GREMLIN Database
ASSY - Argininosuccinate synthase
UniProt: Q9HMQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (384)
Sequences: 2269 (873)
Seq/√Len: 44.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_T223_A5.4521.00
242_A273_T5.3531.00
324_E327_S4.9891.00
60_H108_E3.7071.00
330_S351_H3.7041.00
210_G245_Y3.5281.00
78_R323_D3.4561.00
227_T237_A3.3861.00
76_A92_L3.2071.00
213_D332_T3.2001.00
67_A71_A2.8841.00
67_A230_E2.8831.00
100_A103_S2.8551.00
191_D348_E2.8361.00
38_D66_T2.8141.00
332_T348_E2.8141.00
215_T332_T2.8071.00
237_A240_D2.7941.00
4_G111_A2.7871.00
7_A110_C2.7681.00
210_G244_S2.7601.00
210_G225_D2.7021.00
51_E55_A2.6431.00
106_E135_D2.6121.00
101_I131_W2.6081.00
218_A327_S2.6011.00
206_S336_A2.5151.00
211_T345_I2.5101.00
224_V237_A2.4661.00
113_L131_W2.4651.00
63_V100_A2.4341.00
37_V65_A2.4111.00
278_H326_Q2.4041.00
315_M319_N2.3281.00
154_E158_E2.2701.00
199_Y265_N2.2581.00
25_E159_R2.2261.00
193_Q211_T2.1941.00
301_W319_N2.1791.00
292_D303_Q2.1361.00
257_M309_V2.0750.99
70_A235_I2.0670.99
66_T236_E2.0540.99
45_E48_A2.0440.99
21_P24_K2.0400.99
61_H107_A2.0230.99
33_I60_H1.9760.99
230_E233_A1.9680.99
84_Q255_D1.9580.99
74_F231_P1.9580.99
208_E211_T1.9400.99
196_A204_A1.9270.99
293_F297_V1.9060.99
189_E356_A1.9000.99
215_T330_S1.8720.99
196_A207_G1.8670.99
101_I113_L1.8220.99
214_I221_P1.8160.99
71_A231_P1.7350.98
78_R220_V1.7220.98
334_T346_A1.6960.98
90_T93_A1.6730.97
102_L136_H1.6720.97
4_G137_D1.6690.97
238_L273_T1.6690.97
177_L235_I1.6590.97
229_M237_A1.6350.97
203_D244_S1.6260.97
47_A50_R1.6170.97
72_L311_E1.6160.97
204_A207_G1.6030.97
193_Q336_A1.5680.96
129_A382_G1.5630.96
211_T336_A1.5520.96
217_E222_V1.5390.96
317_A325_T1.5230.96
193_Q345_I1.5200.96
278_H325_T1.5200.96
358_A387_L1.5170.95
45_E175_T1.5120.95
61_H108_E1.5060.95
113_L136_H1.4940.95
184_G361_F1.4840.95
50_R54_A1.4740.95
25_E155_Y1.4690.95
221_P234_L1.4670.95
297_V318_L1.4610.94
217_E228_A1.4500.94
89_G179_S1.4490.94
30_D59_E1.4480.94
67_A232_V1.4460.94
65_A100_A1.4360.94
6_V29_Y1.4310.94
317_A321_Y1.4250.94
202_T249_R1.4190.94
240_D244_S1.4110.93
61_H104_V1.3950.93
281_L333_V1.3950.93
293_F314_L1.3890.93
72_L96_V1.3780.92
191_D334_T1.3590.92
213_D334_T1.3530.92
68_E99_D1.3400.91
47_A51_E1.3390.91
317_A324_E1.3310.91
132_R379_K1.3230.91
300_Q303_Q1.3080.90
205_P338_E1.3070.90
203_D207_G1.3070.90
335_I342_A1.2940.90
98_A130_V1.2910.90
230_E234_L1.2790.89
170_E185_G1.2690.89
45_E49_A1.2640.89
6_V139_C1.2630.89
147_L152_E1.2610.89
132_R386_R1.2530.88
33_I108_E1.2530.88
173_I180_R1.2530.88
214_I274_L1.2400.88
336_A345_I1.2270.87
29_Y111_A1.2160.87
217_E330_S1.2100.87
150_E362_N1.2060.86
369_I374_A1.2060.86
372_A375_T1.2050.86
235_I270_A1.2000.86
100_A104_V1.1950.86
175_T201_W1.1930.86
186_H195_P1.1920.86
285_V329_V1.1900.86
233_A236_E1.1870.85
268_H271_A1.1840.85
229_M234_L1.1770.85
173_I182_V1.1740.85
316_D324_E1.1700.85
237_A241_R1.1650.84
33_I59_E1.1600.84
29_Y112_A1.1600.84
42_P175_T1.1500.84
132_R382_G1.1440.83
68_E100_A1.1440.83
6_V32_V1.1420.83
286_L325_T1.1400.83
360_S364_E1.1370.83
293_F296_A1.1350.83
189_E192_Y1.1250.82
241_R244_S1.1230.82
80_N298_S1.1190.82
212_V238_L1.1120.81
225_D237_A1.1090.81
72_L99_D1.1070.81
178_W271_A1.1030.81
227_T233_A1.1000.81
79_A322_L1.0990.81
38_D42_P1.0940.80
381_H384_Q1.0900.80
169_G185_G1.0770.79
321_Y325_T1.0760.79
80_N275_L1.0700.79
222_V228_A1.0630.78
249_R347_R1.0610.78
102_L131_W1.0600.78
373_D379_K1.0570.78
214_I234_L1.0550.78
238_L270_A1.0530.78
182_V198_I1.0500.78
247_V272_T1.0500.78
374_A378_A1.0470.77
203_D246_G1.0460.77
223_A228_A1.0320.76
196_A249_R1.0310.76
71_A220_V1.0280.76
296_A300_Q1.0250.76
334_T348_E1.0220.76
297_V322_L1.0140.75
74_F220_V1.0090.75
201_W243_G1.0080.75
320_G324_E1.0050.74
194_P346_A1.0020.74
322_L325_T1.0020.74
70_A73_C1.0000.74
171_W197_D0.9970.74
166_G185_G0.9910.73
199_Y249_R0.9900.73
74_F77_V0.9880.73
295_A299_Q0.9860.73
245_Y339_G0.9850.73
63_V107_A0.9820.73
364_E371_Q0.9820.73
69_F73_C0.9770.72
80_N278_H0.9760.72
20_V34_G0.9720.72
70_A231_P0.9700.72
104_V108_E0.9690.72
290_E325_T0.9650.71
215_T228_A0.9650.71
87_P264_E0.9570.71
322_L326_Q0.9510.70
132_R138_V0.9450.70
370_E375_T0.9440.70
286_L294_T0.9400.69
175_T200_A0.9380.69
18_V156_A0.9380.69
153_I165_A0.9340.69
213_D226_G0.9330.69
224_V238_L0.9330.69
255_D292_D0.9290.68
42_P45_E0.9240.68
90_T181_S0.9220.68
177_L232_V0.9210.68
215_T222_V0.9150.67
223_A332_T0.9110.67
205_P245_Y0.9100.67
187_L190_P0.9100.67
77_V274_L0.9090.67
280_A283_G0.9080.67
206_S338_E0.9020.66
37_V97_I0.9010.66
212_V224_V0.9000.66
51_E54_A0.8990.66
221_P274_L0.8980.66
280_A344_P0.8960.66
156_A163_V0.8940.65
70_A74_F0.8890.65
85_G295_A0.8880.65
328_A351_H0.8870.65
165_A185_G0.8810.64
166_G169_G0.8800.64
369_I373_D0.8790.64
224_V229_M0.8790.64
314_L321_Y0.8760.64
268_H272_T0.8760.64
154_E157_A0.8750.64
303_Q307_E0.8730.64
326_Q329_V0.8720.63
365_T368_G0.8700.63
173_I200_A0.8680.63
245_Y338_E0.8670.63
301_W315_M0.8660.63
71_A74_F0.8650.63
52_T161_L0.8650.63
6_V30_D0.8640.63
125_L258_L0.8560.62
294_T298_S0.8530.62
288_K307_E0.8500.61
280_A347_R0.8490.61
186_H197_D0.8480.61
154_E167_N0.8450.61
35_V65_A0.8420.61
281_L330_S0.8420.61
215_T224_V0.8330.60
10_F20_V0.8320.60
338_E341_R0.8210.59
98_A113_L0.8140.58
276_A342_A0.8140.58
36_T49_A0.8100.58
5_T30_D0.8030.57
273_T335_I0.8000.57
277_A335_I0.7980.57
19_C22_L0.7970.56
180_R264_E0.7920.56
190_P333_V0.7910.56
55_A162_P0.7910.56
148_T364_E0.7880.56
74_F234_L0.7860.55
282_E294_T0.7850.55
319_N323_D0.7800.55
50_R60_H0.7790.55
85_G279_K0.7790.55
212_V241_R0.7790.55
312_H385_S0.7770.55
278_H329_V0.7760.54
35_V63_V0.7730.54
29_Y32_V0.7720.54
260_L369_I0.7700.54
4_G29_Y0.7650.53
34_G58_V0.7640.53
37_V63_V0.7630.53
214_I276_A0.7630.53
48_A51_E0.7620.53
216_F274_L0.7600.53
157_A160_D0.7590.53
225_D244_S0.7580.53
87_P179_S0.7560.53
89_G93_A0.7530.52
275_L279_K0.7450.51
82_T87_P0.7440.51
255_D291_R0.7440.51
260_L358_A0.7400.51
195_P198_I0.7390.51
179_S361_F0.7370.51
21_P25_E0.7360.51
142_V264_E0.7340.50
170_E173_I0.7330.50
164_E167_N0.7320.50
214_I224_V0.7320.50
25_E158_E0.7320.50
82_T275_L0.7320.50
364_E368_G0.7310.50
182_V264_E0.7270.50
21_P161_L0.7270.50
244_S273_T0.7260.50
20_V160_D0.7260.50
132_R136_H0.7250.50
209_T245_Y0.7240.49
109_G160_D0.7210.49
21_P56_L0.7180.49
270_A273_T0.7180.49
147_L151_W0.7140.48
35_V101_I0.7130.48
292_D300_Q0.7120.48
150_E154_E0.7110.48
174_D183_E0.7090.48
140_A143_R0.7090.48
247_V337_F0.7040.48
349_S352_A0.7040.48
330_S350_E0.7040.48
77_V231_P0.7040.48
242_A247_V0.7020.47
4_G112_A0.6970.47
239_N270_A0.6960.47
102_L113_L0.6950.47
314_L384_Q0.6920.46
60_H104_V0.6900.46
72_L310_V0.6900.46
17_T52_T0.6890.46
128_E138_V0.6890.46
344_P347_R0.6880.46
73_C235_I0.6870.46
78_R319_N0.6870.46
314_L381_H0.6860.46
290_E317_A0.6850.46
304_K318_L0.6840.46
342_A345_I0.6840.46
157_A167_N0.6830.45
224_V234_L0.6820.45
198_I252_M0.6810.45
282_E329_V0.6810.45
54_A227_T0.6800.45
24_K59_E0.6790.45
213_D348_E0.6780.45
176_N183_E0.6780.45
27_Y144_E0.6760.45
20_V24_K0.6760.45
170_E186_H0.6730.45
328_A391_A0.6700.44
74_F78_R0.6690.44
21_P26_E0.6690.44
54_A58_V0.6680.44
99_D103_S0.6680.44
203_D243_G0.6680.44
360_S371_Q0.6670.44
75_D319_N0.6670.44
73_C178_W0.6660.44
53_A57_G0.6660.44
35_V100_A0.6660.44
7_A33_I0.6650.44
276_A344_P0.6610.43
129_A257_M0.6600.43
87_P142_V0.6590.43
379_K386_R0.6590.43
361_F371_Q0.6560.43
257_M307_E0.6550.43
9_A101_I0.6550.43
233_A237_A0.6540.43
257_M381_H0.6530.43
247_V335_I0.6520.43
210_G241_R0.6520.43
76_A305_A0.6520.43
42_P46_F0.6520.43
208_E245_Y0.6510.42
76_A301_W0.6510.42
151_W363_T0.6500.42
71_A232_V0.6490.42
358_A364_E0.6480.42
130_V311_E0.6480.42
178_W235_I0.6480.42
245_Y341_R0.6480.42
203_D338_E0.6470.42
77_V178_W0.6460.42
87_P272_T0.6440.42
333_V349_S0.6410.41
254_E266_Y0.6410.41
46_F62_V0.6390.41
212_V337_F0.6380.41
258_L369_I0.6370.41
214_I238_L0.6340.41
239_N269_P0.6320.41
43_D47_A0.6310.41
284_L352_A0.6310.41
153_I163_V0.6310.41
287_T290_E0.6300.40
106_E138_V0.6300.40
93_A268_H0.6280.40
93_A179_S0.6280.40
183_E187_L0.6260.40
233_A240_D0.6240.40
242_A337_F0.6220.40
384_Q387_L0.6210.40
266_Y306_Y0.6200.40
211_T334_T0.6200.40
160_D165_A0.6200.40
142_V179_S0.6190.39
103_S107_A0.6190.39
102_L150_E0.6180.39
258_L359_A0.6170.39
46_F175_T0.6140.39
11_S14_L0.6130.39
153_I170_E0.6130.39
153_I164_E0.6130.39
30_D111_A0.6120.39
156_A159_R0.6120.39
228_A237_A0.6100.39
19_C287_T0.6100.39
96_V100_A0.6100.39
178_W270_A0.6080.38
206_S211_T0.6060.38
169_G294_T0.6040.38
264_E361_F0.6030.38
250_T270_A0.6020.38
125_L377_V0.6010.38
305_A310_V0.6010.38
18_V152_E0.6010.38
56_L59_E0.5990.38
294_T325_T0.5990.38
65_A113_L0.5960.37
309_V381_H0.5950.37
135_D197_D0.5950.37
5_T59_E0.5940.37
213_D345_I0.5940.37
156_A166_G0.5940.37
88_L91_A0.5930.37
81_A301_W0.5920.37
179_S264_E0.5920.37
128_E143_R0.5910.37
285_V328_A0.5890.37
173_I198_I0.5890.37
106_E341_R0.5880.37
5_T109_G0.5870.37
358_A371_Q0.5870.37
276_A279_K0.5870.37
50_R62_V0.5870.37
279_K295_A0.5840.36
304_K315_M0.5840.36
148_T264_E0.5840.36
52_T163_V0.5820.36
45_E50_R0.5800.36
212_V247_V0.5780.36
11_S15_D0.5770.36
253_L284_L0.5750.35
247_V273_T0.5730.35
203_D245_Y0.5710.35
225_D380_Y0.5710.35
23_L142_V0.5700.35
34_G54_A0.5700.35
82_T279_K0.5700.35
241_R245_Y0.5700.35
328_A388_A0.5680.35
198_I346_A0.5650.35
182_V252_M0.5640.34
223_A229_M0.5640.34
198_I391_A0.5640.34
93_A181_S0.5640.34
8_L16_T0.5630.34
272_T342_A0.5630.34
168_E197_D0.5630.34
247_V341_R0.5620.34
5_T33_I0.5620.34
176_N188_E0.5610.34
6_V28_G0.5600.34
291_R303_Q0.5590.34
286_L291_R0.5590.34
355_S358_A0.5570.34
302_A337_F0.5550.34
66_T100_A0.5550.34
175_T199_Y0.5540.34
98_A131_W0.5530.34
12_G15_D0.5520.33
174_D254_E0.5510.33
287_T355_S0.5510.33
33_I61_H0.5510.33
278_H282_E0.5490.33
156_A162_P0.5490.33
216_F221_P0.5480.33
321_Y382_G0.5480.33
90_T264_E0.5480.33
148_T362_N0.5470.33
123_D306_Y0.5460.33
193_Q346_A0.5450.33
375_T379_K0.5450.33
107_A111_A0.5450.33
49_A62_V0.5440.33
205_P340_G0.5430.33
293_F300_Q0.5430.33
250_T262_V0.5430.33
216_F277_A0.5430.33
65_A96_V0.5410.32
196_A199_Y0.5390.32
152_E178_W0.5380.32
184_G373_D0.5370.32
335_I346_A0.5360.32
386_R390_A0.5360.32
183_E188_E0.5350.32
191_D380_Y0.5350.32
128_E252_M0.5320.32
183_E254_E0.5310.32
220_V350_E0.5300.32
69_F92_L0.5300.32
218_A227_T0.5300.32
218_A351_H0.5290.31
87_P361_F0.5290.31
309_V385_S0.5290.31
80_N326_Q0.5280.31
148_T361_F0.5280.31
89_G272_T0.5270.31
77_V191_D0.5270.31
42_P48_A0.5270.31
289_A309_V0.5270.31
212_V342_A0.5260.31
275_L294_T0.5260.31
163_V166_G0.5260.31
116_G123_D0.5250.31
165_A170_E0.5240.31
291_R295_A0.5230.31
4_G28_G0.5230.31
187_L251_D0.5230.31
207_G244_S0.5230.31
35_V131_W0.5220.31
153_I265_N0.5220.31
210_G240_D0.5210.31
144_E360_S0.5210.31
142_V145_L0.5200.31
81_A305_A0.5200.31
290_E321_Y0.5200.31
290_E384_Q0.5190.31
207_G210_G0.5190.31
293_F309_V0.5180.31
370_E379_K0.5170.30
212_V345_I0.5170.30
148_T371_Q0.5170.30
121_G124_Q0.5170.30
36_T252_M0.5160.30
309_V384_Q0.5160.30
28_G320_G0.5160.30
130_V133_A0.5150.30
41_Q252_M0.5150.30
187_L354_Y0.5140.30
214_I277_A0.5140.30
180_R200_A0.5130.30
185_G199_Y0.5130.30
125_L378_A0.5120.30
151_W304_K0.5120.30
86_Y121_G0.5100.30
35_V113_L0.5100.30
328_A350_E0.5100.30
46_F49_A0.5100.30
93_A231_P0.5100.30
80_N322_L0.5090.30
58_V125_L0.5090.30
356_A362_N0.5090.30
240_D348_E0.5080.30
87_P182_V0.5080.30
177_L234_L0.5070.30
206_S297_V0.5070.30
34_G62_V0.5060.30
234_L274_L0.5060.30
10_F52_T0.5050.30
123_D143_R0.5040.29
20_V25_E0.5020.29
7_A113_L0.5020.29
66_T70_A0.5020.29
240_D243_G0.5000.29
33_I110_C0.5000.29
275_L298_S0.5000.29
39_V96_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl2A 4 0.9621 100 0.235 Contact Map
2nz2A 4 0.9697 100 0.256 Contact Map
4xfjA 4 0.9823 100 0.276 Contact Map
1k92A 4 0.9924 100 0.277 Contact Map
1korA 4 0.952 100 0.291 Contact Map
4nzpA 4 0.9394 100 0.303 Contact Map
2hmaA 2 0.8182 100 0.83 Contact Map
3rjzA 2 0.5101 99.9 0.864 Contact Map
2derA 1 0.803 99.8 0.872 Contact Map
3k32A 2 0.4798 99.7 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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