GREMLIN Database
DPS - DNA protection during starvation protein
UniProt: Q9HMP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (151)
Sequences: 2922 (1688)
Seq/√Len: 137.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_D117_T3.4191.00
31_V90_G2.9721.00
150_H154_E2.8201.00
141_E149_A2.6371.00
51_H121_N2.5821.00
47_Q125_I2.5661.00
61_R65_L2.4161.00
97_E101_A2.3891.00
40_N104_S2.3551.00
48_L74_A2.2851.00
150_H153_R2.2721.00
137_T153_R2.0431.00
93_H102_E2.0381.00
140_A149_A1.9181.00
68_G72_E1.8491.00
149_A153_R1.7991.00
42_Y99_L1.7851.00
147_A156_L1.7771.00
63_L67_L1.7081.00
73_T162_D1.6731.00
51_H118_S1.6581.00
46_H96_P1.6531.00
35_N93_H1.6311.00
84_R145_D1.6131.00
141_E146_H1.6081.00
138_E142_N1.5701.00
138_E144_G1.5521.00
123_M163_A1.5491.00
127_G167_E1.5371.00
33_A136_H1.5361.00
127_G131_E1.5241.00
146_H149_A1.5131.00
66_F69_E1.5081.00
41_V81_L1.4611.00
23_D26_R1.4581.00
120_A124_A1.4561.00
130_I163_A1.4551.00
66_F70_A1.4271.00
73_T158_E1.4191.00
134_R160_E1.4141.00
43_V100_Q1.3701.00
68_G71_A1.3681.00
29_Q32_D1.3501.00
73_T77_V1.3471.00
84_R148_T1.3421.00
130_I160_E1.3311.00
70_A126_Y1.3141.00
50_K94_A1.3131.00
40_N132_A1.3101.00
77_V155_G1.2861.00
163_A167_E1.2851.00
80_E151_M1.2681.00
51_H108_E1.2351.00
41_V74_A1.2151.00
48_L70_A1.2131.00
116_R120_A1.1991.00
136_H152_L1.1911.00
145_D148_T1.1861.00
137_T149_A1.1861.00
130_I156_L1.1841.00
131_E135_E1.1780.99
39_A102_E1.1720.99
43_V103_A1.1580.99
28_E32_D1.1560.99
77_V158_E1.1470.99
117_T120_A1.1460.99
30_C143_L1.1340.99
127_G163_A1.1250.99
119_L166_I1.0820.99
61_R69_E1.0790.99
45_Y75_E1.0490.99
126_Y162_D1.0430.99
33_A139_L1.0400.99
158_E161_D1.0390.99
84_R160_E1.0380.99
134_R156_L1.0350.99
37_D136_H1.0330.99
61_R66_F1.0190.99
42_Y78_A1.0150.98
49_K78_A1.0140.98
108_E118_S1.0100.98
67_L118_S1.0080.98
123_M167_E1.0050.98
147_A157_I1.0020.98
36_A132_A0.9990.98
35_N85_V0.9700.98
38_L81_L0.9690.98
89_G167_E0.9670.98
43_V96_P0.9660.98
140_A148_T0.9640.98
104_S128_D0.9610.98
88_L148_T0.9540.98
37_D133_T0.9500.98
137_T156_L0.9460.98
75_E78_A0.9420.98
22_M27_A0.9330.97
24_A27_A0.9300.97
36_A104_S0.9220.97
124_A127_G0.9140.97
104_S132_A0.9090.97
40_N103_A0.9040.97
51_H109_D0.8980.97
137_T146_H0.8980.97
30_C140_A0.8860.96
72_E76_E0.8790.96
26_R142_N0.8770.96
146_H153_R0.8770.96
64_H83_E0.8690.96
24_A28_E0.8620.96
31_V85_V0.8580.96
62_D169_Y0.8500.95
98_T110_E0.8500.95
22_M134_R0.8350.95
98_T101_A0.8310.95
126_Y159_L0.8240.95
138_E146_H0.8180.94
33_A135_E0.8140.94
161_D164_H0.7900.93
130_I159_L0.7840.93
37_D132_A0.7830.93
120_A170_L0.7760.93
117_T121_N0.7750.93
49_K71_A0.7740.93
123_M127_G0.7700.92
76_E80_E0.7630.92
56_E171_E0.7560.92
66_F165_H0.7540.92
25_D28_E0.7520.92
65_L69_E0.7490.91
122_D126_Y0.7470.91
46_H94_A0.7450.91
22_M26_R0.7450.91
98_T102_E0.7320.90
67_L119_L0.7290.90
61_R169_Y0.7260.90
54_N92_P0.7230.90
80_E154_E0.7210.90
49_K165_H0.7190.90
154_E157_I0.7180.90
62_D65_L0.7180.90
59_E115_I0.7140.89
60_F83_E0.7140.89
59_E116_R0.7110.89
132_A135_E0.7070.89
52_H64_H0.7060.89
140_A152_L0.7050.89
133_T152_L0.6980.88
38_L41_V0.6960.88
133_T159_L0.6950.88
158_E162_D0.6900.88
55_V118_S0.6880.87
119_L169_Y0.6820.87
45_Y81_L0.6810.87
40_N128_D0.6810.87
133_T155_G0.6810.87
52_H83_E0.6800.87
105_V132_A0.6800.87
35_N39_A0.6760.87
58_A116_R0.6710.86
59_E169_Y0.6710.86
29_Q139_L0.6700.86
29_Q142_N0.6550.85
49_K68_G0.6500.84
41_V77_V0.6480.84
54_N94_A0.6480.84
93_H98_T0.6460.84
33_A140_A0.6460.84
106_D124_A0.6420.84
87_A161_D0.6380.83
56_E168_H0.6380.83
38_L78_A0.6300.83
46_H99_L0.6300.83
33_A36_A0.6270.82
96_P100_Q0.6260.82
135_E139_L0.6250.82
116_R119_L0.6110.81
91_V112_V0.6110.81
70_A166_I0.6090.80
126_Y166_I0.6090.80
123_M170_L0.6070.80
44_L48_L0.6070.80
68_G75_E0.6060.80
85_V90_G0.6040.80
130_I134_R0.6040.80
30_C139_L0.6040.80
147_A160_E0.6030.80
32_D36_A0.5950.79
135_E138_E0.5920.78
108_E111_D0.5890.78
97_E108_E0.5880.78
52_H60_F0.5860.78
60_F64_H0.5770.77
45_Y78_A0.5740.76
130_I147_A0.5740.76
55_V67_L0.5730.76
20_L24_A0.5730.76
109_D121_N0.5730.76
69_E72_E0.5670.75
80_E157_I0.5650.75
84_R88_L0.5630.75
105_V125_I0.5610.75
35_N92_P0.5550.74
63_L119_L0.5490.73
37_D40_N0.5380.72
71_A82_A0.5370.71
145_D160_E0.5370.71
47_Q109_D0.5350.71
165_H168_H0.5330.71
70_A74_A0.5310.71
138_E141_E0.5310.71
37_D152_L0.5290.70
47_Q105_V0.5280.70
156_L160_E0.5260.70
56_E86_Q0.5250.70
137_T140_A0.5200.69
60_F165_H0.5190.69
150_H157_I0.5170.69
36_A102_E0.5170.69
95_S98_T0.5130.68
71_A165_H0.5100.68
33_A132_A0.5100.68
26_R30_C0.5070.67
70_A122_D0.5070.67
63_L118_S0.5050.67
153_R156_L0.5050.67
139_L142_N0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zs3A 6 0.9286 100 0.319 Contact Map
1zujA 6 0.9121 100 0.323 Contact Map
3ak8A 6 0.8516 100 0.324 Contact Map
1tjoA 6 0.9835 100 0.335 Contact Map
2c2uA 6 0.956 100 0.348 Contact Map
4cybA 6 0.9396 100 0.35 Contact Map
2c2jA 6 0.8681 100 0.353 Contact Map
2wluA 6 0.9066 100 0.381 Contact Map
4a25A 8 0.9286 100 0.384 Contact Map
2vxxA 6 0.9505 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.