GREMLIN Database
Q9HMQ9 - Acyl-CoA thioester hydrolase
UniProt: Q9HMQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (132)
Sequences: 3441 (1898)
Seq/√Len: 165.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_M109_F3.7211.00
82_H122_A3.2011.00
49_K121_T2.7751.00
39_G111_F2.7711.00
36_D53_T2.7171.00
42_A75_A2.6681.00
63_R102_E2.5481.00
32_V56_I2.4091.00
32_V59_L2.3231.00
26_A31_V2.2791.00
131_E134_R2.2261.00
20_T67_Q2.2221.00
72_V101_T2.1941.00
78_Y88_R2.0281.00
19_D30_N1.9661.00
103_P106_D1.7791.00
65_V104_T1.7651.00
30_N33_K1.7641.00
69_D102_E1.7421.00
115_D119_Q1.7161.00
69_D95_D1.7151.00
27_H33_K1.6771.00
13_E37_E1.6451.00
134_R138_E1.6081.00
93_R102_E1.5971.00
79_D86_K1.5931.00
15_V26_A1.5721.00
47_A85_I1.5321.00
95_D98_S1.4261.00
94_E101_T1.3751.00
55_R110_V1.3571.00
41_M70_I1.3541.00
66_P69_D1.3541.00
45_R94_E1.3521.00
74_Q92_F1.3211.00
65_V71_C1.3011.00
73_I89_L1.2931.00
10_E74_Q1.2711.00
46_H77_A1.2711.00
40_A44_M1.2651.00
90_R103_P1.2541.00
78_Y86_K1.2531.00
52_V114_V1.2481.00
57_N108_Y1.2281.00
42_A77_A1.2151.00
128_V133_C1.1831.00
88_R108_Y1.1771.00
21_N28_G1.1751.00
33_K37_E1.1561.00
81_G84_S1.1481.00
47_A51_C1.1431.00
130_S133_C1.1221.00
21_N27_H1.1041.00
88_R136_L1.0921.00
92_F101_T1.0851.00
23_Y114_V1.0851.00
88_R106_D1.0801.00
128_V137_R1.0781.00
46_H85_I1.0771.00
85_I123_V1.0700.99
8_F74_Q1.0690.99
132_R135_E1.0590.99
46_H125_D1.0470.99
76_Y88_R1.0460.99
19_D34_W1.0420.99
78_Y136_L1.0290.99
77_A85_I1.0230.99
10_E72_V1.0200.99
89_L109_F1.0000.99
86_K110_V0.9870.99
13_E34_W0.9800.99
42_A87_V0.9760.99
8_F76_Y0.9750.99
43_A51_C0.9600.99
83_T120_P0.9580.99
35_M107_S0.9530.99
131_E135_E0.9520.99
69_D93_R0.9470.99
86_K108_Y0.9380.99
34_W37_E0.9290.99
54_A60_D0.9230.98
56_I109_F0.9120.98
135_E139_A0.9110.98
78_Y108_Y0.9100.98
92_F103_P0.9040.98
31_V65_V0.8820.98
38_I73_I0.8780.98
38_I75_A0.8750.98
36_D52_V0.8720.98
47_A50_T0.8680.98
84_S112_V0.8620.98
39_G109_F0.8490.97
80_T123_V0.8460.97
46_H126_L0.8450.97
95_D100_E0.8420.97
26_A30_N0.8400.97
80_T128_V0.8390.97
79_D137_R0.8280.97
72_V92_F0.8230.97
25_S66_P0.8110.97
9_M42_A0.7980.96
46_H80_T0.7970.96
31_V105_T0.7970.96
31_V91_A0.7850.96
57_N110_V0.7830.96
131_E138_E0.7820.96
114_V120_P0.7720.95
42_A46_H0.7720.95
34_W73_I0.7670.95
115_D120_P0.7590.95
28_G61_F0.7450.94
57_N86_K0.7450.94
77_A87_V0.7430.94
11_N37_E0.7430.94
16_Q37_E0.7420.94
11_N38_I0.7360.94
16_Q27_H0.7350.94
95_D102_E0.7310.94
24_A68_G0.7210.93
128_V134_R0.7210.93
129_G133_C0.7180.93
39_G89_L0.7170.93
129_G134_R0.7140.93
130_S134_R0.7060.93
49_K113_A0.6990.92
40_A111_F0.6960.92
76_Y90_R0.6940.92
35_M89_L0.6920.92
132_R136_L0.6910.92
54_A84_S0.6890.92
39_G87_V0.6870.92
25_S105_T0.6840.92
96_P99_G0.6790.91
113_A123_V0.6720.91
90_R106_D0.6670.91
16_Q22_N0.6640.90
18_D33_K0.6630.90
20_T68_G0.6630.90
127_D134_R0.6630.90
79_D110_V0.6610.90
75_A89_L0.6570.90
32_V109_F0.6540.90
70_I96_P0.6520.90
26_A34_W0.6490.89
30_N34_W0.6400.89
48_G99_G0.6390.89
55_R60_D0.6390.89
74_Q90_R0.6300.88
113_A121_T0.6300.88
26_A65_V0.6280.88
87_V111_F0.6280.88
77_A80_T0.6190.87
116_D121_T0.6170.87
136_L139_A0.6150.87
73_I91_A0.6140.87
34_W71_C0.6130.86
25_S30_N0.6120.86
17_P110_V0.6080.86
82_H120_P0.6070.86
82_H138_E0.6040.86
12_R15_V0.5990.85
53_T56_I0.5980.85
90_R108_Y0.5970.85
44_M96_P0.5930.85
36_D81_G0.5760.83
52_V84_S0.5730.83
57_N62_E0.5700.82
65_V91_A0.5700.82
115_D121_T0.5700.82
78_Y90_R0.5690.82
43_A87_V0.5690.82
35_M91_A0.5630.81
61_F68_G0.5600.81
129_G135_E0.5550.81
66_P118_M0.5520.80
51_C111_F0.5520.80
53_T124_P0.5460.79
31_V71_C0.5460.79
81_G112_V0.5400.79
37_E41_M0.5400.79
83_T122_A0.5360.78
129_G138_E0.5350.78
126_L137_R0.5310.78
43_A85_I0.5310.78
43_A111_F0.5280.77
30_N37_E0.5240.77
45_R72_V0.5230.77
54_A112_V0.5210.76
55_R58_S0.5200.76
62_E79_D0.5190.76
48_G94_E0.5180.76
76_Y136_L0.5150.75
116_D122_A0.5130.75
97_R116_D0.5110.75
114_V118_M0.5100.75
22_N25_S0.5040.74
83_T112_V0.5030.74
94_E99_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mobA 3 0.9524 100 0.308 Contact Map
4ncpA 5 1 100 0.315 Contact Map
4zv3A 3 0.9932 100 0.351 Contact Map
1y7uA 5 1 99.9 0.403 Contact Map
2qq2A 5 1 99.9 0.405 Contact Map
2q2bA 5 0.9524 99.9 0.411 Contact Map
1vpmA 5 1 99.9 0.43 Contact Map
4ienA 5 0.9864 99.9 0.478 Contact Map
2v1oA 5 0.932 99.9 0.491 Contact Map
2gvhA 3 1 99.8 0.538 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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