GREMLIN Database
Q9HMR1 - Phosphoserine phosphatase
UniProt: Q9HMR1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (193)
Sequences: 4377 (2751)
Seq/√Len: 198.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_V155_A3.6151.00
123_K144_R3.0181.00
170_R198_A2.6341.00
26_T113_V2.2781.00
123_K127_A2.2681.00
108_L113_V2.2221.00
109_R138_D2.1721.00
171_D175_A2.1181.00
114_R139_G2.0891.00
57_A61_R2.0701.00
85_E147_A2.0471.00
84_P151_E2.0121.00
164_T167_D1.9981.00
193_V214_H1.9901.00
107_K111_G1.9471.00
61_R66_E1.9441.00
47_A52_G1.9401.00
60_E64_R1.9371.00
146_V157_E1.8971.00
106_A110_D1.8661.00
116_V172_A1.8631.00
173_C180_P1.8561.00
109_R115_V1.8551.00
61_R75_E1.8511.00
102_G134_G1.8491.00
196_L202_A1.8361.00
32_F117_V1.8091.00
119_T126_V1.7981.00
74_R155_A1.7821.00
70_A162_E1.7011.00
98_R205_V1.6971.00
126_V140_V1.6961.00
185_A195_M1.6961.00
117_V137_A1.6821.00
39_S96_R1.6781.00
84_P87_A1.6701.00
89_A93_D1.6671.00
85_E89_A1.6601.00
116_V139_G1.6351.00
193_V211_V1.6181.00
54_E57_A1.6171.00
102_G106_A1.5811.00
141_V171_D1.5571.00
146_V153_T1.5571.00
166_D170_R1.5471.00
141_V168_A1.5281.00
197_D214_H1.5281.00
37_A41_M1.5261.00
68_S71_D1.5251.00
26_T182_A1.4911.00
106_A109_R1.4841.00
48_R94_G1.4591.00
163_G194_P1.4551.00
183_A199_A1.4471.00
130_F140_V1.4461.00
117_V130_F1.4441.00
114_R176_A1.4311.00
169_L195_M1.4301.00
28_V108_L1.4221.00
30_F186_V1.4171.00
180_P183_A1.3921.00
83_L87_A1.3611.00
51_V79_L1.3591.00
115_V137_A1.3571.00
85_E150_G1.3501.00
185_A199_A1.3411.00
114_R138_D1.3241.00
204_G207_P1.3201.00
209_P213_A1.3001.00
32_F129_A1.2701.00
32_F126_V1.2681.00
127_A131_D1.2621.00
44_R47_A1.2521.00
38_E99_D1.2381.00
29_A116_V1.2231.00
51_V54_E1.2181.00
29_A169_L1.2091.00
92_Y128_A1.2001.00
144_R157_E1.1961.00
143_N161_V1.1831.00
141_V161_V1.1781.00
38_E98_R1.1741.00
108_L186_V1.1651.00
38_E96_R1.1511.00
87_A90_A1.1431.00
118_L169_L1.1361.00
167_D171_D1.1241.00
53_D57_A1.1041.00
127_A140_V1.1021.00
204_G215_C1.0941.00
179_T182_A1.0921.00
105_V137_A1.0921.00
56_A60_E1.0801.00
210_G214_H1.0791.00
86_S90_A1.0641.00
184_V201_T1.0521.00
36_L117_V1.0351.00
105_V115_V1.0311.00
184_V203_I1.0301.00
108_L184_V1.0241.00
88_A124_P1.0211.00
139_G175_A1.0161.00
113_V184_V1.0111.00
166_D198_A1.0081.00
173_C183_A1.0041.00
164_T194_P0.9901.00
90_A94_G0.9891.00
190_A210_G0.9831.00
107_K110_D0.9831.00
170_R174_E0.9811.00
139_G176_A0.9801.00
73_L77_A0.9720.99
212_D216_D0.9690.99
70_A74_R0.9540.99
168_A171_D0.9510.99
199_A202_A0.9450.99
59_T63_M0.9360.99
41_M125_G0.9340.99
29_A199_A0.9280.99
211_V214_H0.9210.99
201_T217_H0.9210.99
50_G54_E0.9180.99
73_L76_R0.9150.99
57_A60_E0.9100.99
81_A155_A0.9060.99
71_D75_E0.8980.99
55_V58_I0.8970.99
159_P167_D0.8930.99
67_L71_D0.8870.99
169_L183_A0.8800.99
185_A196_L0.8780.99
28_V184_V0.8710.99
46_A55_V0.8690.99
43_D56_A0.8670.99
58_I79_L0.8650.99
119_T140_V0.8580.99
193_V197_D0.8560.99
196_L211_V0.8560.99
171_D174_E0.8490.99
180_P198_A0.8430.98
93_D131_D0.8310.98
103_D107_K0.8310.98
25_M113_V0.8300.98
109_R136_A0.8290.98
44_R96_R0.8250.98
146_V154_G0.8170.98
50_G53_D0.8040.98
30_F108_L0.8010.98
30_F36_L0.8010.98
170_R180_P0.7970.98
139_G172_A0.7970.98
143_N156_V0.7920.98
127_A130_F0.7850.98
183_A200_G0.7830.98
34_G187_G0.7780.97
62_A65_G0.7760.97
32_F115_V0.7760.97
114_R178_T0.7740.97
69_Y73_L0.7720.97
61_R64_R0.7700.97
88_A92_Y0.7680.97
187_G194_P0.7590.97
184_V202_A0.7560.97
28_V113_V0.7540.97
186_V205_V0.7490.97
166_D194_P0.7480.97
207_P212_D0.7450.97
69_Y72_S0.7450.97
180_P200_G0.7400.97
30_F115_V0.7360.96
40_E189_G0.7310.96
89_A92_Y0.7300.96
90_A93_D0.7280.96
92_Y134_G0.7270.96
98_R206_D0.7250.96
182_A201_T0.7250.96
36_L105_V0.7220.96
39_S44_R0.7210.96
54_E75_E0.7200.96
87_A91_V0.7180.96
48_R91_V0.7180.96
36_L101_A0.7170.96
34_G39_S0.7160.96
182_A200_G0.7160.96
105_V135_V0.7100.96
82_G151_E0.7090.96
172_A176_A0.7060.96
194_P197_D0.6970.95
48_R90_A0.6950.95
88_A152_L0.6950.95
38_E206_D0.6920.95
186_V203_I0.6880.95
212_D218_T0.6860.95
69_Y120_G0.6830.95
43_D52_G0.6810.95
124_P152_L0.6800.95
97_L134_G0.6770.94
161_V168_A0.6730.94
123_K140_V0.6700.94
51_V55_V0.6700.94
69_Y189_G0.6630.94
123_K142_G0.6620.94
148_A153_T0.6600.94
81_A154_G0.6550.93
148_A151_E0.6430.93
60_E63_M0.6420.93
27_L178_T0.6390.93
131_D134_G0.6380.92
89_A127_A0.6350.92
78_Q81_A0.6340.92
69_Y76_R0.6340.92
128_A134_G0.6300.92
72_S76_R0.6270.92
179_T183_A0.6250.92
179_T200_G0.6240.92
173_C178_T0.6200.91
93_D128_A0.6190.91
104_L107_K0.6190.91
101_A104_L0.6160.91
167_D170_R0.6150.91
71_D74_R0.6120.91
55_V59_T0.6090.91
36_L135_V0.6060.90
85_E152_L0.6050.90
34_G40_E0.6040.90
124_P144_R0.6040.90
69_Y191_N0.6020.90
73_L122_F0.6000.90
37_A42_L0.5970.90
126_V137_A0.5960.90
56_A59_T0.5940.90
189_G208_K0.5940.90
168_A172_A0.5930.89
124_P128_A0.5920.89
122_F189_G0.5920.89
43_D46_A0.5920.89
211_V218_T0.5910.89
74_R160_L0.5890.89
69_Y77_A0.5880.89
54_E58_I0.5840.89
61_R71_D0.5830.89
188_D191_N0.5830.89
178_T200_G0.5820.89
147_A150_G0.5790.88
27_L116_V0.5780.88
27_L183_A0.5760.88
122_F145_L0.5750.88
41_M121_G0.5750.88
122_F142_G0.5740.88
214_H217_H0.5730.88
118_L195_M0.5690.87
32_F124_P0.5690.87
104_L108_L0.5650.87
74_R158_G0.5630.87
65_G69_Y0.5620.87
148_A155_A0.5620.87
97_L102_G0.5610.87
42_L122_F0.5610.87
32_F125_G0.5560.86
103_D106_A0.5550.86
137_A140_V0.5540.86
34_G119_T0.5530.86
86_S150_G0.5510.86
40_E120_G0.5510.86
29_A183_A0.5490.86
62_A72_S0.5480.85
77_A156_V0.5460.85
40_E191_N0.5430.85
108_L201_T0.5420.85
40_E76_R0.5380.84
110_D131_D0.5370.84
63_M76_R0.5360.84
52_G56_A0.5330.84
54_E78_Q0.5320.84
31_D188_D0.5320.84
48_R95_V0.5310.84
76_R121_G0.5250.83
101_A105_V0.5230.83
173_C200_G0.5220.83
141_V172_A0.5170.82
45_I83_L0.5120.81
146_V158_G0.5100.81
209_P212_D0.5100.81
115_V118_L0.5100.81
54_E79_L0.5080.81
32_F41_M0.5060.81
62_A189_G0.5060.81
177_G180_P0.5030.80
105_V109_R0.5010.80
73_L156_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l7mA 1 0.8894 100 0.487 Contact Map
3fvvA 2 0.8468 100 0.491 Contact Map
4ezeA 1 0.9745 100 0.493 Contact Map
3m1yA 2 0.8851 100 0.515 Contact Map
4as2A 4 0.9787 100 0.525 Contact Map
3p96A 2 0.9915 100 0.528 Contact Map
4gxtA 1 0.9915 100 0.557 Contact Map
1rkuA 2 0.8383 99.9 0.568 Contact Map
1nnlA 1 0.8468 99.9 0.577 Contact Map
3n28A 1 0.9915 99.9 0.584 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.