_E318_L0.7781.00
322_Q331_A0.7781.00
92_S96_R0.7771.00
147_E150_A0.7751.00
344_A347_L0.7751.00
365_T368_R0.7731.00
284_G291_V0.7721.00
104_A247_G0.7711.00
145_I291_V0.7711.00
173_L230_F0.7711.00
111_K247_G0.7711.00
283_L435_P0.7701.00
29_G340_R0.7691.00
57_V201_I0.7681.00
254_V257_E0.7671.00
115_W119_L0.7671.00
270_L274_F0.7661.00
94_V172_A0.7651.00
188_I192_T0.7651.00
173_L181_T0.7641.00
82_L266_A0.7631.00
100_A324_G0.7621.00
286_F425_L0.7621.00
329_D336_W0.7601.00
343_L347_L0.7591.00
93_V97_F0.7571.00
388_V447_V0.7561.00
95_S175_G0.7561.00
197_N201_I0.7541.00
444_S448_G0.7541.00
232_A235_L0.7521.00
31_E321_Q0.7511.00
71_I141_S0.7511.00
337_Q340_R0.7501.00
32_A337_Q0.7491.00
330_E333_A0.7481.00
126_A130_V0.7471.00
49_L219_T0.7451.00
133_D154_R0.7451.00
42_T186_R0.7431.00
151_A212_V0.7421.00
282_V422_F0.7401.00
48_L52_A0.7361.00
319_V335_G0.7361.00
174_A182_P0.7311.00
420_L424_A0.7291.00
193_N222_A0.7271.00
55_F363_A0.7261.00
113_S168_T0.7261.00
343_L387_S0.7201.00
340_R343_L0.7201.00
425_L434_G0.7171.00
68_A212_V0.7171.00
257_E400_G0.7151.00
131_Y135_M0.7141.00
262_S266_A0.7131.00
416_V420_L0.7111.00
264_P406_L0.7071.00
282_V421_A0.7061.00
381_L384_A0.7031.00
437_V440_A0.7021.00
68_A149_G0.7001.00
144_E148_L0.6991.00
209_E213_V0.6991.00
45_L48_L0.6971.00
188_I225_V0.6961.00
52_A56_M0.6941.00
301_M383_V0.6941.00
346_Q387_S0.6931.00
347_L384_A0.6921.00
141_S284_G0.6921.00
107_N244_S0.6921.00
32_A314_A0.6921.00
104_A107_N0.6911.00
329_D332_A0.6901.00
152_Y197_N0.6901.00
216_A220_A0.6901.00
236_S239_W0.6891.00
338_T391_T0.6881.00
404_W408_G0.6871.00
221_I224_A0.6861.00
58_S66_V0.6851.00
355_V358_G0.6841.00
358_G369_F0.6841.00
181_T229_V0.6811.00
123_P126_A0.6811.00
108_F111_K0.6791.00
356_A360_I0.6791.00
51_T303_L0.6741.00
105_G109_A0.6741.00
118_L122_L0.6721.00
94_V106_A0.6711.00
311_Y345_T0.6711.00
153_L157_M0.6701.00
394_G398_G0.6681.00
157_M160_V0.6651.00
92_S261_V0.6641.00
29_G33_F0.6621.00
282_V425_L0.6621.00
328_P331_A0.6621.00
100_A326_G0.6601.00
278_P418_L0.6591.00
44_G48_L0.6571.00
57_V212_V0.6561.00
259_V263_L0.6551.00
305_L386_F0.6541.00
283_L294_Y0.6521.00
377_R381_L0.6521.00
154_R213_V0.6511.00
235_L242_T0.6491.00
159_T223_N0.6481.00
315_S319_V0.6471.00
357_A361_A0.6471.00
285_L426_D0.6441.00
316_S397_R0.6431.00
261_V402_T0.6431.00
432_S436_W0.6421.00
89_G262_S0.6401.00
79_P160_V0.6381.00
36_A310_G0.6371.00
286_F290_V0.6361.00
210_L213_V0.6361.00
166_G227_G0.6351.00
66_V365_T0.6351.00
158_L162_F0.6331.00
311_Y342_A0.6331.00
418_L422_F0.6281.00
323_L328_P0.6281.00
49_L189_T0.6281.00
31_E330_E0.6281.00
290_V293_A0.6261.00
126_A129_W0.6251.00
365_T369_F0.6241.00
345_T349_I0.6231.00
145_I148_L0.6211.00
395_A399_A0.6211.00
108_F112_Q0.6201.00
49_L223_N0.6171.00
343_L384_A0.6171.00
159_T162_F0.6171.00
85_A266_A0.6161.00
211_G214_G0.6161.00
129_W158_L0.6131.00
170_S174_A0.6131.00
449_P452_T0.6121.00
263_L266_A0.6111.00
202_F210_L0.6101.00
192_T221_I0.6101.00
122_L126_A0.6091.00
121_S157_M0.6091.00
169_A231_F0.6081.00
293_A436_W0.6071.00
222_A225_V0.6051.00
431_I438_I0.6051.00
304_A349_I0.6041.00
287_S290_V0.6011.00
102_D108_F0.5991.00
85_A316_S0.5971.00
279_F435_P0.5951.00
279_F421_A0.5941.00
200_L215_A0.5941.00
57_V61_T0.5931.00
92_S320_G0.5931.00
65_A68_A0.5921.00
321_Q325_A0.5911.00
125_T130_V0.5901.00
65_A211_G0.5901.00
66_V296_I0.5891.00
81_G84_L0.5891.00
350_G384_A0.5871.00
121_S161_V0.5871.00
229_V233_V0.5871.00
91_I171_R0.5861.00
307_P345_T0.5851.00
417_R442_V0.5841.00
136_I150_A0.5831.00
339_L343_L0.5831.00
151_A155_V0.5831.00
48_L190_L0.5831.00
152_Y215_A0.5821.00
157_M161_V0.5811.00
210_L214_G0.5801.00
424_A427_P0.5801.00
227_G231_F0.5801.00
341_V344_A0.5791.00
86_L266_A0.5791.00
32_A36_A0.5791.00
67_A70_E0.5781.00
402_T406_L0.5761.00
253_G257_E0.5721.00
73_F77_F0.5721.00
408_G449_P0.5721.00
423_L426_D0.5701.00
57_V65_A0.5701.00
71_I149_G0.5701.00
275_G413_T0.5701.00
437_V441_T0.5691.00
289_Q292_A0.5681.00
352_L356_A0.5671.00
380_G384_A0.5661.00
187_L190_L0.5651.00
121_S125_T0.5651.00
55_F364_F0.5641.00
192_T195_A0.5641.00
188_I191_P0.5641.00
409_G412_G0.5631.00
61_T212_V0.5631.00
117_A121_S0.5621.00
28_R333_A0.5621.00
141_S146_I0.5621.00
146_I149_G0.5601.00
32_A341_V0.5591.00
420_L423_L0.5581.00
280_L284_G0.5581.00
343_L388_V0.5571.00
122_L125_T0.5561.00
94_V109_A0.5561.00
111_K115_W0.5541.00
193_N218_G0.5531.00
374_T377_R0.5521.00
50_R156_V0.5511.00
112_Q254_V0.5501.00
392_L450_V0.5491.00
308_A387_S0.5491.00
214_G218_G0.5491.00
417_R421_A0.5471.00
26_R29_G0.5461.00
129_W132_A0.5461.00
301_M379_F0.5441.00
69_L152_Y0.5441.00
27_R31_E0.5431.00
445_L449_P0.5431.00
127_G130_V0.5421.00
56_M218_G0.5421.00
162_F220_A0.5401.00
353_L360_I0.5401.00
194_I198_A0.5391.00
389_A446_S0.5391.00
145_I149_G0.5391.00
447_V451_T0.5381.00
161_V224_A0.5371.00
315_S391_T0.5371.00
302_L305_L0.5371.00
139_L277_F0.5361.00
318_L322_Q0.5361.00
396_L401_D0.5351.00
171_R174_A0.5351.00
336_W454_T0.5341.00
288_H292_A0.5321.00
271_S406_L0.5311.00
106_A110_I0.5291.00
64_T67_A0.5281.00
392_L447_V0.5281.00
239_W242_T0.5271.00
421_A435_P0.5271.00
94_V110_I0.5261.00
52_A55_F0.5261.00
28_R334_Y0.5240.99
125_T157_M0.5240.99
316_S394_G0.5230.99
118_L121_S0.5210.99
189_T222_A0.5210.99
128_T132_A0.5200.99
339_L392_L0.5200.99
150_A153_L0.5190.99
235_L238_R0.5190.99
352_L355_V0.5190.99
166_G170_S0.5190.99
392_L451_T0.5190.99
136_I141_S0.5180.99
135_M138_L0.5180.99
88_S313_T0.5180.99
245_F248_K0.5170.99
174_A179_T0.5170.99
296_I365_T0.5160.99
336_W339_L0.5160.99
367_E370_S0.5160.99
358_G377_R0.5160.99
63_S292_A0.5150.99
412_G449_P0.5140.99
33_F341_V0.5130.99
293_A297_G0.5130.99
386_F443_H0.5110.99
101_D325_A0.5080.99
297_G376_I0.5060.99
343_L346_Q0.5050.99
130_V133_D0.5040.99
28_R337_Q0.5030.99
440_A444_S0.5030.99
77_F273_T0.5030.99
85_A89_G0.5030.99
218_G222_A0.5030.99
419_P422_F0.5020.99
255_A259_V0.5020.99
335_G339_L0.5020.99
104_A246_S0.5000.99
61_T201_I0.5000.99
424_A438_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.8791 100 0.421 Contact Map
4humA 1 0.8869 100 0.429 Contact Map
4lz6A 1 0.8635 100 0.44 Contact Map
3w4tA 1 0.8577 100 0.476 Contact Map
4ikvA 1 0.8187 95.5 0.935 Contact Map
4j05A 3 0.7661 91.5 0.945 Contact Map
3wdoA 1 0.8402 89.9 0.947 Contact Map
4w6vA 1 0.7797 87.9 0.949 Contact Map
4xnjA 1 0.7856 86.2 0.95 Contact Map
1pw4A 1 0.7836 84.2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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