GREMLIN Database
Q9HMS1 - Uncharacterized protein
UniProt: Q9HMS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (138)
Sequences: 557 (408)
Seq/√Len: 34.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_G85_V4.1481.00
73_L118_G3.1791.00
94_A104_A3.0771.00
103_F107_G3.0171.00
34_G96_I2.9891.00
99_L155_V2.7911.00
87_F111_F2.7521.00
27_A31_V2.6571.00
42_F89_T2.6131.00
26_I139_T2.2580.99
38_F89_T2.2530.99
64_T67_A2.1430.99
45_L86_I2.0490.98
105_S146_G1.8230.97
19_G22_P1.8160.97
53_D81_G1.7950.96
95_L104_A1.7900.96
65_V70_G1.7900.96
81_G84_V1.7500.96
94_A97_V1.6960.95
54_P81_G1.6620.94
151_L155_V1.6390.94
76_Y80_I1.6340.94
103_F106_F1.6190.94
24_Y148_Y1.6150.94
108_G137_F1.6010.93
154_I157_R1.5920.93
45_L85_V1.5360.92
99_L151_L1.4930.91
144_G147_R1.4880.90
113_T131_F1.4690.90
153_S157_R1.4670.90
23_A148_Y1.4540.89
33_T132_M1.4160.88
69_V74_A1.4120.88
65_V74_A1.3770.87
36_W133_G1.3740.86
80_I131_F1.3710.86
91_I111_F1.3580.86
70_G117_I1.3520.85
64_T74_A1.3510.85
94_A103_F1.3190.84
24_Y28_V1.3080.84
82_P86_I1.2950.83
33_T95_L1.2580.81
65_V118_G1.2560.81
33_T131_F1.2380.80
105_S141_I1.2170.79
117_I133_G1.2110.78
45_L89_T1.1940.77
94_A107_G1.1610.75
112_M133_G1.1600.75
57_Y118_G1.1520.75
97_V101_T1.1460.74
116_W125_G1.1430.74
48_G51_T1.1210.73
20_T29_V1.1040.72
100_L155_V1.0930.71
69_V72_T1.0930.71
73_L76_Y1.0830.70
55_S59_Q1.0590.68
100_L130_D1.0500.68
69_V73_L1.0440.67
87_F110_M1.0410.67
27_A116_W1.0390.67
100_L103_F1.0360.67
87_F107_G1.0350.67
109_V138_T1.0320.66
33_T96_I1.0260.66
32_L135_L1.0220.66
32_L127_V1.0020.64
82_P85_V0.9930.63
78_G116_W0.9810.62
25_W154_I0.9620.61
39_H115_F0.9560.60
29_V135_L0.9530.60
113_T132_M0.9500.60
84_V115_F0.9460.60
42_F45_L0.9430.59
21_W24_Y0.9300.58
111_F131_F0.9280.58
39_H43_T0.9220.58
82_P90_L0.9220.58
29_V134_L0.9180.57
86_I89_T0.9180.57
148_Y152_D0.8890.55
23_A115_F0.8850.54
110_M132_M0.8830.54
109_V136_L0.8760.54
143_F156_E0.8750.54
100_L107_G0.8690.53
19_G24_Y0.8680.53
33_T112_M0.8660.53
18_A143_F0.8560.52
52_F55_S0.8530.52
94_A99_L0.8420.51
131_F134_L0.8410.51
76_Y79_I0.8260.49
147_R156_E0.8260.49
35_W39_H0.8130.48
68_P72_T0.8120.48
99_L110_M0.8080.48
70_G118_G0.8030.47
68_P131_F0.8000.47
146_G150_G0.8000.47
57_Y73_L0.7990.47
70_G73_L0.7980.47
73_L142_V0.7960.47
26_I143_F0.7850.46
62_A70_G0.7760.45
126_V131_F0.7680.44
67_A70_G0.7670.44
34_G131_F0.7650.44
84_V88_E0.7560.43
141_I145_A0.7510.43
113_T117_I0.7500.43
35_W72_T0.7390.42
25_W139_T0.7310.41
125_G132_M0.7310.41
32_L134_L0.7270.41
91_I115_F0.7240.41
75_G78_G0.7200.40
22_P143_F0.7180.40
42_F46_L0.7110.40
27_A146_G0.7080.39
111_F148_Y0.7050.39
87_F94_A0.7020.39
102_R156_E0.6970.39
91_I118_G0.6960.39
60_G65_V0.6940.38
43_T47_E0.6930.38
137_F140_I0.6920.38
36_W42_F0.6850.38
109_V135_L0.6840.38
136_L140_I0.6820.37
158_T161_V0.6740.37
22_P144_G0.6730.37
48_G52_F0.6710.37
127_V131_F0.6690.36
75_G151_L0.6690.36
55_S60_G0.6680.36
53_D85_V0.6590.36
41_G89_T0.6530.35
100_L152_D0.6400.34
130_D134_L0.6380.34
25_W28_V0.6340.34
17_A132_M0.6330.34
48_G117_I0.6290.33
39_H48_G0.6290.33
22_P26_I0.6260.33
61_M77_P0.6180.32
113_T129_S0.6130.32
123_A129_S0.6120.32
100_L106_F0.6070.32
64_T68_P0.6060.32
43_T46_L0.6060.32
88_E111_F0.5970.31
117_I130_D0.5950.31
21_W136_L0.5950.31
109_V139_T0.5950.31
62_A71_T0.5930.31
35_W127_V0.5890.30
87_F135_L0.5850.30
28_V153_S0.5840.30
20_T144_G0.5820.30
61_M118_G0.5800.30
75_G114_M0.5790.30
89_T93_L0.5740.29
105_S133_G0.5720.29
57_Y61_M0.5660.29
143_F158_T0.5650.29
60_G63_G0.5610.28
25_W29_V0.5600.28
85_V89_T0.5580.28
88_E115_F0.5570.28
21_W138_T0.5570.28
47_E51_T0.5550.28
93_L160_L0.5510.28
89_T158_T0.5510.28
101_T104_A0.5500.28
80_I94_A0.5500.28
31_V36_W0.5480.27
54_P75_G0.5440.27
71_T77_P0.5430.27
147_R152_D0.5430.27
18_A38_F0.5380.27
41_G90_L0.5360.27
75_G116_W0.5350.27
20_T75_G0.5310.26
47_E110_M0.5290.26
94_A100_L0.5280.26
54_P58_L0.5280.26
106_F138_T0.5250.26
42_F128_N0.5250.26
71_T123_A0.5220.26
27_A154_I0.5220.26
132_M160_L0.5210.26
29_V35_W0.5190.25
57_Y91_I0.5160.25
32_L36_W0.5150.25
31_V87_F0.5150.25
96_I160_L0.5050.25
39_H78_G0.5050.25
67_A71_T0.5030.24
41_G115_F0.5030.24
33_T133_G0.5020.24
29_V162_Q0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ao6B 1 0 3.1 0.964 Contact Map
3dctB 1 0.0581 2.6 0.965 Contact Map
3wu2D 1 0.7326 1.7 0.968 Contact Map
4wgvA 2 0.314 1.7 0.969 Contact Map
4pj0K 1 0.186 1.1 0.972 Contact Map
3mklA 1 0.1802 1.1 0.972 Contact Map
3aquA 1 0.343 1 0.973 Contact Map
4s06A 1 0.3779 1 0.973 Contact Map
2jy5A 1 0.1163 1 0.973 Contact Map
1onwA 5 0.3314 1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.