GREMLIN Database
Q9HMR3 - O-acetyl homoserine
UniProt: Q9HMR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (420)
Sequences: 3165 (1426)
Seq/√Len: 69.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_R325_D3.8651.00
141_A175_D3.7831.00
65_E69_D3.6171.00
103_S145_D3.4671.00
8_H412_D3.4371.00
193_T196_D3.4321.00
45_G50_E3.1291.00
317_W347_G3.1231.00
103_S130_T2.9281.00
41_A45_G2.9251.00
303_Q307_E2.8531.00
195_I224_A2.8241.00
365_A376_T2.7441.00
186_F371_V2.7001.00
174_H200_D2.6181.00
210_I288_L2.5081.00
347_G402_E2.4501.00
221_L264_A2.4381.00
329_H333_T2.4341.00
305_V416_I2.4221.00
421_E425_E2.4131.00
10_N73_A2.4101.00
308_H421_E2.3811.00
141_A176_N2.3731.00
167_E171_D2.3251.00
307_E324_A2.2591.00
216_T280_D2.2391.00
102_D149_A2.1891.00
45_G51_R2.1821.00
71_L220_A2.1791.00
64_V281_A2.1461.00
130_T145_D2.1391.00
79_G261_T2.0961.00
54_Y60_M2.0751.00
394_Q401_P2.0611.00
144_I151_V2.0431.00
71_L222_V2.0371.00
14_A73_A1.9841.00
167_E334_T1.9831.00
276_Q281_A1.9781.00
296_Q300_R1.9631.00
92_L274_N1.9411.00
231_A234_A1.9381.00
167_E335_Y1.9251.00
413_P417_V1.9201.00
317_W402_E1.9151.00
136_D139_A1.9141.00
228_D231_A1.8961.00
67_L220_A1.8931.00
11_S292_P1.8871.00
150_Y181_L1.8861.00
6_G412_D1.8801.00
153_V164_P1.8571.00
316_S349_E1.8551.00
23_G38_E1.8441.00
365_A420_L1.8431.00
94_T150_Y1.8271.00
81_V264_A1.8191.00
57_S64_V1.8131.00
316_S402_E1.8001.00
167_E197_H1.7931.00
132_V143_A1.7901.00
81_V261_T1.7901.00
137_Y168_R1.7801.00
7_L190_A1.7461.00
25_R366_S1.7441.00
209_W342_G1.7191.00
10_N14_A1.7161.00
171_D175_D1.7131.00
391_P401_P1.6841.00
138_D141_A1.6771.00
358_V378_V1.6721.00
200_D226_S1.6670.99
362_T378_V1.6640.99
406_V420_L1.6620.99
42_D51_R1.6550.99
128_D145_D1.6530.99
390_T393_A1.6510.99
83_T92_L1.6370.99
64_V276_Q1.6360.99
230_D252_T1.6010.99
93_A260_F1.6010.99
32_T35_Y1.5970.99
279_F283_Q1.5950.99
179_P236_Y1.5880.99
38_E42_D1.5840.99
345_T403_M1.5830.99
135_L328_T1.5800.99
380_H383_S1.5680.99
348_V358_V1.5600.99
153_V169_I1.5600.99
75_E204_H1.5430.99
67_L284_T1.5400.99
153_V166_L1.5380.99
137_Y172_I1.5110.99
164_P169_I1.5050.99
42_D46_Q1.5000.99
305_V417_V1.4940.99
206_T284_T1.4900.99
234_A241_Q1.4800.99
41_A356_Q1.4730.99
374_A410_I1.4700.99
234_A240_A1.4500.99
27_P285_L1.4470.99
351_G354_A1.4450.99
151_V178_V1.4440.99
96_L264_A1.4330.98
263_A267_R1.4310.98
140_Y151_V1.4170.98
161_L321_P1.4120.98
195_I202_V1.4100.98
206_T220_A1.4040.98
67_L206_T1.3990.98
277_S280_D1.3870.98
91_D95_F1.3850.98
103_S128_D1.3810.98
191_L299_C1.3730.98
94_T118_L1.3580.98
181_L203_W1.3560.98
300_R304_L1.3480.98
68_Q265_I1.3470.98
153_V182_V1.3420.98
352_Y356_Q1.3420.98
170_A180_L1.3370.98
357_S361_E1.3330.97
305_V406_V1.3320.97
302_A306_A1.3320.97
67_L82_A1.3260.97
138_D142_D1.3170.97
258_A262_Y1.3050.97
369_A379_I1.3030.97
305_V420_L1.2970.97
103_S147_D1.2970.97
165_D168_R1.2960.97
256_G259_A1.2930.97
319_N326_H1.2920.97
365_A378_V1.2880.97
40_S360_E1.2850.97
6_G418_A1.2720.97
206_T276_Q1.2640.97
391_P395_R1.2610.96
29_L282_W1.2520.96
304_L307_E1.2490.96
93_A181_L1.2460.96
64_V82_A1.2440.96
97_L181_L1.2440.96
92_L268_G1.2360.96
81_V221_L1.2240.96
12_V410_I1.2190.96
25_R36_A1.2170.96
314_N424_I1.2110.96
106_A118_L1.2100.96
166_L192_A1.2100.96
144_I176_N1.2050.95
31_Q216_T1.2040.95
137_Y140_Y1.2010.95
109_D162_I1.1970.95
166_L180_L1.1930.95
19_D22_T1.1900.95
304_L417_V1.1750.95
161_L344_L1.1740.95
169_I180_L1.1700.95
365_A416_I1.1690.95
7_L292_P1.1600.94
326_H329_H1.1590.94
17_R69_D1.1550.94
95_F125_R1.1540.94
6_G414_A1.1510.94
84_A274_N1.1480.94
180_L199_A1.1470.94
99_R124_R1.1430.94
239_I252_T1.1310.94
337_D340_Y1.1290.94
353_E356_Q1.1270.93
144_I178_V1.1250.93
238_E263_A1.1250.93
243_N267_R1.1220.93
130_T143_A1.1180.93
330_D333_T1.1110.93
153_V180_L1.1100.93
250_T253_D1.1100.93
98_A104_V1.1070.93
87_M90_L1.1070.93
135_L162_I1.1050.93
305_V413_P1.1050.93
184_N187_A1.0960.93
308_H312_H1.0930.92
8_H292_P1.0930.92
52_D262_Y1.0880.92
223_D261_T1.0880.92
99_R238_E1.0800.92
157_G162_I1.0790.92
301_N410_I1.0720.92
52_D258_A1.0610.91
364_L416_I1.0540.91
197_H335_Y1.0530.91
333_T340_Y1.0520.91
155_T184_N1.0450.91
96_L260_F1.0440.91
168_R172_I1.0410.90
91_D272_L1.0380.90
303_Q322_G1.0300.90
391_P394_Q1.0290.90
34_S217_V1.0280.90
96_L268_G1.0250.90
71_L210_I1.0230.90
93_A97_L1.0230.90
96_L263_A1.0200.90
156_V187_A1.0200.90
7_L193_T1.0170.89
363_T422_T1.0050.89
240_A250_T1.0030.89
206_T218_G1.0010.89
57_S276_Q0.9970.88
200_D224_A0.9950.88
83_T221_L0.9930.88
226_S257_D0.9920.88
197_H334_T0.9890.88
36_A366_S0.9890.88
216_T284_T0.9880.88
304_L413_P0.9850.88
118_L129_T0.9820.88
348_V424_I0.9800.88
72_A80_A0.9800.88
324_A329_H0.9770.87
78_V223_D0.9770.87
78_V258_A0.9740.87
241_Q250_T0.9720.87
365_A406_V0.9670.87
84_A275_Q0.9660.87
27_P66_T0.9650.87
378_V404_V0.9590.86
105_V143_A0.9580.86
24_A30_Y0.9560.86
78_V261_T0.9520.86
310_R326_H0.9460.86
124_R267_R0.9430.85
376_T416_I0.9430.85
90_L117_Y0.9420.85
71_L206_T0.9410.85
123_Q128_D0.9370.85
39_D360_E0.9350.85
314_N348_V0.9340.85
419_D422_T0.9330.85
170_A174_H0.9270.85
363_T426_A0.9250.84
31_Q279_F0.9230.84
134_V139_A0.9220.84
103_S146_A0.9220.84
347_G400_R0.9200.84
77_G222_V0.9180.84
190_A296_Q0.9180.84
106_A110_L0.9130.84
316_S348_V0.9120.84
98_A127_V0.9120.84
83_T269_L0.9110.83
151_V174_H0.9070.83
94_T122_A0.9060.83
282_W286_Q0.9020.83
230_D253_D0.8970.83
211_H284_T0.8960.82
251_F266_A0.8950.82
57_S280_D0.8940.82
361_E426_A0.8930.82
82_A220_A0.8910.82
124_R238_E0.8910.82
215_T374_A0.8900.82
132_V139_A0.8880.82
189_P204_H0.8880.82
60_M65_E0.8870.82
98_A150_Y0.8850.82
67_L288_L0.8850.82
312_H421_E0.8840.82
46_Q53_G0.8810.81
365_A408_V0.8760.81
140_Y169_I0.8730.81
94_T98_A0.8720.81
104_V118_L0.8700.81
382_A394_Q0.8700.81
332_A340_Y0.8690.80
329_H340_Y0.8660.80
107_A134_V0.8660.80
358_V420_L0.8650.80
276_Q284_T0.8650.80
67_L210_I0.8640.80
59_L266_A0.8620.80
182_V199_A0.8610.80
104_V129_T0.8600.80
306_A323_L0.8600.80
106_A129_T0.8550.79
358_V362_T0.8550.79
192_A197_H0.8550.79
305_V408_V0.8550.79
105_V151_V0.8530.79
80_A222_V0.8520.79
186_F343_M0.8460.79
314_N425_E0.8380.78
343_M371_V0.8380.78
94_T181_L0.8360.78
116_T245_A0.8360.78
304_L414_A0.8350.78
243_N251_F0.8350.78
26_A375_K0.8300.77
48_A387_Q0.8290.77
168_R171_D0.8290.77
192_A336_L0.8270.77
309_L346_F0.8260.77
250_T254_R0.8220.77
299_C303_Q0.8210.77
316_S347_G0.8210.77
7_L11_S0.8200.76
92_L272_L0.8180.76
210_I284_T0.8180.76
90_L203_W0.8180.76
306_A322_G0.8170.76
215_T286_Q0.8170.76
322_G340_Y0.8130.76
423_A426_A0.8120.76
299_C302_A0.8110.76
246_Y388_Q0.8090.76
163_T336_L0.8070.75
134_V140_Y0.8040.75
187_A192_A0.8020.75
76_G196_D0.8000.75
395_R400_R0.8000.75
270_R388_Q0.7970.74
177_G228_D0.7950.74
261_T264_A0.7930.74
151_V169_I0.7920.74
130_T147_D0.7920.74
413_P416_I0.7910.74
102_D147_D0.7890.74
46_Q54_Y0.7870.73
308_H417_V0.7870.73
97_L239_I0.7860.73
218_G284_T0.7860.73
57_S216_T0.7860.73
209_W344_L0.7850.73
298_H342_G0.7850.73
418_A421_E0.7820.73
90_L152_L0.7790.73
314_N426_A0.7790.73
360_E367_L0.7760.72
91_D117_Y0.7710.72
16_Q20_P0.7700.72
119_T131_F0.7680.72
78_V224_A0.7670.72
299_C342_G0.7660.71
297_Q300_R0.7610.71
303_Q310_R0.7590.71
329_H332_A0.7580.71
216_T277_S0.7550.70
34_S368_L0.7510.70
139_A142_D0.7500.70
308_H424_I0.7480.70
67_L71_L0.7440.69
168_R331_N0.7320.68
141_A172_I0.7320.68
190_A338_S0.7290.68
352_Y394_Q0.7290.68
204_H220_A0.7260.67
164_P331_N0.7210.67
322_G329_H0.7170.66
71_L288_L0.7170.66
171_D174_H0.7150.66
239_I250_T0.7150.66
376_T420_L0.7140.66
255_F262_Y0.7140.66
376_T408_V0.7140.66
38_E51_R0.7120.66
290_T293_L0.7120.66
166_L170_A0.7100.66
151_V172_I0.7090.66
356_Q383_S0.7080.65
359_T367_L0.7080.65
170_A199_A0.7080.65
188_T191_L0.7030.65
46_Q51_R0.7030.65
307_E310_R0.7020.65
186_F209_W0.7000.65
8_H414_A0.6980.64
164_P182_V0.6970.64
119_T123_Q0.6970.64
353_E357_S0.6960.64
88_A274_N0.6960.64
308_H311_D0.6950.64
392_E396_A0.6950.64
155_T166_L0.6910.64
52_D257_D0.6890.63
130_T146_A0.6860.63
344_L406_V0.6850.63
117_Y121_S0.6850.63
169_I172_I0.6840.63
40_S359_T0.6810.62
258_A261_T0.6800.62
356_Q360_E0.6760.62
395_R401_P0.6750.62
34_S370_N0.6740.62
320_Y342_G0.6720.61
16_Q25_R0.6690.61
96_L201_I0.6690.61
331_N335_Y0.6680.61
293_L410_I0.6670.61
292_P296_Q0.6660.61
178_V235_D0.6660.61
78_V257_D0.6660.61
124_R263_A0.6660.61
147_D235_D0.6630.60
24_A32_T0.6630.60
422_T426_A0.6630.60
16_Q27_P0.6620.60
71_L82_A0.6600.60
310_R323_L0.6590.60
66_T285_L0.6580.60
85_S217_V0.6560.60
59_L217_V0.6560.60
351_G402_E0.6560.60
319_N345_T0.6540.59
295_M372_G0.6530.59
144_I172_I0.6520.59
174_H226_S0.6470.58
151_V173_A0.6440.58
215_T283_Q0.6440.58
177_G231_A0.6440.58
26_A215_T0.6440.58
97_L201_I0.6430.58
72_A222_V0.6430.58
276_Q280_D0.6420.58
9_T364_L0.6420.58
37_F43_A0.6410.58
139_A169_I0.6410.58
18_V36_A0.6410.58
323_L329_H0.6400.58
414_A417_V0.6390.58
64_V81_V0.6390.58
299_C337_D0.6390.58
421_E424_I0.6380.57
179_P229_W0.6360.57
361_E423_A0.6360.57
341_G369_A0.6360.57
46_Q60_M0.6350.57
135_L139_A0.6330.57
98_A149_A0.6320.57
55_I59_L0.6300.56
133_D139_A0.6300.56
16_Q375_K0.6280.56
16_Q36_A0.6280.56
350_D354_A0.6270.56
393_A396_A0.6260.56
331_N334_T0.6260.56
352_Y401_P0.6240.56
57_S275_Q0.6230.56
49_L246_Y0.6230.56
8_H296_Q0.6230.56
378_V406_V0.6230.56
307_E311_D0.6210.55
209_W371_V0.6200.55
229_W239_I0.6190.55
49_L388_Q0.6180.55
224_A261_T0.6180.55
217_V284_T0.6160.55
123_Q129_T0.6160.55
116_T120_H0.6160.55
306_A318_V0.6160.55
304_L308_H0.6140.55
224_A229_W0.6130.54
23_G36_A0.6120.54
378_V420_L0.6120.54
166_L199_A0.6120.54
243_N263_A0.6120.54
173_A200_D0.6110.54
295_M299_C0.6110.54
325_D329_H0.6100.54
57_S278_P0.6090.54
206_T211_H0.6070.54
299_C340_Y0.6070.54
79_G258_A0.6070.54
305_V308_H0.6050.53
99_R102_D0.6040.53
80_A220_A0.6040.53
379_I384_T0.6010.53
166_L197_H0.6010.53
31_Q280_D0.6000.53
195_I223_D0.5990.53
394_Q399_V0.5990.53
218_G276_Q0.5980.53
316_S350_D0.5980.53
103_S143_A0.5980.53
97_L263_A0.5970.52
93_A203_W0.5940.52
111_Y386_H0.5930.52
387_Q394_Q0.5930.52
16_Q66_T0.5930.52
54_Y65_E0.5930.52
104_V150_Y0.5920.52
45_G48_A0.5910.52
223_D227_F0.5890.52
204_H222_V0.5880.51
354_A402_E0.5880.51
67_L285_L0.5860.51
105_V132_V0.5850.51
141_A144_I0.5840.51
118_L127_V0.5830.51
119_T393_A0.5830.51
209_W343_M0.5820.51
13_H375_K0.5820.51
109_D134_V0.5820.51
306_A344_L0.5820.51
194_P202_V0.5810.51
216_T279_F0.5780.50
296_Q412_D0.5770.50
315_V346_F0.5770.50
225_G229_W0.5770.50
322_G332_A0.5770.50
346_F406_V0.5770.50
207_T370_N0.5770.50
128_D147_D0.5760.50
293_L296_Q0.5750.50
25_R33_T0.5740.50
362_T365_A0.5730.50
161_L345_T0.5720.49
209_W341_G0.5700.49
330_D334_T0.5700.49
11_S299_C0.5700.49
368_L375_K0.5700.49
390_T394_Q0.5700.49
299_C320_Y0.5690.49
55_I60_M0.5670.49
82_A276_Q0.5660.49
346_F404_V0.5660.49
33_T217_V0.5650.49
37_F42_D0.5630.48
303_Q324_A0.5620.48
302_A322_G0.5620.48
262_Y266_A0.5600.48
211_H216_T0.5600.48
92_L264_A0.5600.48
8_H297_Q0.5600.48
43_A369_A0.5580.48
195_I226_S0.5580.48
170_A197_H0.5580.48
83_T276_Q0.5570.48
184_N204_H0.5570.48
6_G10_N0.5550.47
92_L271_D0.5530.47
16_Q19_D0.5530.47
236_Y239_I0.5500.47
352_Y383_S0.5490.47
66_T69_D0.5490.47
109_D160_S0.5490.47
13_H19_D0.5490.47
376_T406_V0.5490.47
35_Y55_I0.5490.47
87_M117_Y0.5480.47
16_Q285_L0.5480.47
81_V269_L0.5480.47
107_A162_I0.5470.46
11_S190_A0.5460.46
88_A275_Q0.5450.46
90_L93_A0.5450.46
26_A282_W0.5440.46
328_T331_N0.5430.46
46_Q55_I0.5430.46
167_E196_D0.5400.46
41_A51_R0.5400.46
121_S272_L0.5400.46
206_T210_I0.5400.46
239_I259_A0.5390.45
268_G271_D0.5390.45
414_A418_A0.5380.45
59_L275_Q0.5370.45
239_I260_F0.5370.45
226_S311_D0.5340.45
163_T328_T0.5320.45
344_L403_M0.5320.45
88_A92_L0.5320.45
107_A164_P0.5300.44
133_D136_D0.5300.44
150_Y178_V0.5300.44
188_T295_M0.5290.44
246_Y270_R0.5280.44
155_T192_A0.5270.44
170_A200_D0.5260.44
254_R262_Y0.5260.44
156_V340_Y0.5250.44
310_R324_A0.5250.44
229_W259_A0.5250.44
27_P67_L0.5250.44
223_D226_S0.5230.44
336_L340_Y0.5230.44
118_L152_L0.5220.43
166_L174_H0.5220.43
25_R368_L0.5210.43
115_V119_T0.5210.43
142_D146_A0.5200.43
352_Y391_P0.5190.43
156_V336_L0.5170.43
49_L266_A0.5170.43
252_T259_A0.5160.43
135_L327_D0.5160.43
370_N379_I0.5160.43
210_I218_G0.5160.43
81_V265_I0.5160.43
116_T271_D0.5140.43
189_P295_M0.5140.43
107_A140_Y0.5130.42
177_G235_D0.5130.42
39_D42_D0.5120.42
362_T424_I0.5110.42
207_T217_V0.5110.42
135_L326_H0.5100.42
78_V262_Y0.5100.42
249_V255_F0.5100.42
5_H10_N0.5100.42
410_I416_I0.5100.42
217_V275_Q0.5090.42
370_N377_L0.5080.42
397_G400_R0.5080.42
72_A79_G0.5070.42
166_L335_Y0.5070.42
34_S211_H0.5060.42
107_A397_G0.5050.41
141_A171_D0.5050.41
179_P227_F0.5040.41
358_V404_V0.5030.41
57_S281_A0.5020.41
88_A91_D0.5020.41
157_G345_T0.5010.41
163_T192_A0.5010.41
151_V176_N0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kamA 4 0.9026 100 0.535 Contact Map
3ri6A 4 0.8167 100 0.538 Contact Map
1ibjA 4 0.8817 100 0.54 Contact Map
1qgnA 4 0.9072 100 0.548 Contact Map
3cogA 4 0.9002 100 0.574 Contact Map
4oc9A 5 0.9745 100 0.58 Contact Map
4iy7A 4 0.884 100 0.58 Contact Map
1e5eA 4 0.9095 100 0.593 Contact Map
4itxA 4 0.8979 100 0.596 Contact Map
2ctzA 4 0.9722 100 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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