ARLY - HALSA - GREMLIN Contacts

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ARLY - Argininosuccinate lyase

UniProt:	Q9HMQ3	Sequences: MTGGGDPVVRRDRFSGGPARSFLSSMDGDGRIFEADLAVDRAHVVMLAEQDVIGDEAAAAILGALADVEAAGFDALPPGEDVHEAIETAVVEAVGRDGGKLHTARSRNDEVAACIRYRLRADLLDAIEVVVALRSALADVAAAEAETVMPGFTHLQPAQPTTVAHWALSYAGTLARDTGRLCDAYGRTNESPLGAAAFAGTTFGVDRERTAALLGFDGVVANAADAAASRDFLLEAVSALASVAVTCSGLAADVVFFANRGFVEVSDDYASTSSIMPQKKNPDTMELVRATAGDAVGAQQALATTLQGLPRAYNRDLQRATGHAWTAVDGVTSAVEVAAGVVATAGWPADDLEAAAGEGFSTATGVADALAAGGLPFRTAHEVVALAAERGCEGATLDAVAAATEAVTGEPLSAVVEPAAVADALDPVGSVAARDSAGGPAPAAVEAAVADVRDGIDADEAALAAERASLADAADALAAEVSGYV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	485 (409)
Sequences:	10953 (5558)
Seq/√Len:	274.8

ECOLI - ARLY FUMC ASPA PUR8
BACSU - ARLY PUR8 ASPA FUMC
HALSA - ARLY FUMC Q9HS42
SULSO - Q980P8 ARLY FUMC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_A	58_A	3.893	1.00
57_A	100_K	3.559	1.00
41_R	66_A	3.359	1.00
49_E	209_R	3.316	1.00
351_D	354_A	3.259	1.00
45_V	62_L	3.216	1.00
124_L	185_Y	3.190	1.00
298_A	327_A	2.936	1.00
45_V	213_L	2.903	1.00
244_A	295_A	2.831	1.00
131_V	178_T	2.830	1.00
35_A	121_A	2.821	1.00
134_R	175_A	2.689	1.00
136_A	343_A	2.646	1.00
353_E	357_G	2.638	1.00
136_A	339_A	2.637	1.00
123_L	236_A	2.630	1.00
127_I	182_C	2.611	1.00
31_R	329_D	2.556	1.00
291_T	334_A	2.535	1.00
163_V	347_W	2.498	1.00
67_D	93_A	2.477	1.00
129_V	336_E	2.424	1.00
209_R	212_A	2.383	1.00
187_R	235_E	2.383	1.00
140_V	143_A	2.332	1.00
127_I	178_T	2.331	1.00
120_R	189_N	2.299	1.00
241_A	299_Q	2.290	1.00
48_A	55_D	2.276	1.00
132_A	339_A	2.265	1.00
54_G	57_A	2.247	1.00
266_S	346_G	2.234	1.00
146_E	349_A	2.205	1.00
189_N	217_D	2.185	1.00
131_V	182_C	2.138	1.00
386_L	390_R	2.137	1.00
417_E	420_A	2.127	1.00
339_A	343_A	2.125	1.00
395_A	403_A	2.069	1.00
294_D	323_H	2.027	1.00
139_D	343_A	2.015	1.00
134_R	178_T	2.005	1.00
208_E	212_A	1.957	1.00
354_A	358_E	1.955	1.00
351_D	355_A	1.938	1.00
209_R	213_L	1.936	1.00
129_V	332_T	1.914	1.00
245_V	296_V	1.884	1.00
178_T	182_C	1.879	1.00
251_A	288_V	1.879	1.00
139_D	143_A	1.872	1.00
55_D	59_A	1.869	1.00
183_D	187_R	1.853	1.00
136_A	342_V	1.842	1.00
180_R	235_E	1.833	1.00
130_V	243_V	1.810	1.00
38_A	121_A	1.788	1.00
353_E	428_V	1.780	1.00
59_A	63_G	1.770	1.00
41_R	62_L	1.767	1.00
183_D	186_G	1.736	1.00
138_A	175_A	1.725	1.00
220_V	226_A	1.723	1.00
144_E	147_T	1.714	1.00
191_S	211_A	1.711	1.00
247_C	288_V	1.693	1.00
379_T	382_E	1.692	1.00
134_R	171_A	1.675	1.00
177_D	246_T	1.668	1.00
190_E	218_G	1.667	1.00
93_A	97_D	1.640	1.00
45_V	209_R	1.639	1.00
395_A	400_V	1.629	1.00
176_R	225_D	1.611	1.00
349_A	353_E	1.601	1.00
129_V	339_A	1.550	1.00
251_A	338_A	1.527	1.00
236_A	328_V	1.521	1.00
294_D	326_T	1.512	1.00
288_V	338_A	1.505	1.00
58_A	62_L	1.505	1.00
234_L	306_L	1.505	1.00
301_A	319_R	1.491	1.00
241_A	303_A	1.483	1.00
375_L	383_V	1.478	1.00
119_L	324_A	1.474	1.00
379_T	406_A	1.467	1.00
89_A	93_A	1.465	1.00
141_A	171_A	1.464	1.00
140_V	144_E	1.463	1.00
72_G	92_E	1.455	1.00
195_A	226_A	1.444	1.00
37_L	86_I	1.442	1.00
46_M	209_R	1.426	1.00
176_R	231_D	1.426	1.00
230_R	317_L	1.423	1.00
184_A	239_A	1.401	1.00
134_R	174_L	1.395	1.00
186_G	217_D	1.392	1.00
34_E	69_E	1.370	1.00
348_P	351_D	1.353	1.00
179_G	187_R	1.349	1.00
266_S	348_P	1.349	1.00
132_A	343_A	1.342	1.00
285_M	341_V	1.342	1.00
122_D	332_T	1.341	1.00
411_P	414_A	1.337	1.00
256_F	310_P	1.324	1.00
238_S	242_S	1.323	1.00
34_E	38_A	1.315	1.00
133_L	339_A	1.312	1.00
67_D	72_G	1.310	1.00
167_A	170_Y	1.310	1.00
31_R	122_D	1.305	1.00
127_I	185_Y	1.294	1.00
350_D	354_A	1.286	1.00
41_R	45_V	1.285	1.00
250_L	338_A	1.278	1.00
234_L	242_S	1.276	1.00
138_A	142_A	1.265	1.00
15_S	18_P	1.264	1.00
136_A	139_D	1.264	1.00
119_L	236_A	1.262	1.00
36_D	110_E	1.261	1.00
163_V	167_A	1.249	1.00
237_V	324_A	1.242	1.00
401_A	406_A	1.231	1.00
264_E	348_P	1.229	1.00
170_Y	312_A	1.227	1.00
147_T	349_A	1.221	1.00
104_A	206_D	1.219	1.00
237_V	302_L	1.212	1.00
71_A	75_A	1.206	1.00
300_Q	304_T	1.195	1.00
52_V	103_T	1.194	1.00
142_A	145_A	1.193	1.00
44_V	53_I	1.192	1.00
86_I	90_V	1.186	1.00
13_R	271_S	1.176	1.00
59_A	62_L	1.176	1.00
288_V	334_A	1.175	1.00
144_E	349_A	1.174	1.00
60_A	63_G	1.174	1.00
130_V	174_L	1.172	1.00
63_G	97_D	1.169	1.00
295_A	331_V	1.164	1.00
396_T	399_A	1.156	1.00
243_V	331_V	1.155	1.00
243_V	335_V	1.144	1.00
163_V	352_L	1.138	1.00
62_L	66_A	1.137	1.00
366_V	401_A	1.136	1.00
395_A	399_A	1.130	1.00
181_L	243_V	1.126	1.00
302_L	324_A	1.122	1.00
297_G	301_A	1.121	1.00
211_A	217_D	1.119	1.00
129_V	132_A	1.119	1.00
244_A	331_V	1.112	1.00
90_V	101_L	1.110	1.00
60_A	64_A	1.110	1.00
26_M	326_T	1.107	1.00
138_A	171_A	1.107	1.00
133_L	174_L	1.100	1.00
264_E	346_G	1.098	1.00
42_A	213_L	1.098	1.00
137_L	250_L	1.097	1.00
145_A	164_A	1.096	1.00
233_L	324_A	1.095	1.00
149_M	352_L	1.095	1.00
58_A	65_L	1.094	1.00
127_I	131_V	1.091	1.00
254_V	285_M	1.087	1.00
126_A	331_V	1.086	1.00
160_P	356_A	1.086	1.00
292_A	296_V	1.085	1.00
49_E	213_L	1.082	1.00
15_S	19_A	1.081	1.00
237_V	327_A	1.080	1.00
170_Y	250_L	1.078	1.00
39_V	110_E	1.078	1.00
120_R	216_F	1.078	1.00
91_V	98_G	1.076	1.00
296_V	304_T	1.073	1.00
146_E	164_A	1.072	1.00
248_S	289_R	1.070	1.00
168_L	222_N	1.064	1.00
115_I	321_T	1.061	1.00
133_L	342_V	1.060	1.00
131_V	135_S	1.056	1.00
104_A	205_V	1.056	1.00
426_D	429_G	1.056	1.00
89_A	92_E	1.055	1.00
132_A	336_E	1.053	1.00
294_D	322_G	1.050	1.00
398_D	402_A	1.049	1.00
236_A	324_A	1.047	1.00
147_T	352_L	1.046	1.00
390_R	395_A	1.045	1.00
35_A	117_Y	1.041	1.00
79_G	88_T	1.040	1.00
145_A	162_T	1.039	1.00
157_P	260_R	1.037	1.00
375_L	380_A	1.034	1.00
239_A	243_V	1.034	1.00
301_A	323_H	1.033	1.00
179_G	186_G	1.032	1.00
73_F	93_A	1.030	1.00
23_L	287_L	1.030	1.00
140_V	342_V	1.028	1.00
34_E	121_A	1.027	1.00
38_A	213_L	1.017	1.00
115_I	324_A	1.010	1.00
113_A	191_S	1.010	1.00
55_D	58_A	1.009	1.00
66_A	70_A	1.004	1.00
60_A	97_D	1.003	1.00
123_L	185_Y	1.002	1.00
120_R	185_Y	1.000	1.00
30_G	34_E	1.000	1.00
130_V	178_T	0.998	1.00
140_V	167_A	0.998	1.00
263_V	266_S	0.995	1.00
52_V	206_D	0.993	1.00
402_A	422_A	0.987	1.00
123_L	181_L	0.986	1.00
191_S	210_T	0.986	1.00
245_V	306_L	0.984	1.00
263_V	267_D	0.982	1.00
115_I	233_L	0.982	1.00
172_G	176_R	0.979	1.00
196_A	275_I	0.974	1.00
185_Y	189_N	0.969	1.00
120_R	124_L	0.966	1.00
390_R	400_V	0.966	1.00
265_V	345_A	0.965	1.00
161_T	198_F	0.960	1.00
238_S	299_Q	0.960	1.00
64_A	94_V	0.958	1.00
183_D	235_E	0.956	1.00
152_F	157_P	0.954	1.00
179_G	183_D	0.952	1.00
125_D	332_T	0.952	1.00
269_Y	340_G	0.951	1.00
247_C	335_V	0.945	1.00
154_H	286_E	0.944	1.00
189_N	216_F	0.939	1.00
294_D	330_G	0.938	1.00
254_V	345_A	0.936	1.00
390_R	394_G	0.934	1.00
37_L	69_E	0.929	1.00
56_E	59_A	0.929	1.00
151_G	161_T	0.926	1.00
322_G	326_T	0.925	1.00
48_A	59_A	0.922	1.00
412_L	416_V	0.921	1.00
207_R	211_A	0.915	1.00
36_D	39_V	0.914	1.00
31_R	121_A	0.909	1.00
122_D	328_V	0.909	1.00
386_L	400_V	0.908	1.00
37_L	68_V	0.906	1.00
247_C	338_A	0.901	1.00
46_M	50_Q	0.901	1.00
79_G	85_A	0.901	1.00
134_R	138_A	0.899	1.00
39_V	113_A	0.899	1.00
298_A	326_T	0.898	1.00
240_L	331_V	0.897	1.00
161_T	224_A	0.893	1.00
121_A	125_D	0.886	1.00
410_E	414_A	0.884	1.00
73_F	76_L	0.884	1.00
54_G	100_K	0.884	1.00
237_V	299_Q	0.880	1.00
137_L	167_A	0.877	1.00
67_D	73_F	0.873	1.00
400_V	403_A	0.871	1.00
35_A	118_R	0.871	1.00
38_A	210_T	0.869	1.00
147_T	347_W	0.868	1.00
68_V	73_F	0.859	1.00
50_Q	206_D	0.856	1.00
165_H	223_A	0.856	1.00
248_S	307_Q	0.856	1.00
141_A	168_L	0.855	1.00
155_L	256_F	0.848	1.00
30_G	74_D	0.845	1.00
287_L	337_V	0.844	1.00
229_S	246_T	0.843	1.00
172_G	221_A	0.841	1.00
135_S	139_D	0.840	1.00
72_G	76_L	0.836	1.00
261_G	351_D	0.835	1.00
143_A	346_G	0.832	1.00
148_V	356_A	0.827	0.99
171_A	175_A	0.825	0.99
36_D	86_I	0.825	0.99
49_E	55_D	0.821	0.99
22_F	337_V	0.819	0.99
56_E	60_A	0.819	0.99
67_D	89_A	0.818	0.99
137_L	342_V	0.817	0.99
399_A	403_A	0.815	0.99
34_E	74_D	0.815	0.99
299_Q	303_A	0.815	0.99
398_D	413_S	0.812	0.99
136_A	140_V	0.810	0.99
155_L	259_N	0.804	0.99
72_G	75_A	0.802	0.99
207_R	219_V	0.801	0.99
95_G	98_G	0.795	0.99
166_W	257_F	0.794	0.99
228_A	312_A	0.787	0.99
137_L	171_A	0.787	0.99
133_L	335_V	0.786	0.99
43_H	105_R	0.783	0.99
192_P	226_A	0.781	0.99
143_A	349_A	0.779	0.99
41_R	69_E	0.779	0.99
266_S	344_T	0.778	0.99
174_L	335_V	0.775	0.99
152_F	260_R	0.773	0.99
235_E	238_S	0.769	0.99
23_L	315_R	0.765	0.99
193_L	210_T	0.764	0.99
386_L	403_A	0.763	0.99
401_A	407_V	0.762	0.99
16_G	266_S	0.762	0.99
49_E	206_D	0.762	0.99
369_A	415_V	0.758	0.99
45_V	49_E	0.752	0.99
44_V	58_A	0.751	0.99
305_T	319_R	0.750	0.99
123_L	184_A	0.750	0.99
124_L	216_F	0.747	0.99
57_A	97_D	0.746	0.99
60_A	94_V	0.745	0.99
233_L	302_L	0.745	0.99
157_P	359_G	0.743	0.99
294_D	298_A	0.742	0.99
44_V	61_I	0.742	0.99
144_E	347_W	0.740	0.99
357_G	398_D	0.739	0.99
189_N	211_A	0.738	0.99
137_L	174_L	0.737	0.99
97_D	100_K	0.736	0.99
126_A	328_V	0.733	0.99
150_P	361_S	0.732	0.99
293_G	301_A	0.731	0.99
169_S	249_G	0.731	0.99
395_A	406_A	0.728	0.99
341_V	345_A	0.727	0.99
231_D	246_T	0.725	0.99
386_L	389_E	0.724	0.99
186_G	189_N	0.722	0.99
347_W	352_L	0.721	0.99
365_G	430_S	0.721	0.99
191_S	219_V	0.720	0.99
245_V	303_A	0.717	0.99
387_A	412_L	0.715	0.99
382_E	386_L	0.715	0.99
149_M	166_W	0.714	0.99
375_L	379_T	0.714	0.99
218_G	221_A	0.711	0.98
335_V	339_A	0.710	0.98
174_L	177_D	0.709	0.98
45_V	58_A	0.709	0.98
130_V	335_V	0.708	0.98
52_V	104_A	0.707	0.98
180_R	231_D	0.706	0.98
162_T	431_V	0.706	0.98
125_D	129_V	0.705	0.98
50_Q	209_R	0.705	0.98
224_A	312_A	0.704	0.98
190_E	220_V	0.704	0.98
61_I	90_V	0.702	0.98
251_A	285_M	0.702	0.98
296_V	300_Q	0.700	0.98
32_I	111_V	0.698	0.98
300_Q	303_A	0.696	0.98
48_A	53_I	0.695	0.98
150_P	356_A	0.694	0.98
69_E	72_G	0.692	0.98
177_D	242_S	0.691	0.98
53_I	103_T	0.690	0.98
411_P	415_V	0.690	0.98
236_A	240_L	0.688	0.98
225_D	231_D	0.688	0.98
173_T	246_T	0.687	0.98
41_R	213_L	0.685	0.98
144_E	163_V	0.684	0.98
176_R	190_E	0.683	0.98
148_V	431_V	0.683	0.98
234_L	302_L	0.683	0.98
173_T	229_S	0.682	0.98
355_A	358_E	0.681	0.98
350_D	353_E	0.680	0.98
147_T	353_E	0.679	0.98
148_V	427_P	0.678	0.98
296_V	303_A	0.678	0.98
19_A	24_S	0.678	0.98
225_D	246_T	0.677	0.98
210_T	213_L	0.677	0.98
139_D	142_A	0.676	0.98
147_T	162_T	0.675	0.98
28_G	322_G	0.675	0.98
135_S	138_A	0.675	0.98
42_A	45_V	0.674	0.98
207_R	210_T	0.674	0.98
356_A	427_P	0.673	0.98
184_A	188_T	0.673	0.98
131_V	134_R	0.671	0.98
252_A	289_R	0.669	0.98
96_R	99_G	0.669	0.98
68_V	74_D	0.667	0.98
395_A	401_A	0.667	0.98
291_T	330_G	0.664	0.98
375_L	415_V	0.662	0.98
38_A	69_E	0.662	0.98
62_L	65_L	0.662	0.98
120_R	217_D	0.661	0.98
219_V	223_A	0.661	0.98
116_R	232_F	0.661	0.98
64_A	67_D	0.660	0.98
41_R	58_A	0.658	0.97
410_E	413_S	0.658	0.97
167_A	352_L	0.657	0.97
88_T	92_E	0.654	0.97
399_A	402_A	0.653	0.97
27_D	122_D	0.652	0.97
131_V	175_A	0.651	0.97
179_G	182_C	0.650	0.97
390_R	412_L	0.650	0.97
132_A	136_A	0.649	0.97
180_R	187_R	0.647	0.97
261_G	348_P	0.647	0.97
94_V	97_D	0.646	0.97
57_A	60_A	0.645	0.97
369_A	420_A	0.644	0.97
26_M	322_G	0.643	0.97
44_V	101_L	0.642	0.97
118_R	325_W	0.642	0.97
60_A	96_R	0.642	0.97
93_A	96_R	0.641	0.97
66_A	69_E	0.641	0.97
293_G	305_T	0.639	0.97
269_Y	344_T	0.636	0.97
400_V	406_A	0.633	0.97
21_S	24_S	0.631	0.97
337_V	340_G	0.631	0.97
118_R	328_V	0.631	0.97
257_F	311_R	0.631	0.97
161_T	199_A	0.630	0.97
53_I	57_A	0.628	0.97
142_A	146_E	0.628	0.97
180_R	183_D	0.627	0.97
382_E	406_A	0.626	0.97
94_V	101_L	0.624	0.97
69_E	73_F	0.624	0.97
19_A	340_G	0.624	0.97
297_G	300_Q	0.621	0.96
126_A	240_L	0.619	0.96
119_L	328_V	0.618	0.96
288_V	341_V	0.617	0.96
149_M	161_T	0.616	0.96
398_D	422_A	0.614	0.96
410_E	417_E	0.613	0.96
44_V	62_L	0.611	0.96
179_G	190_E	0.611	0.96
129_V	335_V	0.610	0.96
124_L	182_C	0.609	0.96
362_T	430_S	0.609	0.96
24_S	27_D	0.608	0.96
251_A	289_R	0.608	0.96
357_G	396_T	0.607	0.96
71_A	74_D	0.607	0.96
123_L	127_I	0.606	0.96
173_T	228_A	0.604	0.96
356_A	361_S	0.602	0.96
295_A	327_A	0.601	0.96
41_R	65_L	0.599	0.96
241_A	245_V	0.598	0.96
387_A	390_R	0.596	0.95
184_A	236_A	0.595	0.95
61_I	94_V	0.595	0.95
390_R	403_A	0.594	0.95
382_E	389_E	0.594	0.95
323_H	326_T	0.592	0.95
419_A	423_D	0.591	0.95
234_L	238_S	0.591	0.95
423_D	426_D	0.591	0.95
385_A	389_E	0.590	0.95
100_K	103_T	0.589	0.95
301_A	305_T	0.587	0.95
177_D	180_R	0.587	0.95
394_G	402_A	0.587	0.95
293_G	304_T	0.587	0.95
295_A	330_G	0.584	0.95
349_A	352_L	0.581	0.95
123_L	188_T	0.580	0.95
189_N	218_G	0.580	0.95
57_A	61_I	0.579	0.95
250_L	342_V	0.579	0.95
240_L	243_V	0.578	0.95
130_V	181_L	0.578	0.95
324_A	328_V	0.578	0.95
60_A	98_G	0.578	0.95
284_T	341_V	0.577	0.95
121_A	124_L	0.577	0.95
73_F	89_A	0.577	0.95
22_F	336_E	0.576	0.95
22_F	334_A	0.576	0.95
262_F	267_D	0.576	0.95
174_L	247_C	0.576	0.95
138_A	141_A	0.575	0.95
172_G	222_N	0.574	0.94
174_L	243_V	0.574	0.94
254_V	338_A	0.573	0.94
133_L	136_A	0.573	0.94
170_Y	173_T	0.572	0.94
402_A	410_E	0.570	0.94
235_E	242_S	0.569	0.94
39_V	114_C	0.568	0.94
289_R	316_D	0.567	0.94
70_A	73_F	0.567	0.94
166_W	253_D	0.567	0.94
175_A	179_G	0.567	0.94
79_G	84_E	0.566	0.94
141_A	145_A	0.566	0.94
234_L	303_A	0.565	0.94
38_A	42_A	0.564	0.94
181_L	239_A	0.563	0.94
351_D	358_E	0.563	0.94
76_L	92_E	0.562	0.94
127_I	239_A	0.562	0.94
406_A	411_P	0.560	0.94
122_D	125_D	0.559	0.94
48_A	62_L	0.559	0.94
35_A	38_A	0.558	0.94
186_G	190_E	0.558	0.94
172_G	175_A	0.558	0.94
140_V	345_A	0.558	0.94
381_H	385_A	0.557	0.94
326_T	330_G	0.555	0.93
270_A	283_D	0.554	0.93
211_A	216_F	0.554	0.93
423_D	429_G	0.554	0.93
18_P	77_P	0.551	0.93
43_H	210_T	0.551	0.93
248_S	304_T	0.550	0.93
86_I	114_C	0.550	0.93
26_M	31_R	0.549	0.93
124_L	189_N	0.547	0.93
167_A	345_A	0.545	0.93
254_V	342_V	0.545	0.93
39_V	193_L	0.544	0.93
107_R	192_P	0.544	0.93
161_T	165_H	0.543	0.93
154_H	315_R	0.543	0.93
256_F	311_R	0.542	0.93
73_F	85_A	0.541	0.93
12_D	15_S	0.541	0.93
166_W	312_A	0.541	0.93
254_V	265_V	0.539	0.92
288_V	292_A	0.538	0.92
386_L	411_P	0.538	0.92
176_R	235_E	0.537	0.92
193_L	219_V	0.536	0.92
394_G	397_L	0.535	0.92
400_V	407_V	0.535	0.92
184_A	187_R	0.535	0.92
238_S	241_A	0.534	0.92
346_G	349_A	0.533	0.92
65_L	68_V	0.530	0.92
363_A	384_V	0.530	0.92
369_A	411_P	0.529	0.92
256_F	259_N	0.529	0.92
386_L	395_A	0.528	0.92
128_E	132_A	0.528	0.92
48_A	56_E	0.527	0.92
360_F	397_L	0.526	0.92
306_L	317_L	0.525	0.91
252_A	310_P	0.524	0.91
91_V	99_G	0.523	0.91
38_A	214_L	0.522	0.91
378_R	382_E	0.522	0.91
180_R	242_S	0.522	0.91
420_A	423_D	0.522	0.91
37_L	74_D	0.522	0.91
192_P	227_A	0.521	0.91
231_D	235_E	0.521	0.91
147_T	164_A	0.520	0.91
376_P	379_T	0.519	0.91
37_L	65_L	0.518	0.91
208_E	211_A	0.517	0.91
293_G	307_Q	0.517	0.91
242_S	246_T	0.514	0.91
416_V	420_A	0.514	0.91
366_V	421_V	0.513	0.91
407_V	415_V	0.513	0.91
150_P	355_A	0.513	0.91
127_I	130_V	0.512	0.90
248_S	310_P	0.511	0.90
262_F	265_V	0.511	0.90
390_R	406_A	0.510	0.90
186_G	218_G	0.510	0.90
177_D	239_A	0.507	0.90
394_G	400_V	0.505	0.90
362_T	425_L	0.504	0.90
149_M	257_F	0.503	0.90
120_R	215_G	0.500	0.89
240_L	295_A	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e9fA	4	0.9052	100	0.201	Contact Map
1k7wA	4	0.9093	100	0.202	Contact Map
1tj7A	4	0.9155	100	0.211	Contact Map
1re5A	4	0.8825	100	0.26	Contact Map
1c3cA	4	0.8515	100	0.268	Contact Map
1q5nA	4	0.8495	100	0.27	Contact Map
3c8tA	4	0.8495	100	0.275	Contact Map
2pfmA	4	0.868	100	0.28	Contact Map
4eeiA	4	0.8474	100	0.289	Contact Map
1dofA	4	0.7732	100	0.294	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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