GREMLIN Database
Q9HMQ7 - Threonine synthase
UniProt: Q9HMQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (320)
Sequences: 9017 (4923)
Seq/√Len: 275.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_G157_V4.6031.00
225_I380_V3.7471.00
338_R366_A3.4471.00
163_A185_D3.4351.00
273_A330_T3.3141.00
100_D378_R3.2511.00
197_E201_R3.2281.00
88_E100_D3.2211.00
239_R275_T3.1571.00
156_P180_R2.7541.00
280_A335_S2.7491.00
194_V197_E2.6501.00
158_L180_R2.6441.00
240_I257_F2.5021.00
235_E378_R2.4301.00
374_S377_E2.4051.00
88_E93_A2.3641.00
219_K223_F2.3001.00
86_L380_V2.2381.00
158_L182_C2.1671.00
83_D228_Q2.1391.00
160_L198_L2.1361.00
168_A172_A2.1261.00
83_D227_E2.0871.00
88_E102_R2.0831.00
345_M365_L2.0761.00
125_V213_F2.0661.00
95_A345_M2.0481.00
240_I253_L2.0301.00
277_V363_G2.0081.00
127_E130_G2.0031.00
360_S381_C1.9971.00
335_S338_R1.9801.00
283_A287_E1.9391.00
253_L382_L1.9121.00
222_A253_L1.8741.00
254_Y327_T1.8711.00
111_T148_A1.8341.00
102_R229_S1.7921.00
261_V271_M1.7831.00
322_P326_E1.7821.00
286_V290_E1.7531.00
241_V277_V1.7241.00
90_P94_A1.7181.00
238_D377_E1.6821.00
239_R273_A1.6821.00
102_R378_R1.6651.00
261_V272_P1.6501.00
275_T330_T1.6361.00
222_A256_A1.6311.00
133_R158_L1.5971.00
229_S380_V1.5821.00
187_N190_D1.5731.00
237_P380_V1.5531.00
222_A257_F1.5431.00
91_D94_A1.5421.00
136_C159_V1.5331.00
241_V364_L1.5321.00
226_L260_L1.5131.00
309_I359_A1.5031.00
305_R340_T1.5011.00
282_A289_V1.4891.00
96_A365_L1.4841.00
210_L251_A1.4801.00
84_T109_N1.4701.00
175_A180_R1.4651.00
353_V383_T1.4421.00
332_V363_G1.4411.00
87_Y105_H1.4301.00
239_R379_V1.4301.00
189_D192_L1.4261.00
344_R398_G1.4011.00
241_V367_L1.3971.00
86_L229_S1.3931.00
133_R156_P1.3911.00
250_T328_G1.3861.00
194_V198_L1.3821.00
229_S237_P1.3481.00
258_R329_G1.3471.00
244_V276_G1.3461.00
373_I377_E1.3441.00
238_D378_R1.3441.00
211_N214_R1.3411.00
123_V153_A1.3401.00
103_V346_L1.3391.00
277_V332_V1.3351.00
239_R377_E1.3021.00
306_A339_I1.3011.00
122_G211_N1.3011.00
225_I253_L1.2981.00
171_I175_A1.2961.00
138_S143_S1.2951.00
127_E155_T1.2911.00
357_S384_T1.2861.00
197_E200_A1.2851.00
346_L353_V1.2791.00
281_G336_D1.2721.00
241_V275_T1.2701.00
287_E290_E1.2691.00
340_T397_A1.2671.00
364_L381_C1.2551.00
92_V361_V1.2511.00
229_S378_R1.2511.00
344_R348_G1.2501.00
76_G121_V1.2461.00
298_R313_N1.2421.00
164_G167_A1.2401.00
337_D341_D1.2391.00
283_A333_A1.2281.00
80_Q120_T1.2241.00
342_A362_A1.2241.00
276_G331_A1.2231.00
101_V364_L1.2181.00
343_Q389_K1.2141.00
343_Q358_A1.2141.00
392_A396_A1.2131.00
89_A103_V1.2131.00
69_D72_P1.2121.00
361_V381_C1.2091.00
278_Q284_P1.2051.00
254_Y274_L1.2041.00
239_R373_I1.1991.00
160_L197_E1.1961.00
275_T332_V1.1951.00
279_A309_I1.1921.00
273_A377_E1.1741.00
71_L74_D1.1691.00
304_T310_R1.1641.00
190_D193_D1.1591.00
347_A352_G1.1591.00
216_E219_K1.1591.00
209_S212_P1.1571.00
68_A72_P1.1531.00
70_A73_V1.1471.00
334_V362_A1.1431.00
289_V331_A1.1421.00
342_A361_V1.1421.00
81_E109_N1.1411.00
67_Y71_L1.1351.00
146_L159_V1.1331.00
132_D156_P1.1321.00
357_S383_T1.1311.00
346_L361_V1.1291.00
353_V358_A1.1241.00
75_A79_V1.1241.00
262_A271_M1.1231.00
216_E255_K1.1181.00
393_A396_A1.1091.00
166_V307_T1.1061.00
223_F256_A1.1011.00
286_V333_A1.1011.00
240_I274_L1.0891.00
171_I183_E1.0791.00
287_E291_A1.0751.00
151_G157_V1.0711.00
123_V134_L1.0661.00
324_V328_G1.0651.00
341_D345_M1.0641.00
191_C195_V1.0521.00
143_S174_A1.0461.00
285_M324_V1.0431.00
172_A175_A1.0241.00
161_L174_A1.0161.00
119_M145_A1.0121.00
196_A200_A1.0041.00
290_E293_R1.0021.00
68_A71_L1.0021.00
343_Q394_A1.0001.00
244_V331_A0.9871.00
257_F272_P0.9761.00
198_L202_G0.9761.00
132_D197_E0.9761.00
75_A78_S0.9731.00
284_P287_E0.9711.00
362_A366_A0.9701.00
188_F191_C0.9661.00
163_A183_E0.9641.00
285_M331_A0.9611.00
193_D197_E0.9601.00
255_K259_E0.9591.00
230_R236_W0.9561.00
253_L274_L0.9551.00
340_T355_P0.9551.00
192_L196_A0.9501.00
148_A177_H0.9461.00
283_A286_V0.9441.00
226_L230_R0.9401.00
251_A320_A0.9221.00
286_V331_A0.9211.00
64_V128_R0.9211.00
338_R341_D0.9201.00
100_D376_D0.9141.00
226_L257_F0.9121.00
280_A333_A0.9081.00
103_V383_T0.9071.00
104_K224_E0.9061.00
192_L195_V0.9021.00
188_F192_L0.9001.00
322_P325_Y0.8931.00
221_I249_N0.8931.00
320_A331_A0.8931.00
146_L157_V0.8921.00
395_A399_G0.8921.00
215_L255_K0.8901.00
135_A204_A0.8861.00
241_V363_G0.8851.00
346_L383_T0.8831.00
339_I359_A0.8821.00
342_A365_L0.8791.00
281_G302_V0.8781.00
293_R297_E0.8751.00
137_A188_F0.8731.00
74_D78_S0.8721.00
250_T324_V0.8711.00
105_H108_M0.8671.00
225_I382_L0.8641.00
76_G124_R0.8561.00
123_V133_R0.8511.00
161_L183_E0.8501.00
292_G325_Y0.8481.00
221_I253_L0.8471.00
250_T276_G0.8441.00
147_A179_A0.8431.00
111_T116_D0.8411.00
393_A397_A0.8401.00
242_L253_L0.8391.00
96_A345_M0.8351.00
166_V183_E0.8291.00
86_L225_I0.8280.99
125_V128_R0.8240.99
186_G190_D0.8240.99
208_N211_N0.8210.99
172_A176_L0.8200.99
244_V285_M0.8150.99
148_A152_R0.8140.99
244_V250_T0.8140.99
135_A199_A0.8130.99
324_V331_A0.8120.99
64_V67_Y0.8110.99
215_L319_K0.8090.99
74_D223_F0.8090.99
99_A379_V0.8060.99
273_A329_G0.8040.99
93_A101_V0.8020.99
289_V292_G0.8010.99
160_L194_V0.7990.99
277_V334_V0.7950.99
221_I382_L0.7940.99
309_I356_A0.7910.99
93_A98_V0.7900.99
158_L204_A0.7860.99
332_V366_A0.7860.99
245_G308_A0.7850.99
366_A369_E0.7830.99
273_A372_E0.7820.99
308_A356_A0.7810.99
171_I181_I0.7780.99
363_G367_L0.7780.99
78_S81_E0.7780.99
285_M314_P0.7750.99
174_A179_A0.7730.99
93_A100_D0.7720.99
85_P108_M0.7700.99
92_V345_M0.7700.99
278_Q314_P0.7670.99
236_W378_R0.7670.99
227_E260_L0.7660.99
123_V155_T0.7630.99
275_T367_L0.7590.99
215_L323_G0.7590.99
71_L75_A0.7570.99
334_V363_G0.7550.99
284_P314_P0.7500.99
239_R367_L0.7490.99
81_E116_D0.7480.99
369_E373_I0.7470.99
98_V101_V0.7460.99
225_I237_P0.7450.99
236_W272_P0.7440.99
97_G375_A0.7430.99
207_L210_L0.7420.99
84_T113_S0.7410.99
275_T363_G0.7370.99
105_H383_T0.7370.99
92_V101_V0.7360.99
120_T124_R0.7360.99
353_V357_S0.7350.99
170_K307_T0.7340.99
213_F216_E0.7330.99
258_R271_M0.7320.99
144_A173_Q0.7320.99
277_V333_A0.7310.99
123_V146_L0.7290.99
106_E384_T0.7280.99
198_L204_A0.7260.99
330_T367_L0.7230.99
288_A321_L0.7230.99
96_A364_L0.7210.99
364_L379_V0.7190.99
392_A395_A0.7160.99
330_T372_E0.7160.99
81_E84_T0.7160.99
91_D349_D0.7150.99
172_A395_A0.7130.99
281_G303_E0.7110.98
205_Y208_N0.7100.98
251_A319_K0.7100.98
146_L150_G0.7060.98
116_D148_A0.7030.98
123_V206_L0.7020.98
367_L373_I0.7020.98
133_R150_G0.6950.98
144_A174_A0.6940.98
101_V381_C0.6940.98
130_G205_Y0.6930.98
287_E297_E0.6930.98
89_A349_D0.6870.98
288_A291_A0.6840.98
335_S366_A0.6840.98
180_R202_G0.6830.98
236_W260_L0.6820.98
119_M149_Y0.6790.98
338_R362_A0.6790.98
321_L325_Y0.6780.98
67_Y223_F0.6750.98
93_A96_A0.6740.98
195_V206_L0.6730.98
334_V339_I0.6720.98
90_P152_R0.6690.98
219_K256_A0.6690.98
135_A160_L0.6640.98
125_V129_L0.6620.98
225_I257_F0.6600.98
135_A195_V0.6570.97
196_A199_A0.6570.97
240_I380_V0.6560.97
195_V199_A0.6560.97
160_L184_V0.6560.97
126_A130_G0.6530.97
82_G110_P0.6490.97
347_A394_A0.6480.97
160_L182_C0.6480.97
364_L373_I0.6470.97
107_G351_I0.6450.97
157_V179_A0.6450.97
126_A133_R0.6440.97
334_V366_A0.6430.97
238_D376_D0.6410.97
133_R204_A0.6410.97
223_F259_E0.6370.97
290_E330_T0.6360.97
193_D196_A0.6350.97
128_R131_V0.6340.97
364_L368_R0.6340.97
305_R336_D0.6330.97
219_K259_E0.6300.97
173_Q177_H0.6290.97
242_L250_T0.6260.97
363_G366_A0.6230.97
282_A302_V0.6220.96
137_A195_V0.6200.96
139_T308_A0.6190.96
396_A399_G0.6190.96
99_A376_D0.6180.96
212_P319_K0.6180.96
69_D73_V0.6170.96
337_D340_T0.6160.96
225_I240_I0.6150.96
323_G327_T0.6130.96
313_N318_P0.6130.96
90_P93_A0.6120.96
126_A155_T0.6110.96
89_A92_V0.6100.96
77_V81_E0.6100.96
98_V368_R0.6100.96
318_P322_P0.6070.96
170_K354_E0.6060.96
71_L260_L0.6050.96
368_R373_I0.6040.96
163_A166_V0.6040.96
116_D152_R0.6040.96
184_V194_V0.6010.96
191_C207_L0.6000.96
245_G311_I0.5990.96
341_D348_G0.5970.96
365_L369_E0.5970.96
258_R326_E0.5970.96
378_R382_L0.5950.95
81_E120_T0.5950.95
206_L209_S0.5950.95
135_A198_L0.5940.95
253_L256_A0.5920.95
341_D365_L0.5920.95
318_P321_L0.5910.95
291_A297_E0.5910.95
67_Y70_A0.5900.95
218_Q246_N0.5880.95
226_L256_A0.5870.95
114_F249_N0.5870.95
122_G207_L0.5860.95
294_G297_E0.5860.95
243_P360_S0.5860.95
240_I256_A0.5840.95
321_L324_V0.5830.95
251_A323_G0.5820.95
117_R220_T0.5770.95
134_L155_T0.5750.95
151_G177_H0.5750.95
123_V149_Y0.5750.95
352_G387_L0.5730.94
190_D194_V0.5730.94
96_A368_R0.5660.94
373_I376_D0.5640.94
127_E153_A0.5640.94
317_A321_L0.5610.94
226_L236_W0.5610.94
221_I225_I0.5590.94
373_I379_V0.5560.94
101_V368_R0.5560.94
106_E117_R0.5560.94
196_A298_R0.5560.94
86_L102_R0.5540.93
124_R128_R0.5530.93
121_V124_R0.5530.93
215_L251_A0.5530.93
122_G130_G0.5520.93
74_D77_V0.5500.93
229_S236_W0.5490.93
65_W216_E0.5480.93
139_T170_K0.5460.93
288_A294_G0.5460.93
251_A255_K0.5460.93
67_Y259_E0.5450.93
160_L191_C0.5430.93
66_R227_E0.5380.92
63_G67_Y0.5370.92
235_E238_D0.5370.92
122_G208_N0.5370.92
84_T104_K0.5350.92
63_G69_D0.5340.92
244_V384_T0.5340.92
77_V120_T0.5330.92
166_V175_A0.5330.92
230_R234_G0.5320.92
293_R321_L0.5320.92
257_F260_L0.5310.92
87_Y107_G0.5300.92
369_E372_E0.5280.92
63_G68_A0.5280.92
223_F227_E0.5280.92
219_K255_K0.5240.91
241_V381_C0.5240.91
74_D227_E0.5240.91
98_V375_A0.5230.91
354_E385_G0.5210.91
94_A97_G0.5200.91
150_G155_T0.5180.91
242_L249_N0.5170.91
138_S354_E0.5170.91
258_R323_G0.5170.91
254_Y329_G0.5160.91
86_L228_Q0.5150.91
116_D149_Y0.5130.91
218_Q248_G0.5130.91
164_G183_E0.5130.91
256_A259_E0.5130.91
126_A205_Y0.5120.90
182_C194_V0.5100.90
367_L372_E0.5090.90
258_R274_L0.5080.90
63_G66_R0.5070.90
329_G332_V0.5060.90
287_E292_G0.5060.90
257_F382_L0.5060.90
391_P395_A0.5060.90
176_L344_R0.5050.90
357_S360_S0.5030.90
358_A361_V0.5010.90
73_V128_R0.5000.89
230_R235_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5xA 2 0.9181 100 0.238 Contact Map
2zsjA 2 0.8265 100 0.333 Contact Map
2d1fA 2 0.8265 100 0.335 Contact Map
3aeyA 2 0.8217 100 0.339 Contact Map
3ss7X 1 0.9036 100 0.368 Contact Map
1tdjA 2 0.8096 100 0.37 Contact Map
2gn0A 2 0.7855 100 0.398 Contact Map
1v71A 2 0.759 100 0.399 Contact Map
1kl7A 1 0.9253 100 0.408 Contact Map
2rkbA 2 0.747 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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