Q9HMR1 - HALSA - GREMLIN Contacts

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Q9HMR1 - Phosphoserine phosphatase

UniProt:	Q9HMR1	Sequences: MLCWSAPKYCRMWGVYAGRRATPGMTLVAFDFDGTLAESEMLDRIAARAGVGDEVAAITERAMRGELSYADSLRERAQLVAGLPESAAAAVYDGVRLRDGAGDLVAKLRDGGVRVVVLTGGFKPGVAAAFDAAGVAADGVVGNRLVAADGELTGAVEGPLVEGTKDDALRDACEAAGTTPAAAVAVGDGANDVPMLDAAGTAIGVDPKPGVDAHCDHTVSSMDALGRVLDDHGIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	235 (193)
Sequences:	4377 (2751)
Seq/√Len:	198.0

ECOLI - SERB PGPC
HALSA - Q9HMR1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_V	155_A	3.615	1.00
123_K	144_R	3.018	1.00
170_R	198_A	2.634	1.00
26_T	113_V	2.278	1.00
123_K	127_A	2.268	1.00
108_L	113_V	2.222	1.00
109_R	138_D	2.172	1.00
171_D	175_A	2.118	1.00
114_R	139_G	2.089	1.00
57_A	61_R	2.070	1.00
85_E	147_A	2.047	1.00
84_P	151_E	2.012	1.00
164_T	167_D	1.998	1.00
193_V	214_H	1.990	1.00
107_K	111_G	1.947	1.00
61_R	66_E	1.944	1.00
47_A	52_G	1.940	1.00
60_E	64_R	1.937	1.00
146_V	157_E	1.897	1.00
106_A	110_D	1.866	1.00
116_V	172_A	1.863	1.00
173_C	180_P	1.856	1.00
109_R	115_V	1.855	1.00
61_R	75_E	1.851	1.00
102_G	134_G	1.849	1.00
196_L	202_A	1.836	1.00
32_F	117_V	1.809	1.00
119_T	126_V	1.798	1.00
74_R	155_A	1.782	1.00
70_A	162_E	1.701	1.00
98_R	205_V	1.697	1.00
126_V	140_V	1.696	1.00
185_A	195_M	1.696	1.00
117_V	137_A	1.682	1.00
39_S	96_R	1.678	1.00
84_P	87_A	1.670	1.00
89_A	93_D	1.667	1.00
85_E	89_A	1.660	1.00
116_V	139_G	1.635	1.00
193_V	211_V	1.618	1.00
54_E	57_A	1.617	1.00
102_G	106_A	1.581	1.00
141_V	171_D	1.557	1.00
146_V	153_T	1.557	1.00
166_D	170_R	1.547	1.00
141_V	168_A	1.528	1.00
197_D	214_H	1.528	1.00
37_A	41_M	1.526	1.00
68_S	71_D	1.525	1.00
26_T	182_A	1.491	1.00
106_A	109_R	1.484	1.00
48_R	94_G	1.459	1.00
163_G	194_P	1.455	1.00
183_A	199_A	1.447	1.00
130_F	140_V	1.446	1.00
117_V	130_F	1.444	1.00
114_R	176_A	1.431	1.00
169_L	195_M	1.430	1.00
28_V	108_L	1.422	1.00
30_F	186_V	1.417	1.00
180_P	183_A	1.392	1.00
83_L	87_A	1.361	1.00
51_V	79_L	1.359	1.00
115_V	137_A	1.357	1.00
85_E	150_G	1.350	1.00
185_A	199_A	1.341	1.00
114_R	138_D	1.324	1.00
204_G	207_P	1.320	1.00
209_P	213_A	1.300	1.00
32_F	129_A	1.270	1.00
32_F	126_V	1.268	1.00
127_A	131_D	1.262	1.00
44_R	47_A	1.252	1.00
38_E	99_D	1.238	1.00
29_A	116_V	1.223	1.00
51_V	54_E	1.218	1.00
29_A	169_L	1.209	1.00
92_Y	128_A	1.200	1.00
144_R	157_E	1.196	1.00
143_N	161_V	1.183	1.00
141_V	161_V	1.178	1.00
38_E	98_R	1.174	1.00
108_L	186_V	1.165	1.00
38_E	96_R	1.151	1.00
87_A	90_A	1.143	1.00
118_L	169_L	1.136	1.00
167_D	171_D	1.124	1.00
53_D	57_A	1.104	1.00
127_A	140_V	1.102	1.00
204_G	215_C	1.094	1.00
179_T	182_A	1.092	1.00
105_V	137_A	1.092	1.00
56_A	60_E	1.080	1.00
210_G	214_H	1.079	1.00
86_S	90_A	1.064	1.00
184_V	201_T	1.052	1.00
36_L	117_V	1.035	1.00
105_V	115_V	1.031	1.00
184_V	203_I	1.030	1.00
108_L	184_V	1.024	1.00
88_A	124_P	1.021	1.00
139_G	175_A	1.016	1.00
113_V	184_V	1.011	1.00
166_D	198_A	1.008	1.00
173_C	183_A	1.004	1.00
164_T	194_P	0.990	1.00
90_A	94_G	0.989	1.00
190_A	210_G	0.983	1.00
107_K	110_D	0.983	1.00
170_R	174_E	0.981	1.00
139_G	176_A	0.980	1.00
73_L	77_A	0.972	0.99
212_D	216_D	0.969	0.99
70_A	74_R	0.954	0.99
168_A	171_D	0.951	0.99
199_A	202_A	0.945	0.99
59_T	63_M	0.936	0.99
41_M	125_G	0.934	0.99
29_A	199_A	0.928	0.99
211_V	214_H	0.921	0.99
201_T	217_H	0.921	0.99
50_G	54_E	0.918	0.99
73_L	76_R	0.915	0.99
57_A	60_E	0.910	0.99
81_A	155_A	0.906	0.99
71_D	75_E	0.898	0.99
55_V	58_I	0.897	0.99
159_P	167_D	0.893	0.99
67_L	71_D	0.887	0.99
169_L	183_A	0.880	0.99
185_A	196_L	0.878	0.99
28_V	184_V	0.871	0.99
46_A	55_V	0.869	0.99
43_D	56_A	0.867	0.99
58_I	79_L	0.865	0.99
119_T	140_V	0.858	0.99
193_V	197_D	0.856	0.99
196_L	211_V	0.856	0.99
171_D	174_E	0.849	0.99
180_P	198_A	0.843	0.98
93_D	131_D	0.831	0.98
103_D	107_K	0.831	0.98
25_M	113_V	0.830	0.98
109_R	136_A	0.829	0.98
44_R	96_R	0.825	0.98
146_V	154_G	0.817	0.98
50_G	53_D	0.804	0.98
30_F	108_L	0.801	0.98
30_F	36_L	0.801	0.98
170_R	180_P	0.797	0.98
139_G	172_A	0.797	0.98
143_N	156_V	0.792	0.98
127_A	130_F	0.785	0.98
183_A	200_G	0.783	0.98
34_G	187_G	0.778	0.97
62_A	65_G	0.776	0.97
32_F	115_V	0.776	0.97
114_R	178_T	0.774	0.97
69_Y	73_L	0.772	0.97
61_R	64_R	0.770	0.97
88_A	92_Y	0.768	0.97
187_G	194_P	0.759	0.97
184_V	202_A	0.756	0.97
28_V	113_V	0.754	0.97
186_V	205_V	0.749	0.97
166_D	194_P	0.748	0.97
207_P	212_D	0.745	0.97
69_Y	72_S	0.745	0.97
180_P	200_G	0.740	0.97
30_F	115_V	0.736	0.96
40_E	189_G	0.731	0.96
89_A	92_Y	0.730	0.96
90_A	93_D	0.728	0.96
92_Y	134_G	0.727	0.96
98_R	206_D	0.725	0.96
182_A	201_T	0.725	0.96
36_L	105_V	0.722	0.96
39_S	44_R	0.721	0.96
54_E	75_E	0.720	0.96
87_A	91_V	0.718	0.96
48_R	91_V	0.718	0.96
36_L	101_A	0.717	0.96
34_G	39_S	0.716	0.96
182_A	200_G	0.716	0.96
105_V	135_V	0.710	0.96
82_G	151_E	0.709	0.96
172_A	176_A	0.706	0.96
194_P	197_D	0.697	0.95
48_R	90_A	0.695	0.95
88_A	152_L	0.695	0.95
38_E	206_D	0.692	0.95
186_V	203_I	0.688	0.95
212_D	218_T	0.686	0.95
69_Y	120_G	0.683	0.95
43_D	52_G	0.681	0.95
124_P	152_L	0.680	0.95
97_L	134_G	0.677	0.94
161_V	168_A	0.673	0.94
123_K	140_V	0.670	0.94
51_V	55_V	0.670	0.94
69_Y	189_G	0.663	0.94
123_K	142_G	0.662	0.94
148_A	153_T	0.660	0.94
81_A	154_G	0.655	0.93
148_A	151_E	0.643	0.93
60_E	63_M	0.642	0.93
27_L	178_T	0.639	0.93
131_D	134_G	0.638	0.92
89_A	127_A	0.635	0.92
78_Q	81_A	0.634	0.92
69_Y	76_R	0.634	0.92
128_A	134_G	0.630	0.92
72_S	76_R	0.627	0.92
179_T	183_A	0.625	0.92
179_T	200_G	0.624	0.92
173_C	178_T	0.620	0.91
93_D	128_A	0.619	0.91
104_L	107_K	0.619	0.91
101_A	104_L	0.616	0.91
167_D	170_R	0.615	0.91
71_D	74_R	0.612	0.91
55_V	59_T	0.609	0.91
36_L	135_V	0.606	0.90
85_E	152_L	0.605	0.90
34_G	40_E	0.604	0.90
124_P	144_R	0.604	0.90
69_Y	191_N	0.602	0.90
73_L	122_F	0.600	0.90
37_A	42_L	0.597	0.90
126_V	137_A	0.596	0.90
56_A	59_T	0.594	0.90
189_G	208_K	0.594	0.90
168_A	172_A	0.593	0.89
124_P	128_A	0.592	0.89
122_F	189_G	0.592	0.89
43_D	46_A	0.592	0.89
211_V	218_T	0.591	0.89
74_R	160_L	0.589	0.89
69_Y	77_A	0.588	0.89
54_E	58_I	0.584	0.89
61_R	71_D	0.583	0.89
188_D	191_N	0.583	0.89
178_T	200_G	0.582	0.89
147_A	150_G	0.579	0.88
27_L	116_V	0.578	0.88
27_L	183_A	0.576	0.88
122_F	145_L	0.575	0.88
41_M	121_G	0.575	0.88
122_F	142_G	0.574	0.88
214_H	217_H	0.573	0.88
118_L	195_M	0.569	0.87
32_F	124_P	0.569	0.87
104_L	108_L	0.565	0.87
74_R	158_G	0.563	0.87
65_G	69_Y	0.562	0.87
148_A	155_A	0.562	0.87
97_L	102_G	0.561	0.87
42_L	122_F	0.561	0.87
32_F	125_G	0.556	0.86
103_D	106_A	0.555	0.86
137_A	140_V	0.554	0.86
34_G	119_T	0.553	0.86
86_S	150_G	0.551	0.86
40_E	120_G	0.551	0.86
29_A	183_A	0.549	0.86
62_A	72_S	0.548	0.85
77_A	156_V	0.546	0.85
40_E	191_N	0.543	0.85
108_L	201_T	0.542	0.85
40_E	76_R	0.538	0.84
110_D	131_D	0.537	0.84
63_M	76_R	0.536	0.84
52_G	56_A	0.533	0.84
54_E	78_Q	0.532	0.84
31_D	188_D	0.532	0.84
48_R	95_V	0.531	0.84
76_R	121_G	0.525	0.83
101_A	105_V	0.523	0.83
173_C	200_G	0.522	0.83
141_V	172_A	0.517	0.82
45_I	83_L	0.512	0.81
146_V	158_G	0.510	0.81
209_P	212_D	0.510	0.81
115_V	118_L	0.510	0.81
54_E	79_L	0.508	0.81
32_F	41_M	0.506	0.81
62_A	189_G	0.506	0.81
177_G	180_P	0.503	0.80
105_V	109_R	0.501	0.80
73_L	156_V	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1l7mA	1	0.8894	100	0.487	Contact Map
3fvvA	2	0.8468	100	0.491	Contact Map
4ezeA	1	0.9745	100	0.493	Contact Map
3m1yA	2	0.8851	100	0.515	Contact Map
4as2A	4	0.9787	100	0.525	Contact Map
3p96A	2	0.9915	100	0.528	Contact Map
4gxtA	1	0.9915	100	0.557	Contact Map
1rkuA	2	0.8383	99.9	0.568	Contact Map
1nnlA	1	0.8468	99.9	0.577	Contact Map
3n28A	1	0.9915	99.9	0.584	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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