GREMLIN Database
Y2432 - UPF0145 protein VNG_2432C
UniProt: Q9HMQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (101)
Sequences: 1572 (918)
Seq/√Len: 91.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L102_T3.8461.00
75_D102_T3.7041.00
3_F80_V3.2741.00
16_E102_T2.7831.00
5_T79_N2.5791.00
10_P17_S2.3861.00
23_G65_M2.2611.00
82_L96_A2.1911.00
62_L82_L1.9851.00
63_D66_A1.9511.00
67_E70_R1.8911.00
14_I78_V1.8621.00
55_T59_D1.8421.00
40_R49_A1.8211.00
55_T68_D1.6201.00
46_E64_R1.5831.00
3_F66_A1.5691.00
4_V9_V1.5361.00
18_L75_D1.5221.00
31_V42_I1.4911.00
9_V12_R1.4761.00
27_K60_D1.4661.00
28_A41_N1.4631.00
46_E51_S1.4520.99
26_V92_S1.4230.99
15_T102_T1.4170.99
62_L96_A1.4120.99
21_A72_M1.4000.99
63_D67_E1.3740.99
10_P13_E1.3460.99
27_K53_L1.3340.99
74_A100_A1.3280.99
69_A74_A1.3210.99
59_D63_D1.3100.99
67_E71_S1.2750.99
36_T49_A1.2460.98
68_D71_S1.2370.98
34_D50_Y1.2340.98
60_D63_D1.1720.98
33_R49_A1.1680.98
62_L66_A1.1340.97
21_A65_M1.1270.97
7_E79_N1.1020.97
30_N36_T1.0950.96
22_R68_D1.0640.96
29_R56_D1.0420.95
20_V80_V1.0170.95
25_T60_D1.0170.95
30_N33_R1.0130.95
65_M77_V0.9990.94
53_L56_D0.9960.94
19_G76_A0.9860.94
28_A47_L0.9660.93
13_E102_T0.9550.93
6_T78_V0.9510.92
7_E78_V0.9380.92
8_T13_E0.9240.91
33_R53_L0.9210.91
57_A94_V0.9150.91
23_G61_A0.9130.91
54_L92_S0.9050.90
66_A70_R0.8980.90
35_I39_I0.8910.90
66_A77_V0.8850.89
82_L95_I0.8840.89
29_R53_L0.8830.89
61_A96_A0.8570.88
37_Q54_L0.8560.88
24_N83_E0.8470.87
65_M80_V0.8460.87
65_M96_A0.8450.87
4_V17_S0.8330.86
68_D72_M0.8060.85
56_D60_D0.8040.84
93_E97_Y0.7810.83
32_G36_T0.7800.83
57_A92_S0.7770.82
36_T41_N0.7750.82
41_N47_L0.7740.82
31_V35_I0.7660.81
83_E91_G0.7530.80
37_Q47_L0.7530.80
81_R97_Y0.7520.80
84_S97_Y0.7500.80
52_E56_D0.7440.80
40_R43_T0.7430.79
4_V10_P0.7370.79
40_R53_L0.7210.77
26_V93_E0.7120.76
13_E16_E0.7100.76
6_T10_P0.7080.76
30_N34_D0.7070.76
30_N35_I0.6960.75
8_T78_V0.6950.75
41_N90_G0.6930.75
51_S64_R0.6930.75
78_V101_V0.6920.74
23_G58_R0.6890.74
64_R97_Y0.6870.74
85_S91_G0.6860.74
8_T79_N0.6860.74
15_T75_D0.6760.73
28_A54_L0.6740.73
40_R48_K0.6740.73
31_V43_T0.6630.71
41_N88_A0.6580.71
36_T43_T0.6570.71
38_S41_N0.6450.69
14_I59_D0.6430.69
13_E75_D0.6380.68
4_V8_T0.6300.67
14_I101_V0.6280.67
36_T39_I0.6230.67
83_E95_I0.6210.66
62_L77_V0.6180.66
6_T79_N0.6170.66
6_T17_S0.6140.65
40_R47_L0.6120.65
12_R15_T0.6050.64
29_R52_E0.6040.64
55_T58_R0.6030.64
5_T14_I0.6020.64
16_E63_D0.6020.64
28_A34_D0.5990.64
58_R86_E0.5950.63
53_L60_D0.5880.62
19_G72_M0.5880.62
24_N54_L0.5860.62
18_L72_M0.5830.61
12_R75_D0.5820.61
36_T48_K0.5730.60
29_R33_R0.5660.59
24_N84_S0.5640.59
39_I42_I0.5550.58
84_S95_I0.5540.58
7_E10_P0.5540.58
5_T80_V0.5530.57
2_E25_T0.5380.55
33_R40_R0.5280.54
88_A91_G0.5280.54
9_V73_G0.5220.53
50_Y87_I0.5200.53
22_R95_I0.5200.53
47_L64_R0.5180.53
14_I17_S0.5170.52
2_E8_T0.5160.52
81_R85_S0.5090.51
49_A52_E0.5020.50
56_D101_V0.5020.50
4_V20_V0.5010.50
6_T9_V0.5000.50
84_S94_V0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vr4A 3 0.9904 100 0.046 Contact Map
1y2iA 3 0.9904 100 0.052 Contact Map
3qkbA 3 0.8365 99.9 0.268 Contact Map
2jz7A 3 0.6538 99.8 0.411 Contact Map
2y1bA 1 0.7885 99.1 0.651 Contact Map
3ox4A 2 0.9231 20 0.916 Contact Map
4o5fA 2 0.9712 15.4 0.921 Contact Map
1rrmA 2 0.9231 13.3 0.923 Contact Map
4qgsA 2 0.8846 11.4 0.925 Contact Map
5b8hA 2 0.9712 10.1 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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