GREMLIN Database
Q9HMR8 - Signal sequence peptidase
UniProt: Q9HMR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (198)
Sequences: 124 (98)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_V44_V4.0690.96
19_W23_T3.0000.83
72_K211_W2.7460.77
39_L199_R2.4660.69
33_D118_Y2.2820.63
148_D189_L2.2190.60
168_A192_P2.1770.59
148_D151_I2.1690.58
61_V76_V2.1220.57
105_G138_D2.1010.56
77_F170_F2.0210.53
146_R206_V1.9690.51
144_Y192_P1.9660.51
151_I160_L1.9470.50
129_I171_I1.9460.50
87_E92_G1.8790.47
67_Q110_G1.8350.46
52_S77_F1.8330.46
118_Y189_L1.8290.45
101_A208_F1.7910.44
150_S199_R1.7750.43
116_I121_D1.7060.41
60_A213_R1.6810.40
61_V218_G1.6780.40
157_C164_P1.6750.40
28_V108_K1.6740.40
70_L206_V1.6610.39
124_S198_V1.6470.39
35_L187_A1.6460.39
37_S45_G1.6400.38
43_M50_S1.6390.38
92_G95_V1.6150.38
122_G197_W1.5800.36
19_W28_V1.5770.36
44_V198_V1.5740.36
45_G50_S1.5720.36
68_P213_R1.5590.36
33_D201_T1.5570.35
20_F70_L1.5490.35
21_W61_V1.5470.35
123_N127_V1.5460.35
143_W164_P1.5370.35
95_V170_F1.5330.35
145_D198_V1.5250.34
114_D201_T1.5200.34
79_T201_T1.4780.33
117_V205_R1.4710.32
44_V76_V1.4560.32
143_W163_C1.4550.32
23_T28_V1.4490.32
40_V43_M1.4090.30
57_P213_R1.4080.30
34_A92_G1.4010.30
38_L70_L1.3850.30
144_Y162_N1.3730.29
68_P83_R1.3680.29
93_T170_F1.3670.29
147_A164_P1.3560.29
187_A194_K1.3360.28
44_V204_Y1.3280.28
79_T127_V1.3250.28
144_Y154_A1.3180.28
144_Y168_A1.3060.27
135_F143_W1.3030.27
23_T81_E1.3000.27
162_N168_A1.2950.27
88_Y91_G1.2830.27
106_Y176_N1.2820.26
30_F129_I1.2810.26
98_H112_T1.2800.26
68_P165_A1.2710.26
77_F200_G1.2680.26
122_G200_G1.2660.26
41_V137_V1.2640.26
43_M139_N1.2420.25
147_A157_C1.2400.25
121_D127_V1.2390.25
133_A192_P1.2360.25
24_D161_R1.2310.25
79_T203_E1.2240.25
89_A140_E1.2180.25
114_D127_V1.2150.25
29_L129_I1.2060.24
82_H85_S1.2060.24
171_I192_P1.1980.24
34_A91_G1.1970.24
161_R188_G1.1890.24
114_D121_D1.1820.24
51_V195_P1.1780.23
101_A159_E1.1760.23
130_I214_L1.1700.23
158_S161_R1.1610.23
58_L121_D1.1610.23
97_P102_T1.1540.23
71_Q212_V1.1480.23
77_F116_I1.1480.23
40_V204_Y1.1430.23
83_R197_W1.1430.23
121_D203_E1.1310.22
31_V124_S1.1030.21
76_V196_G1.0970.21
36_S58_L1.0950.21
143_W183_Y1.0840.21
59_V200_G1.0840.21
99_R104_H1.0810.21
51_V109_I1.0720.21
108_K152_V1.0710.21
86_P114_D1.0600.20
142_N183_Y1.0580.20
165_A183_Y1.0470.20
157_C163_C1.0440.20
38_L103_A1.0350.20
43_M95_V1.0330.20
154_A160_L1.0230.19
79_T119_E1.0180.19
49_F52_S1.0130.19
20_F212_V1.0020.19
134_R192_P0.9860.19
144_Y159_E0.9780.18
20_F91_G0.9780.18
108_K114_D0.9750.18
157_C165_A0.9730.18
69_N110_G0.9580.18
143_W157_C0.9410.18
82_H108_K0.9400.18
19_W81_E0.9400.18
30_F134_R0.9290.17
22_S152_V0.9130.17
38_L52_S0.9130.17
88_Y104_H0.9080.17
190_S201_T0.9080.17
50_S195_P0.9050.17
49_F59_V0.9040.17
35_L38_L0.9010.17
52_S136_W0.8920.17
48_L130_I0.8810.16
108_K170_F0.8700.16
111_G187_A0.8660.16
77_F133_A0.8630.16
88_Y198_V0.8630.16
64_G67_Q0.8610.16
29_L39_L0.8610.16
27_D116_I0.8590.16
61_V129_I0.8580.16
33_D114_D0.8570.16
127_V208_F0.8560.16
159_E162_N0.8550.16
26_A86_P0.8520.16
83_R165_A0.8520.16
110_G194_K0.8420.16
51_V70_L0.8400.15
85_S118_Y0.8340.15
176_N198_V0.8300.15
58_L198_V0.8270.15
23_T108_K0.8250.15
122_G127_V0.8220.15
35_L46_L0.8200.15
118_Y192_P0.8170.15
123_N171_I0.8140.15
23_T199_R0.8040.15
20_F35_L0.7990.15
61_V110_G0.7990.15
43_M76_V0.7900.14
42_S196_G0.7900.14
139_N198_V0.7890.14
163_C213_R0.7880.14
60_A68_P0.7860.14
127_V215_V0.7840.14
78_V199_R0.7770.14
37_S200_G0.7700.14
61_V64_G0.7700.14
170_F200_G0.7700.14
111_G121_D0.7660.14
62_E78_V0.7630.14
100_T170_F0.7600.14
150_S182_Y0.7560.14
95_V105_G0.7520.14
78_V149_E0.7370.14
20_F71_Q0.7350.13
26_A208_F0.7340.13
30_F33_D0.7340.13
81_E86_P0.7280.13
181_N194_K0.7240.13
26_A148_D0.7220.13
68_P137_V0.7180.13
81_E114_D0.7170.13
71_Q181_N0.7150.13
35_L70_L0.7140.13
69_N168_A0.7130.13
93_T173_K0.7130.13
46_L98_H0.7120.13
70_L200_G0.7090.13
42_S148_D0.7080.13
64_G116_I0.6990.13
27_D126_A0.6980.13
61_V199_R0.6980.13
42_S153_A0.6980.13
90_S148_D0.6970.13
69_N205_R0.6930.13
106_Y128_P0.6870.13
89_A100_T0.6870.13
134_R199_R0.6820.13
36_S78_V0.6800.13
24_D176_N0.6790.13
60_A77_F0.6770.12
74_D184_D0.6760.12
60_A209_A0.6740.12
70_L109_I0.6730.12
94_G143_W0.6690.12
29_L176_N0.6670.12
98_H156_S0.6620.12
164_P213_R0.6580.12
21_W110_G0.6570.12
47_L141_E0.6570.12
69_N198_V0.6540.12
78_V189_L0.6500.12
104_H138_D0.6470.12
134_R173_K0.6470.12
54_V206_V0.6450.12
28_V198_V0.6430.12
78_V206_V0.6420.12
211_W216_I0.6420.12
114_D126_A0.6370.12
92_G212_V0.6350.12
69_N189_L0.6350.12
29_L106_Y0.6340.12
88_Y111_G0.6330.12
27_D105_G0.6320.12
114_D203_E0.6320.12
29_L80_E0.6320.12
72_K134_R0.6280.12
182_Y187_A0.6190.12
192_P217_S0.6170.11
86_P217_S0.6160.11
201_T218_G0.6150.11
85_S99_R0.6120.11
31_V187_A0.6090.11
138_D176_N0.6080.11
45_G49_F0.6070.11
60_A205_R0.6040.11
202_A214_L0.6040.11
89_A92_G0.6020.11
54_V183_Y0.6020.11
83_R128_P0.6000.11
47_L212_V0.5980.11
23_T112_T0.5980.11
147_A163_C0.5980.11
141_E166_P0.5930.11
135_F163_C0.5920.11
56_P177_N0.5920.11
76_V85_S0.5860.11
39_L201_T0.5840.11
90_S118_Y0.5820.11
68_P205_R0.5790.11
91_G190_S0.5770.11
36_S86_P0.5770.11
49_F165_A0.5720.11
27_D81_E0.5670.11
118_Y190_S0.5670.11
21_W38_L0.5580.11
93_T133_A0.5560.11
151_I194_K0.5560.11
118_Y156_S0.5530.11
31_V215_V0.5510.11
48_L55_W0.5500.10
64_G80_E0.5440.10
121_D171_I0.5420.10
137_V147_A0.5380.10
116_I176_N0.5370.10
47_L155_D0.5370.10
151_I156_S0.5360.10
30_F67_Q0.5350.10
189_L192_P0.5340.10
58_L192_P0.5330.10
110_G201_T0.5330.10
75_L81_E0.5310.10
94_G163_C0.5310.10
151_I181_N0.5290.10
110_G139_N0.5290.10
26_A70_L0.5260.10
86_P156_S0.5260.10
154_A192_P0.5230.10
88_Y161_R0.5190.10
143_W147_A0.5190.10
55_W64_G0.5180.10
93_T206_V0.5180.10
33_D218_G0.5150.10
143_W165_A0.5150.10
159_E176_N0.5140.10
51_V78_V0.5130.10
156_S160_L0.5100.10
92_G206_V0.5100.10
23_T201_T0.5070.10
37_S109_I0.5060.10
55_W60_A0.5020.10
83_R137_V0.5000.10
144_Y160_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n31A 5 0.5356 99.3 0.86 Contact Map
4nv4A 2 0.3808 99.3 0.861 Contact Map
4me8A 1 0.3766 99.2 0.867 Contact Map
4k8wA 2 0.431 99.2 0.868 Contact Map
1b12A 1 0.636 98.2 0.905 Contact Map
1umuA 2 0.4184 35.4 0.966 Contact Map
2hnfA 1 0.5188 24.8 0.968 Contact Map
1kcaA 6 0.3389 24 0.968 Contact Map
3k2zA 2 0.5314 11.9 0.972 Contact Map
1jhfA 2 0.5272 6.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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