GREMLIN Database
ARLY - Argininosuccinate lyase
UniProt: Q9HMQ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (409)
Sequences: 10953 (5558)
Seq/√Len: 274.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A58_A3.8931.00
57_A100_K3.5591.00
41_R66_A3.3591.00
49_E209_R3.3161.00
351_D354_A3.2591.00
45_V62_L3.2161.00
124_L185_Y3.1901.00
298_A327_A2.9361.00
45_V213_L2.9031.00
244_A295_A2.8311.00
131_V178_T2.8301.00
35_A121_A2.8211.00
134_R175_A2.6891.00
136_A343_A2.6461.00
353_E357_G2.6381.00
136_A339_A2.6371.00
123_L236_A2.6301.00
127_I182_C2.6111.00
31_R329_D2.5561.00
291_T334_A2.5351.00
163_V347_W2.4981.00
67_D93_A2.4771.00
129_V336_E2.4241.00
209_R212_A2.3831.00
187_R235_E2.3831.00
140_V143_A2.3321.00
127_I178_T2.3311.00
120_R189_N2.2991.00
241_A299_Q2.2901.00
48_A55_D2.2761.00
132_A339_A2.2651.00
54_G57_A2.2471.00
266_S346_G2.2341.00
146_E349_A2.2051.00
189_N217_D2.1851.00
131_V182_C2.1381.00
386_L390_R2.1371.00
417_E420_A2.1271.00
339_A343_A2.1251.00
395_A403_A2.0691.00
294_D323_H2.0271.00
139_D343_A2.0151.00
134_R178_T2.0051.00
208_E212_A1.9571.00
354_A358_E1.9551.00
351_D355_A1.9381.00
209_R213_L1.9361.00
129_V332_T1.9141.00
245_V296_V1.8841.00
178_T182_C1.8791.00
251_A288_V1.8791.00
139_D143_A1.8721.00
55_D59_A1.8691.00
183_D187_R1.8531.00
136_A342_V1.8421.00
180_R235_E1.8331.00
130_V243_V1.8101.00
38_A121_A1.7881.00
353_E428_V1.7801.00
59_A63_G1.7701.00
41_R62_L1.7671.00
183_D186_G1.7361.00
138_A175_A1.7251.00
220_V226_A1.7231.00
144_E147_T1.7141.00
191_S211_A1.7111.00
247_C288_V1.6931.00
379_T382_E1.6921.00
134_R171_A1.6751.00
177_D246_T1.6681.00
190_E218_G1.6671.00
93_A97_D1.6401.00
45_V209_R1.6391.00
395_A400_V1.6291.00
176_R225_D1.6111.00
349_A353_E1.6011.00
129_V339_A1.5501.00
251_A338_A1.5271.00
236_A328_V1.5211.00
294_D326_T1.5121.00
288_V338_A1.5051.00
58_A62_L1.5051.00
234_L306_L1.5051.00
301_A319_R1.4911.00
241_A303_A1.4831.00
375_L383_V1.4781.00
119_L324_A1.4741.00
379_T406_A1.4671.00
89_A93_A1.4651.00
141_A171_A1.4641.00
140_V144_E1.4631.00
72_G92_E1.4551.00
195_A226_A1.4441.00
37_L86_I1.4421.00
46_M209_R1.4261.00
176_R231_D1.4261.00
230_R317_L1.4231.00
184_A239_A1.4011.00
134_R174_L1.3951.00
186_G217_D1.3921.00
34_E69_E1.3701.00
348_P351_D1.3531.00
179_G187_R1.3491.00
266_S348_P1.3491.00
132_A343_A1.3421.00
285_M341_V1.3421.00
122_D332_T1.3411.00
411_P414_A1.3371.00
256_F310_P1.3241.00
238_S242_S1.3231.00
34_E38_A1.3151.00
133_L339_A1.3121.00
67_D72_G1.3101.00
167_A170_Y1.3101.00
31_R122_D1.3051.00
127_I185_Y1.2941.00
350_D354_A1.2861.00
41_R45_V1.2851.00
250_L338_A1.2781.00
234_L242_S1.2761.00
138_A142_A1.2651.00
15_S18_P1.2641.00
136_A139_D1.2641.00
119_L236_A1.2621.00
36_D110_E1.2611.00
163_V167_A1.2491.00
237_V324_A1.2421.00
401_A406_A1.2311.00
264_E348_P1.2291.00
170_Y312_A1.2271.00
147_T349_A1.2211.00
104_A206_D1.2191.00
237_V302_L1.2121.00
71_A75_A1.2061.00
300_Q304_T1.1951.00
52_V103_T1.1941.00
142_A145_A1.1931.00
44_V53_I1.1921.00
86_I90_V1.1861.00
13_R271_S1.1761.00
59_A62_L1.1761.00
288_V334_A1.1751.00
144_E349_A1.1741.00
60_A63_G1.1741.00
130_V174_L1.1721.00
63_G97_D1.1691.00
295_A331_V1.1641.00
396_T399_A1.1561.00
243_V331_V1.1551.00
243_V335_V1.1441.00
163_V352_L1.1381.00
62_L66_A1.1371.00
366_V401_A1.1361.00
395_A399_A1.1301.00
181_L243_V1.1261.00
302_L324_A1.1221.00
297_G301_A1.1211.00
211_A217_D1.1191.00
129_V132_A1.1191.00
244_A331_V1.1121.00
90_V101_L1.1101.00
60_A64_A1.1101.00
26_M326_T1.1071.00
138_A171_A1.1071.00
133_L174_L1.1001.00
264_E346_G1.0981.00
42_A213_L1.0981.00
137_L250_L1.0971.00
145_A164_A1.0961.00
233_L324_A1.0951.00
149_M352_L1.0951.00
58_A65_L1.0941.00
127_I131_V1.0911.00
254_V285_M1.0871.00
126_A331_V1.0861.00
160_P356_A1.0861.00
292_A296_V1.0851.00
49_E213_L1.0821.00
15_S19_A1.0811.00
237_V327_A1.0801.00
170_Y250_L1.0781.00
39_V110_E1.0781.00
120_R216_F1.0781.00
91_V98_G1.0761.00
296_V304_T1.0731.00
146_E164_A1.0721.00
248_S289_R1.0701.00
168_L222_N1.0641.00
115_I321_T1.0611.00
133_L342_V1.0601.00
131_V135_S1.0561.00
104_A205_V1.0561.00
426_D429_G1.0561.00
89_A92_E1.0551.00
132_A336_E1.0531.00
294_D322_G1.0501.00
398_D402_A1.0491.00
236_A324_A1.0471.00
147_T352_L1.0461.00
390_R395_A1.0451.00
35_A117_Y1.0411.00
79_G88_T1.0401.00
145_A162_T1.0391.00
157_P260_R1.0371.00
375_L380_A1.0341.00
239_A243_V1.0341.00
301_A323_H1.0331.00
179_G186_G1.0321.00
73_F93_A1.0301.00
23_L287_L1.0301.00
140_V342_V1.0281.00
34_E121_A1.0271.00
38_A213_L1.0171.00
115_I324_A1.0101.00
113_A191_S1.0101.00
55_D58_A1.0091.00
66_A70_A1.0041.00
60_A97_D1.0031.00
123_L185_Y1.0021.00
120_R185_Y1.0001.00
30_G34_E1.0001.00
130_V178_T0.9981.00
140_V167_A0.9981.00
263_V266_S0.9951.00
52_V206_D0.9931.00
402_A422_A0.9871.00
123_L181_L0.9861.00
191_S210_T0.9861.00
245_V306_L0.9841.00
263_V267_D0.9821.00
115_I233_L0.9821.00
172_G176_R0.9791.00
196_A275_I0.9741.00
185_Y189_N0.9691.00
120_R124_L0.9661.00
390_R400_V0.9661.00
265_V345_A0.9651.00
161_T198_F0.9601.00
238_S299_Q0.9601.00
64_A94_V0.9581.00
183_D235_E0.9561.00
152_F157_P0.9541.00
179_G183_D0.9521.00
125_D332_T0.9521.00
269_Y340_G0.9511.00
247_C335_V0.9451.00
154_H286_E0.9441.00
189_N216_F0.9391.00
294_D330_G0.9381.00
254_V345_A0.9361.00
390_R394_G0.9341.00
37_L69_E0.9291.00
56_E59_A0.9291.00
151_G161_T0.9261.00
322_G326_T0.9251.00
48_A59_A0.9221.00
412_L416_V0.9211.00
207_R211_A0.9151.00
36_D39_V0.9141.00
31_R121_A0.9091.00
122_D328_V0.9091.00
386_L400_V0.9081.00
37_L68_V0.9061.00
247_C338_A0.9011.00
46_M50_Q0.9011.00
79_G85_A0.9011.00
134_R138_A0.8991.00
39_V113_A0.8991.00
298_A326_T0.8981.00
240_L331_V0.8971.00
161_T224_A0.8931.00
121_A125_D0.8861.00
410_E414_A0.8841.00
73_F76_L0.8841.00
54_G100_K0.8841.00
237_V299_Q0.8801.00
137_L167_A0.8771.00
67_D73_F0.8731.00
400_V403_A0.8711.00
35_A118_R0.8711.00
38_A210_T0.8691.00
147_T347_W0.8681.00
68_V73_F0.8591.00
50_Q206_D0.8561.00
165_H223_A0.8561.00
248_S307_Q0.8561.00
141_A168_L0.8551.00
155_L256_F0.8481.00
30_G74_D0.8451.00
287_L337_V0.8441.00
229_S246_T0.8431.00
172_G221_A0.8411.00
135_S139_D0.8401.00
72_G76_L0.8361.00
261_G351_D0.8351.00
143_A346_G0.8321.00
148_V356_A0.8270.99
171_A175_A0.8250.99
36_D86_I0.8250.99
49_E55_D0.8210.99
22_F337_V0.8190.99
56_E60_A0.8190.99
67_D89_A0.8180.99
137_L342_V0.8170.99
399_A403_A0.8150.99
34_E74_D0.8150.99
299_Q303_A0.8150.99
398_D413_S0.8120.99
136_A140_V0.8100.99
155_L259_N0.8040.99
72_G75_A0.8020.99
207_R219_V0.8010.99
95_G98_G0.7950.99
166_W257_F0.7940.99
228_A312_A0.7870.99
137_L171_A0.7870.99
133_L335_V0.7860.99
43_H105_R0.7830.99
192_P226_A0.7810.99
143_A349_A0.7790.99
41_R69_E0.7790.99
266_S344_T0.7780.99
174_L335_V0.7750.99
152_F260_R0.7730.99
235_E238_S0.7690.99
23_L315_R0.7650.99
193_L210_T0.7640.99
386_L403_A0.7630.99
401_A407_V0.7620.99
16_G266_S0.7620.99
49_E206_D0.7620.99
369_A415_V0.7580.99
45_V49_E0.7520.99
44_V58_A0.7510.99
305_T319_R0.7500.99
123_L184_A0.7500.99
124_L216_F0.7470.99
57_A97_D0.7460.99
60_A94_V0.7450.99
233_L302_L0.7450.99
157_P359_G0.7430.99
294_D298_A0.7420.99
44_V61_I0.7420.99
144_E347_W0.7400.99
357_G398_D0.7390.99
189_N211_A0.7380.99
137_L174_L0.7370.99
97_D100_K0.7360.99
126_A328_V0.7330.99
150_P361_S0.7320.99
293_G301_A0.7310.99
169_S249_G0.7310.99
395_A406_A0.7280.99
341_V345_A0.7270.99
231_D246_T0.7250.99
386_L389_E0.7240.99
186_G189_N0.7220.99
347_W352_L0.7210.99
365_G430_S0.7210.99
191_S219_V0.7200.99
245_V303_A0.7170.99
387_A412_L0.7150.99
382_E386_L0.7150.99
149_M166_W0.7140.99
375_L379_T0.7140.99
218_G221_A0.7110.98
335_V339_A0.7100.98
174_L177_D0.7090.98
45_V58_A0.7090.98
130_V335_V0.7080.98
52_V104_A0.7070.98
180_R231_D0.7060.98
162_T431_V0.7060.98
125_D129_V0.7050.98
50_Q209_R0.7050.98
224_A312_A0.7040.98
190_E220_V0.7040.98
61_I90_V0.7020.98
251_A285_M0.7020.98
296_V300_Q0.7000.98
32_I111_V0.6980.98
300_Q303_A0.6960.98
48_A53_I0.6950.98
150_P356_A0.6940.98
69_E72_G0.6920.98
177_D242_S0.6910.98
53_I103_T0.6900.98
411_P415_V0.6900.98
236_A240_L0.6880.98
225_D231_D0.6880.98
173_T246_T0.6870.98
41_R213_L0.6850.98
144_E163_V0.6840.98
176_R190_E0.6830.98
148_V431_V0.6830.98
234_L302_L0.6830.98
173_T229_S0.6820.98
355_A358_E0.6810.98
350_D353_E0.6800.98
147_T353_E0.6790.98
148_V427_P0.6780.98
296_V303_A0.6780.98
19_A24_S0.6780.98
225_D246_T0.6770.98
210_T213_L0.6770.98
139_D142_A0.6760.98
147_T162_T0.6750.98
28_G322_G0.6750.98
135_S138_A0.6750.98
42_A45_V0.6740.98
207_R210_T0.6740.98
356_A427_P0.6730.98
184_A188_T0.6730.98
131_V134_R0.6710.98
252_A289_R0.6690.98
96_R99_G0.6690.98
68_V74_D0.6670.98
395_A401_A0.6670.98
291_T330_G0.6640.98
375_L415_V0.6620.98
38_A69_E0.6620.98
62_L65_L0.6620.98
120_R217_D0.6610.98
219_V223_A0.6610.98
116_R232_F0.6610.98
64_A67_D0.6600.98
41_R58_A0.6580.97
410_E413_S0.6580.97
167_A352_L0.6570.97
88_T92_E0.6540.97
399_A402_A0.6530.97
27_D122_D0.6520.97
131_V175_A0.6510.97
179_G182_C0.6500.97
390_R412_L0.6500.97
132_A136_A0.6490.97
180_R187_R0.6470.97
261_G348_P0.6470.97
94_V97_D0.6460.97
57_A60_A0.6450.97
369_A420_A0.6440.97
26_M322_G0.6430.97
44_V101_L0.6420.97
118_R325_W0.6420.97
60_A96_R0.6420.97
93_A96_R0.6410.97
66_A69_E0.6410.97
293_G305_T0.6390.97
269_Y344_T0.6360.97
400_V406_A0.6330.97
21_S24_S0.6310.97
337_V340_G0.6310.97
118_R328_V0.6310.97
257_F311_R0.6310.97
161_T199_A0.6300.97
53_I57_A0.6280.97
142_A146_E0.6280.97
180_R183_D0.6270.97
382_E406_A0.6260.97
94_V101_L0.6240.97
69_E73_F0.6240.97
19_A340_G0.6240.97
297_G300_Q0.6210.96
126_A240_L0.6190.96
119_L328_V0.6180.96
288_V341_V0.6170.96
149_M161_T0.6160.96
398_D422_A0.6140.96
410_E417_E0.6130.96
44_V62_L0.6110.96
179_G190_E0.6110.96
129_V335_V0.6100.96
124_L182_C0.6090.96
362_T430_S0.6090.96
24_S27_D0.6080.96
251_A289_R0.6080.96
357_G396_T0.6070.96
71_A74_D0.6070.96
123_L127_I0.6060.96
173_T228_A0.6040.96
356_A361_S0.6020.96
295_A327_A0.6010.96
41_R65_L0.5990.96
241_A245_V0.5980.96
387_A390_R0.5960.95
184_A236_A0.5950.95
61_I94_V0.5950.95
390_R403_A0.5940.95
382_E389_E0.5940.95
323_H326_T0.5920.95
419_A423_D0.5910.95
234_L238_S0.5910.95
423_D426_D0.5910.95
385_A389_E0.5900.95
100_K103_T0.5890.95
301_A305_T0.5870.95
177_D180_R0.5870.95
394_G402_A0.5870.95
293_G304_T0.5870.95
295_A330_G0.5840.95
349_A352_L0.5810.95
123_L188_T0.5800.95
189_N218_G0.5800.95
57_A61_I0.5790.95
250_L342_V0.5790.95
240_L243_V0.5780.95
130_V181_L0.5780.95
324_A328_V0.5780.95
60_A98_G0.5780.95
284_T341_V0.5770.95
121_A124_L0.5770.95
73_F89_A0.5770.95
22_F336_E0.5760.95
22_F334_A0.5760.95
262_F267_D0.5760.95
174_L247_C0.5760.95
138_A141_A0.5750.95
172_G222_N0.5740.94
174_L243_V0.5740.94
254_V338_A0.5730.94
133_L136_A0.5730.94
170_Y173_T0.5720.94
402_A410_E0.5700.94
235_E242_S0.5690.94
39_V114_C0.5680.94
289_R316_D0.5670.94
70_A73_F0.5670.94
166_W253_D0.5670.94
175_A179_G0.5670.94
79_G84_E0.5660.94
141_A145_A0.5660.94
234_L303_A0.5650.94
38_A42_A0.5640.94
181_L239_A0.5630.94
351_D358_E0.5630.94
76_L92_E0.5620.94
127_I239_A0.5620.94
406_A411_P0.5600.94
122_D125_D0.5590.94
48_A62_L0.5590.94
35_A38_A0.5580.94
186_G190_E0.5580.94
172_G175_A0.5580.94
140_V345_A0.5580.94
381_H385_A0.5570.94
326_T330_G0.5550.93
270_A283_D0.5540.93
211_A216_F0.5540.93
423_D429_G0.5540.93
18_P77_P0.5510.93
43_H210_T0.5510.93
248_S304_T0.5500.93
86_I114_C0.5500.93
26_M31_R0.5490.93
124_L189_N0.5470.93
167_A345_A0.5450.93
254_V342_V0.5450.93
39_V193_L0.5440.93
107_R192_P0.5440.93
161_T165_H0.5430.93
154_H315_R0.5430.93
256_F311_R0.5420.93
73_F85_A0.5410.93
12_D15_S0.5410.93
166_W312_A0.5410.93
254_V265_V0.5390.92
288_V292_A0.5380.92
386_L411_P0.5380.92
176_R235_E0.5370.92
193_L219_V0.5360.92
394_G397_L0.5350.92
400_V407_V0.5350.92
184_A187_R0.5350.92
238_S241_A0.5340.92
346_G349_A0.5330.92
65_L68_V0.5300.92
363_A384_V0.5300.92
369_A411_P0.5290.92
256_F259_N0.5290.92
386_L395_A0.5280.92
128_E132_A0.5280.92
48_A56_E0.5270.92
360_F397_L0.5260.92
306_L317_L0.5250.91
252_A310_P0.5240.91
91_V99_G0.5230.91
38_A214_L0.5220.91
378_R382_E0.5220.91
180_R242_S0.5220.91
420_A423_D0.5220.91
37_L74_D0.5220.91
192_P227_A0.5210.91
231_D235_E0.5210.91
147_T164_A0.5200.91
376_P379_T0.5190.91
37_L65_L0.5180.91
208_E211_A0.5170.91
293_G307_Q0.5170.91
242_S246_T0.5140.91
416_V420_A0.5140.91
366_V421_V0.5130.91
407_V415_V0.5130.91
150_P355_A0.5130.91
127_I130_V0.5120.90
248_S310_P0.5110.90
262_F265_V0.5110.90
390_R406_A0.5100.90
186_G218_G0.5100.90
177_D239_A0.5070.90
394_G400_V0.5050.90
362_T425_L0.5040.90
149_M257_F0.5030.90
120_R215_G0.5000.89
240_L295_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e9fA 4 0.9052 100 0.201 Contact Map
1k7wA 4 0.9093 100 0.202 Contact Map
1tj7A 4 0.9155 100 0.211 Contact Map
1re5A 4 0.8825 100 0.26 Contact Map
1c3cA 4 0.8515 100 0.268 Contact Map
1q5nA 4 0.8495 100 0.27 Contact Map
3c8tA 4 0.8495 100 0.275 Contact Map
2pfmA 4 0.868 100 0.28 Contact Map
4eeiA 4 0.8474 100 0.289 Contact Map
1dofA 4 0.7732 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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